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Disease on EC 7.2.2.13 - Na+/K+-exchanging ATPase

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DISEASE
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Acidosis
Disturbances of potassium homeostasis in poisoning.
Effect of partial Na pump and Na-H exchange inhibition on [Ca]i during acidosis in cardiac cells.
Ethyl isopropylamiloride downregulates Na,K-ATPase gene expression which confers cytotoxicity in primary proximal tubule cell cultures.
Impaired cation transport in thymocytes of rats with chronic uremia includes the Na+/H+ antiporter.
Lactic acidosis progressively impairs dopamine uptake in rat striatal synaptosomes by a mechanism partially independent of the Na+/K+-ATPase dysfunction.
Membrane damage in acute brain trauma.
Na+-dependent activation of Na+-K+ pump in human myocardium during recovery from acidosis.
Na+/H+ and Na+/Ca2+ exchange in regulation of [Na+]i and [Ca2+]i during metabolic inhibition.
Novel anti-aging gene NM_026333 contributes to proton-induced aging via NCX1-pathway.
Regulation of intracellular pH in sheep cardiac Purkinje fibre: interactions among Na+, H+, and Ca2+1.
Regulation of ion gradients across myocardial ischemic border zones: a biophysical modelling analysis.
Relations between intracellular ions and energy metabolism under acidotic conditions: a study with nigericin in synaptosomes, neurons, and C6 glioma cells.
Sublethal effects of waterborne copper and copper nanoparticles on the freshwater Neotropical teleost Prochilodus lineatus: A comparative approach.
The acute effects of glycemic control on axonal excitability in human diabetic nerves.
Acquired Immunodeficiency Syndrome
Inhibition of membrane Na+-K+ ATPase activity: a common pathway in central nervous system disorders.
Acromegaly
Increased activity of digoxin-like substance in low-renin hypertension in acromegaly.
Skeletal muscle sodium and potassium changes after successful surgery in acromegaly: relation to body composition, blood glucose, plasma insulin and blood pressure.
Acute Kidney Injury
Acute renal failure leads to dysregulation of lung salt and water channels.
Carnitine, apelin and resveratrol regulate mitochondrial quality control (QC) related proteins and ameliorate acute kidney injury: role of hydrogen peroxide.
Experimental renal failure in the rat modulates cardiac Na,K-ATPase alpha 2 mRNA but not protein.
Lithospermic acid B isolated from Salvia miltiorrhiza ameliorates ischemia/reperfusion-induced renal injury in rats.
Mechanism of intestinal adaptation in rats with acute renal failure.
Protective effect of thyroxine but not parathyroidectomy on gentamicin nephrotoxicity.
Rehmannia glutinose ameliorates renal function in the ischemia/reperfusion-induced acute renal failure rats.
Renal function and Na-K-ATPase in rats after suprarenal ligation of inferior vena cava.
The intestinal profile of Na-K-ATPase in three rat models of acute renal failure.
The intestinal profile of Na-K-ATPase in two rat models of acute renal failure.
Yukmijihwang-tang ameliorates ischemia/reperfusion-induced renal injury in rats.
[Changes in Na-K-ATPase activity in renal cortex and renal medulla experimental acute renal failure]
Acute Lung Injury
Alveolar epithelium and Na,K-ATPase in acute lung injury.
Effects of hyperoxia on type II cell Na-K-ATPase function and expression.
Na(+)-K(+)-ATPase expression in alveolar epithelial cells: upregulation of active ion transport by KGF.
Regulation of Na,K-ATPase during acute lung injury.
Resolvin D1 Stimulates Alveolar Fluid Clearance through Alveolar Epithelial Sodium Channel, Na,K-ATPase via ALX/cAMP/PI3K Pathway in Lipopolysaccharide-Induced Acute Lung Injury.
Rosuvastatin Enhances Alveolar Fluid Clearance in Lipopolysaccharide-Induced Acute Lung Injury by Activating the Expression of Sodium Channel and Na,K-ATPase via the PI3K/AKT/Nedd4-2 Pathway.
Upregulation of rat lung Na-K-ATPase during hyperoxic injury.
Adenocarcinoma
Photosensitizing effects of hematoporphyrin derivative and photofrin II on the plasma membrane enzymes 5'-nucleotidase, Na+K+-ATPase, and Mg2+-ATPase in R3230AC mammary adenocarcinomas.
Recombinant addition of N-glycosylation sites to the basolateral Na,K-ATPase beta1 subunit results in its clustering in caveolae and apical sorting in HGT-1 cells.
Adenocarcinoma of Lung
Na,K-ATPase is a target of cigarette smoke and reduced expression predicts poor patient outcome of smokers with lung cancer.
Adenoma
Aldosterone producing adenoma with a somatic KCNJ5 mutation revealing APC dependent Familial Adenomatous Polyposis.
Aldosterone-Producing Adenomas: Histopathology-Genotype Correlation and Identification of a Novel CACNA1D Mutation.
CACNA1H Mutations Are Associated With Different Forms of Primary Aldosteronism.
Clinical characteristics of somatic mutations in chinese patients with aldosterone-producing adenoma.
Complementary somatic mutations of KCNJ5, ATP1A1, and ATP2B3 in sporadic aldosterone producing adrenal adenomas.
DACH1, a zona glomerulosa selective gene in the human adrenal, activates transforming growth factor-? signaling and suppresses aldosterone secretion.
Different Somatic Mutations in Multinodular Adrenals With Aldosterone-Producing Adenoma.
ENDOCRINE TUMOURS: The genomics of adrenocortical tumors.
Genetic causes of primary aldosteronism.
Genetic Characteristics of Aldosterone-Producing Adenomas in Blacks.
Genetic spectrum and clinical correlates of somatic mutations in aldosterone-producing adenoma.
Genetics of Aldosterone-Producing Adenoma in Korean Patients.
Genetics of primary hyperaldosteronism.
Genomics of benign adrenocortical tumors.
Lubiprostone Targets Prostanoid Signaling and Promotes Ion Transporter Trafficking, Mucus Exocytosis, and Contractility.
Molecular Basis of Primary Aldosteronism and Adrenal Cushing Syndrome.
Na/K Pump Mutations Associated with Primary Hyperaldosteronism Cause Loss of Function.
On the effect of hyperaldosteronism-inducing mutations in Na/K pumps.
Overview of the genetic determinants of primary aldosteronism.
Prevalence and characterization of somatic mutations in Chinese aldosterone-producing adenoma patients.
Role of ANO4 in regulation of aldosterone secretion in the zona glomerulosa of the human adrenal gland.
Somatic ATP1A1, ATP2B3, and KCNJ5 Mutations in Aldosterone-Producing Adenomas.
Somatic mutations in ATP1A1 and ATP2B3 lead to aldosterone-producing adenomas and secondary hypertension.
Somatic mutations of the ATP1A1 gene and aldosterone-producing adenomas.
The landscape of molecular mechanism for aldosterone production in aldosterone-producing adenoma.
Unravelling the Genetic Basis of Primary Aldosteronism.
[Primary aldosteronism : Genetics and pathology].
Adrenocortical Adenoma
Hypomethylation of CYP11B2 in Aldosterone-Producing Adenoma.
Molecular Heterogeneity in Aldosterone-Producing Adenomas.
Adrenocortical Carcinoma
ENDOCRINE TUMOURS: The genomics of adrenocortical tumors.
Agenesis of Corpus Callosum
K-Cl cotransport in red blood cells from patients with KCC3 isoform mutants.
Alkalosis
Disturbances of potassium homeostasis in poisoning.
Effect of low and high potassium diets on H(+)-K(+)-ATPase and Na(+)-K(+)-ATPase activities in the rat inner medullary collecting duct cells.
The effect of cAMP on ion transport in the proximal tubular cells in bullfrog kidney.
Alopecia
Novel anti-aging gene NM_026333 contributes to proton-induced aging via NCX1-pathway.
Altitude Sickness
Increased affinity to substrate in sarcolemmal ATPases from hearts acclimatized to high altitude hypoxia.
Alzheimer Disease
Aging, aluminium and basal forebrain lesions modify substrate kinetics of erythrocyte membrane Na,K-ATPase in the rat.
Alzheimer's disease A?42 peptide induces an increase in Na,K-ATPase glutathionylation.
Biogerontology in Serbia.
Direct interaction of beta-amyloid with Na,K-ATPase as a putative regulator of the enzyme function.
Inhibition of membrane Na+-K+ ATPase activity: a common pathway in central nervous system disorders.
Na,K-ATPase mRNA levels and plaque load in Alzheimer's disease.
Ouabain binding in the human brain. Effects of Alzheimer's disease and aging.
Quantitative measurement of [na+] and [k+] in postmortem human brain tissue indicates disturbances in subjects with Alzheimer's disease and dementia with lewy bodies.
Regulation of the frontocortical sodium pump by Na+ in Alzheimer's disease: difference from the age-matched control but similarity to the rat model.
The effects of different antioxidants on the activity of cerebrocortical MnSOD and Na,K-ATPase from post mortem Alzheimer's disease and age-matched normal brains.
Amyotrophic Lateral Sclerosis
Global loss of Na,K-ATPase and its nitric oxide-mediated regulation in a transgenic mouse model of amyotrophic lateral sclerosis.
Anemia
Calcium accumulated by sickle cell anemia red cells does not affect their potassium (86Rb+) flux components.
Cholesterol-binding protein TSPO2 coordinates maturation and proliferation of terminally differentiating erythroblasts.
Sodium-potassium pump, ion fluxes, and cellular dehydration in sickle cell anemia.
Sublethal effects of waterborne copper and copper nanoparticles on the freshwater Neotropical teleost Prochilodus lineatus: A comparative approach.
The potential role of Na-K-ATPase and its signaling in the development of anemia in chronic kidney disease.
[Studies on Na+-K+-ATPase and the acetylcholinesterase activity in erythrocyte membranes in saturnine anemia]
Anemia, Sickle Cell
Calcium accumulated by sickle cell anemia red cells does not affect their potassium (86Rb+) flux components.
Sodium-potassium pump, ion fluxes, and cellular dehydration in sickle cell anemia.
Angelman Syndrome
Genetic Reduction of the ?1 Subunit of Na/K-ATPase Corrects Multiple Hippocampal Phenotypes in Angelman Syndrome.
Angina, Unstable
Endogenous plasma Na,K-ATPase inhibitory activity and digoxin like immunoreactivity after acute myocardial infarction.
Aortic Coarctation
Na,K-ATPase and Ca-ATPase activities of the myocardial sarcolemma in aging rats after aorta coarctation: role of invertors.
Arrhythmias, Cardiac
A Structural View on the Functional Importance of the Sugar Moiety and Steroid Hydroxyls of Cardiotonic Steroids in Binding to Na,K-ATPase.
Antiarrhythmic Mechanisms of Chinese Herbal Medicine Dingji Fumai Decoction.
Association between activities of SOD, MDA and Na+-K+-ATPase in peripheral blood of patients with acute myocardial infarction and the complication of varying degrees of arrhythmia.
Cardiac glycoside ouabain induces autophagic cell death in non-small cell lung cancer cells via a JNK-dependent decrease of Bcl-2.
Effects of adenosine on transmembrane potential and sarcolemmal Na+-K+ ATPase activity of human atrial myocardium.
How increased sodium influx enhances digoxin-induced arrhythmias in guinea-pig atrial muscle.
Inhibition of myocardial Na(+)-K(+)-ATPase activity by bretylium: role of potassium.
Arthritis, Rheumatoid
Altered fatty acid, cholesterol and Na+/K+ ATPase activity in erythrocyte membrane of rheumatoid arthritis patients.
Inhibition of membrane Na+-K+ ATPase activity: a common pathway in central nervous system disorders.
Modulation of cytokine production by human mononuclear cells following impairment of Na, K-ATPase activity.
Ataxia
Possible implication of an efferent neuropathy in vestibular upset.
Atherosclerosis
Concentration-Dependent Effects of N-3 Long-Chain Fatty Acids on Na,K-ATPase Activity in Human Endothelial Cells.
Modulation of Na,K-ATPase activity by immunoglobulins--II. Na,K-ATPase activity in erythrocytes from patients with various chronic disturbances.
Atrial Fibrillation
Atrial Na,K-ATPase Increase and Potassium Dysregulation Accentuate the Risk of Postoperative Atrial Fibrillation.
Autoimmune mechanisms underlying dilated cardiomyopathy.
Contribution of acquired factors to the pathogenesis of dilated cardiomyopathy. -The cause of dilated cardiomyopathy: genetic or acquired? (Acquired-Side)-.
Digoxin Toxicity in a Patient with Pacemaker: A Case Report.
Inhibition of Na,K-ATPase by external electrical cardioversion in a sheep model of atrial fibrillation.
Remodeling of Na,K-ATPase, and membrane fluidity after atrial fibrillation in sheep.
Sodium pump isoform expression in heart failure: implication for treatment.
[Autoantibodies: new upstream targets of paroxysmal atrial fibrillation in patients with congestive heart failure]
Bartter Syndrome
Abnormalities of erythrocyte sodium transport systems in Bartter's syndrome.
Heterogeneous derangement of cellular sodium metabolism in Bartter's syndrome. Description of two cases and review of the literature.
Lymphocytic sodium and potassium pump function in Bartter's syndrome.
Physiological genomics identifies estrogen-related receptor alpha as a regulator of renal sodium and potassium homeostasis and the renin-angiotensin pathway.
The effect of long-term treatment with spironolactone on sodium pump abnormalities in the red blood cells of patients with Bartter's syndrome.
Bone Resorption
Inhibition of stimulated bone resorption by vanadate.
Botulism
[Activity of erythrocyte membrane Na,K-ATPase in rats with experimental botulism]
Brain Edema
Ammonia-induced Na,K-ATPase/ouabain-mediated EGF receptor transactivation, MAPK/ERK and PI3K/AKT signaling and ROS formation cause astrocyte swelling.
CDP-choline: pharmacological and clinical review.
Chronic daily administration of ethyl docosahexaenoate protects against gerbil brain ischemic damage through reduction of arachidonic acid liberation and accumulation.
Edema, cation content, and ATPase activity after middle cerebral artery occlusion in rats.
Excitatory amino acid receptors, oxido-reductive processes and brain oedema following transient ischaemia in gerbils.
Membrane damage in acute brain trauma.
The role of free radicals and eicosanoids in the pathogenetic mechanism underlying ischemic brain edema.
Brain Infarction
Pre-exposure of voglibose exerts cerebroprotective effects through attenuating activation of the polyol pathway and inflammation.
Promising Anti-stroke Signature of Voglibose: Investigation through In- Silico Molecular Docking and Virtual Screening in In-Vivo Animal Studies.
Brain Injuries
Hypoxia-induced brain cell damage in male albino wistar rat.
Brain Injuries, Traumatic
Inhibition of the electrogenic Na pump underlies delayed depolarization of cortical neurons after mechanical injury or glutamate.
Brain Ischemia
Alterations in synaptosomal membrane Na,K-ATPase of the gerbil cortex and hippocampus following reversible brain ischemia.
Effect of deferoxamine on Na+K+ATPase activity after cerebral ischemia in rabbits.
Effect of enhanced capillary activity on the blood-brain barrier during focal cerebral ischemia in cats.
Ginkgo biloba extract (EGb 761) protects Na,K-ATPase activity during cerebral ischemia in mice.
Ginkgo biloba extract (EGb 761) protects Na,K-ATPase isoenzymes during cerebral ischemia.
[Na,K-atpase activity in different brain regions in cerebral ischemia and influence of quinacrine and indomethacin administration.]
[Protective effects of luteolin on neurons against oxygen-glucose deprivation/reperfusion injury via improving Na+/K+ -ATPase activity]
Brain Neoplasms
Na+/K+ ATPase and cell growth IV: a metabolic marker of human brain tumors?
Na/K-ATPase as a target for anticancer drugs: studies with perillyl alcohol.
Breast Neoplasms
Abnormal expression of ATP1A1 and ATP1A2 in breast cancer.
Actein inhibits the Na+-K+-ATPase and enhances the growth inhibitory effect of digitoxin on human breast cancer cells.
Controllable Drug Delivery by Na+/K+ ATPase ?1 Targeting Peptide Conjugated DSPE-PEG Nanocarriers for Breast Cancer.
Down-regulation of FXYD3 expression in human lung cancers: its mechanism and potential role in carcinogenesis.
Hyaluronic Acid Improves Hydrogen Peroxide Modulatory Effects on Calcium Channel and Sodium-Potassium Pump in 4T1 Breast Cancer Cell Line.
Identification of a sodium pump Na+/K+ ATPase ?1-targeted peptide for PET imaging of breast cancer.
In Vitro-In Vivo Extrapolation Scaling Factors for Intestinal P-Glycoprotein and Breast Cancer Resistance Protein: Part I: A Cross-Laboratory Comparison of Transporter-Protein Abundances and Relative Expression Factors in Human Intestine and Caco-2 Cells.
Na+/K+ ATPase activity promotes invasion of endocrine resistant breast cancer cells.
Potential suitability of Na+/K(+)-transporting ATPase in pre-screens for anti-cancer agents.
Brugada Syndrome
Hypokalemia, high erythrocyte Na+ and low erythrocyte Na,K-ATPase in relatives of patients dying from sudden unexplained death syndrome in north-east Thailand and in survivors from near-fatal attacks.
Carcinogenesis
A pump-independent function of the Na,K-ATPase is required for epithelial junction function and tracheal tube-size control.
GNAS mutations in adrenal aldosterone-producing adenomas [Rapid Communication].
Inhibition of membrane Na+-K+ ATPase activity: a common pathway in central nervous system disorders.
Integrated analysis of miRNA and mRNA transcriptomic reveals antler growth regulatory network.
Membrane potential of rat urinary bladder epithelial cells.
Na,K-ATPase is a target of cigarette smoke and reduced expression predicts poor patient outcome of smokers with lung cancer.
The landscape of molecular mechanism for aldosterone production in aldosterone-producing adenoma.
The Na/Ca Exchange as a Target for Antitumor Effect of 4Hz Pulsing Magnetic Field.
Translationally controlled tumor protein induces human breast epithelial cell transformation through the activation of Src.
Carcinoma
Analysis of the Na,K-ATPase alpha- and beta-subunit expression profiles of bladder cancer using tissue microarrays.
Bufalin induced apoptosis of bladder carcinoma cells through the inactivation of Na+K+-ATPase.
Combined assessment of low PGRMC1/positive ATP1A1 levels has enhanced prognostic value for renal cell carcinoma.
Downregulation of ATP1A1 promotes cancer development in renal cell carcinoma.
Effects of digoxin and Na, K-ATPase immunoexpression on human oral squamous carcinomas.
Epigenetic silencing of Na,K-ATPase ? 1 subunit gene ATP1B1 by methylation in clear cell renal cell carcinoma.
Glucocorticoids suppress renal cell carcinoma progression by enhancing Na,K-ATPase beta-1 subunit expression.
Identification of protein kinase C as an intermediate in Na,K-ATPase Beta-subunit mediated lamellipodia formation and suppression of cell motility in carcinoma cells.
Long-term exposure to hypoxia inhibits tumor progression of lung cancer in rats and mice.
Membrane transporters and signal transduction.
Na,K-adenosine triphosphatase alpha1-subunit predicts survival of renal clear cell carcinoma.
Na,K-ATPase ?1-subunit is a target of sonic hedgehog signaling and enhances medulloblastoma tumorigenicity.
Na,K-ATPase beta-subunit is required for epithelial polarization, suppression of invasion, and cell motility.
Na,K-ATPase is a target of cigarette smoke and reduced expression predicts poor patient outcome of smokers with lung cancer.
Na,K-ATPase subunits as markers for epithelial-mesenchymal transition in cancer and fibrosis.
Na/K-ATPase mimetic pNaKtide inhibits the growth of human cancer cells.
Novel role for Na,K-ATPase in phosphatidylinositol 3-kinase signaling and suppression of cell motility.
Overexpression of ATPase Na+/+ transporting alpha 1 polypeptide, ATP1A1, correlates with clinical diagnosis and progression of esophageal squamous cell carcinoma.
Potential suitability of Na+/K(+)-transporting ATPase in pre-screens for anti-cancer agents.
Reduced expression of beta-subunit of Na,K-ATPase in human clear-cell renal cell carcinoma.
Repression of Na,K-ATPase beta1-subunit by the transcription factor snail in carcinoma.
Transcriptional regulators of Na,K-ATPase subunits.
[Effect of UHF and ionizing radiation on the Na-K-ATPase activity of Ehrlich ascitic carcinoma cells]
[The biological effect of sodium butyrate (NaBT) on SGC-7901 cells]
Carcinoma, Ductal
Single-cell heterogeneity in ductal carcinoma in situ of breast.
Carcinoma, Ehrlich Tumor
A mouse homolog to the avian sarcoma virus src protein is a member of a protein kinase cascade.
Changes in (Na+ + K+)-ATPase activity of Ehrlich ascites tumor cells produced by alteration of membrane fatty acid composition.
Motility, heat, and lactate production in ejaculated bovine sperm.
Phosphorylation of the beta subunit of Na+K+-ATPase in Ehrlich ascites tumor by a membrane-bound protein kinase.
Regulation of phosphorylation of the beta-subunit of th Ehrlich ascites tumor Na+K+-ATPase by a protein kinase cascade.
Regulatory volume increase in Ehrlich ascites tumor cells.
Studies on the relationship between glycolysis and (Na+ + K+)-ATPase in cultured cells.
Transport functions of the liver. Lack of correlation between hepatocellular ouabain uptake and binding to (Na+ + K+)-ATPase.
Carcinoma, Hepatocellular
A high-affinity (Ca2+ + Mg2+)-ATPase in plasma membranes of rat ascites hepatoma AH109A cells.
Identification of Tumor Antigen AF20 as Glycosylated Transferrin Receptor 1 in Complex with Heat Shock Protein 90 and/or Transporting ATPase.
Inhibitors of Na+/K+ ATPase exhibit antitumor effects on multicellular tumor spheroids of hepatocellular carcinoma.
Insulin regulation of Na/K pump activity in rat hepatoma cells.
Isolation and characterization of the plasma membranes from rat ascites hepatomas and from normal rat livers, including newborn, regenerating, and adult livers.
Studies on plasma membranes. VI. Differences in the effect of temperature on the ATPase and (Na+-K+)-ATPase activities of plasma membranes isolated from rat liver and hepatoma.
Tissue-specific expression of Na,K-ATPase beta-subunit. Does beta 2 expression correlate with tumorigenesis?
Transport functions of the liver. Lack of correlation between hepatocellular ouabain uptake and binding to (Na+ + K+)-ATPase.
