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brain natriuretic peptide stimulated membrane-bound GC
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2-4 months old
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prominent for beta1 and to a lesser extent for the other subunits
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high expression of beta1 and moderate to low expression of both alpha subunits
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coronary
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atypical sGC primarily expressed
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co-expression of both alpha and beta subunits of NO-sensitive sGC
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the guanylyl cyclase messenger system is potentially responsive to hormones/neurotranmitters that may control the degree of relaxation in this vascular tissue
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vascular
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lower esophageal sphincter circular smooth muscle
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high levels of alpha2, and moderate levels of alpha1 and beta1 in the lateral amygdaloid nucleus. In the hippocampal formation the presence of alpha1 and alpha2 mRNA is higher in the dentate gyrus and in the presubiculum and lower in the different CA subfields, beta1 mRNA particularly enriched in the hippocampal fields. In the hilus, large neurons contain significantly higher levels of beta1 and alpha2
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low enzyme content
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expression of the beta1 subunit moderate in the ventromedial, dorsomedial, arcuate, and geniculate nuclei. In these hypothalamic nuclei levels for the alpha subunits are low, all three subunits show moderate levels in the interpeduncular nucleus
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in the anterior region expression of atypical sGCs in sensory neurons that innervate the dorsal and terminal organs, believed to be the main chemosensory organs of the larvae. Along the lateral body wall of larvae expressed by individual sensory neurons that express each of the subunits that appear to innervate basiconic sensilla and trachea. In the terminal segments, atypical sGCs are expressed in neurons that innervate peg sensilla on the caudal sensory cones
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sGC alpha2 and beta1 subunits expressed strongly by dentate gyrus granule cells and CA1-CA3 pyramidal neurons, expression of alpha1 mRNA is high in CA2 pyramidal cells but low in the other CA subfields
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expression of alpha1 and beta1 subunits of sGC
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alveolar
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brain- and atrial natriuretic peptide stimulated membrane-bound GC
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high expression of beta1 and moderate to low expression of both alpha subunits
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isozyme GC-D is exclusively expressed in the olfactory neuroepithelium in rodents
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the membrane guanylate cyclase is exclusively expressed in the CO2-responsive olfactory sensory neurons
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adrenal medulla derived cell line
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very low expression of alpha1 and beta1 subunits of sGC
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atypical sGC primarily expressed
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shows high levels of expression for beta1 mRNA and moderate for alpha1 and alpha2 mRNAs
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anterior, sGC alpha2 inhibitory isoform and sGC alpha2 isoform are expressed
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sGC protein enriched at the leading edge of the cell during chemotaxis
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isozyme GC-G
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expression of soluble guanylate cyclase is significantly higher in white vs. black sheep skin both at the mRNA and protein levels
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upon development, mRNA expression of guanylyl cyclase GCA decreases about 5fold during aggregation and subsequently rises, reaching a maximum during the slug stage
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upper villous and crypt cells
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shows high expression of beta1, moderate of alpha2, and low of alpha1
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moderate expression of beta1, alpha subunits expression is very low
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atrial natriuretic peptide stimulated membrane-bound GC and guanylin-stimulated GC-C
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colon cancer cell line
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GC-B is the predominant functional membrane-bound guanylyl cyclase subtype
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soluble guanylyl cyclase sGC is mainly expressed during aggregation phase
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upon development, mRNA expression of guanylyl cyclase GCA decreases about 5fold during aggregation and subsequently rises, reaching a maximum during the slug stage
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primary aortic smooth muscle cells
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human aortic smooth muscle cells
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aortic ring
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vascular wall and smooth muscle cells
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pulmonary
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pulmonary
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pulmonary
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isozymes GC-A
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pulmonary
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isozymes GC-A
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pulmonary
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pulmonary
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pulmonary, but not aorta
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pulmonary
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pulmonary, cultured model
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coronary artery
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beta1-subunit, alpha2-subunit not present
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smooth muscle
