7.2.2.13: Na+/K+-exchanging ATPase

This is an abbreviated version!
For detailed information about Na+/K+-exchanging ATPase, go to the full flat file.

Word Map on EC 7.2.2.13

7.2.2.13

ouabain

cardiac

ouabain-sensitive

basolateral

tubule

erythrocyte

hypertension

epithelium

depolarization

electrogenic

glycoside

cotransporter

reabsorption

cl

contractile

alpha-subunits

hyperpolarization

nephron

medullary

normotensive

amiloride

digoxin

transepithelial

voltage

sarcolemmal

atpases

aldosterone

myocytes

na+,k+-atpase

ca-atpase

rb+

microelectrodes

cardiotonic

sarcoplasmic

short-circuit

phosphoenzyme

vanadate

digitalis

furosemide

inotropic

mg2+-atpase

voltage-clamped

medicine

electroneutral

nai

natriuresis

aldosterone-producing

k+-dependent

amiloride-sensitive

bumetanide

henle

Reaction

Synonyms

(Na+ + K+)-activated ATPase, (Na+ + K+)-ATPase, (Na+, K+)-ATPase, (Na+, K+)-dependent ATPase, (Na+,K+)-activated ATPase, (Na+-K+)-ATPase, alpha2Na+/K+-ATPase, ATP1a1, atp1a1a, ATPalpha, EC 3.6.1.3, EC 3.6.1.37, EC 3.6.3.9, Na pump, Na(+)-K(+)-exchanging ATPase, Na+ pump, Na+, K+ -ATPase, Na+, K+-ATPase, Na+,K+ pump, Na+,K+-adenosine triphosphatase, Na+,K+-ATPase, Na+,K+-pump, Na+-K+ ATPase, Na+-K+ pump, Na+-K+ pump alpha1-isoform, Na+-K+ pump alpha2-isoform, Na+-K+-ATPase, Na+-K+-ATPase alpha2-isoform, Na+-K+-pump, Na+/K+ -ATPase, Na+/K+ ATPase, Na+/K+ pump, Na+/K+-ATPase, Na+K+-ATPase, Na+K+ATPase, Na, K-ATPase, Na,K pump, Na,K-activated ATPase, Na,K-adenosine triphosphatase, Na,K-ATPase, Na,K-Pump, Na-K-ATPase, Na/K pump, Na/K-ATPase, NKA, Nkaalpha protein, nkaalpha1, nkaalpha3a, nkaalpha3b, renal sodium-potassium pump, SNaK1, sodium potassium adenosinetriphosphatase, sodium pump, sodium-potassium pump, sodium/potassium ATPase

ECTree

7 Translocases

7.2 Catalysing the translocation of inorganic cations

7.2.2 Linked to the hydrolysis of a nucleoside triphosphate

7.2.2.13 Na+/K+-exchanging ATPase

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Results	in table
35	Activating Compound
188	AA Sequence
8	Application
1	CAS Registry Number
33	Cloned(Commentary)
2	Cofactor
10	Crystallization (Commentary)
4287	Disease/ Diagnostics
25	Expression
41	General Information
6	General Stability
72	IC50 Value
305	Inhibitors
18	Ki Value [mM]
50	KM Value [mM]
116	Localization
72	Metals/Ions
26	Molecular Weight [Da]
114	Natural Substrates/ Products (Substrates)
249	Organism
28	PDB ID
25	pH Optimum
2	pH Range
1	pI Value
13	Posttranslational Modification
98	Protein Variants
20	Purification (Commentary)
4	Reaction
44	Reaction Type
249	Reference
348	Source Tissue
25	Specific Activity [micromol/min/mg]
1	Storage Stability
213	Substrates and Products (Substrate)
42	Subunits
189	Synonyms
1	Systematic Name
29	Temperature Optimum [°C]
5	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 7.2.2.13 - Na+/K+-exchanging ATPase

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0.00081

(12beta,20R)-12-hydroxy-20,25-epoxydammarane-3,6-dione

Sus scrofa

P05024; P05027

pH and temperature not specified in the publication

750059

0.0017

(1R,2R,3aS,5aS,6aR,7aS,9R,11R,11aS,12aR,13aR,15aR)-2,3a,11,11a-tetrahydroxy-9,15a-dimethyl-1-(5-oxo-2,5-dihydrofuran-3-yl)icosahydro-7aH,13aH-cyclopenta[7,8]phenanthro[2,3-b]pyrano[3,2-e][1,4]dioxine-13a-carbaldehyde

