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7.2.2.13: Na+/K+-exchanging ATPase

This is an abbreviated version!
For detailed information about Na+/K+-exchanging ATPase, go to the full flat file.

Word Map on EC 7.2.2.13

Reaction

ATP
+
H2O
 +
Na+[side 1]
 +
K+[side 2]
=
ADP
 +
phosphate
 +
Na+[side 2]
 +
K+[side 1]

Synonyms

(Na+ + K+)-activated ATPase, (Na+ + K+)-ATPase, (Na+, K+)-ATPase, (Na+, K+)-dependent ATPase, (Na+,K+)-activated ATPase, (Na+-K+)-ATPase, alpha2Na+/K+-ATPase, ATP1a1, atp1a1a, ATPalpha, EC 3.6.1.3, EC 3.6.1.37, EC 3.6.3.9, Na pump, Na(+)-K(+)-exchanging ATPase, Na+ pump, Na+, K+ -ATPase, Na+, K+-ATPase, Na+,K+ pump, Na+,K+-adenosine triphosphatase, Na+,K+-ATPase, Na+,K+-pump, Na+-K+ ATPase, Na+-K+ pump, Na+-K+ pump alpha1-isoform, Na+-K+ pump alpha2-isoform, Na+-K+-ATPase, Na+-K+-ATPase alpha2-isoform, Na+-K+-pump, Na+/K+ -ATPase, Na+/K+ ATPase, Na+/K+ pump, Na+/K+-ATPase, Na+K+-ATPase, Na+K+ATPase, Na, K-ATPase, Na,K pump, Na,K-activated ATPase, Na,K-adenosine triphosphatase, Na,K-ATPase, Na,K-Pump, Na-K-ATPase, Na/K pump, Na/K-ATPase, NKA, Nkaalpha protein, nkaalpha1, nkaalpha3a, nkaalpha3b, renal sodium-potassium pump, SNaK1, sodium potassium adenosinetriphosphatase, sodium pump, sodium-potassium pump, sodium/potassium ATPase

ECTree

     7 Translocases
         7.2 Catalysing the translocation of inorganic cations
             7.2.2 Linked to the hydrolysis of a nucleoside triphosphate
                7.2.2.13 Na+/K+-exchanging ATPase

