Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.6.3 extracted from

  • Shi, G.; Shaw, G.; Liang, Y.H.; Subburaman, P.; Li, Y.; Wu, Y.; Yan, H.; Ji, X.
    Bisubstrate analogue inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: New design with improved properties (2012), Bioorg. Med. Chem., 20, 47-57.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

Crystallization (Comment) Organism
in complex with 2-amino-6-[(2-{4-[5-(6-amino-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-ylmethylsulfanyl]-piperidin-1-yl}-ethylamino)-methyl]-3H-pteridin-4-one, 2-amino-6-[(2-{4-[5-(6-amino-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-ylmethylsulfanyl]-piperidin-1-yl}-ethylamino)-methyl]-7,7-dimethyl-7,8-dihydro-3H pteridin-4-one, or 2-amino-7,7-dimethyl-4-oxo-3,4,7,8-tetrahydro-pteridine-6-carboxylic acid (2-{4-[5-(6-amino-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethylsulfanyl]-piperidin-1-yl}-ethyl)-amide, sitting drop vapor diffusion method, using 20% or 25% (w/v) PEG 3350 as precipitant, at 19°C Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
2-amino-6-[(2-[4-[5-(6-amino-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-ylmethylsulfanyl]-piperidin-1-yl]-ethylamino)-methyl]-3H-pteridin-4-one
-
Escherichia coli
2-amino-6-[(2-[4-[5-(6-amino-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-ylmethylsulfanyl]-piperidin-1-yl]-ethylamino)-methyl]-7,7-dimethyl-7,8-dihydro-3H-pteridin-4-one
-
Escherichia coli
2-amino-7,7-dimethyl-4-oxo-3,4,7,8-tetrahydro-pteridine-6-carboxylic acid (2-[4-[5-(6-amino-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethylsulfanyl]-piperidin-1-yl]-ethyl)-amide
-
Escherichia coli
6-hydroxymethyl-7,7-dimethyl-7,8-dihydropterin
-
Escherichia coli
6-hydroxymethyl-7-methyl-7-phenethyl-7,8-dihydropterin
-
Escherichia coli
P1-(6-hydroxymethylpterin)-P2-(5'-adenosyl)diphosphate
-
Escherichia coli
P1-(6-hydroxymethylpterin)-P3-(5'-adenosyl)triphosphate
-
Escherichia coli
P1-(6-hydroxymethylpterin)-P4-(5'-adenosyl)tetraphosphate
-
Escherichia coli

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required, 5 mM MgCl2 used in assay conditions Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli P26281
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 6-hydroxymethyl-7,8-dihydropteridine
-
Escherichia coli AMP + 6-hydroxymethyl-7,8-dihydropteridine diphosphate
-
?

Synonyms

Synonyms Comment Organism
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
-
Escherichia coli
HPPK
-
Escherichia coli

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00316
-
in 100 mM Tris, pH 8.3, temperature not specified in the publication Escherichia coli 2-amino-7,7-dimethyl-4-oxo-3,4,7,8-tetrahydro-pteridine-6-carboxylic acid (2-[4-[5-(6-amino-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethylsulfanyl]-piperidin-1-yl]-ethyl)-amide
0.1
-
IC50 above 0.1 mM, in 100 mM Tris, pH 8.3, temperature not specified in the publication Escherichia coli 2-amino-6-[(2-[4-[5-(6-amino-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-ylmethylsulfanyl]-piperidin-1-yl]-ethylamino)-methyl]-3H-pteridin-4-one