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Literature summary for 7.2.2.13 extracted from

  • Wu, Q.; Chen, P.; Tu, G.; Li, M.; Pan, B.; Guo, Y.; Zhai, J.; Fu, H.
    Synthesis and evaluation of panaxatriol derivatives as Na+, K+-ATPase inhibitors (2018), Bioorg. Med. Chem. Lett., 28, 2885-2889 .
    View publication on PubMed
Search for more literature for 7.2.2.13

Inhibitors

Inhibitors Comment Organism Structure
(12beta,20R)-12-hydroxy-20,25-epoxydammarane-3,6-dione
-
 Sus scrofa
(1S,3aR,3bR,12aR,14R)-10-fluoro-14-hydroxy-3a,3b,6,6,12a-pentamethyl-1-[(2R)-2,6,6-trimethyloxan-2-yl]-2,3,3a,3b,4,5a,6,7,12,12a,12b,13,14,14a-tetradecahydrocyclopenta[5,6]naphtho[2,1-b]carbazol-5(1H)-one
-
 Sus scrofa
(1S,3aR,3bR,12aR,14R)-14-hydroxy-3a,3b,6,6,12a-pentamethyl-1-[(2R)-2,6,6-trimethyloxan-2-yl]-2,3,3a,3b,4,5a,6,7,12,12a,12b,13,14,14a-tetradecahydrocyclopenta[5,6]naphtho[2,1-b]carbazol-5(1H)-one
-
 Sus scrofa
(1S,3aR,3bR,12aR,14R)-14-hydroxy-3a,3b,6,6,12a-pentamethyl-10-(trifluoromethoxy)-1-[(2R)-2,6,6-trimethyloxan-2-yl]-2,3,3a,3b,4,5a,6,7,12,12a,12b,13,14,14a-tetradecahydrocyclopenta[5,6]naphtho[2,1-b]carbazol-5(1H)-one
-
 Sus scrofa
(20R)-20,25-epoxydammarane-3,6,12-trione
-
 Sus scrofa
(3beta,12beta,20R)-12-hydroxy-3-phenoxy-20,25-epoxydammaran-6-one
-
 Sus scrofa
(3beta,12beta,20R)-12-hydroxy-3-[(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)oxy]-20,25-epoxydammaran-6-one
-
 Sus scrofa
(3beta,12beta,20R)-12-hydroxy-3-[4-(trifluoromethoxy)phenoxy]-20,25-epoxydammaran-6-one
-
 Sus scrofa
(3beta,12beta,20R)-3-(ethenyloxy)-12-hydroxy-20,25-epoxydammaran-6-one
-
 Sus scrofa
(3beta,12beta,20R)-3-ethoxy-12-hydroxy-20,25-epoxydammaran-6-one
-
 Sus scrofa
(5aR,7R,8S,10aR,10bR)-7-hydroxy-1,1,5a,10a,10b-pentamethyl-8-[(2R)-2,6,6-trimethyloxan-2-yl]hexadecahydrocyclopenta[5,6]naphtho[2,1-c]azepine-3,12-dione
-
 Sus scrofa
(5aR,8S,10aR,10bR,12R)-12-hydroxy-1,1,5a,10a,10b-pentamethyl-8-[(2R)-2,6,6-trimethyloxan-2-yl]tetradecahydro-1H-cyclopenta[5,6]naphtho[2,1-c]oxepine-3,7-dione
-
 Sus scrofa
(5aR,8S,10aR,10bR,12S)-12-hydroxy-1,1,5a,10a,10b-pentamethyl-8-[(2R)-2,6,6-trimethyloxan-2-yl]tetradecahydro-1H-cyclopenta[5,6]naphtho[2,1-c]oxepine-3,7-dione
-
 Sus scrofa
(6alpha,12beta,20R)-12-hydroxy-6-[(prop-2-en-1-yl)oxy]-20,25-epoxydammaran-3-one
-
 Sus scrofa
(6alpha,12beta,20R)-6,12-bis(benzyloxy)-20,25-epoxydammaran-3-one
-
 Sus scrofa
(6alpha,12beta,20R)-6,12-bis[(prop-2-en-1-yl)oxy]-20,25-epoxydammaran-3-one
-
 Sus scrofa
(6alpha,12beta,20R)-6-(benzyloxy)-12-hydroxy-20,25-epoxydammaran-3-one
-
 Sus scrofa
(6alpha,20R)-6-hydroxy-20,25-epoxydammarane-3,12-dione
-
 Sus scrofa
3-oxo-panaxatriol
-
 Sus scrofa
3-[(3S,3aS,4R,5aR,6S,9aR,9bS)-4-hydroxy-6,9a,9b-trimethyl-8-oxo-3-[(2R)-2,6,6-trimethyloxan-2-yl]dodecahydro-1H-cyclopenta[a]naphthalen-6-yl]propanoic acid
-
 Sus scrofa
6-oxo-panaxatriol
-
 Sus scrofa
digoxin
-
 Sus scrofa
methyl 3-[(3S,3aS,4R,5aR,6R,7R,9aR,9bS)-4-hydroxy-7-(2-hydroxypropan-2-yl)-6,9a,9b-trimethyl-8-oxo-3-[(2R)-2,6,6-trimethyloxan-2-yl]dodecahydro-1H-cyclopenta[a]naphthalen-6-yl]propanoate
-
 Sus scrofa
methyl 3-[(3S,3aS,4R,5aR,6R,7S,9aR,9bS)-4-hydroxy-6,9a,9b-trimethyl-8-oxo-7-(prop-2-en-1-yl)-3-[(2R)-2,6,6-trimethyloxan-2-yl]dodecahydro-1H-cyclopenta[a]naphthalen-6-yl]propanoate
-
 Sus scrofa
methyl 3-[(3S,3aS,4R,5aR,6S,9aR,9bS)-4-hydroxy-6,9a,9b-trimethyl-8-oxo-3-[(2R)-2,6,6-trimethyloxan-2-yl]dodecahydro-1H-cyclopenta[a]naphthalen-6-yl]propanoate
-
 Sus scrofa
O-[(3beta,12beta,20R)-12-hydroxy-6-oxo-20,25-epoxydammaran-3-yl] O-methyl 2-imidothiodicarbonate
-
 Sus scrofa
panaxatriol
-
 Sus scrofa
uzarigenin
-
 Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Na+[side 1] + K+[side 2] Sus scrofa
-
 ADP + phosphate + Na+[side 2] + K+[side 1]
-
 ?

