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Literature summary for 2.7.6.3 extracted from
- Biosynthesis of folic acid compounds in plasmodia. Purification and properties of the 7,8-dihydropteroate-synthesizing enzyme from Plasmodium chabaudi (1974), Hoppe-Seyler's Z. Physiol. Chem., 355, 431-437.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-Amino-4-hydroxy-6-carboxydihydropteridine | competitive with 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine | Plasmodium chabaudi |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.01 | - |
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine | pH 8.5, 37°C | Plasmodium chabaudi | |
| 0.011 | - |
ATP | pH 8.5, 37°C | Plasmodium chabaudi | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 190000 | - |
gel filtration | Plasmodium chabaudi |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Plasmodium chabaudi | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Plasmodium chabaudi |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Plasmodium chabaudi |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine | - |
Plasmodium chabaudi | AMP + 2-amino-7,8-dihydro-4-hydroxy-6-(diphosphooxymethyl)pteridine | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 7,8-dihydropteroate-synthesizing enzyme | it is not possible to distinguish, whether the enzyme exists as an enzyme complex of 6-hydroxymethyl-7,8-dihydroxypterin pyrophosphokinase and 7,8-dihydropteroate synthase or whether both reactions are catalyzed by a single enzyme | Plasmodium chabaudi |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.7 | - |
- |
Plasmodium chabaudi |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.043 | - |
2-Amino-4-hydroxy-6-carboxydihydropteridine | pH 8.5, 37°C | Plasmodium chabaudi | |
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