Inhibitors

Inhibitors on EC 7.2.2.13 - Na+/K+-exchanging ATPase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(12beta,20R)-12-hydroxy-20,25-epoxydammarane-3,6-dione
P05024; P05027
-
(1R,2R,3aS,5aS,6aR,7aS,9R,11R,11aS,12aR,13aR,15aR)-2,3a,11,11a-tetrahydroxy-9,15a-dimethyl-1-(5-oxo-2,5-dihydrofuran-3-yl)icosahydro-7aH,13aH-cyclopenta[7,8]phenanthro[2,3-b]pyrano[3,2-e][1,4]dioxine-13a-carbaldehyde
-
-
(1R,2R,3aS,5aS,6aR,7aS,9S,11R,11aS,12aR,13aR,15aR)-3a,11,11a-trihydroxy-9-(hydroxymethyl)-15a-methyl-1-(5-oxo-2,5-dihydrofuran-3-yl)-2-(2-oxopropanoyl)icosahydro-7aH,13aH-cyclopenta[7,8]phenanthro[2,3-b]pyrano[3,2-e][1,4]dioxine-13a-carbaldehyde
-
-
(1R,3aS,5aS,6aR,7aS,9R,11R,11aS,12aR,13aR,15aR)-13a-formyl-3a,11a-dihydroxy-9,15a-dimethyl-1-(5-oxo-2,5-dihydrofuran-3-yl)icosahydro-1H,7aH-cyclopenta[7,8]phenanthro[2,3-b]pyrano[3,2-e][1,4]dioxin-11-yl beta-D-glucopyranoside
-
-
(1R,3aS,5aS,6aR,7aS,9R,11R,11aS,12aR,13aR,15aR)-3a,11,11a-trihydroxy-9,15a-dimethyl-1-(5-oxo-2,5-dihydrofuran-3-yl)icosahydro-7aH,13aH-cyclopenta[7,8]phenanthro[2,3-b]pyrano[3,2-e][1,4]dioxine-13a-carbaldehyde
-
-
(1R,3aS,5aS,6aR,7aS,9S,11R,11aS,12aR,13aR,15aR)-3a,11,11a-trihydroxy-9-(hydroxymethyl)-15a-methyl-1-(5-oxo-2,5-dihydrofuran-3-yl)icosahydro-7aH,13aH-cyclopenta[7,8]phenanthro[2,3-b]pyrano[3,2-e][1,4]dioxine-13a-carbaldehyde
-
-
(1S,3aR,3bR,12aR,14R)-10-fluoro-14-hydroxy-3a,3b,6,6,12a-pentamethyl-1-[(2R)-2,6,6-trimethyloxan-2-yl]-2,3,3a,3b,4,5a,6,7,12,12a,12b,13,14,14a-tetradecahydrocyclopenta[5,6]naphtho[2,1-b]carbazol-5(1H)-one
P05024; P05027
-
(1S,3aR,3bR,12aR,14R)-14-hydroxy-3a,3b,6,6,12a-pentamethyl-1-[(2R)-2,6,6-trimethyloxan-2-yl]-2,3,3a,3b,4,5a,6,7,12,12a,12b,13,14,14a-tetradecahydrocyclopenta[5,6]naphtho[2,1-b]carbazol-5(1H)-one
P05024; P05027
-
(1S,3aR,3bR,12aR,14R)-14-hydroxy-3a,3b,6,6,12a-pentamethyl-10-(trifluoromethoxy)-1-[(2R)-2,6,6-trimethyloxan-2-yl]-2,3,3a,3b,4,5a,6,7,12,12a,12b,13,14,14a-tetradecahydrocyclopenta[5,6]naphtho[2,1-b]carbazol-5(1H)-one
P05024; P05027
-
(20R)-20,25-epoxydammarane-3,6,12-trione
P05024; P05027
-
(3beta,12beta,20R)-12-hydroxy-3-phenoxy-20,25-epoxydammaran-6-one
P05024; P05027
-
(3beta,12beta,20R)-12-hydroxy-3-[(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)oxy]-20,25-epoxydammaran-6-one
P05024; P05027
-
(3beta,12beta,20R)-12-hydroxy-3-[4-(trifluoromethoxy)phenoxy]-20,25-epoxydammaran-6-one
P05024; P05027
-
(3beta,12beta,20R)-3-(ethenyloxy)-12-hydroxy-20,25-epoxydammaran-6-one
P05024; P05027
-
(3beta,12beta,20R)-3-ethoxy-12-hydroxy-20,25-epoxydammaran-6-one
P05024; P05027
-
(3E,5beta,15beta,16beta)-16-(acetyloxy)-3-(hydroxyimino)-8-methyl-14,15-epoxybufa-20,22-dienolide
-
-
(3E,5beta,15beta,16beta)-16-(acetyloxy)-3-(methoxyimino)-8-methyl-14,15-epoxybufa-20,22-dienolide
-
-
(3E,5beta,15beta,16beta)-16-(acetyloxy)-3-[(2-aminoethoxy)imino]-8-methyl-14,15-epoxybufa-20,22-dienolide
-
most potent inhibitor
(5aR,7R,8S,10aR,10bR)-7-hydroxy-1,1,5a,10a,10b-pentamethyl-8-[(2R)-2,6,6-trimethyloxan-2-yl]hexadecahydrocyclopenta[5,6]naphtho[2,1-c]azepine-3,12-dione
P05024; P05027
-
(5aR,8S,10aR,10bR,12R)-12-hydroxy-1,1,5a,10a,10b-pentamethyl-8-[(2R)-2,6,6-trimethyloxan-2-yl]tetradecahydro-1H-cyclopenta[5,6]naphtho[2,1-c]oxepine-3,7-dione
P05024; P05027
-
(5aR,8S,10aR,10bR,12S)-12-hydroxy-1,1,5a,10a,10b-pentamethyl-8-[(2R)-2,6,6-trimethyloxan-2-yl]tetradecahydro-1H-cyclopenta[5,6]naphtho[2,1-c]oxepine-3,7-dione
P05024; P05027
-