Homo sapiens

pH 7.8, 37°C

712805

0.0012

(1R,2R,3aS,5aS,6aR,7aS,9S,11R,11aS,12aR,13aR,15aR)-3a,11,11a-trihydroxy-9-(hydroxymethyl)-15a-methyl-1-(5-oxo-2,5-dihydrofuran-3-yl)-2-(2-oxopropanoyl)icosahydro-7aH,13aH-cyclopenta[7,8]phenanthro[2,3-b]pyrano[3,2-e][1,4]dioxine-13a-carbaldehyde

Homo sapiens

pH 7.8, 37°C

712805

0.0005

(1R,3aS,5aS,6aR,7aS,9R,11R,11aS,12aR,13aR,15aR)-13a-formyl-3a,11a-dihydroxy-9,15a-dimethyl-1-(5-oxo-2,5-dihydrofuran-3-yl)icosahydro-1H,7aH-cyclopenta[7,8]phenanthro[2,3-b]pyrano[3,2-e][1,4]dioxin-11-yl beta-D-glucopyranoside

Homo sapiens

pH 7.8, 37°C

712805

0.0004

(1R,3aS,5aS,6aR,7aS,9R,11R,11aS,12aR,13aR,15aR)-3a,11,11a-trihydroxy-9,15a-dimethyl-1-(5-oxo-2,5-dihydrofuran-3-yl)icosahydro-7aH,13aH-cyclopenta[7,8]phenanthro[2,3-b]pyrano[3,2-e][1,4]dioxine-13a-carbaldehyde

Homo sapiens

pH 7.8, 37°C

712805

0.0005

(1R,3aS,5aS,6aR,7aS,9S,11R,11aS,12aR,13aR,15aR)-3a,11,11a-trihydroxy-9-(hydroxymethyl)-15a-methyl-1-(5-oxo-2,5-dihydrofuran-3-yl)icosahydro-7aH,13aH-cyclopenta[7,8]phenanthro[2,3-b]pyrano[3,2-e][1,4]dioxine-13a-carbaldehyde

Homo sapiens

pH 7.8, 37°C

712805

0.000091

(1S,3aR,3bR,12aR,14R)-10-fluoro-14-hydroxy-3a,3b,6,6,12a-pentamethyl-1-[(2R)-2,6,6-trimethyloxan-2-yl]-2,3,3a,3b,4,5a,6,7,12,12a,12b,13,14,14a-tetradecahydrocyclopenta[5,6]naphtho[2,1-b]carbazol-5(1H)-one

Sus scrofa

P05024; P05027

pH and temperature not specified in the publication

750059

0.00077

(1S,3aR,3bR,12aR,14R)-14-hydroxy-3a,3b,6,6,12a-pentamethyl-1-[(2R)-2,6,6-trimethyloxan-2-yl]-2,3,3a,3b,4,5a,6,7,12,12a,12b,13,14,14a-tetradecahydrocyclopenta[5,6]naphtho[2,1-b]carbazol-5(1H)-one

Sus scrofa

P05024; P05027

pH and temperature not specified in the publication

750059

0.00036

(1S,3aR,3bR,12aR,14R)-14-hydroxy-3a,3b,6,6,12a-pentamethyl-10-(trifluoromethoxy)-1-[(2R)-2,6,6-trimethyloxan-2-yl]-2,3,3a,3b,4,5a,6,7,12,12a,12b,13,14,14a-tetradecahydrocyclopenta[5,6]naphtho[2,1-b]carbazol-5(1H)-one

Sus scrofa

P05024; P05027

pH and temperature not specified in the publication

750059

0.00076

(20R)-20,25-epoxydammarane-3,6,12-trione

Sus scrofa

P05024; P05027

pH and temperature not specified in the publication

750059

0.0003

(3beta,12beta,20R)-12-hydroxy-3-phenoxy-20,25-epoxydammaran-6-one

Sus scrofa

P05024; P05027

pH and temperature not specified in the publication

750059

0.00096

(3beta,12beta,20R)-12-hydroxy-3-[(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)oxy]-20,25-epoxydammaran-6-one

Sus scrofa

P05024; P05027

pH and temperature not specified in the publication

750059

0.00045

(3beta,12beta,20R)-12-hydroxy-3-[4-(trifluoromethoxy)phenoxy]-20,25-epoxydammaran-6-one

Sus scrofa

P05024; P05027

pH and temperature not specified in the publication

750059

0.00105

(3beta,12beta,20R)-3-(ethenyloxy)-12-hydroxy-20,25-epoxydammaran-6-one

Sus scrofa

P05024; P05027

pH and temperature not specified in the publication

750059

0.00114

(3beta,12beta,20R)-3-ethoxy-12-hydroxy-20,25-epoxydammaran-6-one

Sus scrofa

P05024; P05027

pH and temperature not specified in the publication

750059

0.00041

(5aR,7R,8S,10aR,10bR)-7-hydroxy-1,1,5a,10a,10b-pentamethyl-8-[(2R)-2,6,6-trimethyloxan-2-yl]hexadecahydrocyclopenta[5,6]naphtho[2,1-c]azepine-3,12-dione