Turnover of the catalytic subunit of Na,K-ATPase in HTC cells.
Carcinoma, Intraductal, Noninfiltrating
Single-cell heterogeneity in ductal carcinoma in situ of breast.
Carcinoma, Lewis Lung
Long-term exposure to hypoxia inhibits tumor progression of lung cancer in rats and mice.
Carcinoma, Renal Cell
Combined assessment of low PGRMC1/positive ATP1A1 levels has enhanced prognostic value for renal cell carcinoma.
Downregulation of ATP1A1 promotes cancer development in renal cell carcinoma.
Epigenetic silencing of Na,K-ATPase ? 1 subunit gene ATP1B1 by methylation in clear cell renal cell carcinoma.
Glucocorticoids suppress renal cell carcinoma progression by enhancing Na,K-ATPase beta-1 subunit expression.
Na,K-adenosine triphosphatase alpha1-subunit predicts survival of renal clear cell carcinoma.
Reduced expression of beta-subunit of Na,K-ATPase in human clear-cell renal cell carcinoma.
Carcinoma, Transitional Cell
Analysis of the Na,K-ATPase alpha- and beta-subunit expression profiles of bladder cancer using tissue microarrays.
Cardiomegaly
Alteration of Na,K-ATPase subunit mRNA and protein levels in hypertrophied rat heart.
Cardiac hypertrophy in mice expressing unphosphorylatable phospholemman.
Cardiac Oxidative Signaling and Physiological Hypertrophy in the Na/K-ATPase ?1s/s?2s/s Mouse Model of High Affinity for Cardiotonic Steroids.
Coordinated shifts in Na/K-ATPase isoforms and their endogenous ligands during cardiac hypertrophy and failure in NaCl-sensitive hypertension.
Differential regulation of Na/K-ATPase alpha-subunit isoform gene expressions in cardiac myocytes by ouabain and other hypertrophic stimuli.
Greasing the wheels or a spanner in the works? Regulation of the cardiac sodium pump by palmitoylation.
High blood pressure, oxygen radicals and antioxidants: etiological relationships.
Intracellular Na+ and altered Na+ transport mechanisms in cardiac hypertrophy and failure.
Mice expressing ouabain-sensitive {alpha}1 Na,K-ATPase have increased susceptibility to pressure overload-induced cardiac hypertrophy.
Na+, K(+)-ATPase and Na+/Ca2+ exchange isoforms: physiological and physiopathological relevance.
Na,K-pump concentration in hypertrophied human hearts.
Overexpression of the Na+/K+ ATPase ?2 but not ?1 isoform attenuates pathological cardiac hypertrophy and remodeling.
The Redox-Sensitive Na/K-ATPase Signaling in Uremic Cardiomyopathy.
Cardiomyopathies
Abnormalities in heart membranes and myofibrils during bacterial infective cardiomyopathy in the rabbit.
Anti-apoptotic potential of gymnemic acid phospholipid complex pretreatment in Wistar rats with experimental cardiomyopathy.
Attenuation of Na/K-ATPase Mediated Oxidant Amplification with pNaKtide Ameliorates Experimental Uremic Cardiomyopathy.
Central Role for Adipocyte Na,K-ATPase Oxidant Amplification Loop in the Pathogenesis of Experimental Uremic Cardiomyopathy.
Corrigendum: Attenuation of Na/K-ATPase Mediated Oxidant Amplification with pNaKtide Ameliorates Experimental Uremic Cardiomyopathy.
Decreased Na,K-ATPase gene expression in cardiomyopathic hamster hearts.
Gender differences in the development of uremic cardiomyopathy following partial nephrectomy: Role of progesterone.
Molecular insights into uremic cardiomyopathy: cardiotonic steroids and na/k ATPase signaling.
Oxidant-Induced Alterations in the Adipocyte Transcriptome: Role of the Na,K-ATPase Oxidant Amplification Loop.
Rapamycin Attenuates Cardiac Fibrosis in Experimental Uremic Cardiomyopathy by Reducing Marinobufagenin Levels and Inhibiting Downstream Pro-Fibrotic Signaling.
Sodium potassium adenosine triphosphatase (Na/K-ATPase) as a therapeutic target for uremic cardiomyopathy.
Targeting Na/K-ATPase Signaling: A New Approach to Control Oxidative Stress.
The Na,K-pump in human myocardium: quantification in normal subjects and patients with suspected cardiomyopathy.
The Redox-Sensitive Na/K-ATPase Signaling in Uremic Cardiomyopathy.
Cardiomyopathy, Dilated
Autoantibodies produced against sarcolemmal Na-K-ATPase: possible upstream targets of arrhythmias and sudden death in patients with dilated cardiomyopathy.
Defective activity and isoform of the Na,K-ATPase in the dilated cardiomyopathic hamster.
Myocardial adenine nucleotides, glycogen, and Na, K-ATPase in patients with idiopathic dilated cardiomyopathy requiring mechanical circulatory support.
Na,K-ATPase expression in normal and failing human left ventricle.
Na,K-ATPase receptor subunits alpha 1, alpha 2 and alpha 3 mRNA in dilated cardiomyopathy.
Relation of left ventricular function and Na,K-pump concentration in suspected idiopathic dilated cardiomyopathy.
[Autoantibodies against sarcolemmal Na-K-ATPase in patients with dilated cardiomyopathy: autoimmune basis for ventricular arrhythmias in patients with congestive heart failure]
[Autoantibodies: new upstream targets of paroxysmal atrial fibrillation in patients with congestive heart failure]
[Correlation of intra-erythrocytic Na, K, Ca, Mg contents and ATPase activity with dilated cardiomyopathy]
Cardiotoxicity
Anti-apoptotic potential of gymnemic acid phospholipid complex pretreatment in Wistar rats with experimental cardiomyopathy.
Cardiac sodium, potassium-adenosine triphosphatase as a possible site of adriamycin-induced cardiotoxicity.
Development of Orthogonal Linear Separation Analysis (OLSA) to Decompose Drug Effects into Basic Components.
Cardiovascular Diseases
Allopurinol and valproic acid improve cardiac triglyceride and Na+-K+-ATPase activity independent of circulating aldosterone in female rats with glucose intolerance.
Mechanisms of isoform-specific Na/K pump regulation by short- and long-term adrenergic activation in rat ventricular myocytes.
Membrane transporters and signal transduction.
Omegacoeur, a Mediterranean nutritional complement, stimulates Na,K-ATPase activity in human endothelial cells.
Renovascular hypertension using a modified two-kidney, one-clip approach in mice is not dependent on the {alpha}1 or {alpha}2 Na,K-ATPase ouabain-binding site.
Synthesis of an Endogenous Steroidal Na Pump Inhibitor Marinobufagenin, Implicated in Human Cardiovascular Diseases, Is Initiated by CYP27A1 via Bile Acid Pathway.
The Na/K-ATPase-mediated signal transduction as a target for new drug development.
The Role of Na/K-ATPase Signaling in Oxidative Stress Related to Aging: Implications in Obesity and Cardiovascular Disease.
The Role of Na/K-ATPase Signaling in Oxidative Stress Related to Obesity and Cardiovascular Disease.
The role of red blood cell deformability and Na,K-ATPase function in selected risk factors of cardiovascular diseases in humans: focus on hypertension, diabetes mellitus and hypercholesterolemia.
The Trade-Off between Dietary Salt and Cardiovascular Disease; A Role for Na/K-ATPase Signaling?
Cataract
Altered Na,K-ATPase pattern in gamma-crystallin mutant mice.
ATP hydrolysis kinetics of Na,K-ATPase in cataract.
Cataract development induced by repeated oral dosing with FK506 (tacrolimus) in adult rats.
Effect of glutathione depletion on cation transport and metabolism in the rabbit lens.
Effect of inhibition of lens membrane Na+-K+ ATPase by ouabain pre-treatment--an in vitro study.
Expression, regulation and function of Na,K-ATPase in the lens.
Failure of Oxysterols Such as Lanosterol to Restore Lens Clarity from Cataracts.
Immunodetection of Na,K-ATPase in guinea-pig retinal layers, cornea and lens.
Lens lipids.
Lenticular alterations in hypertensive rats.
Lipid composition and (Na+ + K+)-ATPase activity in rat lens during triparanol-induced cataract formation.
Myotonia induced by diazacholesterol: increased (Na+ + K+)-ATPase activity of erythrocyte ghosts and development of cataracts.
Na,K-ATPase and phospholipid degradation in bovine and human lenses.
Na,K-ATPase in lens epithelia from patients with senile cataracts.
Na,K-ATPase in simulated eye bank and cryoextracted rabbit lenses, and human eye bank lenses and cataracts.
Over-expression of translationally controlled tumor protein in lens epithelial cells seems to be associated with cataract development.
Prefeeding of aldose reductase inhibitor and galactose cataractogenesis.
Pyruvate inhibits galactosemic changes in cultured cat lens epithelial cells.
Sodium-potassium--dependent ATPase. II. Cytochemical localization during the reversal of galactose cataracts in rat.
Sodium-potassium-dependent-ATPase activity in Emory mouse lens.
Synergism between phospholipase D2 and sorbitol accumulation in diabetic cataract formation through modulation of Na,K-ATPase activity and osmotic stress.
The effect of endothelin-1 on Src-family tyrosine kinases and Na,K-ATPase activity in porcine lens epithelium.
The effect of near-UV light on Na-K-ATPase of the rat lens.
The effect of X-irradiation on the sodium-potassium-activated adenosine triphosphatase (Na-K-ATPase) activity in the epithelium of the rat lens. A histochemical and biochemical study.
The influence of protein tyrosine phosphatase-1B on Na,K-ATPase activity in lens.
The molecular chaperone alpha-crystallin incorporated into red cell ghosts protects membrane Na/K-ATPase against glycation and oxidative stress.
The Na-K-ATPase in relation to the Na, K and taurine levels in the senile cataract.
[Metabolic abnormality of the senile cataract report II, the Na+-K+-ATPase in relation to the ATP level in the senile cataract]
[Na-K-ATPase activity in the normal aging crystalline lens and in senile cataract]
Celiac Disease
Decreased Na+/K+ pump activity in the erythrocytes of children with treated celiac disease.
Central Nervous System Diseases
Inhibition of membrane Na+-K+ ATPase activity: a common pathway in central nervous system disorders.
Charcot-Marie-Tooth Disease
ATP1A1 mutations cause intermediate Charcot-Marie-Tooth disease.
Hereditary spastic paraplegia is a novel phenotype for germline de novo ATP1A1 mutation.
Chediak-Higashi Syndrome
Na,K-ATPase activity in red blood cells from patients with Chediak-Higashi syndrome.
Cholera
Acute and chronic regulation of Na+/K+-ATPase transport activity in the RN22 Schwann cell line in response to stimulation of cyclic AMP production.
Antisecretory effects of berberine in rat ileum.
Evidence for role of glycoprotein carbohydrates in membrane transport: specific inhibition by tunicamycin.
Prevention and reversal of cholera enterotoxin-induced intestinal secretion by methylprednisolone induction of Na+-K+-ATPase.
Regulation of Na+-K+-ATPase activity in kidney proximal tubules: involvement of GTP binding proteins.
Cholestasis
Effects of chlorpromazine on Na+-K+-ATPase pumping and solute transport in rat hepatocytes.
Colitis
Na,K-ATPase activity in rectal mucosa of children with ulcerative colitis and Crohn's disease.
Colitis, Ulcerative
Decreased colonic Na-K-ATPase activity in active ulcerative colitis.
Inverse relationship between colonic (Na+ + K+)-ATPase activity and degree of mucosal inflammation in inflammatory bowel disease.
Na,K-ATPase activity in rectal mucosa of children with ulcerative colitis and Crohn's disease.
Colonic Neoplasms
Identification of Tumor Antigen AF20 as Glycosylated Transferrin Receptor 1 in Complex with Heat Shock Protein 90 and/or Transporting ATPase.
Long-term exposure to hypoxia inhibits tumor progression of lung cancer in rats and mice.
Opposite expression pattern of the human Na,K-ATPase beta 1 isoform in stomach and colon adenocarcinomas.
Colorectal Neoplasms
Na,K-ATPase Isozymes in Colorectal Cancer and Liver Metastases.
Ouabain-induced alterations of the apical junctional complex involve ?1 and ?1 Na,K-ATPase downregulation and ERK1/2 activation independent of caveolae in colorectal cancer cells.
Confusion
[Molecular mechanisms of idiopathic nephrotic syndrome]
Contracture
Calcium induced contracture stimulates Na,K-pump rate in isolated sheep cardiac Purkinje fibers.
Excitation-contraction uncoupling in the rat diaphragm by 2,3-butanedione monoxime.
Na+/H+ and Na+/Ca2+ exchange in regulation of [Na+]i and [Ca2+]i during metabolic inhibition.
Pathogenesis and the role of Ca2+ overload during myocardial ischemia/reperfusion.
Potential and tension changes induced by sodium removal in dog Purkinje fibres: role of an electrogenic sodium-calcium exchange.
Separate sites for the dantrolene-induced inhibition of contracture of the rat diaphragm preparation due to depolarization or to caffeine.
[Protective effects of m-nisoldipine and nisoldipine on myocardial damage in working rabbit hearts after ischemia-reperfusion]
Coronary Artery Disease
Increased membrane lipid peroxidation and decreased Na+/K+-ATPase activity in erythrocytes of patients with stable coronary artery disease.
Coronary Occlusion
Alterations in heart membrane calcium transport during the development of ischemia-reperfusion injury.
Ischemia-induced alterations in myocardial (Na+ + K+)-ATPase and cardiac glycoside binding.
COVID-19
Molecular mechanisms of Na,K-ATPase dysregulation driving alveolar epithelial barrier failure in severe COVID-19.
Craniocerebral Trauma
[An influence of cytoflavin on oxidative stress and activity of Na/K-ATPase of erythrocytes after brain trauma].
Crohn Disease
Na,K-ATPase activity in rectal mucosa of children with ulcerative colitis and Crohn's disease.
Total body potassium depletion and the need for preoperative nutritional support in Chrohn's disease.
Cushing Syndrome
Endogenous natriuretic factors: atrial natriuretic hormone and digitalis-like substance in Cushing's syndrome.
GNAS mutations in adrenal aldosterone-producing adenomas [Rapid Communication].
Increased activity of the Na-K-ATPase in red cell-ghosts of patients with Cushing's syndrome: possible significance for the pathogenesis of glucocorticoid-induced hypertension.
Na-K pump activity in erythrocytes of patients with endogenous and exogenous glucocorticoid excess.
Na-K-ATPase in erythrocyte ghosts is not a marker for primary hypertension.
Sodium-potassium-dependent ATPase activity in erythrocyte ghosts of patients with primary and secondary hypertension.
Cystic Fibrosis
Azaspiracids Increase Mitochondrial Dehydrogenases Activity in Hepatocytes: Involvement of Potassium and Chloride Ions.
Calcium and sodium transport processes in patients with cystic fibrosis. I. A specific decrease in Mg2+-dependent, Ca2+-adenosine triphosphatase activity in erythrocyte membranes from cystic fibrosis patients.
Calcium-ATPase activity in cystic fibrosis erythrocyte membranes: decreased activity in patients with pancreatic insufficiency.
Characterization of ion channel and transporter mRNA expressions in isolated gill chloride and pavement cells of seawater acclimating eels.
Characterization of oncocytes in deep esophageal glands.
Differences in the protein-kinase-A-dependent regulation of CFTR Cl- channels and Na+-K+ pumps in guinea-pig ventricular myocytes.
Dual regulation of cardiac Na+-K+ pumps and CFTR Cl- channels by protein kinases A and C.
Effects of potassium ion supplementation on survival and ion regulation in Gulf killifish Fundulus grandis larvae reared in ion deficient saline waters.
Enhanced osmoregulatory ability marks the smoltification period in developing chum salmon (Oncorhynchus keta).
Identification of the cofilin-binding sites in the large cytoplasmic domain of Na,K-ATPase.
Immunolocalization of ion transport proteins in human autosomal dominant polycystic kidney epithelial cells.
Inflammatory Responses Regulating Alveolar Ion Transport during Pulmonary Infections.
Knockout mice reveal key roles for claudin 18 in alveolar barrier properties and fluid homeostasis.
Lubiprostone Targets Prostanoid Signaling and Promotes Ion Transporter Trafficking, Mucus Exocytosis, and Contractility.
Lung epithelial fluid transport and the resolution of pulmonary edema.
Na and K dependence of the Na/K pump in cystic fibrosis fibroblasts.
Na+/K+ ATPase in lower airway epithelium from cystic fibrosis and non-cystic-fibrosis lung.
Plumbagin Prevents Secretory Diarrhea by Inhibiting CaCC and CFTR Channel Activities.
Simulation analysis of intracellular Na+ and Cl- homeostasis during beta 1-adrenergic stimulation of cardiac myocyte.
Specialized Pro-resolving Mediators Regulate Alveolar Fluid Clearance during Acute Respiratory Distress Syndrome.
Ursodeoxycholic acid inhibits ENaC and Na/K pump activity to restore airway surface liquid height in cystic fibrosis bronchial epithelial cells.
Vocal Fold Surface Hydration: A Review.
Cystinosis
Decreased intracellular ATP content and intact mitochondrial energy generating capacity in human cystinotic fibroblasts.
Cysts
Analysis of the role of membrane polarity in polycystic kidney disease of transgenic SBM mice.
Both mitogen activated protein kinase and the mammalian target of rapamycin modulate the development of functional renal proximal tubules in matrigel.
Cell polarity in human renal cystic disease.
Cystic fibrosis transmembrane conductance regulator in the kidney: clues to its role?
Histopathological analysis of renal cystic epithelia in the Pkd2WS25/- mouse model of ADPKD.
Immunolocalization of ion transport proteins in human autosomal dominant polycystic kidney epithelial cells.
In vitro modulation of tubular cyst regression in murine polycystic kidney disease.
Na transport in autosomal recessive polycystic kidney disease (ARPKD) cyst lining epithelial cells.
Ouabain Regulates CFTR-Mediated Anion Secretion and Na,K-ATPase Transport in ADPKD Cells.
Polymorphism and structure of the gene coding for the alpha 1 subunit of the Artemia franciscana Na/K-ATPase.
Regulation of Na,K-ATPase biosynthesis in developing Artemia salina.
Renal tubule Na,K-ATPase polarity in different animal models of polycystic kidney disease.
Renal tubule Na,K-ATPase polarity in glucocorticoid-induced polycystic kidney disease.
Sequential tubular cell and basement membrane changes in polycystic kidney disease.
Sodium pump distribution is not reversed in the DBA/2FG-pcy, polycystic kidney disease model mouse.
The {beta}1 subunit of the Na,K-ATPase pump interacts with megalencephalic leucoencephalopathy with subcortical cysts protein 1 (MLC1) in brain astrocytes: new insights into MLC pathogenesis.
Triiodothyronine-induced cyst formation in metanephric organ culture: the role of increased Na-K-adenosine triphosphatase activity.
Deafness
CRYM mutations cause deafness through thyroid hormone binding properties in the fibrocytes of the cochlea.
Late-onset hearing loss in a mouse model of DFN3 non-syndromic deafness: morphologic and immunohistochemical analyses.
Death, Sudden, Cardiac
Autoantibodies produced against sarcolemmal Na-K-ATPase: possible upstream targets of arrhythmias and sudden death in patients with dilated cardiomyopathy.
Autoimmune mechanisms underlying dilated cardiomyopathy.
Contribution of acquired factors to the pathogenesis of dilated cardiomyopathy. -The cause of dilated cardiomyopathy: genetic or acquired? (Acquired-Side)-.
[Autoantibodies against sarcolemmal Na-K-ATPase in patients with dilated cardiomyopathy: autoimmune basis for ventricular arrhythmias in patients with congestive heart failure]
Dehydration
Acute and chronic effects of hyperosmolality on mRNA and protein expression and the activity of Na-K-ATPase in the IMCD.
Brain water and aging.
Distribution of aquaporins and sodium transporters in the gastrointestinal tract of a desert hare, Lepus yarkandensis.
Sodium-potassium pump, ion fluxes, and cellular dehydration in sickle cell anemia.
The 4Hz mechanical vibration-activated Na/Ca exchange as a quantum-sensitive novel target for pain therapy.
The Na/Ca Exchange as a Target for Antitumor Effect of 4Hz Pulsing Magnetic Field.
[Congenital xerocytosis]
Dementia
Inhibition of membrane Na+-K+ ATPase activity: a common pathway in central nervous system disorders.
Diabetes Complications
Are disturbances of sorbitol, phosphoinositide, and Na+-K+-ATPase regulation involved in pathogenesis of diabetic neuropathy?
Association between erythrocyte Na+K+-ATPase activity and some blood lipids in type 1 diabetic patients from Lagos, Nigeria.
Glomerular Na+-K+-ATPase activity in acute and chronic diabetes and with aldose reductase inhibition.
Na+-K+-ATPase pumping activity is not directly linked to myo-inositol levels after sorbinil treatment in lenses of diabetic rats.
Reduced glomerular sodium/potassium adenosine triphosphatase activity in acute streptozocin diabetes and its prevention by oral sorbinil.
The relationship between red blood cell Na/K-ATPase activities and diabetic complications in patients with type 2 diabetes mellitus.
Diabetes Insipidus, Nephrogenic
Changes of rat kidney AQP2 and Na,K-ATPase mRNA expression in lithium-induced nephrogenic diabetes insipidus.
Diabetes Mellitus
Acute diabetes mellitus and its influence on renal Na,K-ATPase in both genders.
Association between a novel G94A single nucleotide polymorphism in ATP1A1 gene and type 2 diabetes mellitus among Egyptian patients.
Association between erythrocyte Na+K+-ATPase activity and some blood lipids in type 1 diabetic patients from Lagos, Nigeria.
Dietary lipid modulation of Na+/glucose co-transporter (SGLT1), Na+/K+ ATPase, and ornithine decarboxylase gene expression in the rat small intestine in diabetes mellitus.
Effects of C-peptide on microvascular blood flow and blood hemorheology.
Effects of sprint training on extrarenal potassium regulation with intense exercise in Type 1 diabetes.
Endogenous digitalis-like ligands and Na/K-ATPase inhibition in experimental diabetes mellitus.
Endogenous sodium pump inhibitors, diabetes mellitus and preeclampsia Preliminary observations and a hypothesis.
Evaluation of sodium and potassium pump activity and number in diabetic erythrocytes.
Marinobufagenin, an endogenous inhibitor of alpha-1 Na/K-ATPase, is a novel factor in pathogenesis of diabetes mellitus.
Mechanism of sodium load-induced hypertension in non-insulin dependent diabetes mellitus model rats: defective dopaminergic system to inhibit Na-K-ATPase activity in renal epithelial cells.