(6alpha,12beta,20R)-12-hydroxy-6-[(prop-2-en-1-yl)oxy]-20,25-epoxydammaran-3-one
P05024; P05027
-
(6alpha,12beta,20R)-6,12-bis(benzyloxy)-20,25-epoxydammaran-3-one
P05024; P05027
-
(6alpha,12beta,20R)-6,12-bis[(prop-2-en-1-yl)oxy]-20,25-epoxydammaran-3-one
P05024; P05027
-
(6alpha,12beta,20R)-6-(benzyloxy)-12-hydroxy-20,25-epoxydammaran-3-one
P05024; P05027
-
(6alpha,20R)-6-hydroxy-20,25-epoxydammarane-3,12-dione
P05024; P05027
-
1,8,9-trihydroxy-3-methoxy-6H-[1]benzofuro[3,2-c]chromen-6-one
-
i.e. wedelolactone, inhibitor of kidney Na+K+-ATPase and ligand for the central benzodiazepine receptor
1-chloro-2,4-dinitrobenzene
-
inhibition of the transport activity of the Na-K pump
12,20-dihydroxydammar-24-en-3-yl 2-O-D-glucopyranosyl-D-glucopyranoside
-
-
12,20-dihydroxydammar-24-en-3-yl D-glucopyranoside
-
-
19-hydroxy-2''-oxovoruscharin
-
i.e. UNBS1450, a trans-trans-cis cardiotonic steroid
1H-[1,2,4]oxadiazole[4,3-a]quinoxalin-1-one
-
ODQ, inhibition of SNP-induced pump stimulation
2,3-dihydroxy-6H-[1,3]dioxolo[5,6][1]benzofuro[3,2-c]chromen-6-one
-
inhibitor of kidney Na+K+-ATPase and ligand for the central benzodiazepine receptor
2,8,9-trihydroxy-3-methoxy-6H-[1]benzofuro[3,2-c]chromen-6-one
-
inhibitor of kidney Na+K+-ATPase and ligand for the central benzodiazepine receptor
2,9-dihydroxy-3,8-dimethoxy-6H-[1]benzofuro[3,2-c]chromen-6-one
-
inhibitor of kidney Na+K+-ATPase and ligand for the central benzodiazepine receptor
2-aminoethyl-methanethiosulfonate
-
inhibition of mutants F323C, P333C, E334C, G335C, I322C, G326C and A330C
3,8,9-trihydroxy-2-methoxy-6H-[1]benzofuro[3,2-c]chromen-6-one
-
inhibitor of kidney Na+K+-ATPase and ligand for the central benzodiazepine receptor
3-oxo-panaxatriol
P05024; P05027
-
3-[(2-O-D-glucopyranosyl-D-glucopyranosyl)oxy]-12-hydroxydammar-24-en-20-yl D-glucopyranoside
-
-
3-[(3S,3aS,4R,5aR,6S,9aR,9bS)-4-hydroxy-6,9a,9b-trimethyl-8-oxo-3-[(2R)-2,6,6-trimethyloxan-2-yl]dodecahydro-1H-cyclopenta[a]naphthalen-6-yl]propanoic acid
P05024; P05027
-
4,7-diacetoxy-14-hydroxydolast-1(15),8-diene
-
-
4-acetoxy-9,14-dihydroxydolast-1(15),7-diene
-
-
4-[(1R,3aS,5aS,6aR,7aS,9R,11R,11aS,12aR,13aR,15R,15aS)-3a,11,11a,15-tetrahydroxy-13a-(hydroxymethyl)-9,15a-dimethylicosahydro-1H,7aH-cyclopenta[7,8]phenanthro[2,3-b]pyrano[3,2-e][1,4]dioxin-1-yl]furan-2(5H)-one
-
-
4-[(1R,3aS,5aS,6aR,7aS,9S,11R,11aS,12aR,13aR,15aR)-3a,11,11a-trihydroxy-9,13a-bis(hydroxymethyl)-15a-methylicosahydro-1H,7aH-cyclopenta[7,8]phenanthro[2,3-b]pyrano[3,2-e][1,4]dioxin-1-yl]furan-2(5H)-one
-
-
4-[(1R,3aS,5aS,6aR,7aS,9S,11R,11aS,12aR,13aR,15R,15aS)-3a,11,11a,15-tetrahydroxy-9,13a-bis(hydroxymethyl)-15a-methylicosahydro-1H,7aH-cyclopenta[7,8]phenanthro[2,3-b]pyrano[3,2-e][1,4]dioxin-1-yl]furan-2(5H)-one
-
-
5-hydroxydecanoate
-
presence of 5 mM ATP, inhibitory above 1 mM. Presence of 0.05 mM ATP, inhibitory above 0.25 mM. No effect on ouabain-sensitiviy of the enzyme
6-oxo-panaxatriol
P05024; P05027
-
8-methoxycoumestrol
-
inhibits the isozyme alpha1beta1 Na,K-ATPase, mechanism, overview
A-769662
-
inhibits the Na+-K+-ATPase transport activity and cell surface abundance in L6 cells, which is independent of AMP kinase activation, overview
alpha2-adrenergic agonists
-
negative modulator
-
astragaloside III
-
from dried roots of Astragalus membraneceus or var. mongholicus
ATP
-
competitive inhibitor of K+-phosphatase activity
AuCl4-
-
-
BAY-K8644
benzyltriethylammonium chloride
-