Sus scrofa

P05024; P05027

pH and temperature not specified in the publication

750059

0.00123

(5aR,8S,10aR,10bR,12R)-12-hydroxy-1,1,5a,10a,10b-pentamethyl-8-[(2R)-2,6,6-trimethyloxan-2-yl]tetradecahydro-1H-cyclopenta[5,6]naphtho[2,1-c]oxepine-3,7-dione

Sus scrofa

P05024; P05027

pH and temperature not specified in the publication

750059

0.00113 - 0.00118

(5aR,8S,10aR,10bR,12S)-12-hydroxy-1,1,5a,10a,10b-pentamethyl-8-[(2R)-2,6,6-trimethyloxan-2-yl]tetradecahydro-1H-cyclopenta[5,6]naphtho[2,1-c]oxepine-3,7-dione

2 entries

0.00091

(6alpha,12beta,20R)-12-hydroxy-6-[(prop-2-en-1-yl)oxy]-20,25-epoxydammaran-3-one

Sus scrofa

P05024; P05027

pH and temperature not specified in the publication

750059

0.00087

(6alpha,12beta,20R)-6,12-bis(benzyloxy)-20,25-epoxydammaran-3-one

Sus scrofa

P05024; P05027

pH and temperature not specified in the publication

750059

0.00075

(6alpha,12beta,20R)-6,12-bis[(prop-2-en-1-yl)oxy]-20,25-epoxydammaran-3-one

Sus scrofa

P05024; P05027

pH and temperature not specified in the publication

750059

0.00033

(6alpha,12beta,20R)-6-(benzyloxy)-12-hydroxy-20,25-epoxydammaran-3-one

Sus scrofa

P05024; P05027

pH and temperature not specified in the publication

750059

0.0007

(6alpha,20R)-6-hydroxy-20,25-epoxydammarane-3,12-dione

Sus scrofa

P05024; P05027

pH and temperature not specified in the publication

750059

0.0007

1,8,9-trihydroxy-3-methoxy-6H-[1]benzofuro[3,2-c]chromen-6-one

Rattus norvegicus

37°C, pH 7.4

685509

0.055

12,20-dihydroxydammar-24-en-3-yl D-glucopyranoside

Sus scrofa

695408

0.003

2,3-dihydroxy-6H-[1,3]dioxolo[5,6][1]benzofuro[3,2-c]chromen-6-one

Rattus norvegicus

37°C, pH 7.4

685509

0.0007

2,8,9-trihydroxy-3-methoxy-6H-[1]benzofuro[3,2-c]chromen-6-one

Rattus norvegicus

37°C, pH 7.4

685509

0.006

2,9-dihydroxy-3,8-dimethoxy-6H-[1]benzofuro[3,2-c]chromen-6-one

Rattus norvegicus

37°C, pH 7.4

685509

0.003

3,8,9-trihydroxy-2-methoxy-6H-[1]benzofuro[3,2-c]chromen-6-one

Rattus norvegicus

37°C, pH 7.4

685509

0.00114

3-oxo-panaxatriol

Sus scrofa

P05024; P05027

pH and temperature not specified in the publication

750059

0.00054

3-[(3S,3aS,4R,5aR,6S,9aR,9bS)-4-hydroxy-6,9a,9b-trimethyl-8-oxo-3-[(2R)-2,6,6-trimethyloxan-2-yl]dodecahydro-1H-cyclopenta[a]naphthalen-6-yl]propanoic acid

Sus scrofa

P05024; P05027

pH and temperature not specified in the publication

750059

0.171

4,7-diacetoxy-14-hydroxydolast-1(15),8-diene

Cavia porcellus

enzym preparation from kidney

700691

0.0007

4-[(1R,3aS,5aS,6aR,7aS,9R,11R,11aS,12aR,13aR,15R,15aS)-3a,11,11a,15-tetrahydroxy-13a-(hydroxymethyl)-9,15a-dimethylicosahydro-1H,7aH-cyclopenta[7,8]phenanthro[2,3-b]pyrano[3,2-e][1,4]dioxin-1-yl]furan-2(5H)-one

Homo sapiens

pH 7.8, 37°C

712805

0.0004

4-[(1R,3aS,5aS,6aR,7aS,9S,11R,11aS,12aR,13aR,15aR)-3a,11,11a-trihydroxy-9,13a-bis(hydroxymethyl)-15a-methylicosahydro-1H,7aH-cyclopenta[7,8]phenanthro[2,3-b]pyrano[3,2-e][1,4]dioxin-1-yl]furan-2(5H)-one

