6.3.5.4: asparagine synthase (glutamine-hydrolysing)

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Word Map on EC 6.3.5.4

6.3.5.4

leukemia

lymphoblastic

children

remission

vincristine

lymphoma

methotrexate

l-asparagine

prednisone

cyclophosphamide

marrow

erwinia

daunorubicin

doxorubicin

relapsed

cr

dexamethasone

consolidation

thrombosis

l-aspartic

chrysanthemi

etoposide

pegylated

reinduction

thromboembolism

cytarabine

antileukemic

glutaminase

intrathecal

prophylaxis

non-hodgkin

ifosfamide

event-free

arabinoside

antithrombin

carotovora

6-mercaptopurine

extranodal

philadelphia

agriculture

lymphosarcoma

smile

medicine

multiagent

myelosuppression

hypofibrinogenemia

standard-risk

pseudocysts

nutrition

teniposide

drug development

analysis

daunomycin

epipodophyllotoxins

idarubicin

Reaction

Synonyms

AS, AS-A, AS-B, AS1, ASN3, AsnA, ASNase, AsnB, ASNS, AsnS1, AsnS2, AsnS3, AsnS4, asparagine amidotransferase, Asparagine synthetase, Asparagine synthetase (glutamine hydrolyzing), Asparagine synthetase (glutamine), Asparagine synthetase (glutamine-hydrolysing), asparagine synthetase 1, asparagine synthetase 2, Asparagine synthetase A, Asparagine synthetase B, asparagine synthetase, glutamine-dependent, asparagine synthetase1, asparagine synthetase2, At5g10240, bacterial type asparagine synthetase A, CaAS1, glutamine-dependent amidotransferase, Glutamine-dependent asparagine synthetase, HvAS1 protein, HvAS2 protein, HvASN1, HvASN2, HvASN3, HvASN4, HvASN5, L-asparaginase, L-Asparagine synthetase, LDBPK_300470, LiAS-A, MLOC_37219, MLOC_44080, MLOC_63089, MLOC_72774, MLOC_75057, More, NAS2, Os03g0291500, Os06g0265000, OsAS1, OsAS2, PVAS1 protein, PVAS2, Ste10, Synthetase, Asn (glutamine), TaASN1, TaASN2, TaASN4, TaSN1, TaSN2, TS11 cell cycle control protein, type -II asparagine synthetase, type I asparagine synthetase, type II asparagine synthetase

ECTree

6 Ligases

6.3 Forming carbon-nitrogen bonds

6.3.5 Carbon-nitrogen ligases with glutamine as amido-N-donor

6.3.5.4 asparagine synthase (glutamine-hydrolysing)

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Results	in table
8	Activating Compound
20517	AA Sequence
12	Application
1	CAS Registry Number
60	Cloned(Commentary)
14	Cofactor
3	Crystallization (Commentary)
5649	Disease/ Diagnostics
7	Expression
46	General Information
7	General Stability
16	IC50 Value
176	Inhibitors
28	kcat/KM [mM/s]
28	Ki Value [mM]
165	KM Value [mM]
18	Localization
45	Metals/Ions
31	Molecular Weight [Da]
71	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
260	Organism
6	Pathway
6	PDB ID
23	pH Optimum
4	pH Range
1	pH Stability
6	pI Value
2	Posttranslational Modification
55	Protein Variants
34	Purification (Commentary)
12	Reaction
1	Reaction Type
148	Reference
3	Renatured (Commentary)
249	Source Tissue
11	Specific Activity [micromol/min/mg]
5	Storage Stability
206	Substrates and Products (Substrate)
32	Subunits
157	Synonyms
1	Systematic Name
9	Temperature Optimum [°C]
6	Temperature Stability [°C]
87	Turnover Number [1/s]

Turnover Number

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Turnover Number on EC 6.3.5.4 - asparagine synthase (glutamine-hydrolysing)

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0.52 - 1.37

Asp

8 entries

0.43 - 7.46

ATP

23 entries

0.4 - 1.31

Gln

8 entries

1.7 - 5.8

glutamine

2 entries

1.03 - 1.17

hydroxylamine

2 entries

0.3 - 0.75

L-Asp

8 entries

5.8

L-asparagine

Vibrio cholerae serotype O1

661315

1.05 - 9.19

L-aspartate

4 entries

1.3 - 1.7

L-aspartic acid

2 entries

0.05 - 10.02

L-Gln

10 entries

0.1 - 0.15

L-glutamic acid gamma-monohydroxamate

2 entries

0.8 - 6.08

L-glutamine

10 entries

1.8 - 4.18

NH3

2 entries

0.59 - 0.65

NH4+

2 entries

additional information

2 entries