Modulation of Na,K-ATPase activity by immunoglobulins--II. Na,K-ATPase activity in erythrocytes from patients with various chronic disturbances.
Proximal tubular cell sodium concentration in early diabetic nephropathy assessed by electron microprobe analysis.
Regulation of myocardial and skeletal muscle Na,K-ATPase in diabetes mellitus in humans and animals.
Relation of erythrocyte Na+-K+ ATPase activity and cholesterol and oxidative stress in patients with type 2 diabetes mellitus.
The effect of streptozotocin-induced diabetes mellitus on urinary excretion of sodium and renal Na+-K+-ATPase activity.
The relationship between red blood cell Na/K-ATPase activities and diabetic complications in patients with type 2 diabetes mellitus.
The role of red blood cell deformability and Na,K-ATPase function in selected risk factors of cardiovascular diseases in humans: focus on hypertension, diabetes mellitus and hypercholesterolemia.
Diabetes Mellitus, Experimental
Endogenous digitalis-like ligands and Na/K-ATPase inhibition in experimental diabetes mellitus.
Insulin stimulates renal glomerular sodium-potassium adenosine triphosphatase activity.
Small intestinal Na+,K+-adenosine triphosphatase activity and gene expression in experimental diabetes mellitus.
[Effect of alloxan diabetes on (Na+ + K+)-activated ATPase in brush border membrane of the mucosal cell of rat small intestine]
[Increase of (Na+ + K+)-activated ATPase activity of basolateral plasma membranes from intestinal mucosa of diabetic rats]
Diabetes Mellitus, Type 1
Altered platelet membrane dynamic properties in type 1 diabetes.
Association between erythrocyte Na+K+-ATPase activity and some blood lipids in type 1 diabetic patients from Lagos, Nigeria.
C-peptide increases Na,K-ATPase expression via PKC- and MAP kinase-dependent activation of transcription factor ZEB in human renal tubular cells.
Changes in Na,K-adenosine triphosphatase (ATPase) concentration and Na,K-ATPase-dependent adenosine triphosphate turnover in human erythrocytes in diabetes.
Decreased nitric oxide synthase activity in platelets from IDDM and NIDDM patients.
Effects of sprint training on extrarenal potassium regulation with intense exercise in Type 1 diabetes.
Erythrocyte cation transport systems in insulin-dependent diabetics: correlation with prorenin and albuminuria.
Glucose-specific regulation of aldose reductase in capan-1 human pancreatic duct cells In vitro.
Hypothesis: low Na/K-ATPase activity in the red cell membrane, a potential marker of the predisposition to diabetic neuropathy.
Membrane lipid alterations and Na+-pumping activity in erythrocytes from IDDM and NIDDM subjects.
[Erythrocyte membrane sodium transport in patients with type I diabetes mellitus (insulin-dependent diabetes mellitus)]
Diabetes Mellitus, Type 2
Association between a novel G94A single nucleotide polymorphism in ATP1A1 gene and type 2 diabetes mellitus among Egyptian patients.
Association of hypoglutathionemia with reduced Na+/K+ ATPase activity in type 2 diabetes and microangiopathy.
Changes in Na,K-adenosine triphosphatase (ATPase) concentration and Na,K-ATPase-dependent adenosine triphosphate turnover in human erythrocytes in diabetes.
Decreased nitric oxide synthase activity in platelets from IDDM and NIDDM patients.
Effect of resistance training on Na,K pump and Na+/H+ exchange protein densities in muscle from control and patients with type 2 diabetes.
Impact of the metabolic syndrome on peripheral nerve structure and function in type 2 diabetes.
Membrane lipid alterations and Na+-pumping activity in erythrocytes from IDDM and NIDDM subjects.
Relation of erythrocyte Na+-K+ ATPase activity and cholesterol and oxidative stress in patients with type 2 diabetes mellitus.
The relationship between red blood cell Na/K-ATPase activities and diabetic complications in patients with type 2 diabetes mellitus.
Diabetic Cardiomyopathies
?3-Adrenoceptor, glutathionylation, and diabetic cardiomyopathy. Focus on "?3-Adrenoceptor activation relieves oxidative inhibition of the cardiac Na+-K+ pump in hyperglycemia induced by insulin receptor blockade".
Alteration of Na,K-ATPase isoenzymes in diabetic cardiomyopathy: effect of dietary supplementation with fish oil (n-3 fatty acids) in rats.
Diabetic Nephropathies
Aldose reductase, glomerular metabolism, and diabetic nephropathy.
Reduced glomerular sodium/potassium adenosine triphosphatase activity in acute streptozocin diabetes and its prevention by oral sorbinil.
Diabetic Neuropathies
Activity-dependent excitability changes suggest Na+/K+ pump dysfunction in diabetic neuropathy.
Alpha-lipoic Acid and diabetic neuropathy.
Alterations of Na,K-ATPase isoenzymes in the rat diabetic neuropathy: protective effect of dietary supplementation with n-3 fatty acids.
Altered nerve excitability properties in established diabetic neuropathy.
Association between a novel G94A single nucleotide polymorphism in ATP1A1 gene and type 2 diabetes mellitus among Egyptian patients.
Effect of cilostazol on experimental diabetic neuropathy in the rat.
Effect of experimental diabetes on Na/K-ATPase activity in red blood cells, peripheral nerve and kidney.
Effect of gangliosides on nerve conduction velocity during diabetic neuropathy in the rat.
Fish oil supplementation prevents diabetes-induced nerve conduction velocity and neuroanatomical changes in rats.
Genetic and environmental regulation of Na/K adenosine triphosphatase activity in diabetic patients.
Glutathione redox state is not the link between polyol pathway activity and myo-inositol-related Na+-K+-ATPase defect in experimental diabetic neuropathy.
Hypothesis: low Na/K-ATPase activity in the red cell membrane, a potential marker of the predisposition to diabetic neuropathy.
In vitro correction of impaired Na+-K+-ATPase in diabetic nerve by protein kinase C agonists.
Localization of Na,K-ATPase alpha/beta isoforms in rat sciatic nerves: effect of diabetes and fish oil treatment.
NA+/K+ ATPase impairment and experimental glycation: the role of glucose autoxidation.
Sciatic nerve ATPase activity is unaffected in diabetic mutant C57Bl/Ks (db/db) mice.
The pathogenesis and prevention of diabetic neuropathy and nephropathy.
[New trend in pathogenesis of diabetic neuropathy]
Down Syndrome
Cerebral chemical dominance and neural regulation of cell division, cell proliferation, neoplastic transformation, and genomic function.
Inhibition of membrane Na+-K+ ATPase activity: a common pathway in central nervous system disorders.
Dyslipidemias
Allopurinol and valproic acid improve cardiac triglyceride and Na+-K+-ATPase activity independent of circulating aldosterone in female rats with glucose intolerance.
Green tea impedes dyslipidemia, lipid peroxidation, protein glycation and ameliorates Ca2+ -ATPase and Na+/K+ -ATPase activity in the heart of streptozotocin-diabetic rats.
Dystocia
X-ray microanalysis of myometrium in parturient women at term.
Dystonia
Deficiency in Na,K-ATPase alpha isoform genes alters spatial learning, motor activity, and anxiety in mice.
Distribution of Na/K-ATPase alpha 3 isoform, a sodium-potassium P-type pump associated with rapid-onset of dystonia parkinsonism (RDP) in the adult mouse brain.
Enhanced inhibitory neurotransmission in the cerebellar cortex of Atp1a3-deficient heterozygous mice.
Heterozygous mice deficient in Atp1a3 exhibit motor deficits by chronic restraint stress.
Hypothermia-induced dystonia and abnormal cerebellar activity in a mouse model with a single disease-mutation in the sodium-potassium pump.
Mutations in the Na+/K+ -ATPase alpha3 gene ATP1A3 are associated with rapid-onset dystonia parkinsonism.
Paying the price at the pump: dystonia from mutations in a Na+/K+ -ATPase.
[Dystonia 12: A rare and difficult diagnosis].
Encephalomyelitis, Autoimmune, Experimental
[Na+-K+-ATPase activity in guinea pig brain synaptosomal fraction in experimental allergic encephalomyelitis]
Endolymphatic Hydrops
Na,K-ATPase in the cochlear lateral wall of human temporal bones with endolymphatic hydrops.
Na-K-ATPase activity in the guinea pig stria vascularis in experimentally-induced endolymphatic hydrops.
Endotoxemia
Endotoxemia stimulates skeletal muscle Na+-K+-ATPase and raises blood lactate under aerobic conditions in humans.
Inhibition of Na/K-ATPase promotes myocardial tumor necrosis factor-alpha protein expression and cardiac dysfunction via calcium/mTOR signaling in endotoxemia.
Enteritis
Mechanism of Na-K-ATPase Inhibition by PGE2 in Intestinal Epithelial Cells.
Molecular Mechanism of Stimulation of Na-K-ATPase by Leukotriene D4 in Intestinal Epithelial Cells.
Neutral Na-amino acid cotransport is differentially regulated by glucocorticoids in the normal and chronically inflamed rabbit small intestine.
Epilepsy
Alterations in the alpha2 isoform of Na,K-ATPase associated with familial hemiplegic migraine type 2.
Brain synaptosomes in epilepsy: organization of ionic channels and the Na+-K+ pump.
Changes in the isoprenoid pathway with transcendental meditation and Reiki healing practices in seizure disorder.
Epilepsy and membrane Na+K+ATPase: changes in activity using an experimental model of epilepsy.
Glial and neuronal Na+-K+ pump in epilepsy.
Hypothesis on neurophysiopathological mechanisms linking epilepsy and headache.
Increased susceptibility to cortical spreading depression in the mouse model of familial hemiplegic migraine type 2.
Kinetic alterations due to a missense mutation in the Na,K-ATPase alpha2 subunit cause familial hemiplegic migraine type 2.
Na,K-ATPase is decreased in hippocampus of kainate-lesioned rats.
The Na,K-ATPase of nervous tissue.
Epilepsy, Absence
Abnormal cortical unit activity of the reticular formation.
Epilepsy, Generalized
Inhibition of membrane Na+-K+ ATPase activity: a common pathway in central nervous system disorders.
Epilepsy, Temporal Lobe
Na,K-ATPase is decreased in hippocampus of kainate-lesioned rats.
Esophageal Squamous Cell Carcinoma
Overexpression of ATPase Na+/+ transporting alpha 1 polypeptide, ATP1A1, correlates with clinical diagnosis and progression of esophageal squamous cell carcinoma.
Essential Hypertension
Abnormal relationship between dietary sodium intake and red cell sodium transport in salt-sensitive patients with essential hypertension.
Acute hypotensive effect of calcium antagonists and endogenous digitalis-like immunoreactivity in human essential hypertension.
Altered sodium permeability, calcium binding and Na-K-ATPase activity in the red blood cell membrane in essential hypertension.
An Na+-K+-ATPase inhibitor which circulates in renal failure but not in essential hypertension.
Association of ATP1A1 and dear single-nucleotide polymorphism haplotypes with essential hypertension: sex-specific and haplotype-specific effects.
Blood pressure in essential hypertension correlates with the concentration of a circulating inhibitor of the sodium pump.
Calcium antagonist treatment by lercanidipine prevents hyperpolarization in essential hypertension.
Cation fluxes and (Na+ + K+)-activated ATPase activity in erythrocytes of patients with essential hypertension.
Digoxin-like immunoreactivity, displacement of ouabain and inhibition of Na+/K+ ATPase by four steroids known to be increased in essential hypertension.
Diuretics and cation transport in hypertensive blacks.
Effects of captopril and of other antihypertensive drugs on cell membrane ion transport--a preliminary report.
Effects of ouabain and potassium on rabbit arterial smooth muscle cells in culture.
Effects of rat atrial extract on sodium transport and blood pressure in the rat.
Erythrocyte membrane sodium transport in patients with treated and untreated essential hypertension.
Erythrocyte Na+,K+ cotransport and Na+,K+ pump in black and caucasian hypertensive patients.
Evidence for a circulating Na,K-pump inhibitor in essential hypertension.
Familial abnormality of erythrocyte cation transport in essential hypertension.
Hormonal and nutritional enhancement of Na+-K+-ATPase activity may aid the prevention and treatment of essential hypertension.
Humoral Na+-K+ pump inhibitory activity in essential hypertension and in normotensive subjects after acute volume expansion.
Hypothalamic sodium-transport inhibitor is a high-affinity reversible inhibitor of Na+-K+-ATPase.
Increased activity of digoxin-like substance in low-renin hypertension in acromegaly.
Inhibition of the arteriolar smooth muscle NA+ -K+-pump induces an enhanced vasoconstriction in borderline but not in established essential hypertension.
Interaction of alpha(1)-Na,K-ATPase and Na,K,2Cl-cotransporter genes in human essential hypertension.
Kinetic analysis of erythrocyte Na+-K+ pump and cotransport in essential hypertension.
Kinetic aspects of red blood cell sodium transport systems in essential hypertension.
Measurement of circulating sodium-pump inhibitory activity in uraemia and essential hypertension.
Na-K-ATPase in erythrocyte ghosts is not a marker for primary hypertension.
Na-K-ATPase-inhibiting and glucose-6-phosphate dehydrogenase-stimulating activity of plasma and hypothalamus of the Okamoto spontaneously hypertensive rat.
Observations on the "cascade" of Na-K-ATPase inhibitory and digoxin-like immunoreactive material in human urine: possible relevance to essential hypertension.
Pattern of Na-K-ATPase inhibitors in plasma and urine of hypertensive patients: a preliminary report.
Raised concentration of a circulating Na+-K+-ATPase inhibitor in essential hypertension.
Red blood cell Na+,K+-ATPase in men with newly diagnosed or previously treated essential hypertension.
Simultaneous measurement of marinobufagenin, ouabain, and hypertension-associated protein in various disease states.
Sodium pump inhibitor in the serum of patients with essential hypertension and its partial purification from hemofiltrate.
Some properties of erythrocyte Na+-K+-ATPase in essential hypertension.
The change and significance of the Na+-K+-ATPase alpha-subunit in ouabain-hypertensive rats.
The endogenous cytochemically assayable Na-K-ATPase inhibitor and its relation to hypertension.
The relation of the natriuretic hormone to essential hypertension.
The role of a circulating inhibitor of Na+-K+-ATPase in essential hypertension.
The role of a humoral Na+,K+-ATPase inhibitor in regulating precapillary vessel tone.
The role of Na,K-ATPase inhibitor on pressor responsiveness in patients with benign essential hypertension.
The role of Na,K-ATPase inhibitors in hypertension and end-stage renal disease.
[A study on the relationship between reduced activity of red cell membrane sodium-potassium pump and essential hypertension]
[Association of the polymorphisms of sodium transport related genes with essential hypertension]
[ATPase activity and sodium transport in erythrocytes of patients with essential hypertension (author's transl)]
[Circulating inhibitor of the Na+-K+ pump in essential hypertension. Physiological and pharmacological variations]
[Effects of saline infusion on the activity of erythrocyte sodium-potassium pump in normal subjects and in patients with essential hypertension]
[Therapeutic response to canrenone of patients with essential hypertension as a function of sodium transport anomalies and ouabain sensitivity of erythrocytes]
Exocrine Pancreatic Insufficiency
Calcium-ATPase activity in cystic fibrosis erythrocyte membranes: decreased activity in patients with pancreatic insufficiency.
Fanconi Anemia
Mutagenic response of Fanconi's anemia cells from a defined complementation group after treatment with photoactivated bifunctional psoralens.
Fanconi Syndrome
Experimental Fanconi syndrome. I. Effect of maleic acid on renal cortical Na-K-ATPase activity and ATP levels.
Further studies on epithelial transport defect in experimental and human Fanconi syndrome. Effects of maleic acid and L-cystine on sodium transport and (Na+-K+)-ATPase of the isolated frog skin.
Inhibition of sodium intestinal transport and mucosal (Na+-K+)-ATPase in experimental Fanconi syndrome.
Nephrotoxicity of cadmium & lead.
[A drug-induced transient Fanconi syndrome associated with pure red cell aplasia: pathophysiology of the electrolyte disorders]
Fatigue Syndrome, Chronic
Hypothalamic digoxin, cerebral chemical dominance and myalgic encephalomyelitis.
Feline Infectious Peritonitis
ATP1A1-mediated Src signaling inhibits coronavirus entry into host cells.
Fetal Growth Retardation
Activity and protein expression of Na+/K+ ATPase are reduced in microvillous syncytiotrophoblast plasma membranes isolated from pregnancies complicated by intrauterine growth restriction.
Fetal Nutrition Disorders
Selective fetal malnutrition: effect of acute and chronic ethanol exposure upon rat placental Na,K-ATPase activity.
Gastroenteritis
Absence of a cAMP-mediated antiabsorptive effect in an undifferentiated jejunal epithelium.
Gitelman Syndrome
Renal Mg handling, FXYD2 and the central role of the Na,K-ATPase.
Glaucoma
Harnessing the tunable cavity of nanoceria for enhancing Y-27632-mediated alleviation of ocular hypertension.
[Digitalis glycosides as inhibitors of the Na-K-ATPase in glaucoma treatment]
Glioblastoma
Bufalin inhibits glioblastoma growth by promoting proteasomal degradation of the Na+/K+-ATPase ?1 subunit.
Cerebral chemical dominance and neural regulation of cell division, cell proliferation, neoplastic transformation, and genomic function.
Targeting the alpha 1 subunit of the sodium pump to combat glioblastoma cells.
The anticancer drug perillyl alcohol is a Na/K-ATPase inhibitor.
Glioma
(Na+ + K+)-ATPase in C6 glioma and rat cerebrum.
Alterations of membrane integrity and cellular constituents by arachidonic acid in neuroblastoma and glioma cells.
ATP1A1 Integrates AKT and ERK Signaling via Potential Interaction With Src to Promote Growth and Survival in Glioma Stem Cells.
Determination of total (Na+ + K+)-ATPase activity of isolated or cultured cells.
Effects of methyl mercury and triethyllead on Na+K+ATPase and pyruvate dehydrogenase activities in glioma C6 cells.
Inhibition of membrane Na+-K+ ATPase activity: a common pathway in central nervous system disorders.
Mechanism of high K+ and Tl+ uptake in cultured human glioma cells.
The sodium pump ?1 subunit regulates bufalin sensitivity of human glioblastoma cells through the p53 signaling pathway.
Tissue-specific expression of the Na,K-ATPase beta3 subunit. The presence of beta3 in lung and liver addresses the problem of the missing subunit.
Glucose Intolerance
Allopurinol and valproic acid improve cardiac triglyceride and Na+-K+-ATPase activity independent of circulating aldosterone in female rats with glucose intolerance.
Gout
Decreased NA+, K+-ATPase activity in erythrocyte membrane from rheumatoid arthritis patients.
Hearing Disorders
Cochlear distribution of Na,K-ATPase and corticosteroid receptors in two mouse strains with congenital hearing disorders.
Hearing Loss
Status of cochlear Na,K-ATPase in the aged SHR rat and its possible role in hearing loss.
Hearing Loss, Sensorineural
Simultaneously reduced NKCC1 and Na,K-ATPase expression in murine cochlear lateral wall contribute to conservation of endocochlear potential following a sensorineural hearing loss.
Heart Arrest
Nitration of the striatal Na,K-ATPase alpha3 isoform occurs in normal brain development but is not increased during hypoxia-ischemia in newborn piglets.
Heart Diseases
Correlations between plasma levels of an endogenous digitalis-like substance and haemodynamic parameters measured during cardiac catheterization.
Human myocardial Na,K-ATPase concentration in heart failure.
Interleukin-1 beta inhibits Na+-K+ ATPase activity and protein expression in cardiac myocytes.
Myocardial Na,K-ATPase: Clinical aspects.
Ouabain, a steroid hormone that signals with slow calcium oscillations.
Regulation of myocardial Na,K-ATPase concentration in experimental and human heart disease.
Heart Failure
"Don't flog the heart!" - development of specific drug therapies for heart failure.
A Structural View on the Functional Importance of the Sugar Moiety and Steroid Hydroxyls of Cardiotonic Steroids in Binding to Na,K-ATPase.
Cardiac function evaluation for a novel one-step detoxification product of Aconiti Lateralis Radix Praeparata.
Cardiac glycoside ouabain induces autophagic cell death in non-small cell lung cancer cells via a JNK-dependent decrease of Bcl-2.
Changes in the expression of cardiac Na+-K+ ATPase subunits in the UM-X7.1 cardiomyopathic hamster.
Cytotoxic effects of the cardenolide convallatoxin and its Na,K-ATPase regulation.
Defective activity and isoform of the Na,K-ATPase in the dilated cardiomyopathic hamster.
Digitalis.
Digoxin affects potassium homeostasis during exercise in patients with heart failure.
Digoxin downregulates NDRG1 and VEGF through the inhibition of HIF-1? under hypoxic conditions in human lung adenocarcinoma A549 cells.
Digoxin Toxicity in a Patient with Pacemaker: A Case Report.
Effects of Na/K-ATPase and its ligands on bone marrow stromal cell differentiation.
Expression of functional Na,K-ATPase isozymes in normal human cardiac biopsies.
Greasing the wheels or a spanner in the works? Regulation of the cardiac sodium pump by palmitoylation.
Heart failure drug proscillaridin A targets MYC overexpressing leukemia through global loss of lysine acetylation.
Heterogeneous transport of digitalis-like compounds by P-glycoprotein in vesicular and cellular assays.
Human myocardial and skeletal muscular Na,K-ATPase in relation to digoxin therapy of heart failure.
Human myocardial Na,K-ATPase concentration in heart failure.
Influence of long-term treatment of imidapril on mortality, cardiac function, and gene expression in congestive heart failure due to myocardial infarction.
Inhibiting na+/k+ ATPase can impair mitochondrial energetics and induce abnormal Ca2+ cycling and automaticity in Guinea pig cardiomyocytes.
Interaction between Cardiotonic Steroids and Na,K-ATPase. Effects of pH and Ouabain-Induced Changes in Enzyme Conformation.
Intra-cellular electrolyte changes and levels of endogenous digoxin-like substance within the plasma in patients with congestive heart failure.
Intracellular Na(+) concentration is elevated in heart failure but Na/K pump function is unchanged.
Intracellular Na+ and altered Na+ transport mechanisms in cardiac hypertrophy and failure.
Isoform-specific regulation of myocardial Na,K-ATPase alpha-subunit in congestive heart failure. Role of norepinephrine.
Istaroxime, a first in class new chemical entity exhibiting SERCA-2 activation and Na-K-ATPase inhibition: a new promising treatment for acute heart failure syndromes?