Homo sapiens

pH 7.8, 37°C

712805

0.0003

4-[(1R,3aS,5aS,6aR,7aS,9S,11R,11aS,12aR,13aR,15R,15aS)-3a,11,11a,15-tetrahydroxy-9,13a-bis(hydroxymethyl)-15a-methylicosahydro-1H,7aH-cyclopenta[7,8]phenanthro[2,3-b]pyrano[3,2-e][1,4]dioxin-1-yl]furan-2(5H)-one

Homo sapiens

pH 7.8, 37°C

712805

0.00118

6-oxo-panaxatriol

Sus scrofa

P05024; P05027

pH and temperature not specified in the publication

750059

0.00009

8-methoxycoumestrol

Homo sapiens

isozyme alpha1beta1 Na,K-ATPase, pH 7.4, 30°C

712538

0.000575

AuCl4-

Sus scrofa

at pH 7.4 and 37°C

734421

0.000587

beta-acetyldigoxin

Homo sapiens

isozyme alpha1beta1 Na,K-ATPase, pH 7.4, 30°C

712538

0.003

bufalin

Homo sapiens

684332

0.000287

digitoxin

Homo sapiens

isozyme alpha1beta1 Na,K-ATPase, pH 7.4, 30°C

712538

0.00027 - 0.000409

digoxin

2 entries

0.031

diphenyl diselenide

Rattus norvegicus

pH 7.4, 37°C

713007

0.2

epicatechin

Sus scrofa

pH 7.0, 37°C

711155

0.0008

epicatechin-3-gallate

Sus scrofa

pH 7.0, 37°C

711155

0.001

epigallocatechin-3-gallate

Sus scrofa

pH 7.0, 37°C

711155

0.006

m-trifluoromethyl-diphenyl diselenide

Rattus norvegicus

pH 7.4, 37°C

713007

0.00026

methyl 3-[(3S,3aS,4R,5aR,6R,7R,9aR,9bS)-4-hydroxy-7-(2-hydroxypropan-2-yl)-6,9a,9b-trimethyl-8-oxo-3-[(2R)-2,6,6-trimethyloxan-2-yl]dodecahydro-1H-cyclopenta[a]naphthalen-6-yl]propanoate

Sus scrofa

P05024; P05027

pH and temperature not specified in the publication

750059

0.00109

methyl 3-[(3S,3aS,4R,5aR,6R,7S,9aR,9bS)-4-hydroxy-6,9a,9b-trimethyl-8-oxo-7-(prop-2-en-1-yl)-3-[(2R)-2,6,6-trimethyloxan-2-yl]dodecahydro-1H-cyclopenta[a]naphthalen-6-yl]propanoate

Sus scrofa

P05024; P05027

pH and temperature not specified in the publication

750059

0.00041

methyl 3-[(3S,3aS,4R,5aR,6S,9aR,9bS)-4-hydroxy-6,9a,9b-trimethyl-8-oxo-3-[(2R)-2,6,6-trimethyloxan-2-yl]dodecahydro-1H-cyclopenta[a]naphthalen-6-yl]propanoate

Sus scrofa

P05024; P05027

pH and temperature not specified in the publication

750059

0.000282

methyldigoxin

Homo sapiens

isozyme alpha1beta1 Na,K-ATPase, pH 7.4, 30°C

712538

0.0008 - 0.012

Mg2+

3 entries

0.00138

O-[(3beta,12beta,20R)-12-hydroxy-6-oxo-20,25-epoxydammaran-3-yl] O-methyl 2-imidothiodicarbonate

Sus scrofa

P05024; P05027

pH and temperature not specified in the publication

750059

0.0012

odoroside A

Homo sapiens

pH 7.0, 37°C

711156

0.115

oleic acid

Cavia porcellus

enzym preparation from kidney

700691

0.0001 - 0.4

Ouabain

5 entries

0.006

p-chloro-diphenyl diselenide

Rattus norvegicus

pH 7.4, 37°C

713007

0.045

p-methoxyl-diphenyl diselenide

Rattus norvegicus

pH 7.4, 37°C

713007

0.00109

panaxatriol

Sus scrofa

P05024; P05027

pH and temperature not specified in the publication

750059

0.0398

[Au(2,2'-bipyridine)Cl2]+

Sus scrofa

at pH 7.4 and 37°C

734421

0.0055

[Au(dimethylsulfoxide)2Cl2]+

Sus scrofa

at pH 7.4 and 37°C

734421

0.0121

[PdCl(dien)]+

Sus scrofa

pH 7.4, 37°C

688017

0.0236

[PdCl(Me4dien)]+

Sus scrofa

pH 7.4, 37°C

688017

0.0225

[PdCl4]2-

Sus scrofa

pH 7.4, 37°C

688017