Inhibitors | Comment | Organism | Structure |
---|---|---|---|
alpha,beta-methyleneadenosine triphosphate | competitive with respect to ATP | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 6-hydroxymethyl-7,8-dihydropteridine | Escherichia coli | the product 6-hydroxymethyl-7,8-dihydropterin diphosphate is an intermediate in the pathway for folic acid biosynthesis | AMP + 6-hydroxymethyl-7,8-dihydropteridine diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | P26281 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 6-hydroxymethyl-7,8-dihydropteridine | enzyme binds ATP first, followed by 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine | Escherichia coli | AMP + 6-hydroxymethyl-7,8-dihydropteridine diphosphate | - |
? | |
ATP + 6-hydroxymethyl-7,8-dihydropteridine | the product 6-hydroxymethyl-7,8-dihydropterin diphosphate is an intermediate in the pathway for folic acid biosynthesis | Escherichia coli | AMP + 6-hydroxymethyl-7,8-dihydropteridine diphosphate | - |
? | |
additional information | binding affinity for GTP and GMP, 75fold weaker than for ATP | Escherichia coli | ? | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00031 | - |
alpha,beta-methyleneadenosine triphosphate | - |
Escherichia coli |