Metal Fluoride Complexes of Na,K-ATPase: CHARACTERIZATION OF FLUORIDE-STABILIZED PHOSPHOENZYME ANALOGUES AND THEIR INTERACTION WITH CARDIOTONIC STEROIDS.
Mice expressing ouabain-sensitive {alpha}1 Na,K-ATPase have increased susceptibility to pressure overload-induced cardiac hypertrophy.
Modification of sarcolemmal Na+-K+-ATPase and Na+/Ca2+ exchanger expression in heart failure by blockade of renin-angiotensin system.
Modulators of Na/K-ATPase: a patent review.
Myocardial Na,K-ATPase and digoxin therapy in human heart failure.
Myocardial Na,K-ATPase: Clinical aspects.
Myocardial Na,K-ATPase: the molecular basis for the hemodynamic effect of digoxin therapy in congestive heart failure.
Myocardial sarcolemmal ATPase in dogs with induced mitral insufficiency.
Na,K-ATPase expression in normal and failing human left ventricle.
Na,K-ATPase in isolated nephron segments in rats with experimental heart failure.
Na,K-ATPase receptor subunits alpha 1, alpha 2 and alpha 3 mRNA in dilated cardiomyopathy.
Na/K pump regulation of cardiac repolarization: insights from a systems biology approach.
No upregulation of digitalis glycoside receptor (Na,K-ATPase) concentration in human heart left ventricle samples obtained at necropsy after long term digitalisation.
Reduced 3H-ouabain binding site (Na,K-ATPase) concentration in ventricular myocardium of dogs with tachycardia induced heart failure.
Reduction of Na/K-ATPase potentiates marinobufagenin-induced cardiac dysfunction and myocyte apoptosis.
Reductions of myocardial Na-K-ATPase activity and ouabain binding sites in heart failure: prevention by nadolol.
Role of sarcolemmal changes in cardiac pathophysiology.
RT-PCR detection of the Na,K-ATPase beta3-isoform in human heart.
Sodium pump isoform expression in heart failure: implication for treatment.
Targeting Cardiac Myocyte Na+-K+ Pump Function With ?3 Adrenergic Agonist in Rabbit Model of Severe Congestive Heart Failure.
The concentration of the Na,K-pump in skeletal and heart muscle in congestive heart failure.
The H?-H? domain of the ?? isoform of Na+-K+-ATPase is involved in ouabain toxicity in rat ventricular myocytes.
The sodium pump and digitalis drugs: Dogmas and fallacies.
The use of beta3-adrenergic receptor agonists in the treatment of heart failure.
Training-induced changes in skeletal muscle Na+-K+ pump number and isoform expression in rats with chronic heart failure.
Voltage-dependent K+ channels as oncotargets in malignant gliomas.
[Autoantibodies against sarcolemmal Na-K-ATPase in patients with dilated cardiomyopathy: autoimmune basis for ventricular arrhythmias in patients with congestive heart failure]
[Autoantibodies: new upstream targets of paroxysmal atrial fibrillation in patients with congestive heart failure]
[Changes of sarcolemma Na+/K+ ATPase and sarcoplasmic reticulum membrane Ca2+ ATPase activity after stem cell transplantation in chronic heart failure]
[The effect of carnosine on the activity of Na,K,ATPase: prospective uses in clinical cardiology]
Hemiplegia
Alternating Hemiplegia of Childhood: Retrospective Genetic Study and Genotype-Phenotype Correlations in 187 Subjects from the US AHCF Registry.
Direct evidence of impaired neuronal Na/K-ATPase pump function in alternating hemiplegia of childhood.
Neuronal modeling of alternating hemiplegia of childhood reveals transcriptional compensation and replicates a trigger-induced phenotype.
Hepatic Encephalopathy
Ammonia-induced Na,K-ATPase/ouabain-mediated EGF receptor transactivation, MAPK/ERK and PI3K/AKT signaling and ROS formation cause astrocyte swelling.
Effects of methanethiol on erythrocyte membrane stabilization and on Na+,K+-adenosine triphosphatase: relevance to hepatic coma.
Hepatitis
ATP1A1-mediated Src signaling inhibits coronavirus entry into host cells.
Hepatitis B
Modulation of Na,K-ATPase activity by immunoglobulins--II. Na,K-ATPase activity in erythrocytes from patients with various chronic disturbances.
Hepatitis B, Chronic
The effect of interferon therapy on erythrocyte membrane Na+,K+ ATP activity in patients with chronic hepatitis B and C virus infections.
Hepatitis C, Chronic
The effect of interferon therapy on erythrocyte membrane Na+,K+ ATP activity in patients with chronic hepatitis B and C virus infections.
Hepatitis, Chronic
Modulation of Na,K-ATPase activity by immunoglobulins--II. Na,K-ATPase activity in erythrocytes from patients with various chronic disturbances.
Hereditary Sensory and Motor Neuropathy
K-Cl cotransport in red blood cells from patients with KCC3 isoform mutants.
Hernias, Diaphragmatic, Congenital
Congenital diaphragmatic hernia prevents absorption of distal air space fluid in late-gestation rat fetuses.
Herpes Simplex
Role of the Na+,K+ pump in herpes simplex type 1-induced cell fusion: melittin causes specific reversion of syncytial mutants with the syn1 mutation to Syn+ (wild-type) phenotype.
Herpes Zoster
DACH1, a zona glomerulosa selective gene in the human adrenal, activates transforming growth factor-? signaling and suppresses aldosterone secretion.
Immunohistochemical, genetic and clinical characterization of sporadic aldosterone-producing adenomas.
NEFM (Neurofilament Medium) Polypeptide, a Marker for Zona Glomerulosa Cells in Human Adrenal, Inhibits D1R (Dopamine D1 Receptor)-Mediated Secretion of Aldosterone.
Role of ANO4 in regulation of aldosterone secretion in the zona glomerulosa of the human adrenal gland.
Somatic mutations in ATP1A1 and CACNA1D underlie a common subtype of adrenal hypertension.
Y-27632 Promotes the Repair Effect of Umbilical Cord Blood-Derived Endothelial Progenitor Cells on Corneal Endothelial Wound Healing.
Huntington Disease
Cerebral chemical dominance and neural regulation of cell division, cell proliferation, neoplastic transformation, and genomic function.
Hydronephrosis
Renal function and (NA+ + K+)-ATPase in chronic unilateral hydronephrosis in dogs.
Hydrothorax
Electrolyte transport across the pleura of rabbits.
Hyperaldosteronism
CACNA1H Mutations Are Associated With Different Forms of Primary Aldosteronism.
Genetics of primary hyperaldosteronism.
Mechanism of increased tubular Na-K-ATPase during streptozotocin-induced diabetes.
Myocardial Na,K-ATPase: Clinical aspects.
Na-K-ATPase in erythrocyte ghosts is not a marker for primary hypertension.
Na/K Pump Mutations Associated with Primary Hyperaldosteronism Cause Loss of Function.
Novel genetic determinants of adrenal aldosterone regulation.
Sodium-potassium-dependent ATPase activity in erythrocyte ghosts of patients with primary and secondary hypertension.
The landscape of molecular mechanism for aldosterone production in aldosterone-producing adenoma.
The role of endogenous inhibition of Na-K-ATPase in human hypertension--sodium pump activity as a determinant of peripheral vascular resistance.
[Progress on genetic basis of primary aldosteronism].
Hyperalgesia
Maltol, a food flavor enhancer, attenuates diabetic peripheral neuropathy in streptozotocin-induced diabetic rats.
Modulation of Na, K-ATPase activity by prostaglandin E(1) and [d-Ala(2),N-Me-Phe(4),Gly(5)-ol]-enkephalin.
Hypercholesterolemia
Cholesterol enrichment inhibits Na+/K+ pump in endothelial cells.
Dietary cholesterol alters Na+/K+ selectivity at intracellular Na+/K+ pump sites in cardiac myocytes.
Relation of erythrocyte Na+-K+ ATPase activity and cholesterol and oxidative stress in patients with type 2 diabetes mellitus.
The role of red blood cell deformability and Na,K-ATPase function in selected risk factors of cardiovascular diseases in humans: focus on hypertension, diabetes mellitus and hypercholesterolemia.
Hyperesthesia
Morphophysiologic characterization of peripheral neuropathy in zinc-deficient guinea pigs.
Hyperglycemia
?3-Adrenoceptor activation relieves oxidative inhibition of the cardiac Na+-K+ pump in hyperglycemia induced by insulin receptor blockade.
?3-Adrenoceptor, glutathionylation, and diabetic cardiomyopathy. Focus on "?3-Adrenoceptor activation relieves oxidative inhibition of the cardiac Na+-K+ pump in hyperglycemia induced by insulin receptor blockade".
Are disturbances of sorbitol, phosphoinositide, and Na+-K+-ATPase regulation involved in pathogenesis of diabetic neuropathy?
Characterization of protein kinase C beta isoform activation on the gene expression of transforming growth factor-beta, extracellular matrix components, and prostanoids in the glomeruli of diabetic rats.
Effect of chronic hyperglycemia and vanadate treatment on erythrocyte Na/K-ATpase and Mg-ATpase in streptozotocin diabetic rats.
Erythrocyte Ca, Na/K-ATPase in long-term streptozotocin diabetic rats. Effect of good glycemic control and a Ca antagonist.
Glucose-specific regulation of aldose reductase in capan-1 human pancreatic duct cells In vitro.
Hyperglycemia increases endothelial superoxide that impairs smooth muscle cell Na+-K+-ATPase activity.
Nerve Na+-K+-ATPase, conduction, and myo-inositol in the insulin-deficient BB rat.
Neurons and Microglia; A Sickly-Sweet Duo in Diabetic Pain Neuropathy.
Oxidative stress and eicosanoids in the kidneys of hyperglycemic rats treated with dehydroepiandrosterone.
Prophylactic role of arjunolic acid in response to streptozotocin mediated diabetic renal injury: activation of polyol pathway and oxidative stress responsive signaling cascades.
Pyridoxine and pyridoxamine inhibits superoxide radicals and prevents lipid peroxidation, protein glycosylation, and (Na+ + K+)-ATPase activity reduction in high glucose-treated human erythrocytes.
Strength-duration properties and glycemic control in human diabetic motor nerves.
[New trend in pathogenesis of diabetic neuropathy]
Hyperinsulinism
Animal and human tissue Na,K-ATPase in normal and insulin-resistant states: regulation, behaviour and interpretative hypothesis on NEFA effects.
Animal and human tissue Na,K-ATPase in obesity and diabetes: A new proposed enzyme regulation.
Hypokalemic periodic paralysis in a patient with acquired growth hormone deficiency.
[Theoretical aspects of the relationship between diabetic macroangiopathy and hyperinsulinism]
Hyperkalemia
Disturbances of potassium homeostasis in poisoning.
Hydroelectrolytic equilibrium change in dialysis.
Mechanism of the exercise hyperkalemia: an alternate hypothesis.
Regulation of Na/K-ATPase gene expression by thyroid hormone and hyperkalemia in the heart.
Renal function and Na-K-ATPase in rats after suprarenal ligation of inferior vena cava.
Renal Mg handling, FXYD2 and the central role of the Na,K-ATPase.
Studies on the mechanism of trimethoprim-induced hyperkalemia.
[Case of hyperkalemia possibly caused by gabexate mesilate]
Hyperlipidemias
Accelerated maximal velocity of the red blood cell Na+/K+ pump in hyperlipidemia is related to increase in 1-palmitoyl,2-arachidonoyl-plasmalogen phosphatidylethanolamine.
Gender specific influence of fish oil or atorvastatin on functional properties of renal Na,K-ATPase in healthy Wistar and hypertriglyceridemic rats.
Hypersensitivity
A serotonin agonist-antagonist reversible effect on Na+-K+-ATPase activity in the developing rat brain.
Hypertension
A circulating Na+-K+ATPase inhibitor, erythrocyte sodium transport and hypertension in patients with chronic renal failure.
A functional 12T-insertion polymorphism in the ATP1A1 promoter confers decreased susceptibility to hypertension in a male Sardinian population.
A Review of the Epidemiological Evidence for Adducin Family Gene Polymorphisms and Hypertension.
Abnormal Na+-K+ ATPase kinetics in a subset of essential hypertensive patients.
Acute salt loading and cardiotonic steroids in resistant hypertension.
alpha-Adducin mutations increase Na/K pump activity in renal cells by affecting constitutive endocytosis: implications for tubular Na reabsorption.
Alpha1 Na,K-ATPase and Na,K,2Cl-cotransporte/D3mit3 loci interact to increase susceptibility to salt-sensitive hypertension in Dahl S(HSD) rats.
Alterations in sodium-potassium regulation in mononuclear leucocytes from young borderline hypertensive and offspring of hypertensive patients.
Altered activity of the sodium-potassium pump in arteries of rats with steroid hypertension.
ANGIOTENSIN II-INDUCED HYPERTENSION INCREASES PLASMA MEMBRANE Na PUMP ACTIVITY BY ENHANCING Na ENTRY IN RAT THICK ASCENDING LIMBS.
Animal and human tissue Na,K-ATPase in normal and insulin-resistant states: regulation, behaviour and interpretative hypothesis on NEFA effects.
Antihypertensive compounds that modulate the Na-K pump.
Antioxidant resveratrol restores renal sodium transport regulation in SHR.
Arteriolar responses to norepinephrine and ouabain in early 1-kidney, 1-clip hypertension in rats.
Association of ATP1A1 and dear single-nucleotide polymorphism haplotypes with essential hypertension: sex-specific and haplotype-specific effects.
Augmented Na,K-ATPase gene expression in spontaneously hypertensive rat hearts.
Cardiotonic Steroids in Adaptation to Dietary Salt Intake.
Cellular mechanism relating sodium and potassium to hypertension.
Changes of sodium and ATP affinities of the renal Na,K-ATPase during and after nitric oxide-deficient hypertension.
Characteristics of hypertensive patients with increased plasma Na+-K+ pump inhibitory activity.
Chronobiological evidence for an uncoupling of the Na,K-ATPase to aldosterone in normal renin hypertension.
Circulating inhibitors of sodium transport at the prehypertensive stage of essential hypertension.
Coordinated shifts in Na/K-ATPase isoforms and their endogenous ligands during cardiac hypertrophy and failure in NaCl-sensitive hypertension.
Corroboration of Dahl S Q276L alpha1Na,K-ATPase protein sequence: impact on affinities for ligands and on E1 conformation.
Decreased intraocular pressure in dogs with one-kidney, one wrapped hypertension.
Decreased myocardial Na+-K+-ATPase activity in one-kidney, one-clip hypertensive rats.
Decreased myocardial Na+K+ATPase activity in rats with reduced renal mass-saline hypertension.
Decreased Na+K+ATPase activity in the aortic endothelium and smooth muscle of the spontaneously hypertensive rats.
Demonstration of a humoral inhibitor of the Na+-K+ pump in some models of experimental hypertension.
Depressed function of a ouabain-sensitive sodium-potassium pump in blood vessels from renal hypertensive dogs.
Differences in renal tubular Na-K-adenosine triphosphatase in spontaneously hypertensive and normotensive rats.
Digitalislike circulating factor in hypertension: potential messenger between salt balance and intracellular sodium.
Direct regulation of the Na,K pump by signal transduction mechanisms.
DOCA-Salt Hypertension Does Not Require the Ouabain-Sensitive Binding Site of the ?2 Na,K-ATPase.
Downstream shift in sodium pump activity along the nephron during acute hypertension.
Effect of gender in centrally induced angiotensin II hypertension in dogs.
Effect of green tea extract on cardiac hypertrophy following 5/6 nephrectomy in the rat.
Effect of hypertensive rat plasma on ion transport of cultured vascular smooth muscle.
Effect of ouabain on hemodynamics in acute volume expanded hypertensive dogs.
Effect of quercetin on kinetic properties of renal Na,K-ATPase in normotensive and hypertensive rats.
Effect of treatment with hydrochlorothiazide on the red cell Na,K-adenosine triphosphatase in men with hypertension.
Effects of canrenone on blood pressure in rats with reduced renal mass.
Effects of lead and natriuretic hormone on kinetics of sodium-potassium-activated adenosine triphosphatase: possible relevance to hypertension.
Elevated endogenous Na-K-ATPase inhibitor activity in hypertensive diabetic patients with a family history of hypertension.
Endogenous brain Na pumps, brain ouabain-like substance and the alpha2 isoform in salt-dependent hypertension.
Endogenous bufadienolide mediates pressor response to ethanol withdrawal in rats.
Endogenous digitalis-like factors. An historical overview.
Endogenous digitalis-like factors: their possible pathophysiological implications with particular regard to the perinatal period.
Endogenous natriuretic factors: atrial natriuretic hormone and digitalis-like substance in Cushing's syndrome.
Endogenous sodium pump inhibitors, diabetes mellitus and preeclampsia Preliminary observations and a hypothesis.
Endogenous sodium-potassium pump inhibitor in low renin hypertension.
Endothelium stimulates the vascular smooth muscle cell Na/K pump of normotensive and hypertensive rats by a protein kinase C pathway.
Erythrocyte Li-Na countertransport in hypertension: lack of atrial natriuretic peptide effect.
Erythrocyte Na,K pump activity and arterial hypertension in uremic dialyzed patients.
Evidence for a circulating endogenous Na+-K+ pump inhibitor in low-renin hypertension.
Evidence for a circulating sodium-potassium pump inhibitor in low renin hypertension.
Evidence for increased functional vascular Na+/K+ pump activity in the obese Zucker rat.
First Clinical Experience With Targeted REnal Nerve Demodulation (TREND-1) Using a Neurotropic Agent for the Treatment of Sympathetic Hypertension.
High Na+ Salt Diet and Remodeling of Vascular Smooth Muscle and Endothelial Cells.
Humoral factors and the sodium-potassium pump in low renin hypertension.
Humoral factors and the sodium-potassium pump in volume expanded hypertension.
Hypertensive dog plasma inhibits the Na+-K+ pump of cultured vascular smooth muscle.
Hypothalamic sodium-transport inhibitor is a high-affinity reversible inhibitor of Na+-K+-ATPase.
Impaired calcium metabolism associated with hypertension in Zucker obese rats.
Impairment of Na/K-ATPase signaling in renal proximal tubule contributes to Dahl salt-sensitive hypertension.
Increased (Na+K+Cl) cotransport in rat arterial smooth muscle in deoxycorticosterone (DOCA)/salt-induced hypertension.
Increased activity of digoxin-like substance in low-renin hypertension in acromegaly.
Increased activity of the Na-K-ATPase in red cell-ghosts of patients with Cushing's syndrome: possible significance for the pathogenesis of glucocorticoid-induced hypertension.
Increased cytosolic sodium and reduced Na,K-ATPase activity in transgenic rats.
Increased dietary potassium and magnesium attenuate experimental volume dependent hypertension possibly through endogenous sodium-potassium pump inhibitor.
Increased Expression of Na,K-ATPase and a Selective Increase in Phosphorylation at Ser-11 in the Cortex of the 2-Kidney, 1-Clip Hypertensive Rat.
Increased Na,K,Cl cotransporter and Na, K-ATPase activity of vascular tissue in two-kidney Goldblatt hypertension.
Increased renal tubular Na-K-ATPase activity in Milan hypertensive rats in the prehypertensive period.
Individual variability in membrane sodium transport during salt loading--evidence against the production of a Na+-K+-ATPase inhibitor in hypertension.
Inhibition of intestinal villus cell Na/K-ATPase mediates altered glucose and NaCl absorption in obesity-associated diabetes and hypertension.
Inhibition of Na+,K+ pump affects nucleic acid synthesis and smooth muscle cell proliferation via elevation of the [Na+]i/[K+]i ratio: possible implication in vascular remodelling.
Inhibition of natriuretic factors increases blood pressure in rats.
Interaction of alpha(1)-Na,K-ATPase and Na,K,2Cl-cotransporter genes in human essential hypertension.
Is the endogenous digitalis-like factor the link between hypertension and metabolic disorders as diabetes mellitus, obesity and acromegaly?
Kinetic analysis of erythrocyte Na+-K+ pump and cotransport in essential hypertension.
Loss of NHERF-1 expression prevents dopamine-mediated Na-K-ATPase regulation in renal proximal tubule cells from rat models of hypertension: aged F344 rats and spontaneously hypertensive rats.
Marinobufagenin-induced vascular fibrosis is a likely target for mineralocorticoid antagonists.
Mechanism of sodium load-induced hypertension in non-insulin dependent diabetes mellitus model rats: defective dopaminergic system to inhibit Na-K-ATPase activity in renal epithelial cells.
Mechanisms and consequences of Na+,K+-pump regulation by insulin and leptin.
Mechanisms of pressure natriuresis: how blood pressure regulates renal sodium transport.
Metabolic Syndrome and Salt-Sensitive Hypertension in Polygenic Obese TALLYHO/JngJ Mice: Role of Na/K-ATPase Signaling.
Monoclonal antibody to an endogenous bufadienolide, marinobufagenin, reverses preeclampsia-induced Na/K-ATPase inhibition and lowers blood pressure in NaCl-sensitive hypertension.
Monoclonal Antibody to Marinobufagenin Downregulates TGF? Profibrotic Signaling in Left Ventricle and Kidney and Reduces Tissue Remodeling in Salt-Sensitive Hypertension.
Myocardial Na+-K+-ATPase activity and [3H]ouabain binding sites in hypertensive rats.
Myocardial Na,K-ATPase activity in rats with steroid and spontaneous hypertension.
Myocardial PKC beta2 and the sensitivity of Na/K-ATPase to marinobufagenin are reduced by cicletanine in Dahl hypertension.
Na-K-adenosine triphosphatase in the kidney of rats with renal hypertension and spontaneously hypertensive rats.
Na-K-ATPase alpha-isoform expression in heart and vascular endothelia: cellular and developmental regulation.
Na-K-ATPase in erythrocyte ghosts is not a marker for primary hypertension.
Na-K-ATPase in nephron segments of rats developing spontaneous hypertension.
Na-K-ATPase in single nephron segments of hypertension-prone rats.
Na/K Pump Mutations Associated with Primary Hyperaldosteronism Cause Loss of Function.
Natriuresis and renal Na-K-ATPase activity in kidneys of normotensive and spontaneously hypertensive rats.
Neither the New Zealand genetically hypertensive strain nor Dahl salt-sensitive strain has an A1079T transversion in the alpha1 isoform of the Na(+),K(+)-ATPase gene.
NKCC2 is activated in Milan hypertensive rats contributing to the maintenance of salt-sensitive hypertension.
Non-association of the thiazide-sensitive Na,Cl-cotransporter gene with polygenic hypertension in both rats and humans.