inhibition of pump current is dependent on membrane potential
beta-acetyldigoxin
-
-
bradykinin
-
negative modulator
bufalin
chlorpromazine
-
-
cholic acid
-
from dried bile of Ursus arctos or Selenarctos thibetanus
cinobufagin
-
-
cinobufotalin
-
27.5% inhibition at 0.01 mM
cyclosporin A
-
diminishs induction of alpha1 protein in activated lymphocytes
dammar-24-ene-3,12,20-triol
-
-
dammar-24-ene-3,6,12,20-tetrol
-
-
dansylcysteinyl-mercuric chloride
-
-
digitoxigenin
digitoxin
-
-
digoxin
dihydroouabain
-
-
diphenyl diselenide
-
activity is restored by DTT
dopamine
-
negative modulator
endobain E
-
-
-
endothelin
-
negative modulator
-
epicatechin
-
-
epicatechin-3-gallate
-
solubilization of the Na+,K+-ATPase with a nonionic detergent reduces sensitivity to epigallocatechin-3-gallate
epigallocatechin
-
-
epigallocatechin-3-gallate
-
noncompetitive with respect to ATP, reduces the affinity for vanadate, shifts the equilibrium of E1P and E2P toward E1P, and reduces the rate of the E1P to E2P transition
epinephrine
-
0.5 mM epinephrine added for 20 min, decreases the activity of the enzyme by around 50%. Treatment with Rp-cAMP, indomethacin, PP2, SB202190, and PD98059 completely abrogate the effect of epinephrine
Ethacrynic acid
ethanol
ethylester of glutathione
-
inhibition of the transport activity of the Na-K pump
ethylmercurithiosalicylate
-
-
fenoldopam
-
induces inhibition of Na+ ?K+-ATPase activity in HK-2 cells. Ouabain protects against the cyclic adenosine monophosphate accumulation and Na+ ?K+-ATPase inhibition induced by the D1 receptor agonist fenoldopam in HK-2 cells. Chronic ouabain treatment decreases the protein and mRNA expression levels of the D1 receptor and increases the basal phosphorylation of the D1 receptor in HK-2 cells
foliandrin
-
-
genistein
-
tyrosine kinase inhibitor, block phosphorylation of alpha-subunit of the Na+,K+-ATPase
ginsenoside Rh2
-
from dried roots of Panax ginseng or Panax notoginseng
glibenclamide
-
-
glyburide
-
presence of 5 mM ATP, slightly stimulating up to 1 mM, inhibitory above. Presence of 0.05 mM ATP, stimulating at least up to 3 mM
glycyrrhizin
-
from roots of Glycyrrhiza uralensis , Glycyrrhiza inflata, or Glycyrrhiza glabra
herbimycin A
-
tyrosine kinase inhibitor, block phosphorylation of alpha-subunit of the Na+,K+-ATPase
isovaleric acid
-
isovaleric acid injection significantly inhibits Na+,K+-ATPase activity by 25% in cerebral cortex of rats 2 or 24 h after administration, while pre-treatment of rats with creatine completely prevents the inhibitory effects of isovaleric acid on Na+,K+-ATPase
istaroxime
-
-
jujuboside B
-
from mature seeds of Ziziphus jujube var. spinosa
L-homocysteine
-
inhibitory effect is reversed by alanine
L-phenylalanine
-
-
lauric acid
-
presence of 5 mM ATP, inhibitory above 0.25 mM. Presence of 0.05 mM ATP, stimulating up to 0.3 mM, inhibitory above
lavendustin A
-
tyrosine kinase inhibitor, block phosphorylation of alpha-subunit of the Na+,K+-ATPase
Lyn kinase
-
Lyn kinase directly binds to the Na+,K+-ATPase alpha3 subunit for regulation of activity
-
m-trifluoromethyl-diphenyl diselenide
-
i.e. (m-CF3–C6H4Se)2, activity is restored by DTT
marinobufagenin
-
-
methyl 3-[(3S,3aS,4R,5aR,6R,7R,9aR,9bS)-4-hydroxy-7-(2-hydroxypropan-2-yl)-6,9a,9b-trimethyl-8-oxo-3-[(2R)-2,6,6-trimethyloxan-2-yl]dodecahydro-1H-cyclopenta[a]naphthalen-6-yl]propanoate
P05024; P05027
-
