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4.6.1.2: guanylate cyclase

This is an abbreviated version!
For detailed information about guanylate cyclase, go to the full flat file.

Word Map on EC 4.6.1.2

Reaction

GTP
=
3',5'-cyclic GMP
+
diphosphate

Synonyms

alpha1 sGC, alpha1 soluble guanylyl cyclase, alpha1beta1 guanylyl cyclase, alpha1beta1 sGC, ANF-RGC, ANPRA, ANPRB, atrial natriuretic factor receptor guanylate cyclase, Atrial natriuretic peptide A-type receptor, Atrial natriuretic peptide B-type receptor, atrial natriuretic peptide receptor 2, BERhGC, BR1-GC, brassinosteroid receptor 1, CaRhGC, CNP-sensitive guanyly cyclase, CNP-sensitive guanylyl cyclase, CsGC-YO1, GC-A, GC-A receptor, GC-B, GC-C, GC-D, GC-G, GC1, GC2, GCA, GCC, gcy-18, gcy-23, GCY-35, gcy-8, GTP-pyrophosphate liase cyclizing, GTP-pyrophosphate lyase, guanyl cyclase, guanyl cyclase B, Guanylate cyclase, guanylate cyclase 1, guanylate cyclase 2, Guanylate cyclase 2D, retinal, Guanylate cyclase 2E, Guanylate cyclase 2F, retinal, guanylate cyclase A, guanylate cyclase B, guanylate cyclase C, Guanylate cyclase, olfactory, guanylyl cyclase, guanylyl cyclase A, guanylyl cyclase B, guanylyl cyclase C, guanylyl cyclase C receptor, guanylyl cyclase-A, guanylyl cyclase-A receptor, guanylyl cyclase-C, guanylyl cyclase-D, guanylyl cyclase-G, Gyc-88E, Gyc-89Da, Gyc-89Db, Gyca-99B, Gycb-100B, H-NOX, hSTAR, Intestinal guanylate cyclase, KSGC, L1 H-NOX, L2 H-NOX, membrane bound guanylate cyclase, membrane bound guanylyl cyclase, membrane guanylate cyclase, membrane guanylyl cyclase receptor, membrane-bound GC, membrane-bound guanylate cyclase, membrane-bound guanylyl cyclase, mGc, More, natriuretic peptide-activated guanylate cyclase, nitric oxid sensitive guanylyl cyclase, nitric oxide sensitive guanylyl cyclase, nitric oxide sensitive-guanylyl cyclase, nitric oxide-sensitive guanylate cyclase, nitric-oxide-sensitive guanylyl cyclase, NO receptor, NO receptor soluble guanylyl cyclase, NO sensitive guanylyl cyclase, NO- and haem-independent sGC, NO- and haem-independent soluble guanylate cyclase, NO-GC, NO-GC1, NO-GC2, NO-independent, heme-dependent soluble guanylate cyclase, NO-sensitive GC, NO-sensitive guanylyl cyclase, NO-sGC, NOGC1, NOsGC, NP-GC, NPR A, NPR-A, NPR-B, NPR1, NPR2, ONE-GC, ONE-GC membrane guanylate cyclase, Pac2, Pac3, particulate GC, particulate guanylate cyclase, particulate guanylyl cyclase, PepR1-GC, peptide hormone receptor guanylyl cyclase-C, PGC, photoreceptor guanylyl cyclase, phytosulfokine receptor, PSK receptor, PSKR1, ratGC, receptor guanylyl cyclase, receptor-type guanylyl cyclase, RET-GC1, retGC, RetGC1, RetGC2, retinal guanylate cyclase, retinal guanylyl cyclase, retinal membrane guanylyl cyclase, rGC, rhodopsin-guanylyl cyclase, Rod outer segment membrane guanylate cyclase, rod outer segment membrane guanylate cyclase type 1, ROS-GC, ROS-GC1, ROS-GC2, sGC, sGC alpha2 inhibitory isoform, sGC alpha2 isoform, sGCalpha1, sGCalpha2beta1, sGCbeta1, sGCbeta3, soluble GC, soluble guanylate cyclase, soluble guanylate cyclase alpha1, soluble guanylate cyclase alpha2, soluble guanylyl cyclase, SONO, STA, STA receptor, Tar4 protein

ECTree

     4 Lyases
         4.6 Phosphorus-oxygen lyases
             4.6.1 Phosphorus-oxygen lyases (only sub-subclass identified to date)
                4.6.1.2 guanylate cyclase

Molecular Weight

Molecular Weight on EC 4.6.1.2 - guanylate cyclase

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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
106000
sequence analysis
109000
-
x * 109000, isozyme RetGC2, SDS-PAGE
110000
111000
calculated from amino acid sequence
112000
115000
120000
124000
2 * 130000, SDS-PAGE, 2 * 124000, about, sequence calculation
130000
135000 - 160000
143000
-
gel filtration
150000
155000
gel filtration, recombinant His-tagged sGC
160000
-
gel filtration
180000
19500
1 * 38500 + 1 * 19500, gel filtration, homodimers of sGC have also been observed but are not functionally active
200000
-
gel filtatrion
21500
250000
native PAGE in presence of beta-mercaptoethanol
30000
-
gel filtration, SDS-PAGE + dithiothreitol
300000
38500
1 * 38500 + 1 * 19500, gel filtration, homodimers of sGC have also been observed but are not functionally active
40000
x * 40000, SDS-PAGE
450000
-
soluble form, gel filtration
50000
x * 130000, SDS-PAGE, x * 50000, recombinant isolated extracellular domain, SDS-PAGE, x * 51300, about, extracellular domain, sequence calculation
500000
native PAGE
50300
-
x * 50300, His-tagged SUMO fusion protein, calculated from amino acid sequence
51300
x * 130000, SDS-PAGE, x * 50000, recombinant isolated extracellular domain, SDS-PAGE, x * 51300, about, extracellular domain, sequence calculation
60000
-
1 * 60000, SDS-PAGE
69000
-
alpha,beta 1 * 74000 + 1 * 69000, SDS-PAGE
70000
700000 - 900000
-
particulate form, gel filtration
70400
-
1 * 78600 + 1 * 70400, calculated from amino acid sequence
70500
1 * 77532, alpha subunit, + 1 * 70500, beta subunit, SDS-PAGE
71000
-
1 * 83000 + 1 * 71000, SDS-PAGE
72000
73000
alpha,beta 1 * 73000 + 1 * 70000, SDS-PAGE, soluble form
74000
77000
77532
1 * 77532, alpha subunit, + 1 * 70500, beta subunit, SDS-PAGE
78600
-
1 * 78600 + 1 * 70400, calculated from amino acid sequence
79400
-
1 * 79400 + 1 * 74000
80000
82000
83000
-
1 * 83000 + 1 * 71000, SDS-PAGE