Novel receptors for ouabain: studies in adrenocortical cells and membranes.
Oleic and linoleic acids are active principles in Nigella sativa and stabilize an E(2)P conformation of the Na,K-ATPase. Fatty acids differentially regulate cardiac glycoside interaction with the pump.
Ouabain vasoconstricts human forearm arterioles through alpha-adrenergic stimulation.
Ouabain-induced elevation in forearm vascular resistance, calcium entry and alpha-adrenoceptor blockade, and release and removal of noradrenaline.
Ouabain-like factor: is this the natriuretic hormone?
Ouabain-Sensitive alpha1 Na,K-ATPase enhances natriuretic response to saline load.
Over-expression of translationally controlled tumor protein in lens epithelial cells seems to be associated with cataract development.
Paradoxical activation of the sodium chloride cotransporter (NCC) without hypertension in kidney deficient in a regulatory subunit of Na,K-ATPase, FXYD2.
Pathogenesis of arterial hypertension in chronic uraemia: the role of reduced Na,K-ATPase activity.
Pathophysiological consequences of changes in the coupling ratio of Na,K-ATPase for renal sodium reabsorption and its implications for hypertension.
Periventricular forebrain mechanisms for blood pressure regulation.
Physiological role of the alpha1- and alpha2-isoforms of the Na+-K+-ATPase and biological significance of their cardiac glycoside binding site.
Plasma inhibitors of Na,K-ATPase: relation to salt balance and hypertension.
Plasma levels of digitalis-like substance in Nigerians with essential hypertension.
Plasma Na+-K+ ATPase inhibitory activity in normal and hypertensive subjects: relationship to intracellular electrolytes and blood pressure.
Plasma sodium-potassium ATPase inhibition activity in low- and normal-renin hypertension.
Platelet membrane fluidity and Na+/K+ ATPase activity in acute stroke.
Potassium, Na+-K+ pump inhibitor and low-renin hypertension.
Proximal tubule Na transporter responses are the same during acute and chronic hypertension.
PST 2238: A new antihypertensive compound that modulates Na,K-ATPase in genetic hypertension.
Purification of a Na+/K+ ATPase inhibitor from borderline hypertensives' plasma.
Reactive Oxygen Species Modulation of Na/K-ATPase Regulates Fibrosis and Renal Proximal Tubular Sodium Handling.
Recent aspects in the genetic renal mechanisms involved in hypertension.
Reciprocal regulation of cardiac Na-K-ATPase and Na/Ca exchanger: hypertension, thyroid hormone, development.
Reduced electrogenic sodium-potassium pump in arterioles during renovascular hypertension.
Reduced sodium concentration and increased sodium-potassium pump activity of erythrocytes in human hypertension.
Reduced sodium-potassium dependent ATPase and its possible role in the development of hypertension in spontaneously hypertensive rats.
Reduction of Na/K-ATPase affects cardiac remodeling and increases c-kit cell abundance in partial nephrectomized mice.
Reflux nephropathy and hypertension.
Regulation of Na,K-ATPase activity.
Relationship between erythrocyte volume and sodium transport in the Milan hypertensive rat and age-dependent changes.
Renal Mg handling, FXYD2 and the central role of the Na,K-ATPase.
Renal Na+-K+-ATPase in weanling and adult spontaneously hypertensive rats.
Renal Na,K-ATPase in genetic hypertension.
Renovascular hypertension using a modified two-kidney, one-clip approach in mice is not dependent on the {alpha}1 or {alpha}2 Na,K-ATPase ouabain-binding site.
Role of a humoral sodium-potassium pump inhibitor in experimental low renin hypertension.
Role of digitalis-like substance in the hypertension of streptozotocin-induced diabetes and simulated weightlessness in rats.
Role of kidney in hypertension.
Role of ouabain-like factors and Na-K-ATPase inhibitors in hypertension--some old and recent findings.
Role of ouabain-like factors in hypertension: effects of ouabain and certain endogenous ouabain-like factors in hypertension.
Roles of renal cytochrome P450-dependent arachidonic acid metabolites in hypertension.
Short-term vs. sustained inhibition of proximal tubule Na,K-ATPase activity by dopamine: cellular mechanisms.
Sodium and potassium ion transport accelerations in erythrocytes of DOC, DOC-salt, two-kidney, one clip, and spontaneously hypertensive rats. Role of hypokalemia and cell volume.
Sodium chloride sensitivity, intracellular sodium concentration in erythrocytes and lymphocytes, and renin profile in essential hypertension.
Sodium content and sodium efflux of mononuclear leucocytes from young subjects at increased risk of developing essential hypertension.
Sodium transport in hypertension.
Sodium-22 uptake in erythrocytes can differentiate between the essential and the secondary hypertensive patient.
Sodium-potassium ATPase in deoxycorticosterone-salt hypertension: opposing effects of sodium load and mineralocorticoids.
Sodium-potassium pump activity in reduced renal-mass hypertension.
Sodium-potassium pump in low-renin hypertension.
Sodium-potassium pump inhibitor in the mechanism of one-kidney, one wrap hypertension in dogs.
Sodium-potassium-adenosine triphosphatase in nephron segments of spontaneously hypertensive rats.
Sodium-potassium-dependent ATPase activity in erythrocyte ghosts of patients with primary and secondary hypertension.
Somatic mutations in ATP1A1 and ATP2B3 lead to aldosterone-producing adenomas and secondary hypertension.
Somatic mutations in ATP1A1 and CACNA1D underlie a common subtype of adrenal hypertension.
Some effects of aldosterone on sodium kinetics and distribution in porcine arterial wall.
Studies on the role of sodium- and potassium-activated adenosine triphosphatase inhibition in the pathogenesis of human hypertension. Changes in vascular and cardiac function following inhibition of the sodium pump in normotensive subjects and effects of calcium entry blockade.
Study of plasma and intraerythrocytic cations and erythrocytic membrane Na+-K+-ATPase in primary hypertension.
Synthesis of an Endogenous Steroidal Na Pump Inhibitor Marinobufagenin, Implicated in Human Cardiovascular Diseases, Is Initiated by CYP27A1 via Bile Acid Pathway.
Systemic Hypertension: The Roles of Salt, Vascular Na+/K+ ATPase and The Endogenous Glycosides, Ouabain and Marinobufagenin.
The alpha1 Na,K-ATPase gene is a susceptibility hypertension gene in the Dahl salt-sensitiveHSD rat.
The alpha1-Na/K pump does not mediate the involvement of ouabain in the development of hypertension in rats.
The alpha2-isoform of Na-K-ATPase mediates ouabain-induced hypertension in mice and increased vascular contractility in vitro.
The central effects of the renin-angiotensin system.
The central role of the brain in salt-sensitive hypertension.
The change and significance of the Na+-K+-ATPase alpha-subunit in ouabain-hypertensive rats.
The cytochrome P-450 inhibitor cobalt chloride prevents inhibition of renal Na,K-ATPase and redistribution of apical NHE-3 during acute hypertension.
The effects of captopril and losartan on erythrocyte membrane Na+/K(+)-ATPase activity in experimental diabetes mellitus.
The endogenous cytochemically assayable Na-K-ATPase inhibitor and its relation to hypertension.
The highly conserved cardiac glycoside binding site of Na,K-ATPase plays a role in blood pressure regulation.
The possible role of digitalislike factors in pregnancy-induced hypertension.
The role of a humoral Na+,K+-ATPase inhibitor in regulating precapillary vessel tone.
The role of a humoral sodium-potassium pump inhibitor in low-renin hypertension.
The role of endogenous inhibition of Na-K-ATPase in human hypertension--sodium pump activity as a determinant of peripheral vascular resistance.
The role of Na,K-ATPase inhibitors in hypertension and end-stage renal disease.
The role of red blood cell deformability and Na,K-ATPase function in selected risk factors of cardiovascular diseases in humans: focus on hypertension, diabetes mellitus and hypercholesterolemia.
The role of sodium intake, the Na+-K+ pump and a ouabain-like humoral agent in the genesis of reduced renal mass hypertension.
The role of vascular Na,K-ATPase activity in salt induced hypertension in Dahl rats.
The sodium pump and hypertension: a physiological role for the cardiac glycoside binding site of the Na,K-ATPase.
The sodium-potassium pump in volume expanded hypertension.
The vascular Na+-K+ pump in experimental hypertension.
The vascular Na+-K+ pump in low renin hypertension.
Transcriptional Regulation of Renal Dopamine D1 Receptor Function During Oxidative Stress.
Up-regulation of Rhoa/Rho kinase pathway by translationally controlled tumor protein in vascular smooth muscle cells.
Vascular sodium-potassium pump activity in various models of experimental hypertension.
Volume hormones and blood pressure.
[A search for genetic loci responsible for emotional stress-induced arterial hypertension in the ISIAH rats]
[A study on the relationship between reduced activity of red cell membrane sodium-potassium pump and essential hypertension]
[Abnormal erythrocyte sodium transport in patients with adult polycystic kidney and hypertension]
[Activity of the sodium-potassium pump and values of sodium and potassium in erythrocytes in patients with non-dialyzed renal failure and arterial hypertension treated conservatively]
[Age-related changes in Na,K-ATPase activity of the plasma membrane of kidney cells and erythrocytes in spontaneously hypertensive and normotensive rats]
[Arterial hypertension in patients with obesity. Role of hyperinsulinism and insulin resistance]
[Autoantibodies: new upstream targets of paroxysmal atrial fibrillation in patients with congestive heart failure]
[Effect of an antiglucocorticoid steroid on the arterial hypertension induced by glucocorticoids in the rat]
[Fundamental and applied studies on transport and metabolism of electrolytes and glucose--aim to contact with molecular biology]
[Na,K-ATPase in kidneys of rats with hereditary hypertension induced by stress]
[Sodium transport in red blood cell membranes in essential arterial hypertension]
[The activity and properties of Na,K-ATPase in the erythrocytes and the Na-pump inhibitor in the plasma of subjects with borderline arterial hypertension]
[The activity of the sodium-potassium pump of the mesenteric arteries and veins in normal rats and in DOCA-salt hypertension]
[The role of the kidney in the pathogenesis of hypertension]
[The sodium-potassium pump in hypertension. Mechanisms of action of potassium]
Hypertension, Pregnancy-Induced
Endogenous inhibition of red blood cell Na,K-ATPase in essential and pregnancy-induced hypertension.
Human hypertensive placenta contains an increased amount of Na,K-ATPase with higher affinity for cardiac glycosides.
Na,K-ATPase from placenta of women with pregnancy-induced hypertension exhibits an increased affinity for cardiac glycosides.
[Preliminary study of Na/K-ATPase activity in erythrocyte ghosts in pregnancy-induced hypertension]
Hypertension, Renal
Na-K-adenosine triphosphatase in the kidney of rats with renal hypertension and spontaneously hypertensive rats.
Na-K-ATPase in erythrocyte ghosts is not a marker for primary hypertension.
Sodium-potassium-dependent ATPase activity in erythrocyte ghosts of patients with primary and secondary hypertension.
Hypertension, Renovascular
Alterations in renal Na+K+ATPase activity and [3H]ouabain binding in Goldblatt hypertensive rabbits.
Increased Expression of Na,K-ATPase and a Selective Increase in Phosphorylation at Ser-11 in the Cortex of the 2-Kidney, 1-Clip Hypertensive Rat.
Reciprocal regulation of cardiac Na-K-ATPase and Na/Ca exchanger: hypertension, thyroid hormone, development.
Reduced electrogenic sodium-potassium pump in arterioles during renovascular hypertension.
Renovascular hypertension using a modified two-kidney, one-clip approach in mice is not dependent on the {alpha}1 or {alpha}2 Na,K-ATPase ouabain-binding site.
Hyperthyroidism
Dietary omega 6 fatty acids and the effects of hyperthyroidism in mice.
Dorsolateral prostatic phosphomonoesterases and adenosine triphosphatases in hypo- and hyperthyroid rats.
Erythrocyte sodium/potassium adenosine triphosphatase in thyroid disease and nonthyroidal illness.
Hyperthyroidism and cation pumps in human skeletal muscle.
Increased acylphosphatase levels in erythrocytes from hyperthyroid patients.
Increased lymphocyte thermogenesis in hyperthyroid patients. Role of Na/K pump function. Evaluation of aerobic/anaerobic metabolism.
Interaction of age and thyroid hormone status on Na+-K+ ATPase in rat renal cortex and liver.
Na+K+ATPase activity and ouabain binding sites in erythrocytes in hyperthyroidism before and after treatment.
No major thermogenic role for (Na+ + K+)-dependent adenosine triphosphatase apparent in hepatocytes from hyperthyroid rats.
Platelet Na,K-adenosine triphosphatase as a tissue marker of hyperthyroidism.
Quantity of Na/K-ATPase and glucose transporters in the plasma membrane of rat adipocytes is reduced by in vivo triiodothyronine.
Status of the red cell Na,K-pump in hyper- and hypothyroidism.
Thyroid hormone increases mRNA and protein expression of Na+-K+-ATPase alpha2 and beta1 subunits in human skeletal muscles.
Thyrotoxic Periodic Paralysis With Features of Andersen-Tawil Syndrome: A Case Report and Literature Review.
Hypertriglyceridemia
Antioxidant SMe1EC2 may attenuate the disbalance of sodium homeostasis in the organism induced by higher intake of cholesterol.
Gender specific influence of fish oil or atorvastatin on functional properties of renal Na,K-ATPase in healthy Wistar and hypertriglyceridemic rats.
Hypertrophy, Left Ventricular
Effect of green tea extract on cardiac hypertrophy following 5/6 nephrectomy in the rat.
Effects of crocetin on the matrix metalloproteinases in cardiac hypertrophy induced by norepinephrine in rats.
Hypokalemia
Age-related changes in renal function, membrane protein metabolism, and Na,K-ATPase activity and abundance in hypokalemic F344 x BNF(1) rats.
Disturbances of potassium homeostasis in poisoning.
Dopamine and dobutamine induce hypokalemia in anesthetized dogs.
Effects of alterations in cell phenotype and hypokalemia on sodium-potassium pump activity in rabbit vascular smooth muscle.
Effects of hypokalemia on the cardiotropic actions of digoxin in dogs. Correlation with inhibition of cardiac Na+,K+-adenosine triphosphatase.
Hypokalemia after pediatric albuterol overdose: a case series.
Hypokalemia, high erythrocyte Na+ and low erythrocyte Na,K-ATPase in relatives of patients dying from sudden unexplained death syndrome in north-east Thailand and in survivors from near-fatal attacks.
Hypokalemic periodic paralysis in a patient with acquired growth hormone deficiency.
In rat inner medullary collecting duct, NH uptake by the Na,K-ATPase is increased during hypokalemia.
In rat tIMCD, NH4+ uptake by Na+-K+-ATPase is critical to net acid secretion during chronic hypokalemia.
Mechanisms of NH4+ and NH3 transport during hypokalemia.
Regulation of collecting tubule adenosine triphosphatases by aldosterone and potassium.
Hypokalemic Periodic Paralysis
Hypokalemic periodic paralysis in a patient with acquired growth hormone deficiency.
Hyponatremia
Na-K-ATPase activity decreases with aging in female rat brain synaptosomes.
Hypothyroidism
Amiodarone decreases Na,K-ATPase alpha 2 and beta 2 expression specifically in cardiac ventricle.
Developmental acquisition of T3-sensitive Na-K-ATPase stimulation by rat alveolar epithelial cells.
Differential effects of hypothyroidism on Na-K-ATPase mRNA alpha isoforms in the developing rat brain.
Effect of amiodarone on 3H-ouabain binding sites in human skeletal muscle.
Effects of thyroid hormone on Na+-K+ transport in resting and stimulated rat skeletal muscle.
Erythrocyte Na/K-ATPase is increased in subjects with subclinical hypothyroidism.
Erythrocyte sodium/potassium adenosine triphosphatase in thyroid disease and nonthyroidal illness.
Selective decrease of Na+/k+ -ATPase activity in the brain of hypothyroid rats.
Status of the red cell Na,K-pump in hyper- and hypothyroidism.
Stimulation of Na,K-ATPase by hypothyroidism in the thyroid gland.
Triiodothyronine enhances renal response to aldosterone in the rabbit collecting tubule.
Hypoventilation
Inhibition of erythrocyte Na,K-ATPase activity during anticipatory hypoventilation in micropigs.
Ileitis
Corticosteroids reverse the inhibition of Na-glucose cotransport in the chronically inflamed rabbit ileum.
Immune System Diseases
Comparative transcriptome analysis of Eriocheir japonica sinensis response to environmental salinity.
Infarction, Middle Cerebral Artery
Effect of enhanced capillary activity on the blood-brain barrier during focal cerebral ischemia in cats.
Pre-ischemic treatment with memantine reversed the neurochemical and behavioural parameters but not energy metabolites in middle cerebral artery occluded rats.
Infections
ATP1A1-mediated Src signaling inhibits coronavirus entry into host cells.
Augmentation of lung liquid clearance via adenovirus-mediated transfer of a Na,K-ATPase beta1 subunit gene.
Cation content in poliovirus-infected HeLa cells.
DNA immunization with Na+-K+ ATPase (Sseat-6) induces protective immunity to larval Strongyloides stercoralis in mice.
Downregulation of Aquaporins (AQP1 and AQP5) and Na,K-ATPase in Porcine Reproductive and Respiratory Syndrome Virus-Infected Pig Lungs.
Evidence for poliovirus-induced cytoplasmic alkalinization in HeLa cells.
Experimental infection by Neospora caninum in gerbil reduces activity of enzymes involved in energy metabolism.
Helicobacter pylori infection impairs chaperone-assisted maturation of Na,K-ATPase in gastric epithelium.
Inflammatory Responses Regulating Alveolar Ion Transport during Pulmonary Infections.
Influenza leaves a TRAIL to pulmonary edema.
Inhibition of Na+K+ATPase activity in membranes of Sindbis virus-infected chick cells.
Inhibition of Na,K-ATPase activity reduces Babesia gibsoni infection of canine erythrocytes with inherited high K, low Na concentrations.
Interactome analysis of the lymphocytic choriomeningitis virus nucleoprotein in infected cells reveals ATPase Na+/K+ transporting subunit Alpha 1 and prohibitin as host-cell factors involved in the life cycle of mammarenaviruses.
Intestinal enzyme profiles in normal and rotavirus-infected mice.
Leptospira and inflammation.
Macrophage-epithelial paracrine crosstalk inhibits lung edema clearance during influenza infection.
Mitochondrial ATP-ASE as a measure of uncoupling of rat muscle mitochondria in experimental infection with Trichinella spiralis and Trichinella pseudospiralis.
Modulation of epithelial sodium channel (ENaC) expression in mouse lung infected with Pseudomonas aeruginosa.
Tacaribe virus infection may induce inhibition of the activity of the host cell Ca2+ and Na+/K+ pumps.
The alpha-1 subunit of the Na+,K+-ATPase (ATP1A1) is required for macropinocytic entry of respiratory syncytial virus (RSV) in human respiratory epithelial cells.
The effect of interferon therapy on erythrocyte membrane Na+,K+ ATP activity in patients with chronic hepatitis B and C virus infections.
The influence of porcine epidemic diarrhea virus on pig small intestine mucosal epithelial cell function.
Translational regulation of Na,K-ATPase alpha1 and beta1 polypeptide expression in epithelial cells.
Ubiquitination Participates in the Lysosomal Degradation of the Na,K-ATPase in Steady-State Conditions.
[Effect of extracted ZG from gardenia on Hep-2 cell membrane post infected with parainfluenza virus type 1 (PIV-1)]
Inflammatory Bowel Diseases
Hypothalamic digoxin, hemispheric chemical dominance, and inflammatory bowel disease.
Inhibition of human colonic (Na+ + K+)-ATPase by arachidonic and linoleic acid.
Inverse relationship between colonic (Na+ + K+)-ATPase activity and degree of mucosal inflammation in inflammatory bowel disease.
Molecular mechanism of regulation of villus cell Na-K-ATPase in the chronically inflamed mammalian small intestine.
Influenza, Human
Cardiac glycosides decrease influenza virus replication by inhibiting cell protein translational machinery.
Immortalization of polarized rat retinal pigment epithelium.
Influenza leaves a TRAIL to pulmonary edema.
Localization of cytoplasmic and extracellular domains of Na,K-ATPase by epitope tag insertion.
Insulin Resistance
Differences in blacks and whites with essential hypertension: biochemistry and endocrine. State of the art lecture.
Effect of chronic renal failure on Na,K-ATPase alpha 1 and alpha 2 mRNA transcription in rat skeletal muscle.
Estrogen-progestin oral contraceptive and nicotine exposure synergistically confers cardio-renoprotection in female Wistar rats.
Hormonal and nutritional enhancement of Na+-K+-ATPase activity may aid the prevention and treatment of essential hypertension.
Lymphocyte (Na,K) ATPase-dependent 86Rb+ uptake in human obesity.
Membrane lipid alterations and Na+-pumping activity in erythrocytes from IDDM and NIDDM subjects.
pNaKtide inhibits Na/K-ATPase reactive oxygen species amplification and attenuates adipogenesis.
Response of insulin, glucagon, lactate, and nonesterified fatty acids to glucose in visceral obesity with and without NIDDM: relationship to hypertension.
Role of muscle in regulating extracellular [K+].
[Arterial hypertension in patients with obesity. Role of hyperinsulinism and insulin resistance]
[Theoretical aspects of the relationship between diabetic macroangiopathy and hyperinsulinism]
Insulinoma
Sulfonylurea binding to a low-affinity site inhibits the Na/K-ATPase and the KATP channel in insulin-secreting cells.
Intellectual Disability
Germline De Novo Mutations in ATP1A1 Cause Renal Hypomagnesemia, Refractory Seizures, and Intellectual Disability.
Hereditary spastic paraplegia is a novel phenotype for germline de novo ATP1A1 mutation.
Iron Overload
Effects of Iron Overload on the Activity of Na,K-ATPase and Lipid Profile of the Human Erythrocyte Membrane.
Ischemic Stroke
Platelet membrane fluidity and Na+/K+ ATPase activity in acute stroke.
Kidney Diseases
Changes in erythrocyte ATPase activity under different pathological conditions.
Multiple functions of Na,K-ATPase in epithelial cells.
Kidney Failure, Chronic
A circulating Na+-K+ATPase inhibitor, erythrocyte sodium transport and hypertension in patients with chronic renal failure.
Atrial natriuretic peptide concentration and natriuretic hormone activity in plasma of patients with chronic renal failure.
Dysnatremia in Renal Failure.
Effect of chronic renal failure on Na,K-ATPase alpha 1 and alpha 2 mRNA transcription in rat skeletal muscle.
