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Literature summary for 7.2.2.13 extracted from

  • Ochiai, H.; Takeda, K.; Soeda, S.; Tahara, Y.; Takenaka, H.; Abe, K.; Hayashi, Y.; Noguchi, S.; Inoue, M.; Schwarz, S.; Schwarz, W.; Kawamura, M.
    Epigallocatechin-3-gallate is an inhibitor of Na+, K+-ATPase by favoring the E1 conformation (2009), Biochem. Pharmacol., 78, 1069-1074.
    View publication on PubMed
Search for more literature for 7.2.2.13

Inhibitors

Inhibitors Comment Organism Structure
epicatechin
-
 Sus scrofa
epicatechin-3-gallate solubilization of the Na+,K+-ATPase with a nonionic detergent reduces sensitivity to epigallocatechin-3-gallate Sus scrofa
epigallocatechin
-
 Sus scrofa
epigallocatechin-3-gallate noncompetitive with respect to ATP, reduces the affinity for vanadate, shifts the equilibrium of E1P and E2P toward E1P, and reduces the rate of the E1P to E2P transition Sus scrofa
vanadate epigallocatechin-3-gallate reduces the affinity for vanadate, shifts the equilibrium of E1P and E2P toward E1P, and reduces the rate of the E1P to E2P transition Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Sus scrofa
-
-
plasma membrane
-
 Sus scrofa 5886
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Na+/in + K+/out Sus scrofa
-
 ADP + phosphate + Na+/out + K+/in
-
 ?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein reversible phosphorylation of theenzyme during reaction Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
kidney outer medulla Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Na+/in + K+/out
-
 Sus scrofa ADP + phosphate + Na+/out + K+/in
-
 ?

Synonyms

Synonyms Comment Organism
Na+, K+-ATPase
-
 Sus scrofa

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Sus scrofa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7 7.4 assay at Sus scrofa

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0008
-
 pH 7.0, 37°C Sus scrofa epicatechin-3-gallate
0.001
-
 pH 7.0, 37°C Sus scrofa epigallocatechin-3-gallate
0.2
-
 pH 7.0, 37°C Sus scrofa epicatechin