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Literature summary for 3.4.21.21 extracted from

  • Franchini, M.; Manzato, F.; Salvagno, G.L.; Lippi, G.
    Potential role of recombinant activated factor VII for the treatment of severe bleeding associated with disseminated intravascular coagulation: a systematic review (2007), Blood Coagul. Fibrinolysis, 18, 589-593.
    View publication on PubMed

Application

Application Comment Organism
medicine the recombinant enzyme is useful as hemostatic agent in the treatment of hemorrhage in hemophiliacs with inhibitors, and in use as hemostatic agent in severe bleeding unresponsive to standard treatment, associated with disseminated intravascular coagulation, clinical trials, mode of action, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
thrombinogen + H2O Homo sapiens
-
thrombin + ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification factor VII is activated by thrombin Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
thrombinogen + H2O
-
Homo sapiens thrombin + ?
-
?

Synonyms

Synonyms Comment Organism
activated factor VII
-
Homo sapiens
FVIIa
-
Homo sapiens