Organism

Organism UniProt Comment Textmining
Sus scrofa P05024 and P05027 subunits alpha and beta
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Na+[side 1] + K+[side 2]
-
 Sus scrofa ADP + phosphate + Na+[side 2] + K+[side 1]
-
 ?

Synonyms

Synonyms Comment Organism
Na+, K+-ATPase
-
 Sus scrofa

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000091
-
 pH and temperature not specified in the publication Sus scrofa (1S,3aR,3bR,12aR,14R)-10-fluoro-14-hydroxy-3a,3b,6,6,12a-pentamethyl-1-[(2R)-2,6,6-trimethyloxan-2-yl]-2,3,3a,3b,4,5a,6,7,12,12a,12b,13,14,14a-tetradecahydrocyclopenta[5,6]naphtho[2,1-b]carbazol-5(1H)-one
0.00026
-
 pH and temperature not specified in the publication Sus scrofa methyl 3-[(3S,3aS,4R,5aR,6R,7R,9aR,9bS)-4-hydroxy-7-(2-hydroxypropan-2-yl)-6,9a,9b-trimethyl-8-oxo-3-[(2R)-2,6,6-trimethyloxan-2-yl]dodecahydro-1H-cyclopenta[a]naphthalen-6-yl]propanoate
0.00027
-
 pH and temperature not specified in the publication Sus scrofa digoxin
0.0003
-
 pH and temperature not specified in the publication Sus scrofa (3beta,12beta,20R)-12-hydroxy-3-phenoxy-20,25-epoxydammaran-6-one
0.00033
-
 pH and temperature not specified in the publication Sus scrofa (6alpha,12beta,20R)-6-(benzyloxy)-12-hydroxy-20,25-epoxydammaran-3-one
0.00036
-
 pH and temperature not specified in the publication Sus scrofa (1S,3aR,3bR,12aR,14R)-14-hydroxy-3a,3b,6,6,12a-pentamethyl-10-(trifluoromethoxy)-1-[(2R)-2,6,6-trimethyloxan-2-yl]-2,3,3a,3b,4,5a,6,7,12,12a,12b,13,14,14a-tetradecahydrocyclopenta[5,6]naphtho[2,1-b]carbazol-5(1H)-one
0.00041
-
 pH and temperature not specified in the publication Sus scrofa (5aR,7R,8S,10aR,10bR)-7-hydroxy-1,1,5a,10a,10b-pentamethyl-8-[(2R)-2,6,6-trimethyloxan-2-yl]hexadecahydrocyclopenta[5,6]naphtho[2,1-c]azepine-3,12-dione
0.00041
-
 pH and temperature not specified in the publication Sus scrofa methyl 3-[(3S,3aS,4R,5aR,6S,9aR,9bS)-4-hydroxy-6,9a,9b-trimethyl-8-oxo-3-[(2R)-2,6,6-trimethyloxan-2-yl]dodecahydro-1H-cyclopenta[a]naphthalen-6-yl]propanoate
0.00045
-
 pH and temperature not specified in the publication Sus scrofa (3beta,12beta,20R)-12-hydroxy-3-[4-(trifluoromethoxy)phenoxy]-20,25-epoxydammaran-6-one
0.00054
-
 pH and temperature not specified in the publication Sus scrofa 3-[(3S,3aS,4R,5aR,6S,9aR,9bS)-4-hydroxy-6,9a,9b-trimethyl-8-oxo-3-[(2R)-2,6,6-trimethyloxan-2-yl]dodecahydro-1H-cyclopenta[a]naphthalen-6-yl]propanoic acid
0.0007
-
 pH and temperature not specified in the publication Sus scrofa (6alpha,20R)-6-hydroxy-20,25-epoxydammarane-3,12-dione
0.00075
-
 pH and temperature not specified in the publication Sus scrofa (6alpha,12beta,20R)-6,12-bis[(prop-2-en-1-yl)oxy]-20,25-epoxydammaran-3-one
