Ligand S-adenosyl-L-homocysteine

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

Basic Ligand Information

Molecular Structure
Picture of S-adenosyl-L-homocysteine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C14H20N6O5S
S-adenosyl-L-homocysteine
ZJUKTBDSGOFHSH-WFMPWKQPSA-N
Synonyms:
(2S)-2-amino-4-({[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}sulfanyl)butanoic acid, 5'-deoxy-5'-S-adenosyl-L-homocysteine, adenosyl-L-homocysteine, adenosylhomocysteine, AdoCys, Analogs of S-adenosyl-L-homocysteine, S-(5'-adenosyl)-L-homocysteine, S-5'-adenosyl-L-homocysteine, S-adenosyl-homocysteine, S-adenosyl-L-homocystein, S-adenosyl-L-homocysteine analogs, S-Adenosyl-L-homocysteine structural analogues, S-adenosylhomocysteine, S-adenosyl homocysteine, S-formycinylhomocysteine, Structure analogues of S-adenosyl-L-homocysteine
Pathway Source
Pathways
MetaCyc
(+)-pisatin biosynthesis, (S)-reticuline biosynthesis I, (S)-reticuline biosynthesis II, 1,3,5-trimethoxybenzene biosynthesis, 10,13-epoxy-11-methyl-octadecadienoate biosynthesis more


Show all pahtways known for Show all BRENDA pathways known for S-adenosyl-L-homocysteine

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (32 results)

EC NUMBER
LITERATURE
REACTION DIAGRAM
PROVEN IN VIVO REACTION
ENZYME 3D STRUCTURE
show the reaction diagram
[methionine synthase]-methylcob(I)alamin + S-adenosylhomocysteine + NADP+ = [methionine synthase]-cob(II)alamin + NADPH + S-adenosyl-L-methionine
-
show the reaction diagram
S-adenosyl-L-homocysteine + (S)-reticuline = S-adenosyl-L-methionine + 3'-hydroxy-N-methyl-(S)-coclaurine
-
show the reaction diagram
S-adenosyl-L-homocysteine + H2O = S-inosyl-L-homocysteine + NH3
-

In Vivo Product in Enzyme-catalyzed Reactions (2011 results)

