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7.2.2.13: Na+/K+-exchanging ATPase

This is an abbreviated version!
For detailed information about Na+/K+-exchanging ATPase, go to the full flat file.

Word Map on EC 7.2.2.13

Reaction

ATP
+
H2O
 +
Na+[side 1]
 +
K+[side 2]
=
ADP
 +
phosphate
 +
Na+[side 2]
 +
K+[side 1]

Synonyms

(Na+ + K+)-activated ATPase, (Na+ + K+)-ATPase, (Na+, K+)-ATPase, (Na+, K+)-dependent ATPase, (Na+,K+)-activated ATPase, (Na+-K+)-ATPase, alpha2Na+/K+-ATPase, ATP1a1, atp1a1a, ATPalpha, EC 3.6.1.3, EC 3.6.1.37, EC 3.6.3.9, Na pump, Na(+)-K(+)-exchanging ATPase, Na+ pump, Na+, K+ -ATPase, Na+, K+-ATPase, Na+,K+ pump, Na+,K+-adenosine triphosphatase, Na+,K+-ATPase, Na+,K+-pump, Na+-K+ ATPase, Na+-K+ pump, Na+-K+ pump alpha1-isoform, Na+-K+ pump alpha2-isoform, Na+-K+-ATPase, Na+-K+-ATPase alpha2-isoform, Na+-K+-pump, Na+/K+ -ATPase, Na+/K+ ATPase, Na+/K+ pump, Na+/K+-ATPase, Na+K+-ATPase, Na+K+ATPase, Na, K-ATPase, Na,K pump, Na,K-activated ATPase, Na,K-adenosine triphosphatase, Na,K-ATPase, Na,K-Pump, Na-K-ATPase, Na/K pump, Na/K-ATPase, NKA, Nkaalpha protein, nkaalpha1, nkaalpha3a, nkaalpha3b, renal sodium-potassium pump, SNaK1, sodium potassium adenosinetriphosphatase, sodium pump, sodium-potassium pump, sodium/potassium ATPase

ECTree

     7 Translocases
         7.2 Catalysing the translocation of inorganic cations
             7.2.2 Linked to the hydrolysis of a nucleoside triphosphate
                7.2.2.13 Na+/K+-exchanging ATPase

Specific Activity

Specific Activity on EC 7.2.2.13 - Na+/K+-exchanging ATPase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.085
-
high salt diet
0.133
-
enzyme activity in HK-2 cells in presence of fenoldopam, pH not specified in the publication, temperature not specified in the publication
0.165
-
high normal diet
0.183
-
enzyme activity in HK-2 cells, pH not specified in the publication, temperature not specified in the publication
0.1835
-
at pH 7.5 and 25°C
0.25
-
enzyme activity in ouabain-pretreated HK-2 cells in presence of fenoldopam, pH not specified in the publication, temperature not specified in the publication
0.267
-
enzyme activity in ouabain-pretreated HK-2 cells, pH not specified in the publication, temperature not specified in the publication
11.96
-
-
1105
-
wild-type
120
-
mutant K691A
175
-
mutant D714A
19.84
-
in reconstituted vesicles
195
-
mutant K691R
259.1
-
with p-nitrophenolphosphate as substrate
30
at pH 7.0 and 37°C
42
-
with p-nitrophenyl phosphate as substrate
575
-
mutant D714E
686.1
-
with ATP as substrate
700
-
with ATP as substrate
additional information
-
decrease in specific activity by 78.5% in neonatal hypothyroidism