Effects of haemodialysis and continuous ambulatory peritoneal dialysis on abnormalities of ion transport in vivo in patients with chronic renal failure.
Endogenous cardiotonic steroids in chronic renal failure.
Extrarenal potassium tolerance in chronic renal failure: implications for the treatment of acute hyperkalemia.
Increased cytosolic free sodium in platelets from patients with early-stage chronic renal failure.
Increased inward passive permeability in vitro to sodium in uraemic erythrocytes.
Measurement of circulating sodium-pump inhibitory activity in uraemia and essential hypertension.
Molecular insights into uremic cardiomyopathy: cardiotonic steroids and na/k ATPase signaling.
Na+-K+ pump in chronic renal failure.
Neuropathy, axonal Na+/K+ pump function and activity-dependent excitability changes in end-stage kidney disease.
The role of Na,K-ATPase inhibitors in hypertension and end-stage renal disease.
[Activity of the sodium-potassium pump and values of sodium and potassium in erythrocytes in patients with non-dialyzed renal failure and arterial hypertension treated conservatively]
[Effect of hemodialysis on the level of serum digoxin-like substance and sodium-potassium pump activity in erythrocytes from patients with chronic renal failure]
Kidney Neoplasms
Downregulation of ATP1A1 promotes cancer development in renal cell carcinoma.
Na,K-adenosine triphosphatase alpha1-subunit predicts survival of renal clear cell carcinoma.
Na/K-ATPase Y260 Phosphorylation-mediated Src Regulation in Control of Aerobic Glycolysis and Tumor Growth.
Kwashiorkor
High erythrocyte membrane (Na+ + K+)-ATPase in kwashiorkor, in vivo reversal by diuretic.
The absence of adapted sodium and potassium transport in erythrocytes of cerebral palsied children with secondary malnutrition.
Labyrinth Diseases
Immunohistochemical location of Na+, K+-ATPase ?1 subunit in the human inner ear.
Leptospirosis
Downregulation of the Na/K-ATPase Pump by Leptospiral Glycolipoprotein Activates the NLRP3 Inflammasome.
Inhibition of Na,K-ATPase by an endotoxin extracted from Leptospira interrogans: a possible mechanism for the physiopathology of leptospirosis.
Leptospira and inflammation.
Leptospira interrogans activation of peripheral blood monocyte glycolipoprotein demonstrated in whole blood by the release of IL-6.
Na,K-ATPase: a molecular target for Leptospira interrogans endotoxin.
Leukemia
Inhibition of Na,K-ATPase and sodium pump by protein kinase C regulators sphingosine, lysophosphatidylcholine, and oleic acid.
Inhibition of protein kinase C, (sodium plus potassium)-activated adenosine triphosphatase, and sodium pump by synthetic phospholipid analogues.
Membrane interactions of amphiphilic polypeptides mastoparan, melittin, polymyxin B, and cardiotoxin. Differential inhibition of protein kinase C, Ca2+/calmodulin-dependent protein kinase II and synaptosomal membrane Na,K-ATPase, and Na+ pump and differentiation of HL60 cells.
Membrane interactions of mastoparan analogues related to their differential effects on protein kinase C, Na, K-ATPase and HL60 cells.
New microbial secondary metabolites under preclinical development for cancer treatment.
Plasma membrane depolarization and Na,K-ATPase impairment induced by mitochondrial toxins augment leukemia cell apoptosis via a novel mitochondrial amplification mechanism.
Leukemia, Erythroblastic, Acute
Erythroid differentiation and the Na+,K+-pump in ouabain-sensitive and ouabain-resistant Friend erythroleukemia cell lines.
Lung Injury
Adenoviral-mediated overexpression of the NA,K-ATPase beta1 subunit gene increases lung edema clearance and improves survival during acute hyperoxic lung injury in rats.
Alveolar epithelium and Na,K-ATPase in acute lung injury.
beta-adrenergic stimulation restores rat lung ability to clear edema in ventilator-associated lung injury.
Carbonic anhydrase inhibitor attenuates ischemia-reperfusion induced acute lung injury.
Decreased expression of both the alpha1- and alpha2-subunits of the Na-K-ATPase reduces maximal alveolar epithelial fluid clearance.
Epidermal growth factor increases lung liquid clearance in rat lungs.
HIF and HOIL-1L-mediated PKC? degradation stabilizes plasma membrane Na,K-ATPase to protect against hypoxia-induced lung injury.
Hyperbaric oxygenation upregulates rat lung Na,K-ATPase.
Hyperoxic lung injury increases HOCl-modified lung proteins and NA,K-adenosine triphosphatase nitrotyrosine content.
Influence of inhaled nitric oxide and hyperoxia on Na,K-ATPase expression and lung edema in newborn piglets.
Leptin resistance protects mice from hyperoxia-induced acute lung injury.
Lung liquid clearance and Na,K-ATPase during acute hyperoxia and recovery in rats.
Mechanisms of pulmonary edema clearance during acute hypoxemic respiratory failure: role of the Na,K-ATPase.
Murine lung injury caused by Leptospira interrogans glycolipoprotein, a specific Na/K-ATPase inhibitor.
Na,K-ATPase gene transfer increases liquid clearance during ventilation-induced lung injury.
Na/K-ATPase assay in the intact mice lung subjected to perfusion.
Oleic acid inhibits lung Na/K-ATPase in mice and induces injury with lipid body formation in leukocytes and eicosanoid production.
Overexpression of the Na-K-ATPase alpha2-subunit improves lung liquid clearance during ventilation-induced lung injury.
Regulation of Na,K-ATPase during acute lung injury.
Role of ubiquitination in Na,K-ATPase regulation during lung injury.
Ubiquitination and proteolysis in acute lung injury.
Upregulation of rat lung Na-K-ATPase during hyperoxic injury.
Ventilator-associated lung injury decreases lung ability to clear edema and downregulates alveolar epithelial cell Na,K-adenosine triphosphatase function.
Lung Neoplasms
Cardiac glycosides display selective efficacy for STK11 mutant lung cancer.
Cytotoxic and cytostatic effects of digitoxigenin monodigitoxoside (DGX) in human lung cancer cells and its link to Na,K-ATPase.
Long-term exposure to hypoxia inhibits tumor progression of lung cancer in rats and mice.
Na,K-ATPase is a target of cigarette smoke and reduced expression predicts poor patient outcome of smokers with lung cancer.
Na/K Pump and Beyond: Na/K-ATPase as a Modulator of Apoptosis and Autophagy.
Predicting chemotherapeutic response to small-cell lung cancer of platinum compounds by thallium-201 single-photon emission computerized tomography.
Steroidal Cardiac Na+/K+ ATPase Inhibitors Exhibit Strong Anti-Cancer Potential in Vitro and in Prostate and Lung Cancer Xenografts in Vivo.
[Ca2+, Mg2+-ATPase activity of the erythrocyte membrane in patients with lung cancer]
[Effect of electron-acceptor compounds on the immunoregulatory mechanisms and ATPase activity of the erythrocyte membranes from patients with inoperable lung cancer]
Lymphatic Metastasis
Long-term exposure to hypoxia inhibits tumor progression of lung cancer in rats and mice.
Lymphoma
A Tool for Computation of Changes in Na+, K+, Cl- Channels and Transporters Due to Apoptosis by Data on Cell Ion and Water Content Alteration.
Genotoxicity of 2-amino-6-N-hydroxyadenine (AHA) to mouse lymphoma and CHO cells.
Mutagenicity of 2-amino-N6-hydroxyadenine (AHA) at three loci in L5178Y/tk+/- mouse lymphoma cells: molecular and preliminary cytogenetic characterizations of AHA-induced tk-/- mutants.
Lymphoma, Non-Hodgkin
Cerebral chemical dominance and neural regulation of cell division, cell proliferation, neoplastic transformation, and genomic function.
Magnesium Deficiency
Effects of dietary magnesium on sodium-potassium pump action in the heart of rats.
Malnutrition
Development of Na+-K+-ATPase in neonatal rat brain synaptosomes after perinatal protein malnutrition.
Effect of exercise during rehabilitation on swimming performance, metabolism and function of muscle in rats.
Effect of nutritional status and ozone exposure on some biomarkers of oxidative stress in rat brain regions.
Effects of malnutrition and quipazine on rat cerebral cortex ATPase activity during development.
Ouabain protects against adverse developmental programming of the kidney.
Sick cell syndrome in a burned patient.
The absence of adapted sodium and potassium transport in erythrocytes of cerebral palsied children with secondary malnutrition.
Mania
An animal model for mania: preliminary results.
Effect of ouabain on sodium pump alpha-isoform expression in an animal model of mania.
Intracerebroventricular administration of ouabain alters synaptic plasticity and dopamine release in rat medial prefrontal cortex.
Intracerebroventricular administration of ouabain, a Na/K-ATPase inhibitor, activates mTOR signal pathways and protein translation in the rat frontal cortex.
The Na,K-ATPase hypothesis for bipolar illness.
Mastitis
Polymorphisms of the ATP1A1 gene associated with mastitis in dairy cattle.
Mastocytoma
Synthesis and activation of mitotic Ca2+-adenosinetriphosphatase during the cell cycle of mouse mastocytoma cells.
Medulloblastoma
Inhibition of epidermal growth factor signaling by the cardiac glycoside ouabain in medulloblastoma.
Na,K-ATPase ?1-subunit is a target of sonic hedgehog signaling and enhances medulloblastoma tumorigenicity.
Melanoma
Synergistic effects of ion transporter and MAP kinase pathway inhibitors in melanoma.
Toad Venom Antiproliferative Activities on Metastatic Melanoma: Bio-Guided Fractionation and Screening of the Compounds of Two Different Venoms.
Memory Disorders
Deficiency in Na,K-ATPase alpha isoform genes alters spatial learning, motor activity, and anxiety in mice.
Dysregulation of Na+/K+ ATPase by amyloid in APP+PS1 transgenic mice.
Meniere Disease
Immunohistochemical location of Na+, K+-ATPase ?1 subunit in the human inner ear.
Na,K-ATPase in the cochlear lateral wall of human temporal bones with endolymphatic hydrops.
Metabolic Diseases
Metabolic Syndrome and Salt-Sensitive Hypertension in Polygenic Obese TALLYHO/JngJ Mice: Role of Na/K-ATPase Signaling.
Understanding the sodium pump and its relevance to disease.
Metabolic Syndrome
Impact of the metabolic syndrome on peripheral nerve structure and function in type 2 diabetes.
Metabolic Syndrome and Salt-Sensitive Hypertension in Polygenic Obese TALLYHO/JngJ Mice: Role of Na/K-ATPase Signaling.
pNaKtide inhibits Na/K-ATPase reactive oxygen species amplification and attenuates adipogenesis.
Regulation of the Na,K-ATPase: Special implications for cardiovascular complications of metabolic syndrome.
Migraine Disorders
A G301R Na+/K+ -ATPase mutation causes familial hemiplegic migraine type 2 with cerebellar signs.
A novel ATP1A2 variant associated with severe stepwise regression, hemiplegia, epilepsy and movement disorders in two unrelated patients.
A novel missense ATP1A2 mutation in a Finnish family with familial hemiplegic migraine type 2.
Alterations in the alpha2 isoform of Na,K-ATPase associated with familial hemiplegic migraine type 2.
Amino acid changes in the amino terminus of the Na,K-adenosine triphosphatase alpha-2 subunit associated to familial and sporadic hemiplegic migraine.
Astrocytes in Atp1a2-deficient heterozygous mice exhibit hyperactivity after induction of cortical spreading depression.
Deficiency in Na,K-ATPase alpha isoform genes alters spatial learning, motor activity, and anxiety in mice.
Familial hemiplegic migraine mutations affect Na,K-ATPase domain interactions.
First case of compound heterozygosity in Na,K-ATPase gene ATP1A2 in familial hemiplegic migraine.
Functional effects of Na+,K+-ATPase gene mutations.
Genome-wide screen for modifiers of Na + /K + ATPase alleles identifies critical genetic loci.
Haploinsufficiency of ATP1A2 encoding the Na+/K+ pump alpha2 subunit associated with familial hemiplegic migraine type 2.
Increased susceptibility to cortical spreading depression in the mouse model of familial hemiplegic migraine type 2.
Involvement of the Na,K-ATPase isoforms in control of cerebral perfusion.
Kinetic alterations due to a missense mutation in the Na,K-ATPase alpha2 subunit cause familial hemiplegic migraine type 2.
Migraine- and dystonia-related disease-mutations of Na+/K+-ATPases: relevance of behavioral studies in mice to disease symptoms and neurological manifestations in humans.
Na,K-ATPase mutations in familial hemiplegic migraine lead to functional inactivation.
Significant linkage to migraine with aura on chromosome 11q24.
Smooth muscle Ca
Two de novo mutations in the Na,K-ATPase gene ATP1A2 associated with pure familial hemiplegic migraine.
[From gene to disease; familial hemiplegic migraine as a result of mutations in a sodium-potassium pump gene]
Migraine with Aura
A G301R Na+/K+ -ATPase mutation causes familial hemiplegic migraine type 2 with cerebellar signs.
A novel ATP1A2 variant associated with severe stepwise regression, hemiplegia, epilepsy and movement disorders in two unrelated patients.
A novel missense ATP1A2 mutation in a Finnish family with familial hemiplegic migraine type 2.
Alterations in the alpha2 isoform of Na,K-ATPase associated with familial hemiplegic migraine type 2.
Astrocytes in Atp1a2-deficient heterozygous mice exhibit hyperactivity after induction of cortical spreading depression.
Deficiency in Na,K-ATPase alpha isoform genes alters spatial learning, motor activity, and anxiety in mice.
Familial hemiplegic migraine mutations affect Na,K-ATPase domain interactions.
First case of compound heterozygosity in Na,K-ATPase gene ATP1A2 in familial hemiplegic migraine.
Haploinsufficiency of ATP1A2 encoding the Na+/K+ pump alpha2 subunit associated with familial hemiplegic migraine type 2.
Increased susceptibility to cortical spreading depression in the mouse model of familial hemiplegic migraine type 2.
Involvement of the Na,K-ATPase isoforms in control of cerebral perfusion.
Kinetic alterations due to a missense mutation in the Na,K-ATPase alpha2 subunit cause familial hemiplegic migraine type 2.
Migraine- and dystonia-related disease-mutations of Na+/K+-ATPases: relevance of behavioral studies in mice to disease symptoms and neurological manifestations in humans.
Na,K-ATPase mutations in familial hemiplegic migraine lead to functional inactivation.
Significant linkage to migraine with aura on chromosome 11q24.
Smooth muscle Ca
Two de novo mutations in the Na,K-ATPase gene ATP1A2 associated with pure familial hemiplegic migraine.
[From gene to disease; familial hemiplegic migraine as a result of mutations in a sodium-potassium pump gene]
Mitral Valve Insufficiency
Effect of prazosin treatment on the cardiac sarcolemmal ATPase in failing heart due to mitral insufficiency in dogs.
Effects of chronic digoxin treatment on cardiac function, electrolytes, and sarcolemmal ATPase in the canine failing heart due to chronic mitral regurgitation.
Myocardial sarcolemmal ATPase in dogs with induced mitral insufficiency.
Mucositis
Spondias pinnata bark extract- an ameliorator of inflammatory derangement in etoposide induced mucositis: An experimental approach.
Multiple Sclerosis
Imaging correlates of decreased axonal Na+/K+ ATPase in chronic multiple sclerosis lesions.
Inhibition of membrane Na+-K+ ATPase activity: a common pathway in central nervous system disorders.
Muscle Weakness
Biochemical changes in primary culture of skeletal muscle cells following dimethoate exposure.
Muscle strength, Na,K-pumps, magnesium and potassium in patients with alcoholic liver cirrhosis -- relation to spironolactone.
Muscular Atrophy
Isoform-Specific Na,K-ATPase Alterations Precede Disuse-Induced Atrophy of Rat Soleus Muscle.
Melatonin attenuates chronic immobilization stress-induced muscle atrophy in rats: Influence on lactate-to-pyruvate ratios and Na+/K+ ATPase activity.
Muscular Diseases
[3H]-Ouabain binding to peripheral organs of cats: effect of ethanol.
[Ouabain-sensitive (Na+-K+)-ATPase activity of skeletal muscle sarcolemmal fraction in steroid myopathy mice (author's transl)]
Muscular Dystrophies
Isoform-specific Na,K-ATPase and membrane cholesterol remodeling in motor endplates in distinct mouse models of myodystrophy.
Loop diuretics inhibit detubulation and vacuolation in amphibian muscle fibres exposed to osmotic shock.
Study on the erythrocytes from myotonic dystrophy with multi-nuclear NMR.
Muscular Dystrophy, Duchenne
Erythrocyte ghost Na+,K+-adenosine triphosphatase in Duchenne muscular dystrophy.
Myocardial Infarction
Association between activities of SOD, MDA and Na+-K+-ATPase in peripheral blood of patients with acute myocardial infarction and the complication of varying degrees of arrhythmia.
Both enalapril and losartan attenuate sarcolemmal Na+-K+-ATPase remodeling in failing rat heart due to myocardial infarction.
Endogenous plasma Na,K-ATPase inhibitory activity and digoxin like immunoreactivity after acute myocardial infarction.
Influence of long-term treatment of imidapril on mortality, cardiac function, and gene expression in congestive heart failure due to myocardial infarction.
Studies on the Na+-K+-ATPase in myocardial infarction.
Total Saponins of Aralia Elata (Miq) Seem Alleviate Calcium Homeostasis Imbalance and Endoplasmic Reticulum Stress-Related Apoptosis Induced by Myocardial Ischemia/Reperfusion Injury.
Ventricular performance and Na+-K+ ATPase activity are reduced early and late after myocardial infarction in rats.
[The effect of carnosine on the activity of Na,K,ATPase: prospective uses in clinical cardiology]
[The role of an endogenous digoxin-like factor in regulating blood circulation and in the origin of arrhythmia in myocardial ischemia]
Myocardial Ischemia
Effects of adenosine on transmembrane potential and sarcolemmal Na+-K+ ATPase activity of human atrial myocardium.
Preconditioning attenuates ischemia-reperfusion-induced remodeling of Na+-K+-ATPase in hearts.
The balance between inactivation and activation of the Na+-K+ pump underlies the triphasic accumulation of extracellular K+ during myocardial ischemia.
The effect of lipid intermediates on Ca2+ and Na+ permeability and (Na+ + K+)-ATPase of cardiac sarcolemma. A possible role in myocardial ischemia.
[Na,K-ATPase activity in the myocardial sarcolemma in ischemia]
Myocardial Stunning
Myocardial stunning: do we know the mechanism?
Myocarditis
Erythrocyte Na+-K+ ATPase activity inhibition & increase in red cell fragility in experimental myocarditis produced by Indian red scorpion venom.
Myotonia
(Na+ + K+)-ATPase activity in rats with 20, 25-diazacholesterol-induced myotonia.
Myotonia induced by diazacholesterol: increased (Na+ + K+)-ATPase activity of erythrocyte ghosts and development of cataracts.
Myotonia induced by single doses of 20, 25 diazacholesterol: increased muscle and plasma desmosterol levels, unaltered (Na+ + K+)-ATPase activity of erythrocyte ghosts.
Myotonic muscular dystrophy associated with ritodrine tocolysis.
Myotonia Congenita
Na+-K+-ATPase is not involved in the warming-up phenomenon in generalized myotonia.
Myotonic Dystrophy
Erythrocyte membrane abnormalities in human myotonic dystrophy.
na+/k+-exchanging atpase deficiency
Lactic acidosis progressively impairs dopamine uptake in rat striatal synaptosomes by a mechanism partially independent of the Na+/K+-ATPase dysfunction.
Narcolepsy
Abnormal cortical unit activity of the reticular formation.
Neoplasm Metastasis
Carbonic anhydrase 2 inhibits epithelial-mesenchymal transition and metastasis in hepatocellular carcinoma.
Circulating Tumor Cell Clustering Shapes DNA Methylation to Enable Metastasis Seeding.
Local and metastatic tumor growth and membrane properties of LM fibroblasts in athymic (nude) mice.
Long-term exposure to hypoxia inhibits tumor progression of lung cancer in rats and mice.
Na,K-ATPase Isozymes in Colorectal Cancer and Liver Metastases.
Quantitative protein expression of blood-brain barrier transporters in the vasculature of brain metastases of patients with lung and breast cancer.
Translationally Controlled Tumor Protein induces epithelial to mesenchymal transition and promotes cell migration, invasion and metastasis.
Neoplasms
"The Lower Threshold" phenomenon in tumor cells toward endogenous digitalis-like compounds: Responsible for tumorigenesis?
21-Benzylidene digoxin: a proapoptotic cardenolide of cancer cells that up-regulates Na,K-ATPase and epithelial tight junctions.
?-Benzylidene digoxin derivatives synthesis and molecular modeling: Evaluation of anticancer and the Na,K-ATPase activity effect.
A link between FXYD3 (Mat-8)-mediated Na,K-ATPase regulation and differentiation of Caco-2 intestinal epithelial cells.
A mouse homolog to the avian sarcoma virus src protein is a member of a protein kinase cascade.
A Steroidal Na+/K+ ATPase Inhibitor Triggers Pro-apoptotic Signaling and Induces Apoptosis in Prostate and Lung Tumor Cells.
Activating mutations in CTNNB1 in aldosterone producing adenomas.
Adrenocortical tumorigenesis: Lessons from genetics.
Analysis of 8-hydroxyguanine in rat kidney genomic DNA after administration of a renal carcinogen, ferric nitrilotriacetate.
Analysis of the Na,K-ATPase alpha- and beta-subunit expression profiles of bladder cancer using tissue microarrays.
Anticancer and Immunogenic Properties of Cardiac Glycosides.
Application of an LC-MS/MS method for the simultaneous quantification of human intestinal transporter proteins absolute abundance using a QconCAT technique.
Biomarkers of induced electromagnetic field and cancer.
Bufadienolide glycosides and bufadienolides from the whole plants of Helleborus lividus, and their cytotoxic activity.
Bufalin inhibits glioblastoma growth by promoting proteasomal degradation of the Na+/K+-ATPase ?1 subunit.
Calcium-mobilizing hormones and phorbol myristate acetate mediate heterologous desensitization of the hormone-sensitive hepatic Na+/K+ pump.
Changes in (Na+ + K+)-ATPase activity of Ehrlich ascites tumor cells produced by alteration of membrane fatty acid composition.
Changes in sodium pump expression dictate the effects of ouabain on cell growth.
Choroid plexus papilloma. II. Ultrastructure and ultracytochemical localization of Na-K-ATPase.
Combined assessment of low PGRMC1/positive ATP1A1 levels has enhanced prognostic value for renal cell carcinoma.