methyl 3-[(3S,3aS,4R,5aR,6R,7S,9aR,9bS)-4-hydroxy-6,9a,9b-trimethyl-8-oxo-7-(prop-2-en-1-yl)-3-[(2R)-2,6,6-trimethyloxan-2-yl]dodecahydro-1H-cyclopenta[a]naphthalen-6-yl]propanoate
P05024; P05027
-
methyl 3-[(3S,3aS,4R,5aR,6S,9aR,9bS)-4-hydroxy-6,9a,9b-trimethyl-8-oxo-3-[(2R)-2,6,6-trimethyloxan-2-yl]dodecahydro-1H-cyclopenta[a]naphthalen-6-yl]propanoate
P05024; P05027
-
methyldigoxin
-
-
monosodium glutamate
-
selenofuranoside therapy is able to prevent the inhibition of the enzyme activity in the hippocampus but not in the brain cortex
MTSET
-
[2-(trimethylammonium)ethyl]methanethiosulphonate bromide, inhibits mutants G803C, V805C
Na+
-
25% inhibition at 80 mmol/l
Na/K ATPase-alpha1-specific siRNA A1
-
Na/K ATPase-alpha1-specific siRNA A2
-
Na/K ATPase-alpha1-specific siRNA A3
-
Na/K ATPase-alpha1-specific siRNA A4
-
Na2CO3
-
inactivation
O-[(3beta,12beta,20R)-12-hydroxy-6-oxo-20,25-epoxydammaran-3-yl] O-methyl 2-imidothiodicarbonate
P05024; P05027
-
odoroside A
-
i.e. 3beta-O-(beta-D-diginosyl)-14-hydroxy-5beta,14beta-card-20(22)-enolide, isolated from the stems and twigs of Nerum oleander, inhibits the enzyme's ATPase activity
oleandrin
oleanolic acid
oleic acid
-
-
oligomycin
Omeprazole
-
inhibit mutants G803C, T804C, V805C
orthovanadate
ouabagenin
-
Ouabain
oubain
p-chloro-diphenyl diselenide
-
i.e. (p-Cl–C6H4Se)2, activity is restored by DTT
p-methoxyl-diphenyl diselenide
-
i.e. (p-CH3O–C6H4Se)2, activity is restored by DTT
palytoxin
panaxatriol
P05024; P05027
-
Pb2+
-
inhibitory effect of Pb2+ on the transport cycle of the Na+,K+-ATPase, overview. Pb2+ inhibits cycling of the enzyme, but it does not affect cytoplasmic Na+ binding and release of Na+ ions at the extracellular side at concentrations below 0.010 mM
PCMB
-
-
perillyl alcohol
polygalacic acid
-
from dried roots of Platycodon grandiflorum
PP1
-
Src kinase inhibitor
prostaglandin E2
Prostaglandins
-
negative modulator
-
putrescine
reduced glutathione
-
extracellular and, or intracellular, inhibition of the transport activity of the Na-K pump
rottlerin
-
-
saikosaponin A
-
from dried roots of Bupleurum chinense or Bupleurum scorzonerifolium
sarsasapogenin
-
from dried roots of Anemarrhena asphodeloides
spermidine
spermine
-
-
strophanthidin
strophantidine
-
-
superoxide
-
-
suramin
-
potent inhibitor, acts on the inside surface of the sodium pump
tetraethylammonium chloride
-
inhibition of pump current is independent on membrane potential
thapsigargin
-
-
theophylline
-
-
Tumor necrosis factor alpha
-
TNF-alpha, TNF-alpha affects the Na+-K+ pump via PGE2-dependent pathways
-
ursolic acid
-
from whole plant of Prunella vulgaris with dried flowers
uzarigenin
P05024; P05027
-
vanadate
Yes kinase
-
regulator of the Na+,K+-ATPase activity
-
[Au(2,2'-bipyridine)Cl2]+
-
-
[Au(dimethylsulfoxide)2Cl2]+
-
-
[PdCl(dien)]+
-
noncompetitive, affinity for binding in decreasing order: [PdCl4]2-, [PdCl(dien)]+, [PdCl(Me4dien)]+. Addition of L-cysteine or glutathoione before exposure to Pd(II) complexes prevents inhibition
[PdCl(Me4dien)]+
-
noncompetitive, affinity for binding in decreasing order: [PdCl4]2-, [PdCl(dien)]+, [PdCl(Me4dien)]+. Addition of L-cysteine or glutathoione before exposure to Pd(II) complexes prevents inhibition
-
[PdCl4]2-
-
noncompetitive, affinity for binding in decreasing order: [PdCl4]2-, [PdCl(dien)]+, [PdCl(Me4dien)]+. Addition of L-cysteine or glutathoione before exposure to Pd(II) complexes prevents inhibition
additional information
-