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EC Number	Protein Variants	Commentary	Reference
2.7.6.3	A383G	dominant drug resistance mutation. Mutation subtly alters the intricate enzyme-4-amino benzoic acid-sulfadoxine interactions such that DHPS affinity for 4-amino benzoic acid is diminished only moderately, but its affinity for sulfadoxine is changed substantially	759490
2.7.6.3	A383G	natural mutation, generates resistance to sulfadoxine. DHPS affinity for 4-amino benzoic acid is diminished only moderately, but its affinity for sulfadoxine is changed substantially	759490
2.7.6.3	A437G	6fold increase in kcat/Km value of 4-aminobenzoate	759184
2.7.6.3	A437G/K540E	decrease in Km value of 4-aminobenzoate	759184
2.7.6.3	A553G	dominant drug resistance mutation. Mutation subtly alters the intricate enzyme-4-amino benzoic acid-sulfadoxine interactions such that DHPS affinity for 4-amino benzoic acid is diminished only moderately, but its affinity for sulfadoxine is changed substantially	759490
2.7.6.3	A553G	natural mutation, generates resistance to sulfadoxine. DHPS affinity for 4-amino benzoic acid is diminished only moderately, but its affinity for sulfadoxine is changed substantially	759490
2.7.6.3	A581G	decrease in Km value of 4-aminobenzoate	759184
2.7.6.3	A613S	decrease in Km value of 4-aminobenzoate	759184
2.7.6.3	A613T	decrease in Km value of 4-aminobenzoate	759184
2.7.6.3	K512D	dominant drug resistance mutation. Mutation subtly alters the intricate enzyme-4-amino benzoic acid-sulfadoxine interactions such that DHPS affinity for 4-amino benzoic acid is diminished only moderately, but its affinity for sulfadoxine is changed substantially	759490

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Release 2023.1 (January 2023)