Comprehensive analysis of the expression of sodium/potassium-ATPase ? subunits and prognosis of ovarian serous cystadenocarcinoma.
Differences of lipid membrane modulation and oxidative stress by digoxin and 21-benzylidene digoxin.
Digitoxin is a potential anticancer agent for several types of cancer.
Discovery of selective, antimetastatic and anti-cancer stem cell metallohelices via post-assembly modification.
Downregulation of ATP1A1 promotes cancer development in renal cell carcinoma.
Dysadherin specific drug conjugates for the treatment of thyroid cancers with aggressive phenotypes.
Effects of dietary monoterpene, myrcene, administration on immune- and health-related genes expression in common carp gill following exposure to copper sulfate.
Effects of digoxin and Na, K-ATPase immunoexpression on human oral squamous carcinomas.
Electrolyte levels in neoplastic and nonneoplastic human urothelium after ouabain treatment: X-ray microanalysis of bulk hydrated samples.
ENDOCRINE TUMOURS: The genomics of adrenocortical tumors.
Evidence for a potential tumor suppressor role for the Na,K-ATPase beta1-subunit.
FCY-302, a Novel Small Molecule, Induces Apoptosis in Leukemia and Myeloma Cells by Attenuating Key Antioxidant and Mitochondrial Enzymes.
Functional characterization and anti-cancer action of the clinical phase II cardiac Na+/K+ ATPase inhibitor istaroxime: in vitro and in vivo properties and cross talk with the membrane androgen receptor.
GENETICS IN ENDOCRINOLOGY: Impact of race and sex on genetic causes of aldosterone-producing adenomas.
Genomics of benign adrenocortical tumors.
Glucocorticoids suppress renal cell carcinoma progression by enhancing Na,K-ATPase beta-1 subunit expression.
Hyperthermia, Na+K+ATPase and lactic acid production in some human tumour cells.
Identification of a sodium pump Na+/K+ ATPase ?1-targeted peptide for PET imaging of breast cancer.
Improved Brain Tumor Classification by Sodium MR Imaging: Prediction of IDH Mutation Status and Tumor Progression.
Influence of N-methyl-D-aspartate receptors on ouabain activation of nuclear factor-?B in the rat hippocampus.
Inhibition of epidermal growth factor signaling by the cardiac glycoside ouabain in medulloblastoma.
Inhibition of membrane Na+-K+ ATPase activity: a common pathway in central nervous system disorders.
Inhibition of Na/K-ATPase promotes myocardial tumor necrosis factor-alpha protein expression and cardiac dysfunction via calcium/mTOR signaling in endotoxemia.
Inhibitors of Na+/K+ ATPase exhibit antitumor effects on multicellular tumor spheroids of hepatocellular carcinoma.
Insulin induces phosphorylation of serine residues of translationally controlled tumor protein in 293T cells.
Inverse agonism at the Na/K-ATPase receptor reverses EMT in prostate cancer cells.
Kidney damage in rats bearing an adrenocorticotropin and prolactin secreting tumor.
Leucine transport in relation to the activities of Na+-H+ antiporter and Na+/K+ pump stimulated by serum and a tumor promoter.
Local and metastatic tumor growth and membrane properties of LM fibroblasts in athymic (nude) mice.
Long-circulating and fusogenic liposomes loaded with a glucoevatromonoside derivative induce potent antitumor response.
Long-term exposure to hypoxia inhibits tumor progression of lung cancer in rats and mice.
Modulation of Na,K-ATPase activity by immunoglobulins--II. Na,K-ATPase activity in erythrocytes from patients with various chronic disturbances.
Modulators of Na/K-ATPase: a patent review.
Molecular Genetic and Genomic Alterations in Cushing's Syndrome and Primary Aldosteronism.
Motility, heat, and lactate production in ejaculated bovine sperm.
Multiple functions of Na,K-ATPase in epithelial cells.
Na+/K+ ATPase and cell growth IV: a metabolic marker of human brain tumors?
Na+/K+ ATPase inhibitors in cancer.
Na,K-adenosine triphosphatase alpha1-subunit predicts survival of renal clear cell carcinoma.
Na,K-ATPase ?1-subunit is a target of sonic hedgehog signaling and enhances medulloblastoma tumorigenicity.
Na,K-ATPase is a target of cigarette smoke and reduced expression predicts poor patient outcome of smokers with lung cancer.
Na,K-ATPase subunits as markers for epithelial-mesenchymal transition in cancer and fibrosis.
Na/K Pump and Beyond: Na/K-ATPase as a Modulator of Apoptosis and Autophagy.
Na/K-ATPase as a target for anticancer drugs: studies with perillyl alcohol.
Na/K-ATPase mimetic pNaKtide inhibits the growth of human cancer cells.
Na/K-ATPase Y260 Phosphorylation-mediated Src Regulation in Control of Aerobic Glycolysis and Tumor Growth.
Na/K-ATPase, endogenous digitalis like compounds and cancer development -- a hypothesis.
Na/K-ATPase: Their role in cell adhesion and migration in cancer.
Novel somatic mutations and distinct molecular signature in aldosterone-producing adenomas.
Oleandrin-mediated inhibition of human tumor cell proliferation: importance of Na,K-ATPase alpha subunits as drug targets.
Ouabain-induced alterations of the apical junctional complex involve ?1 and ?1 Na,K-ATPase downregulation and ERK1/2 activation independent of caveolae in colorectal cancer cells.
Over-expression of translationally controlled tumor protein in lens epithelial cells seems to be associated with cataract development.
Overexpression of ATPase Na+/+ transporting alpha 1 polypeptide, ATP1A1, correlates with clinical diagnosis and progression of esophageal squamous cell carcinoma.
Phosphorylation of the beta subunit of Na+K+-ATPase in Ehrlich ascites tumor by a membrane-bound protein kinase.
Photosensitizing effects of hematoporphyrin derivative and photofrin II on the plasma membrane enzymes 5'-nucleotidase, Na+K+-ATPase, and Mg2+-ATPase in R3230AC mammary adenocarcinomas.
Potassium bicarbonate and D-ribose effects on A72 canine and HTB-126 human cancer cell line proliferation in vitro.
Predicting chemotherapeutic response to small-cell lung cancer of platinum compounds by thallium-201 single-photon emission computerized tomography.
Protective effects of St. John's wort in the hepatic ischemia/reperfusion injury in rats.
Protein synthesis in dextran sulfate-treated ascites tumor cells.
Regulation of phosphorylation of the beta-subunit of th Ehrlich ascites tumor Na+K+-ATPase by a protein kinase cascade.
Regulatory volume increase in Ehrlich ascites tumor cells.
RNA Sequencing Provides Novel Insights into the Transcriptome of Aldosterone Producing Adenomas.
Role of Na-K-ATPase in the assembly of tight junctions.
Roles of ERK, PI3 kinase, and PLC-gamma pathways induced by overexpression of translationally controlled tumor protein in HeLa cells.
S163 is critical for FXYD5 modulation of wound healing in airway epithelial cells.
Sodium-calcium Exchanger 1 Regulates Epithelial Cell Migration via Calcium-Dependent Extracellular-Signal-Regulated Kinase Signaling.
Some Biological Consequences of the Inhibition of Na,K-ATPase by Translationally Controlled Tumor Protein (TCTP).
Steroidal Cardiac Na+/K+ ATPase Inhibitors Exhibit Strong Anti-Cancer Potential in Vitro and in Prostate and Lung Cancer Xenografts in Vivo.
Studies on the relationship between glycolysis and (Na+ + K+)-ATPase in cultured cells.
Subchronic treatment with vanadate does not potentiate the toxicity of cardiac glycosides.
Sulfonylurea binding to a low-affinity site inhibits the Na/K-ATPase and the KATP channel in insulin-secreting cells.
The common occurrence of ATP diphosphohydrolase in mammalian plasma membranes.
The expression of the alpha1 subunit of Na+/K+-ATPase is related to tumor development and clinical outcomes in gastric cancer.
The influence of Na+,K(+)-pump blockade on doxorubicin-mediated cytotoxicity and DNA strand breakage in human tumor cells.
The Na/Ca Exchange as a Target for Antitumor Effect of 4Hz Pulsing Magnetic Field.
The Neuro-Immune Pathophysiology of Central and Peripheral Fatigue in Systemic Immune-Inflammatory and Neuro-Immune Diseases.
The relationship between 67Ga accumulation and ATP metabolism in tumor cells in vitro.
The steroidal Na+/K+ ATPase inhibitor 3-[(R)-3-pyrrolidinyl]oxime derivative (3-R-POD) induces potent pro-apoptotic responses in colonic tumor cells.
TRAF2 Is a Novel Ubiquitin E3 Ligase for the Na,K-ATPase ?-Subunit That Drives Alveolar Epithelial Dysfunction in Hypercapnia.
Transcriptional regulators of Na,K-ATPase subunits.
Translationally Controlled Tumor Protein induces epithelial to mesenchymal transition and promotes cell migration, invasion and metastasis.
Translationally controlled tumor protein interacts with the third cytoplasmic domain of Na,K-ATPase alpha subunit and inhibits the pump activity in HeLa cells.
Transport functions of the liver. Lack of correlation between hepatocellular ouabain uptake and binding to (Na+ + K+)-ATPase.
Tumor interstitial fluid promotes malignant phenotypes of lung cancer independently of angiogenesis.
Tumor necrosis factor alpha alters Na+-K+ ATPase activity in rat cardiac myocytes: involvement of NF-kappaB, AP-1 and PGE2.
Tumor necrosis factor alpha down-regulates the Na+-K+ ATPase and the Na+-K+2Cl- cotransporter in the kidney cortex and medulla.
Tumor suppression in basal keratinocytes via dual non-cell-autonomous functions of a Na,K-ATPase beta subunit.
Up-regulation of Rhoa/Rho kinase pathway by translationally controlled tumor protein in vascular smooth muscle cells.
[Binding of the antileukemia drug Escherichia coli L-asparaginase to the plasma membrane of normal human mononuclear cells]
[Changes in the microviscosity of lipid bilayer membranes of various malignant cells and tumor transplantability]
[Transmembrane transfer of sodium ions in cell membranes of normal and tumor cells]
Nephritis
[Na,K-Atpase in renal tissue of rats in the dynamics of experimental nephritis]
Nephrosis
Increased synthesis and avp unresponsiveness of Na,K-ATPase in collecting duct from nephrotic rats.
Nephrotic syndrome is associated with increased plasma K+ concentration, intestinal K+ losses, and attenuated urinary K+ excretion: a study in rats and humans.
Nephrotic Syndrome
Mechanism of enhanced Na-K-ATPase activity in cortical collecting duct from rats with nephrotic syndrome.
[Renal K-ATPases: structure, function and dysfunction]
[Role of tubular Na-K-ATPase in nephrotic syndrome induced by puromycin in the rat]
Nervous System Diseases
Abnormal cortical unit activity of the reticular formation.
Factors in the disease severity of ATP1A3 mutations: Impairment, misfolding, and allele competition.
Maturation of the Na,K-ATPase in the Endoplasmic Reticulum in Health and Disease.
Region- and neuronal-subtype-specific expression of Na,K-ATPase alpha and beta subunit isoforms in the mouse brain.
Neuroacanthocytosis
Decreased Na+/K+ ATPase Expression and Depolarized Cell Membrane in Neurons Differentiated from Chorea-Acanthocytosis Patients.
Neuroblastoma
Alterations of membrane integrity and cellular constituents by arachidonic acid in neuroblastoma and glioma cells.
Determination of total (Na+ + K+)-ATPase activity of isolated or cultured cells.
Direct interaction of beta-amyloid with Na,K-ATPase as a putative regulator of the enzyme function.
Effect of galactose and glucose levels and sorbinil treatment on myo-inositol metabolism and Na+-K+ pump activity in cultured neuroblastoma cells.
Effect of increased glucose levels on Na+/K+-pump activity in cultured neuroblastoma cells.
Reduced Na+/K+ ATPase transport activity, resting membrane potential, and bradykinin-stimulated phosphatidylinositol synthesis by polyol accumulation in cultured neuroblastoma cells.
Regulation of Na-K-Cl cotransport, Na,K-adenosine triphosphatase, and Na/H exchanger in human neuroblastoma NB-OK-1 cells by atrial natriuretic peptide.
Resting membrane potential in 41A3 mouse neuroblastoma cells. Effect of increased glucose and galactose concentrations.
Reversal of hyperglycemic-induced defects in myo-inositol metabolism and Na+/K+ pump activity in cultured neuroblastoma cells by normalizing glucose levels.
Tissue-specific expression of Na,K-ATPase beta-subunit. Does beta 2 expression correlate with tumorigenesis?
Weak A.C. magnetic field effects: changes in cell sodium pump activity following whole animal exposure.
Neurodegenerative Diseases
Inhibition of the electrogenic Na pump underlies delayed depolarization of cortical neurons after mechanical injury or glutamate.
Localization dependent sensitivity of cerebral Na,K-ATPase to irradiation induced oxidative imbalance in rats.
Na,K-ATPase: increases in alpha1-messenger RNA and decreases in alpha3-messenger RNA levels in aging rat cerebral cortex.
Repeated Restraint Stress Decreases Na,K-ATPase Activity via Oxidative and Nitrosative Damage in the Frontal Cortex of Rats.
Non-alcoholic Fatty Liver Disease
Mechanistic Insight of Na/K-ATPase Signaling and HO-1 into Models of Obesity and Nonalcoholic Steatohepatitis.
Phenotypic Alteration of Hepatocytes in Non-Alcoholic Fatty Liver Disease.
Obesity
Abnormalities of sodium transport by sodium, potassium-activated adenosine triphosphatase in erythrocytes from obese children.
Activity of (Na+ + K+)-ATPase in the liver of animals with experimental obesity.
Altered brown adipose tissue and Na,K pump activities during diet-induced obesity and weight loss in rats.
Altered erythrocyte Na+ + K+ pump in adolescent obesity.
Animal and human tissue Na,K-ATPase in normal and insulin-resistant states: regulation, behaviour and interpretative hypothesis on NEFA effects.
Animal and human tissue Na,K-ATPase in obesity and diabetes: A new proposed enzyme regulation.
Author Correction: The Adipocyte Na/K-ATPase Oxidant Amplification Loop is the Central Regulator of Western Diet-Induced Obesity and Associated Comorbidities.
Catecholamine-stimulated potassium transport in erythrocytes from normal and obese subjects.
Changes in cell membrane Na,K-ATPase activity associated with induction of dietary obesity in the rat.
Erythrocyte heat production in human obesity: microcalorimetric investigation of sodium-potassium pump and cell metabolism.
Erythrocyte Na+-K+ ATPase activity in childhood: regulation by genetic factors independent of body weight.
Erythrocyte Na-K-ATPase membrane activity in obese patients fed over a long-term period with a very-low-calorie diet.
Erythrocyte sodium-potassium-stimulated adenosine triphosphatase activity is not related to obesity.
Hepatic sodium-potassium pump in obesity.
Heterogeneity of the erythrocyte Na-K pump status in human obesity.
Hyperphagia and obesity in Na,K-ATPase alpha2 subunit-defective mice.
Impaired calcium metabolism associated with hypertension in Zucker obese rats.
Inhibition of intestinal villus cell Na/K-ATPase mediates altered glucose and NaCl absorption in obesity-associated diabetes and hypertension.
Mechanisms and consequences of Na+,K+-pump regulation by insulin and leptin.
Mechanistic Insight of Na/K-ATPase Signaling and HO-1 into Models of Obesity and Nonalcoholic Steatohepatitis.
Metabolic Syndrome and Salt-Sensitive Hypertension in Polygenic Obese TALLYHO/JngJ Mice: Role of Na/K-ATPase Signaling.
pNaKtide inhibits Na/K-ATPase reactive oxygen species amplification and attenuates adipogenesis.
Red-cell sodium-potassium pump and sodium-lithium countertransport in human obesity. Re-evaluation of the methods and association in a Finnish population.
Red-cell sodium-potassium pump in obesity.
Reduced activity of the red-cell sodium-potassium pump in human obesity.
Sodium-potassium pump in cultured fibroblasts from obese donors; no evidence for an inherent decrease of basal or insulin-stimulated activity.
The Adipocyte Na/K-ATPase Oxidant Amplification Loop is the Central Regulator of Western Diet-Induced Obesity and Associated Comorbidities.
The Na+-K+-pump, energy metabolism, and obesity.
The Pivotal Role of Adipocyte-Na K peptide in Reversing Systemic Inflammation in Obesity and COVID-19 in the Development of Heart Failure.
The Role of Na/K-ATPase Signaling in Oxidative Stress Related to Aging: Implications in Obesity and Cardiovascular Disease.
The Role of Na/K-ATPase Signaling in Oxidative Stress Related to Obesity and Cardiovascular Disease.
The role of obesity and its bioclinical correlates in the progression of chronic kidney disease.
Olfaction Disorders
Dietary sodium protects fish against copper-induced olfactory impairment.
Osteoarthritis
Decreased NA+, K+-ATPase activity in erythrocyte membrane from rheumatoid arthritis patients.
Osteoporosis
Immunization with Na+/K+ ATPase DR peptide prevents bone loss in an ovariectomized rat osteoporosis model.
Osteosarcoma
Insulin stimulation of Na+-K+ pump in clonal rat osteosarcoma cells.
Parathyroid hormone stimulation of the Na+/K+ pump in rat clonal osteosarcoma cells.
The Na+/K+ ATPase Inhibitor Ouabain Attenuates Stemness and Chemoresistance of Osteosarcoma Cells.
Otitis Media
Labeling of the glucocorticoid receptor and Na,K-ATPase in a rat otitis media model.
Otosclerosis
Spiral ligament and stria vascularis changes in cochlear otosclerosis: effect on hearing level.
Ototoxicity
Effect of cisplatin on hair cell morphology and lateral wall Na,K-ATPase activity.
Ovarian Neoplasms
New bufadienolides extracted from Rhinella marina inhibit Na,K-ATPase and induce apoptosis by activating caspases 3 and 9 in human breast and ovarian cancer cells.
Overweight
Effects of ouabain and potassium on rabbit arterial smooth muscle cells in culture.
Pancreatic Neoplasms
Oleandrin-mediated inhibition of human tumor cell proliferation: importance of Na,K-ATPase alpha subunits as drug targets.
Pancreatitis
Montelukast, a selective cysteinyl leukotriene receptor 1 antagonist, reduces cerulein-induced pancreatic injury in rats.
Pancreatitis, Chronic
Modulation of Na,K-ATPase activity by immunoglobulins--II. Na,K-ATPase activity in erythrocytes from patients with various chronic disturbances.
Papilloma
Choroid plexus papilloma. II. Ultrastructure and ultracytochemical localization of Na-K-ATPase.
Papilloma, Choroid Plexus
Choroid plexus papilloma. II. Ultrastructure and ultracytochemical localization of Na-K-ATPase.
Paralysis
A novel family of transmembrane proteins interacting with {beta} subunits of the Na,K-ATPase.
Altered axonal excitability properties in juvenile muscular atrophy of distal upper extremity (Hirayama disease).
Erythrocyte sodium-potassium pump in thyrotoxic periodic paralysis.
Genome-wide screen for modifiers of Na + /K + ATPase alleles identifies critical genetic loci.
Na+,K+-pump stimulation improves contractility in isolated muscles of mice with hyperkalemic periodic paralysis.
Periodic paralysis and the sodium-potassium pump.
Potassium uptake in muscle during paramyotonic weakness.
Thyrotoxic Periodic Paralysis With Features of Andersen-Tawil Syndrome: A Case Report and Literature Review.
Thyrotoxicosis presenting as a life threatening hypokalaemic paralysis: investigation of the Na/K pump in isolated leucocytes.
[Periodic hypokalemic paralysis disclosing thyrotoxicosis]
[Thyrotoxic periodic paralysis. Discussion of the role of Na-K-ATPase, apropos of a case]
Paralysis, Hyperkalemic Periodic
Na+,K+-pump stimulation improves contractility in isolated muscles of mice with hyperkalemic periodic paralysis.
Potassium uptake in muscle during paramyotonic weakness.
Paraneoplastic Syndromes, Nervous System
Neuronal Na+/K+ ATPase is an autoantibody target in paraneoplastic neurologic syndrome.
Parkinson Disease
Inhibition of membrane Na+-K+ ATPase activity: a common pathway in central nervous system disorders.
Parkinsonian Disorders
Deficiency in Na,K-ATPase alpha isoform genes alters spatial learning, motor activity, and anxiety in mice.
Distribution of Na/K-ATPase alpha 3 isoform, a sodium-potassium P-type pump associated with rapid-onset of dystonia parkinsonism (RDP) in the adult mouse brain.
Enhanced inhibitory neurotransmission in the cerebellar cortex of Atp1a3-deficient heterozygous mice.
Heterozygous mice deficient in Atp1a3 exhibit motor deficits by chronic restraint stress.
Mutations in the Na+/K+ -ATPase alpha3 gene ATP1A3 are associated with rapid-onset dystonia parkinsonism.
Pediatric Obesity
Childhood obesity: plasma potassium and Na-K-ATPase indicate that the electrolyte content of food may be important.
Peripheral Nervous System Diseases
A sodium-pump defect in diabetic peripheral nerve corrected by sorbinil administration: relationship to myo-inositol metabolism and nerve conduction slowing.
Decreased myo-inositol content and Na+-K+-ATPase activity in superior cervical ganglion of STZ-diabetic rat and prevention by aldose reductase inhibition.
Morphophysiologic characterization of peripheral neuropathy in zinc-deficient guinea pigs.
Sciatic Nerve Structural and Functional Recovery with Extract of Phyllanthus amarus and Esculetin in STZ-Induced Hyperglycemic Rats.
Peritonitis
ATP1A1-mediated Src signaling inhibits coronavirus entry into host cells.
Increased aerobic glycolysis through beta2 stimulation is a common mechanism involved in lactate formation during shock states.
Pheochromocytoma
Determination of total (Na+ + K+)-ATPase activity of isolated or cultured cells.
Differential response of adenylate cyclase and ATPase activities after chronic ethanol exposure of PC12 cells.
Plasmacytoma
Characterization of a beta-actinin-like protein in purified non-muscle cell membranes. Its activity on (Na+ + K+)-ATPase.
Pneumonia
Oleic acid induces lung injury in mice through activation of the ERK pathway.
Polycystic Kidney Diseases
Cell polarity in human renal cystic disease.
Cystic fibrosis transmembrane conductance regulator in the kidney: clues to its role?
Novel role of ouabain as a cystogenic factor in autosomal dominant polycystic kidney disease.