EC NUMBER
LITERATURE
REACTION DIAGRAM
PROVEN IN VIVO REACTION
ENZYME 3D STRUCTURE
show the reaction diagram
S-adenosyl-L-methionine + L-homocysteine = S-adenosyl-L-homocysteine + L-methionine
-
-
show the reaction diagram
S-adenosyl-L-methionine + macrocin = S-adenosylhomocysteine + tylosin
-
-
show the reaction diagram
S-adenosyl-L-methionine + demethylmacrocin = S-adenosyl-L-homocysteine + macrocin
-
-
show the reaction diagram
S-adenosyl-L-methionine + L-tryptophan = S-adenosyl-L-homocysteine + L-2-methyltryptophan
-
show the reaction diagram
S-adenosyl-L-methionine + 6-hydroxymellein = S-adenosyl-L-homocysteine + 6-methoxymellein
-
show the reaction diagram
S-adenosyl-L-methionine + 6-demethylsterigmatocystin = S-adenosyl-L-homocysteine + sterigmatocystin
-
show the reaction diagram
S-adenosyl-L-methionine + sterigmatocystin = S-adenosyl-L-homocysteine + 8-O-methylsterigmatocystin
-
-
show the reaction diagram
S-adenosyl-L-methionine + anthranilate = S-adenosyl-L-homocysteine + N-methylanthranilate
-
-
show the reaction diagram
S-Adenosyl-L-methionine + 3'-hydroxy-N-methyl-(S)-coclaurine = S-Adenosyl-L-homocysteine + (S)-reticuline
-
-
show the reaction diagram
S-adenosyl-L-methionine + 10-hydroxydihydrosanguinarine = S-adenosyl-L-homocysteine + dihydrochelirubine
-
-
show the reaction diagram
S-adenosyl-L-methionine + myo-inositol = S-adenosyl-L-homocysteine + 1D-4-O-methyl-myo-inositol
-
-
show the reaction diagram
S-adenosyl-L-methionine + cobalt-precorrin-2 = S-adenosyl-L-homocysteine + cobalt-precorrin-3A
-
show the reaction diagram
S-adenosyl-L-methionine + cobalt-precorrin-6Y + 6 H+ = S-adenosyl-L-homocysteine + cobalt-precorrin-8X + 2 H2O
show the reaction diagram
S-adenosyl-L-methionine + 3'-demethylstaurosporine = S-adenosyl-L-homocysteine + staurosporine
-
show the reaction diagram
S-adenosyl-L-methionine + jasmonate = S-adenosyl-L-homocysteine + methyl jasmonate
-
-
show the reaction diagram
S-adenosyl-L-methionine + trans-aconitate = S-adenosyl-L-homocysteine + (E)-3-(methoxycarbonyl)pent-2-enedioate
-
show the reaction diagram
S-adenosyl-L-methionine + trans-aconitate = S-adenosyl-L-homocysteine + (E)-2-(methoxycarbonylmethyl)butenedioate
show the reaction diagram
S-adenosyl-L-methionine + a fatty acid = S-adenosyl-L-homocysteine + a fatty acid methyl ester
-
-
show the reaction diagram
S-adenosyl-L-methionine + 7,4'-dihydroxyisoflavone = S-adenosyl-L-homocysteine + 4'-hydroxy-7-methoxyisoflavone
show the reaction diagram
S-adenosyl-L-methionine + cobalt-factor II = S-adenosyl-L-homocysteine + cobalt-factor III
-
show the reaction diagram
S-adenosyl-L-methionine + precorrin-5 + H2O = S-adenosyl-L-homocysteine + precorrin-6A + acetate
-
-
show the reaction diagram
S-adenosyl-L-methionine + vitexin 2''-O-beta-L-rhamnoside = S-adenosyl-L-homocysteine + 7-O-methylvitexin 2''-O-beta-L-rhamnoside
-
-
show the reaction diagram
S-adenosyl-L-methionine + isoliquiritigenin = S-adenosyl-L-homocysteine + 2'-O-methylisoliquiritigenin
-
-
show the reaction diagram
S-adenosyl-L-methionine + xanthosine = S-adenosyl-L-homocysteine + 7-methylxanthosine
-
-
show the reaction diagram
S-adenosyl-L-methionine + N,N-dimethylglycine = S-adenosyl-L-homocysteine + N,N,N-trimethylglycine
-
-
show the reaction diagram
4'-demethylrebeccamycin + S-adenosyl-L-methionine = rebeccamycin + S-adenosyl-L-homocysteine
-
-
show the reaction diagram
S-adenosyl-L-methionine + chloride = S-adenosyl-L-homocysteine + methyl chloride
-
-
show the reaction diagram
S-adenosyl-L-methionine + uridine2552 in 23S rRNA = S-adenosyl-L-homocysteine + 2'-O-methyluridine2552 in 23S rRNA
-
-
show the reaction diagram
S-adenosyl-L-methionine + uridine2791 in 21S rRNA = S-adenosyl-L-homocysteine + 2'-O-methyluridine2791 in 21S rRNA
-
-
show the reaction diagram
