EC Number   |
General Information |
Reference |
|---|
    2.7.6.3 | metabolism |
6-hydroxymethyl-7,8-dihydropterin diphosphokinase catalyzes the first reaction in the folate biosynthetic pathway |
737717 |
| 2.7.6.3 | metabolism |
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinae is a committed enzyme in the folate pathway of Streptococcus aureus playing an integral role in the biosynthesis of tetrahydrofolate |
721193 |
| 2.7.6.3 | metabolism |
essential enzyme in the microbial folate biosynthetic pathway |
737836 |
| 2.7.6.3 | metabolism |
the enzyme is a member of the folate biosynthesis pathway |
738849 |
| 2.7.6.3 | metabolism |
the enzyme is involved in the folate biosynthesis pathway catalyzing the diphosphoryl transfer from ATP to 6-hydroxymethyl-7,8-dihydropterin |
738835 |
| 2.7.6.3 | more |
movements of Arg82 and Arg92 adjacent to the phosphate groups of the bound ATP play an essential role in HPPK catalysis |
737836 |
| 2.7.6.3 | more |
putative large-scale induced-fit conformational change of enzyme HPPK. The loops 2 and 3 remain rather flexible when the enzyme is in its apoform, but loops 2 and 3 adopt the open, semi-open, and closed conformations throughout its catalytic cycle, flexibility of the three catalytic loops in the apoform of the enzyme. Molecular dynamics simulations of the apoenzyme at two different temperatures, overview |
737717 |
| 2.7.6.3 | physiological function |
essential enzyme in the microbial folate biosynthetic pathway |
737836 |
| 2.7.6.3 | physiological function |
gene encodes a protein fused of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase (HPPK) and dihydropteroate synthase (DHPS) domains that catalyze sequential reactions in the folate biosynthetic pathway |
-, 759490 |
| 2.7.6.3 | physiological function |
the enzyme is essential for microbial growth |
737717 |