Ouabain activates the Na,K-ATPase signalosome to induce autosomal dominant polycystic kidney disease cell proliferation.
Ouabain binds with high affinity to the Na,K-ATPase in human polycystic kidney cells and induces extracellular signal-regulated kinase activation and cell proliferation.
Renal tubule Na,K-ATPase polarity in different animal models of polycystic kidney disease.
Renal tubule Na,K-ATPase polarity in glucocorticoid-induced polycystic kidney disease.
Role of Na-K-ATPase in the assembly of tight junctions.
Selective basolateral localization of overexpressed Na-K-ATPase beta1- and beta2- subunits is disrupted by butryate treatment of MDCK cells.
Sequential tubular cell and basement membrane changes in polycystic kidney disease.
Sodium pump distribution is not reversed in the DBA/2FG-pcy, polycystic kidney disease model mouse.
Polycystic Kidney, Autosomal Dominant
Cystic fibrosis transmembrane conductance regulator in the kidney: clues to its role?
Epithelial cell polarity and disease.
Novel role of ouabain as a cystogenic factor in autosomal dominant polycystic kidney disease.
Ouabain activates the Na,K-ATPase signalosome to induce autosomal dominant polycystic kidney disease cell proliferation.
Ouabain binds with high affinity to the Na,K-ATPase in human polycystic kidney cells and induces extracellular signal-regulated kinase activation and cell proliferation.
Ouabain Regulates CFTR-Mediated Anion Secretion and Na,K-ATPase Transport in ADPKD Cells.
Selective basolateral localization of overexpressed Na-K-ATPase beta1- and beta2- subunits is disrupted by butryate treatment of MDCK cells.
Sodium pump distribution is not reversed in the DBA/2FG-pcy, polycystic kidney disease model mouse.
[Abnormal erythrocyte sodium transport in patients with adult polycystic kidney and hypertension]
Polycystic Kidney, Autosomal Recessive
Na transport in autosomal recessive polycystic kidney disease (ARPKD) cyst lining epithelial cells.
Sodium pump distribution is not reversed in the DBA/2FG-pcy, polycystic kidney disease model mouse.
Polyneuropathies
Effect of aldose reductase inhibitor (Ponalrestat) on erythrocyte Na,K-ATPase activity in non-insulin-dependent diabetic patients with polyneuropathy.
Hypothesis: low Na/K-ATPase activity in the red cell membrane, a potential marker of the predisposition to diabetic neuropathy.
Polyuria
Altered expression of renal AQPs and Na(+) transporters in rats with lithium-induced NDI.
Effect of potassium depletion on ischemic renal failure.
[Fundamental and applied studies on transport and metabolism of electrolytes and glucose--aim to contact with molecular biology]
Porcine Reproductive and Respiratory Syndrome
Downregulation of Aquaporins (AQP1 and AQP5) and Na,K-ATPase in Porcine Reproductive and Respiratory Syndrome Virus-Infected Pig Lungs.
Potassium Deficiency
Effect of low potassium-diet on Na-K-ATPase in rat nephron segments.
Increase in the (Na+ + K+)-ATPase activity in heart muscle after chronic treatment with digitoxin or potassium deficient diet.
Pre-Eclampsia
Antibody against Na/K-ATPase inhibitor lowers blood pressure and increases vascular Fli1 in experimental preeclampsia.
Antibody to Marinobufagenin Reverses Placenta-Induced Fibrosis of Umbilical Arteries in Preeclampsia.
Circulating bufodienolide and cardenolide sodium pump inhibitors in preeclampsia.
DigiFab Interacts With Endogenous Cardiotonic Steroids and Reverses Preeclampsia-Induced Na/K-ATPase Inhibition.
Endogenous Bufadienolides, Fibrosis and Preeclampsia.
Endogenous Na/K-ATPase inhibitors in patients with preeclampsia.
Endogenous sodium pump inhibitors, diabetes mellitus and preeclampsia Preliminary observations and a hypothesis.
Erythrocyte sodium/potassium ATPase activity in severe preeclampsia.
Interaction of Digibind with endogenous cardiotonic steroids from preeclamptic placentae.
Magnesium Sulfate Potentiates Effect of Digifab on Marinobufagenin-Induced Na/K-ATPase Inhibition.
Monoclonal antibody to an endogenous bufadienolide, marinobufagenin, reverses preeclampsia-induced Na/K-ATPase inhibition and lowers blood pressure in NaCl-sensitive hypertension.
Preeclampsia and Na,K-ATPase activity of red blood cell ghosts from neonatal and maternal blood.
Preeclampsia: Cardiotonic Steroids, Fibrosis, Fli1 and Hint to Carcinogenesis.
S-glutathionylation of the Na+-K+ Pump: A Novel Redox Mechanism in Preeclampsia.
Synthesis of an Endogenous Steroidal Na Pump Inhibitor Marinobufagenin, Implicated in Human Cardiovascular Diseases, Is Initiated by CYP27A1 via Bile Acid Pathway.
Uncovering the molecular cause of preeclampsia - The role of glutathionylation of the Na+/K+ ATPase transporter.
Prostatic Neoplasms
Inverse agonism at the Na/K-ATPase receptor reverses EMT in prostate cancer cells.
Istaroxime, a potential anticancer drug in prostate cancer, exerts beneficial functional effects in healthy and diseased human myocardium.
Voltage-dependent K+ channels as oncotargets in malignant gliomas.
Protein Deficiency
Interaction of alcohol and protein deficiency on rat brain synaptosomal (Na+-K+)-ATPase.
Protein-Energy Malnutrition
The absence of adapted sodium and potassium transport in erythrocytes of cerebral palsied children with secondary malnutrition.
Proteinuria
Ageing reduces angiotensin II type 1 receptor antagonism mediated pre-conditioning effects in ischemic kidneys by inducing oxidative and inflammatory stress.
Genetic and biochemical determinants of abnormal monovalent ion transport in primary hypertension.
Rostafuroxin protects from podocyte injury and proteinuria induced by adducin genetic variants and ouabain.
[Molecular mechanisms of idiopathic nephrotic syndrome]
Pulmonary Edema
Alveolar epithelium and Na,K-ATPase in acute lung injury.
Alveolar type II cell Na,K-ATPase is upregulated during mechanical ventilation-induced pulmonary edema.
Decreased expression of both the alpha1- and alpha2-subunits of the Na-K-ATPase reduces maximal alveolar epithelial fluid clearance.
Dopamine stimulates sodium transport and liquid clearance in rat lung epithelium.
Influence of inhaled nitric oxide and hyperoxia on Na,K-ATPase expression and lung edema in newborn piglets.
Influenza leaves a TRAIL to pulmonary edema.
Lipoxin A4 Activates Alveolar Epithelial ENaC, Na,K-ATPase and Increases Alveolar Fluid Clearance.
Mechanisms of pulmonary edema clearance during acute hypoxemic respiratory failure: role of the Na,K-ATPase.
Na,K-ATPase overexpression improves alveolar fluid clearance in a rat model of elevated left atrial pressure.
Regulation of lung edema clearance by dopamine.
Role and regulation of lung Na,K-ATPase.
Upregulation of rat lung Na-K-ATPase during hyperoxic injury.
[Respiratory distress. New Perspectives to lung edema treatment]
Renal Insufficiency
Altered distribution pattern of Na+-K+-ATPase and succinate dehydrogenase activities along the nephron in human acute post-transplant renal failure.
An Na+-K+-ATPase inhibitor which circulates in renal failure but not in essential hypertension.
Disturbances of potassium homeostasis in poisoning.
Effect of hemodialysis on red blood cell Na+-K+-ATPase activity in terminal renal failure.
Effect of potassium depletion on ischemic renal failure.
Effects of dialysis and transplantation on red cell Na pump function in renal failure.
Experimental renal failure in the rat modulates cardiac Na,K-ATPase alpha 2 mRNA but not protein.
Measurement of circulating sodium-pump inhibitory activity in uraemia and essential hypertension.
Renal function and Na-K-ATPase in rats after suprarenal ligation of inferior vena cava.
Sodium potassium ATPase activity in human rectal mucosa with and without renal insufficiency.
Sodium-22 uptake in erythrocytes can differentiate between the essential and the secondary hypertensive patient.
[Activity of the sodium-potassium pump and values of sodium and potassium in erythrocytes in patients with non-dialyzed renal failure and arterial hypertension treated conservatively]
[Physiological effects of the connecting peptide]
Renal Insufficiency, Chronic
Jejunal dopamine and Na,K-ATPase activity in early chronic renal insufficiency.
Mechanism of potassium adaptation.
Na/K-ATPase signaling mediates miR-29b-3p regulation and cardiac fibrosis formation in mice with chronic kidney disease.
Sodium potassium ATPase activity in human rectal mucosa with and without renal insufficiency.
Synthesis of an Endogenous Steroidal Na Pump Inhibitor Marinobufagenin, Implicated in Human Cardiovascular Diseases, Is Initiated by CYP27A1 via Bile Acid Pathway.
The potential role of Na-K-ATPase and its signaling in the development of anemia in chronic kidney disease.
Reperfusion Injury
DRm217 attenuates myocardial ischemia-reperfusion injury via stabilizing plasma membrane Na+-K+-ATPase, inhibiting Na+-K+-ATPase/ROS pathway and activating PI3K/Akt and ERK1/2.
Enhencement of Na/K pump activity by chronic intermittent hypobaric hypoxia protected against reperfusion injury.
O2 free radicals: cause of ischemia-reperfusion injury to cardiac Na+-K+-ATPase.
Sex differences in heat shock protein 72 expression and localization in rats following renal ischemia-reperfusion injury.
[Effect of cardiomyopeptidin for injection on energy metabolism in isolated hearts of young rats after ischemia-reperfusion injury]
[Effect of electroacupuncture of "Neiguan" (PC 6) on Na+-K+-ATPase activity and its gene expression in cardiocyte membrane in rats with myocardial ischemia-reperfusion injury]
Respiratory Distress Syndrome
Leukotriene D4 activates alveolar epithelial Na,K-ATPase and increases alveolar fluid clearance.
Na/K-ATPase assay in the intact mice lung subjected to perfusion.
Respiratory Insufficiency
Mechanisms of pulmonary edema clearance during acute hypoxemic respiratory failure: role of the Na,K-ATPase.
Regulation of lung edema clearance by dopamine.
TRAF2 Is a Novel Ubiquitin E3 Ligase for the Na,K-ATPase ?-Subunit That Drives Alveolar Epithelial Dysfunction in Hypercapnia.
Retinal Degeneration
[Early changes in retinal 5'-nucleotidase activity in hereditary retinal degeneration]
Retinal Diseases
(Na+ + K+)-ATPase and opsin in retinas of RCS dystrophic rats: time course study.
Retinoschisis
The Na/K-ATPase is obligatory for membrane anchorage of retinoschisin, the protein involved in the pathogenesis of X-linked juvenile retinoschisis.
Rhabdomyolysis
Disturbances of potassium homeostasis in poisoning.
Sarcoma
A moving new role for the sodium pump in epithelial cells and carcinomas.
Identification of protein kinase C as an intermediate in Na,K-ATPase Beta-subunit mediated lamellipodia formation and suppression of cell motility in carcinoma cells.
Na,K-ATPase beta-subunit is required for epithelial polarization, suppression of invasion, and cell motility.
Na,K-ATPase beta1-subunit increases the translation efficiency of the alpha1-subunit in MSV-MDCK cells.
Novel role for Na,K-ATPase in phosphatidylinositol 3-kinase signaling and suppression of cell motility.
Sarcoma, Yoshida
Inactivation of (Na-++K-+)-stimulated ATPase by a cytotoxic protein from cobra venom in relation to its lytic effects on cells.
Influence of charge on the inactivation of membrane bound (Na+ + K+)-ATPase of Yoshida sarcoma cells by inhibitor proteins from cobra venom.
Schistosomiasis
Heterogeneity of ouabain binding sites in Schistosoma mansoni. First evidence for the presence of two (Na+ + K+)-ATPase isoforms in platyhelminths.
Seizures
Abnormal cortical unit activity of the reticular formation.
Altered Na+-K+ ATPase immunoreactivity within GABAergic neurons in the gerbil hippocampal complex induced by spontaneous seizure and vigabatrin treatment.
Evolving in thin air-Lessons from the llama fetus in the altiplano.
Extracellular K+ accumulations and synchronous GABA-mediated potentials evoked by 4-aminopyridine in the adult rat hippocampus.
Genome-wide screen for modifiers of Na + /K + ATPase alleles identifies critical genetic loci.
Germline De Novo Mutations in ATP1A1 Cause Renal Hypomagnesemia, Refractory Seizures, and Intellectual Disability.
Hereditary spastic paraplegia is a novel phenotype for germline de novo ATP1A1 mutation.
Membrane Na+K+ATPase activity: changes using an experimental model of alcohol dependence and withdrawal.
NA+, K+-ATPase Activity in the Brain of the Rats with Kainic Acid-Induced Seizures: Influence of Lamotrigine.
Na+-K+-ATPase functions in the developing hippocampus: regional differences in CA1 and CA3 neuronal excitability and role in epileptiform network bursting.
Neuropathology in Drosophila mutants with increased seizure susceptibility.
Oxidative stress and Na,K-ATPase activity differential regulation in brainstem and forebrain of Wistar Audiogenic rats may lead to increased seizure susceptibility.
Perinatal cardiopulmonary adaptation to the thin air of the Alto Andino by a native Altiplano dweller, the llama.
Possible mechanism of digoxin-induced convulsions.
Sodium pathway markers in normal and kindled frog brains.
The (Na+ + K+)-ATPase activity in brain of Quaking mice.
Sepsis
Alterations of Na+-K+-ATPase, Ca2+-ATPase, and Mg2+-ATPase activities in erythrocyte, muscle, and liver of traumatic and septic patients.
Externalization and internalization of (Na+ + K+)-ATPase in rat heart during different phases of sepsis.
Lactate and shock state: the metabolic view.
Role of skeletal muscle Na+-K+ ATPase activity in increased lactate production in sub-acute sepsis.
Sepsis Impairs Alveolar Epithelial Function by Down-regulating Na,K-ATPase Pump.
Sick cell syndrome in a burned patient.
Shock, Septic
Lactate and shock state: the metabolic view.
Shoulder Impingement Syndrome
Changes in muscle fiber cross-sectional area and concentrations of Na,K-ATPase in deltoid muscle in patients with impingement syndrome of the shoulder.
Sinusitis
Na/K-ATPase in rabbit paranasal sinus mucosa during induced sinusitis.
Sleep Deprivation
Ouabain, a Na-K-ATPase inhibitor, enhances wakefulness in rats.
Stimulatory role of calcium in rapid eye movement sleep deprivation-induced noradrenaline-mediated increase in Na-K-ATPase activity in rat brain.
Spastic Paraplegia, Hereditary
Hereditary spastic paraplegia is a novel phenotype for germline de novo ATP1A1 mutation.
Spinal Cord Injuries
Progesterone neuroprotection in spinal cord trauma involves up-regulation of brain-derived neurotrophic factor in motoneurons.
Progesterone neuroprotection in traumatic CNS injury and motoneuron degeneration.
Role of monoamines in experimental spinal cord injury in rats. Relationship between Na+-K+-ATPase and lipid peroxidation.
Squamous Cell Carcinoma of Head and Neck
Effects of digoxin and Na, K-ATPase immunoexpression on human oral squamous carcinomas.
Starvation
Alterations in amino acid transport in Na,K-ATPase amplified HeLa cells.
Effect of starvation, alloxan diabetes and adrenalectomy on Na+ K+-ATPase of the mucosa of the small intestine of rat.
Influence of nutrition on biochemical sea water adaptation of the rainbow trout (Salmo gairdneri richardson).
Low doses of ouabain protect from serum deprivation-triggered apoptosis and stimulate kidney cell proliferation via activation of NF-kappaB.
Reduced ion transport in erythrocytes of male Sprague-Dawley rats during starvation.
[Effect of stress actions on some hematologic and biochemical parameters of rat blood and on energetic intermolecular interactions in lipid extract under effect of light radiation].
[Na,K-ATPase activity of erythrocytes of rats during prolonged starvation].
[The ability of cells to adjust to the low oxigen content associated with Na,K-ATPase glutationilation].
Stomach Neoplasms
Identification of genes differentially expressed between gastric cancers and normal gastric mucosa with cDNA microarrays.
The expression of the alpha1 subunit of Na+/K+-ATPase is related to tumor development and clinical outcomes in gastric cancer.
Stroke
Blocking the anoxic depolarization protects without functional compromise following simulated stroke in cortical brain slices.
DR-region of Na+/K+ ATPase is a target to treat excitotoxicity and stroke.
Genetic and biochemical determinants of abnormal monovalent ion transport in primary hypertension.
Platelet membrane fluidity and Na+/K+ ATPase activity in acute stroke.
Subacute Sclerosing Panencephalitis
Inhibition of membrane Na+-K+ ATPase activity: a common pathway in central nervous system disorders.
Tachycardia
Reduced 3H-ouabain binding site (Na,K-ATPase) concentration in ventricular myocardium of dogs with tachycardia induced heart failure.
Tachycardia, Ventricular
Autoantibodies produced against sarcolemmal Na-K-ATPase: possible upstream targets of arrhythmias and sudden death in patients with dilated cardiomyopathy.
[Autoantibodies against sarcolemmal Na-K-ATPase in patients with dilated cardiomyopathy: autoimmune basis for ventricular arrhythmias in patients with congestive heart failure]
Tachypnea
Hypothyroxinemia and Risk for Transient Tachypnea of Newborn.
Thymoma
Properties of Na+/K+ ATPase and alkaline phosphatase alter during spontaneous and radiation-induced leukemogenesis in mice.
Thyroid Neoplasms
Changes in localization of ouabain-sensitive, potassium-dependent p-nitrophenylphosphatase activity in human thyroid carcinoma cells.
Thyrotoxicosis
Thyrotoxicosis presenting as a life threatening hypokalaemic paralysis: investigation of the Na/K pump in isolated leucocytes.
Toxemia
[Na,K-ATPase activity as one of criteria in identifying the risk group for development of late toxemia in pregnancy screening]
Transient Tachypnea of the Newborn
Hypothyroxinemia and Risk for Transient Tachypnea of Newborn.
Uremia
Abnormal cation transport in uremia. Mechanisms in adipocytes and skeletal muscle from uremic rats.
Digoxin-like immunoreacting substance(s) in the serum of patients with chronic uremia.
Effect of chronic renal failure on Na,K-ATPase alpha 1 and alpha 2 mRNA transcription in rat skeletal muscle.
Erythrocyte Na,K pump in uremia. Acute correction of a transport defect by hemodialysis.
Experimental renal failure in the rat modulates cardiac Na,K-ATPase alpha 2 mRNA but not protein.
Impaired cation transport in thymocytes of rats with chronic uremia includes the Na+/H+ antiporter.
Na pump defects in chronic uremia cannot be attributed to changes in Na-K-ATPase mRNA or protein.
Post-obstructive nephropathy in the rat: relationship between NA-K-ATPase activity and renal function.
Red blood cell sodium transport and phosphate release in uremia.
Ureteral Obstruction
alpha-MSH prevents impairment in renal function and dysregulation of AQPs and Na-K-ATPase in rats with bilateral ureteral obstruction.
Effect of osmolality on renal medullary Na-K-ATPase activity in the postobstructive kidney.
Involvement of NOX in the regulation of renal tubular expression of Na/K-ATPase in acute unilateral ureteral obstruction rats.
pNaKtide ameliorates renal interstitial fibrosis through inhibition of sodium-potassium adenosine triphosphatase-mediated signaling pathways in unilateral ureteral obstruction mice.
Transport defects of rabbit medullary thick ascending limb cells in obstructive nephropathy.
Urinary Bladder Neoplasms
Analysis of the Na,K-ATPase alpha- and beta-subunit expression profiles of bladder cancer using tissue microarrays.
Na,K-adenosine triphosphatase alpha1-subunit predicts survival of renal clear cell carcinoma.
Vaccinia
Translational regulation of Na,K-ATPase alpha1 and beta1 polypeptide expression in epithelial cells.
Vascular Diseases
Electrolytes and sodium transport mechanism in diabetes mellitus.
Ventricular Dysfunction
Digitalis.
Ventricular performance and Na+-K+ ATPase activity are reduced early and late after myocardial infarction in rats.
Ventricular Fibrillation
Endogenous plasma Na,K-ATPase inhibitory activity and digoxin like immunoreactivity after acute myocardial infarction.
Mechanisms of protective effects of berbamine on ischemia/reperfusion injury in isolated rat heart.
Specific up-regulation of mitochondrial F0F1-ATPase activity after short episodes of atrial fibrillation in sheep.
[The role of an endogenous digoxin-like factor in regulating blood circulation and in the origin of arrhythmia in myocardial ischemia]
Vesicular Stomatitis
Immortalization of polarized rat retinal pigment epithelium.
Membrane proteins follow multiple pathways to the basolateral cell surface in polarized epithelial cells.
Virus Diseases
Basal Glutathionylation of Na,K-ATPase ?-Subunit Depends on Redox Status of Cells during the Enzyme Biosynthesis.
Inhibition of Na+K+ATPase activity in membranes of Sindbis virus-infected chick cells.
Modulation of Na,K-ATPase activity by immunoglobulins--II. Na,K-ATPase activity in erythrocytes from patients with various chronic disturbances.
Vitamin B 6 Deficiency
Effects of salinity on vitamin B6 deficiency in rainbow trout (Salmo gairdneri Richardson).
Whooping Cough
Beta adrenergic modulation of cardiac rhythm in a rat model of altered sympathetic neural development.
Human kidney-2 cells harbor functional dopamine D1 receptors that require Gi? for Gq/11? signaling.
Hyposmotic stress causes ATP release and stimulates Na, K-ATPase activity in porcine lens.
Pertussis toxin modulates dopamine inhibition of Na,K-ATPase activity in rat proximal convoluted tubule segments.
Regulation of Na+-K+-ATPase activity in kidney proximal tubules: involvement of GTP binding proteins.
Short-term regulation of Na+/K+ adenosine triphosphatase by recombinant human serotonin 5-HT1A receptor expressed in HeLa cells.
Stimulation of cardiac alpha receptors increases Na/K pump current and decreases gK via a pertussis toxin-sensitive pathway.
[The role of a GTP-binding protein in coupling of a muscarinic cholinergic receptor and Na,K-ATPase in myocardial sarcolemma]
Wolfram Syndrome
Sodium-potassium ATPase 1 subunit is a molecular partner of Wolframin, an endoplasmic reticulum protein involved in ER stress.
Zika Virus Infection
Inhibition of Na+/K+ ATPase blocks Zika virus infection in mice.