S-adenosyl-L-methionine + guanine527 in 16S rRNA = S-adenosyl-L-homocysteine + N7-methylguanine527 in 16S rRNA
-
-
show the reaction diagram
S-adenosyl-L-methionine + guanine1207 in 16S rRNA = S-adenosyl-L-homocysteine + N2-methylguanine1207 in 16S rRNA
-
-
show the reaction diagram
S-adenosyl-L-methionine + guanine1835 in 23S rRNA = S-adenosyl-L-homocysteine + N2-methylguanine1835 in 23S rRNA
-
-
show the reaction diagram
S-adenosyl-L-methionine + cytosine967 in 16S rRNA = S-adenosyl-L-homocysteine + 5-methylcytosine967 in 16S rRNA
-
-
show the reaction diagram
S-adenosyl-L-methionine + pseudouridine1915 in 23S rRNA = S-adenosyl-L-homocysteine + N3-methylpseudouridine1915 in 23S rRNA
-
show the reaction diagram
S-adenosyl-L-methionine + 1,4-alpha-D-glucooligosaccharide = S-adenosyl-L-homocysteine + oligosaccharide containing 6-methyl-D-glucose units
-
-
show the reaction diagram
S-adenosyl-L-methionine + adenine1618 in 23S rRNA = S-adenosyl-L-homocysteine + 6-methyladenine1618 in 23S rRNA
-
-
show the reaction diagram
S-adenosyl-L-methionine + adenine1518/adenine1519 in 16S rRNA = S-adenosyl-L-homocysteine + N6-dimethyladenine1518/N6-dimethyladenine1519 in 16S rRNA
-
-
show the reaction diagram
S-adenosyl-L-methionine + adenine2085 in 23S rRNA = S-adenosyl-L-homocysteine + N6-dimethyladenine2085 in 23S rRNA
-
-
show the reaction diagram
S-adenosyl-L-methionine + guanosine2251 in 23S rRNA = S-adenosyl-L-homocysteine + 2'-O-methylguanosine2251 in 23S rRNA
-
-
show the reaction diagram
S-adenosyl-L-methionine + cytidine2498 in 23S rRNA = S-adenosyl-L-homocysteine + 2'-O-methylcytidine2498 in 23S rRNA
-
-
show the reaction diagram
S-adenosyl-L-methionine + guanine745 in 23S rRNA = S-adenosyl-L-homocysteine + N1-methylguanine745 in 23S rRNA
-
-
show the reaction diagram
S-adenosyl-L-methionine + uracil747 in 23S rRNA = S-adenosyl-L-homocysteine + 5-methyluracil747 in 23S rRNA
-
-
show the reaction diagram
S-adenosyl-L-methionine + uracil1939 in 23S rRNA = S-adenosyl-L-homocysteine + 5-methyluracil1939 in 23S rRNA
-
-
show the reaction diagram
S-adenosyl-L-methionine + uracil1498 in 16S rRNA = S-adenosyl-L-homocysteine + N3-methyluracil1498 in 16S rRNA
-
-
show the reaction diagram
cobalt-precorrin-5B + S-adenosyl-L-methionine = cobalt-precorrin-6A + S-adenosyl-L-homocysteine
-
-
show the reaction diagram
cobalt-precorrin-6B + S-adenosyl-L-methionine = cobalt-precorrin-7 + S-adenosyl-L-homocysteine + CO2
-
-
show the reaction diagram
S-adenosyl-L-methionine + uridine2479 in 23S rRNA = S-adenosyl-L-homocysteine + 2'-O-methyluridine2479 in 23S rRNA
-
-
show the reaction diagram
S-adenosyl-L-methionine + guanine2535 in 23S rRNA = S-adenosyl-L-homocysteine + N1-methylguanine2535 in 23S rRNA
-
-
show the reaction diagram
S-adenosyl-L-methionine + uridine44 in tRNASer = S-adenosyl-L-homocysteine + 2'-O-methyluridine44 in tRNASer
-
-
show the reaction diagram
S-adenosyl-L-methionine + guanine10 in tRNA = S-adenosyl-L-homocysteine + N2-methylguanine10 in tRNA
-
-
show the reaction diagram
S-adenosyl-L-methionine + guanine10 in tRNA = S-adenosyl-L-homocysteine + N2-methylguanine10 in tRNA
-
-
show the reaction diagram
S-adenosyl-L-methionine + adenine37 in tRNA1(Val) = S-adenosyl-L-homocysteine + N6-methyladenine37 in tRNA1(Val)
-
-
show the reaction diagram
S-adenosyl-L-methionine + cytidine1409 in 16S rRNA = S-adenosyl-L-homocysteine + 2'-O-methylcytidine1409 in 16S rRNA
-
-
show the reaction diagram
S-adenosyl-L-methionine + adenosine1067 in 23S rRNA = S-adenosyl-L-homocysteine + 2'-O-methyladenosine1067 in 23S rRNA
-
-
show the reaction diagram
S-adenosyl-L-methionine + mycinamicin VI = S-adenosyl-L-homocysteine + mycinamicin III
-
-
show the reaction diagram
S-adenosyl-L-methionine + L-olivosyl-erythronolide B = S-adenosyl-L-homocysteine + L-oleandrosyl-erythronolide B
