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Information on EC 2.7.6.3 - 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase

for references in articles please use BRENDA:EC2.7.6.3
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IUBMB Comments
Binds 2 Mg2+ ions that are essential for activity . The enzyme participates in the biosynthetic pathways for folate (in bacteria, plants and fungi) and methanopterin (in archaea). The enzyme exists in varying types of multifunctional proteins in different organisms. The enzyme from the bacterium Streptococcus pneumoniae also harbours the activity of EC 4.1.2.25, dihydroneopterin aldolase , the enzyme from the plant Arabidopsis thaliana harbours the activity of EC 2.5.1.15, dihydropteroate synthase , while the enzyme from yeast Saccharomyces cerevisiae is trifunctional with both of the two above mentioned activities .
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Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase (hppk), 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, cythppk/dhps, fthppk-dhps, hppk/dhps, 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, hydroxymethyldihydropterin pyrophosphokinase (hppk), 7,8-dihydroxymethylpterin-pyrophosphokinase, mithppk/dhps, hydroxymethyldihydropteridine pyrophosphokinase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + 6-hydroxymethyl-7,8-dihydropterin = AMP + 6-hydroxymethyl-7,8-dihydropterin diphosphate
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