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Literature summary for 2.1.1.204 extracted from

  • Schaefer, M.; Pollex, T.; Hanna, K.; Tuorto, F.; Meusburger, M.; Helmm M.; Lyko, F.
    RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage (2010), Genes Dev., 24, 1590-1595.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.204

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm granular cytoplasmic distribution with minor signals in the nucleus. Large structures appear in the cytoplasm and in the nucleus upon heat stress Drosophila melanogaster 5737
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + cytosine38 in tRNA Drosophila melanogaster RNA methylation by Dnmt2 protects tRNAs against stress-induced cleavage S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNA
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 ?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster Q9U6H7
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Source Tissue

Source Tissue Comment Organism Textmining
embryo
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 Drosophila melanogaster
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larva
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 Drosophila melanogaster
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ovary
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 Drosophila melanogaster
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S2 cell
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 Drosophila melanogaster
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testis
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 Drosophila melanogaster
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + cytosine38 in tRNA RNA methylation by Dnmt2 protects tRNAs against stress-induced cleavage Drosophila melanogaster S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNA
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 ?
S-adenosyl-L-methionine + cytosine38 in tRNA methylation of cytosine 38 in the anti-codon lopp of tRNAAsp(GTC), tRNAVal(AAC) and tRNAGly(GCC). Other C38-containing tRNAs-including tRNAMet(ATG), tRNAGlu(CTC), and tRNAHis(GTG) are not detectably methylated in a Dnmt2-dependent manner Drosophila melanogaster S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNA
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 ?

Synonyms

Synonyms Comment Organism
Dnmt2
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 Drosophila melanogaster

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
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 Drosophila melanogaster

General Information

General Information Comment Organism
malfunction Drosophila Dnmt2 mutants show reduced viability under stress conditions, and Dnmt2 relocalizes to stress granules following heat shock Drosophila melanogaster
physiological function RNA methylation by Dnmt2 protects tRNAs against stress-induced cleavage by ribonuclease Drosophila melanogaster