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Information on EC 2.1.1.204 - tRNA (cytosine38-C5)-methyltransferase

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EC Tree
     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.204 tRNA (cytosine38-C5)-methyltransferase
IUBMB Comments
The eukaryotic enzyme catalyses methylation of cytosine38 in the anti-codon loop of tRNAAsp(GTC), tRNAVal(AAC) and tRNAGly(GCC). Methylation by Dnmt2 protects tRNAs against stress-induced cleavage by ribonuclease .
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Word Map
The enzyme appears in viruses and cellular organisms
Reaction Schemes
Synonyms
trdmt1, dna methyltransferase 2, dnmt2 methyltransferase, pombe methyltransferase 1, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + cytosine38 in tRNA = S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNA
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