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Literature summary for 3.4.21.21 extracted from

  • Parlow, J.J.; Kurumbail, R.G.; Stegeman, R.A.; Stevens, A.M.; Stallings, W.C.; South, M.S.
    Design, Synthesis, and crystal structure of selective 2-pyridone tissue factor VIIa inhibitors (2003), J. Med. Chem., 46, 4696-4701.
    View publication on PubMed
Search for more literature for 3.4.21.21

Inhibitors

Inhibitors Comment Organism Structure
3-amino-5-(1-(1-((4-(amino(imino)methyl)benzyl)-amino)-2-oxoethyl)-5-(isopropylamino)-6-oxo-1,6-dihydropyridin-2-yl)benzoic acid IC50: 118 nM Homo sapiens
N-(4-(amino(imino)methyl)benzyl)-2-(6-(3,5-diaminophenyl)-3-(isopropylamino)-2-oxopyridin-1(2H)-yl)acetamide IC50: 52 nM Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-methylsulfonyl-D-Phe-Gly-Arg-p-nitroanilide + H2O
-
 Homo sapiens N-methylsulfonyl-D-Phe-Gly-Arg + p-nitroaniline
-
 ?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000052
-
 IC50: 52 nM Homo sapiens N-(4-(amino(imino)methyl)benzyl)-2-(6-(3,5-diaminophenyl)-3-(isopropylamino)-2-oxopyridin-1(2H)-yl)acetamide
0.000118
-
 IC50: 118 nM Homo sapiens 3-amino-5-(1-(1-((4-(amino(imino)methyl)benzyl)-amino)-2-oxoethyl)-5-(isopropylamino)-6-oxo-1,6-dihydropyridin-2-yl)benzoic acid