Any feedback?
Literature summary for 3.4.21.21 extracted from
- Alteration of the substrate and inhibitor specificities of blood coagulation factor VIIa: importance of amino acid residue K (1995), Biochemistry, 34, 8701-8707.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| K192E | completely ineffective mutant enzyme | Homo sapiens |
| K192Q | mutant has 44% of the activity compared to the wild-type enzyme | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Bovine pancreatic trypsin inhibitor | mutant enzyme K192E is poorly inhibited, mutant enzyme K192Q is inhibited more than the wild-type enzyme | Homo sapiens | |
| tissue factor pathway inhibitor | no inhibition of the mutant enzymes K192E and K192Q | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| chromozym t-PA + H2O | - |
Homo sapiens | ? | - |
? |  |
| D-cyclohexylglycyl-L-2-aminobutyryl-L-arginyl-4-nitroanilide + H2O | - |
Homo sapiens | D-cyclohexylglycyl-L-2-aminobutyryl-L-arginine + 4-nitroaniline | - |
? | |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | turnover-number of wild-type and mutant enzymes | Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