-
-
show the reaction diagram
S-adenosyl-L-methionine + 5-guanidino-2-oxopentanoate = S-adenosyl-L-homocysteine + 5-guanidino-3-methyl-2-oxopentanoate
-
-
show the reaction diagram
S-adenosyl-L-methionine + geranyl diphosphate = S-adenosyl-L-homocysteine + (E)-2-methylgeranyl diphosphate
-
-
show the reaction diagram
S-adenosyl-L-methionine + pseudouridine54 in tRNA = S-adenosyl-L-homocysteine + N1-methylpseudouridine54 in tRNA
-
-
show the reaction diagram
S-adenosyl-L-methionine + [fructose 1,6-bisphosphate aldolase]-L-lysine = S-adenosyl-L-homocysteine + [fructose 1,6-bisphosphate aldolase]-N6,N6,N6-trimethyl-L-lysine
-
-
show the reaction diagram
S-adenosyl-L-methionine + pseudouridine1191 in yeast 18S rRNA = S-adenosyl-L-homocysteine + N1-methylpseudouridine1191 in yeast 18S rRNA
-
show the reaction diagram
S-adenosyl-L-methionine + 4-dimethylallyl-L-tryptophan = S-adenosyl-L-homocysteine + 4-dimethylallyl-L-abrine
-
-
show the reaction diagram
S-adenosyl-L-methionine + guanine2069 in 23S rRNA = S-adenosyl-L-homocysteine + N7-methylguanine2069 in 23S rRNA
-
-
show the reaction diagram
S-adenosyl-L-methionine + tellurite = S-adenosyl-L-homocysteine + methanetelluronate
-
-
show the reaction diagram
S-adenosyl-L-methionine + (+)-6a-hydroxymaackiain = S-adenosyl-L-homocysteine + (+)-pisatin
-
-
show the reaction diagram
S-adenosyl-L-methionine + gibberellin A9 = S-adenosyl-L-homocysteine + methyl gibberellin A9
-
-
show the reaction diagram
S-adenosyl-L-methionine + anthranilate = S-adenosyl-L-homocysteine + O-methyl anthranilate
-
-
show the reaction diagram
S-adenosyl-L-methionine + trans-anol = S-adenosyl-L-homocysteine + trans-anethole
-
-
show the reaction diagram
S-adenosyl-L-methionine + emodin = S-adenosyl-L-homocysteine + questin
-
-
show the reaction diagram
S-adenosyl-L-methionine + 8-demethylnovobiocic acid = S-adenosyl-L-homocysteine + novobiocic acid
-
show the reaction diagram
S-adenosyl-L-methionine + demethyldecarbamoylnovobiocin = S-adenosyl-L-homocysteine + decarbamoylnovobiocin
-
-
show the reaction diagram
S-adenosyl-L-methionine + adenine2142 in 25S rRNA = S-adenosyl-L-homocysteine + N1-methyladenine2142 in 25S rRNA
-
-
show the reaction diagram
S-adenosyl-L-methionine + aklanonate = S-adenosyl-L-homocysteine + methyl aklanonate
-
-
show the reaction diagram
cobalt-precorrin-7 + S-adenosyl-L-methionine = cobalt-precorrin-8 + S-adenosyl-L-homocysteine
-
-
show the reaction diagram
S-adenosyl-L-methionine + 7-[(3S)-3-amino-3-carboxypropyl]wyosine72 in tRNA = S-adenosyl-L-homocysteine + wybutosine72 in tRNAPhe
-
-
show the reaction diagram
S-adenosyl-L-methionine + 6-hydroxytryprostatin B = S-adenosyl-L-homocysteine + tryprostatin A
-
-
show the reaction diagram
S-adenosyl-L-methionine + a 5'-(N7-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleotide)-(ribonucleotide)-[mRNA] = S-adenosyl-L-homocysteine + a 5'-(N7-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleotide)-(2'-O-methyl-ribonucleotide)-[mRNA]
-
-
show the reaction diagram
S-adenosyl-L-methionine + [ribosomal protein L3]-L-glutamine = S-adenosyl-L-homocysteine + [ribosomal protein L3]-N5-methyl-L-glutamine
-
-
show the reaction diagram
S-adenosyl-L-methionine + N-terminal L-alanine-[cypemycin] = S-adenosyl-L-homocysteine + N-terminal N,N-dimethyl-L-alanine-[cypemycin]
-
-
show the reaction diagram
S-adenosyl-L-methionine + 3-hydroxy-5-methylnaphthoate = S-adenosyl-L-homocysteine + 3-methoxy-5-methylnaphthoate
-
-
show the reaction diagram
S-adenosyl-L-methionine + 2,7-dihydroxy-5-methyl-1-naphthoate = S-adenosyl-L-homocysteine + 2-hydroxy-7-methoxy-5-methyl-1-naphthoate
-
-
show the reaction diagram
S-adenosyl-L-methionine + L-tyrosine = S-adenosyl-L-homocysteine + 3-methyl-L-tyrosine