Activating Compound | Comment | Organism | Structure |
---|---|---|---|
tissue factor | the enzyme initiates blood clotting after interacting with its cofactor tissue factor. Soluble tissue factor concentrations of 5.0 nM and 22.4 nM for the activated wild-type factor VII and for the mutant form A294V of the activated wild-type factor yield an activity of 50% towards spectrozyme fVIIa | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
A294V | mutant enzyme shows delayed activation by activated factor X as well as reduced activity towards peptidyl and macromolecular substrates without impairing the catalytic efficiency of the triad | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | the KM-value for spectrozyme fVIIa for the mutant enzyme A294V is above 2.5 mM | Homo sapiens | |
0.67 | - |
spectrozyme fVIIa | wild-type enzyme | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
factor X + H2O | Homo sapiens | the enzyme initiates blood clotting after interacting with its cofactor tissue factor. The product of the reaction, activated factor X, is also the most efficient activator of zymogen factor VII | activated factor X + ? | - |
? | |
spectrozyme fVIIa + H2O | Homo sapiens | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | the product of the reaction with factor X, the activated factor X is also the most efficient activator of zymogen factor VII | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood plasma | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
factor X + H2O | the enzyme initiates blood clotting after interacting with its cofactor tissue factor. The product of the reaction, activated factor X, is also the most efficient activator of zymogen factor VII | Homo sapiens | activated factor X + ? | - |
? | |
spectrozyme fVIIa + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
FVIIa | - |
Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
16 | - |
spectrozyme fVIIa | mutant enzyme A294V | Homo sapiens | |
17 | - |
spectrozyme fVIIa | wild-type enzyme | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
vitamin K | dependent on | Homo sapiens |