0.00076
-
 pH and temperature not specified in the publication Sus scrofa (20R)-20,25-epoxydammarane-3,6,12-trione
0.00077
-
 pH and temperature not specified in the publication Sus scrofa (1S,3aR,3bR,12aR,14R)-14-hydroxy-3a,3b,6,6,12a-pentamethyl-1-[(2R)-2,6,6-trimethyloxan-2-yl]-2,3,3a,3b,4,5a,6,7,12,12a,12b,13,14,14a-tetradecahydrocyclopenta[5,6]naphtho[2,1-b]carbazol-5(1H)-one
0.00081
-
 pH and temperature not specified in the publication Sus scrofa (12beta,20R)-12-hydroxy-20,25-epoxydammarane-3,6-dione
0.00087
-
 pH and temperature not specified in the publication Sus scrofa (6alpha,12beta,20R)-6,12-bis(benzyloxy)-20,25-epoxydammaran-3-one
0.00091
-
 pH and temperature not specified in the publication Sus scrofa (6alpha,12beta,20R)-12-hydroxy-6-[(prop-2-en-1-yl)oxy]-20,25-epoxydammaran-3-one
0.00096
-
 pH and temperature not specified in the publication Sus scrofa (3beta,12beta,20R)-12-hydroxy-3-[(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)oxy]-20,25-epoxydammaran-6-one
0.00105
-
 pH and temperature not specified in the publication Sus scrofa (3beta,12beta,20R)-3-(ethenyloxy)-12-hydroxy-20,25-epoxydammaran-6-one
0.00109
-
 pH and temperature not specified in the publication Sus scrofa methyl 3-[(3S,3aS,4R,5aR,6R,7S,9aR,9bS)-4-hydroxy-6,9a,9b-trimethyl-8-oxo-7-(prop-2-en-1-yl)-3-[(2R)-2,6,6-trimethyloxan-2-yl]dodecahydro-1H-cyclopenta[a]naphthalen-6-yl]propanoate
0.00109
-
 pH and temperature not specified in the publication Sus scrofa panaxatriol
0.00113
-
 pH and temperature not specified in the publication Sus scrofa (5aR,8S,10aR,10bR,12S)-12-hydroxy-1,1,5a,10a,10b-pentamethyl-8-[(2R)-2,6,6-trimethyloxan-2-yl]tetradecahydro-1H-cyclopenta[5,6]naphtho[2,1-c]oxepine-3,7-dione
0.00114
-
 pH and temperature not specified in the publication Sus scrofa (3beta,12beta,20R)-3-ethoxy-12-hydroxy-20,25-epoxydammaran-6-one
0.00114
-
 pH and temperature not specified in the publication Sus scrofa 3-oxo-panaxatriol
0.00118
-
 pH and temperature not specified in the publication Sus scrofa (5aR,8S,10aR,10bR,12S)-12-hydroxy-1,1,5a,10a,10b-pentamethyl-8-[(2R)-2,6,6-trimethyloxan-2-yl]tetradecahydro-1H-cyclopenta[5,6]naphtho[2,1-c]oxepine-3,7-dione
0.00118
-
 pH and temperature not specified in the publication Sus scrofa 6-oxo-panaxatriol
0.00123
-
 pH and temperature not specified in the publication Sus scrofa (5aR,8S,10aR,10bR,12R)-12-hydroxy-1,1,5a,10a,10b-pentamethyl-8-[(2R)-2,6,6-trimethyloxan-2-yl]tetradecahydro-1H-cyclopenta[5,6]naphtho[2,1-c]oxepine-3,7-dione
0.00138
-
 pH and temperature not specified in the publication Sus scrofa O-[(3beta,12beta,20R)-12-hydroxy-6-oxo-20,25-epoxydammaran-3-yl] O-methyl 2-imidothiodicarbonate