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beta1-subunit, alpha2-subunit not present
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beta1-subunit, alpha2-subunit not present
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alpha1 subunit most prominent
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myelin
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sGC beta1 is the most abundant and ubiquitous subunit
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expression pattern of sGC in tissue form wild-type and spontaneously hypertensive rats, e.g. in rostral ventrolateral medulla, overview
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mRNAs coding for all subunits high and homogeneously distributed
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highest levels of mRNA for beta1, alpha1 and alpha2 subunits
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alpha2-subunit most prominent in the molecular layer followed by the ganglionic layer, low amounts in the granular layer
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alpha2-subunit most prominent in the molecular layer followed by the ganglionic layer, low amounts in the granular layer
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mRNA coding for beta1 and alpha2 subunits is high in Purkinje cells, small cells located close to the Purkinje cells, probably Bergmann glia, contain high densities of alpha1 mRNA. The granule cell layer is enriched in beta1 mRNA and shows moderate levels for alpha2 and low for alpha1 mRNA. The medial and lateral inferior olive nuclei show intense levels of beta1
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alpha2-subunit most prominent in the molecular layer followed by the ganglionic layer, low amounts in the granular layer
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alpha2 and beta1 abundant in Purkinje cells, small cells close to Purkinje cells express high levels of alpha1 mRNA, alpha2 and beta1 expression very high and homogeneous in the granule cell layer
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present at weaker levels
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all neocortical areas with high expression of all subunits, expression of the three subunits in all cortical layers, alpha1 subunit enriched in layer VI
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beta1 subunit mRNA widely distributed through all cortical areas and cell layers with higher intensity in layer V, alpha2 mRNA homogeneously distributed through all cortical layers and alpha1 expression higher in layers IIIII and V
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low expression of all subunit mRNAs in many of the white matter tracts
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moderate expression of alpha1 and alpha2 mRNAs in many white matter tracts, beta1 mRNA expression is very low
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smooth muscle, low enzyme expression
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distal
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guanylyl cyclase C is a protein that is expressed in the cells that line the normal intestine and by metastatic colorectal cancer cells. Isozyme GCC is universally expressed by primary and metastatic colorectal tumors
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guanylyl cyclase C is a protein that is expressed in the cells that line the normal intestine and by metastatic colorectal cancer cells. Isozyme GCC is universally expressed by primary and metastatic colorectal tumors
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purified sGC from lung
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dsRetGC1
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isozyme GC-B
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isozyme GC-B
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isozyme GC-C
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isozyme GC-C
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retina and rod segements, retGC is a transmembrane protein localized in the outer segment
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larval and adult eyes
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anterior segment
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retina and rod segements, retGC is a transmembrane protein localized in the outer segment
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retina and rod segements, retGC is a transmembrane protein localized in the outer segment
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anterior segment
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eyestalk
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cardiac, tissue localization, overview
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dorsal root ganglion, NO-GC is restricted to non-neuronal cells in dorsal root ganglia
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smooth muscle and myenteric layer
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atrial- and C-type natriuretic peptide stimulated membrane-bound GC
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at both tissue and single myocyte levels, sGC protein expression is heterogeneous, being high in sinoatrial node, right atrium, right ventricle and left ventricular subepicardium, but markedly reduced to absent in left atrium and left ventricular subendocardium
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isozymes GC-A
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isozymes GC-A
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at both tissue and single myocyte levels, sGC protein expression is heterogeneous, being high in sinoatrial node, right atrium, right ventricle and left ventricular subepicardium, but markedly reduced to absent in left atrium and left ventricular subendocardium
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from lean and obese rats, enzyme localization at left ventricle and coronary arteriole
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right and left
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right and left
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isozyme GC-C
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epithelium
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guanylyl cyclase C is a protein that is expressed in the cells that line the normal intestine and by metastatic colorectal cancer cells
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isozymes GC-C and GC-G
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mucosal cell
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epithelium
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guanylyl cyclase C is a protein that is expressed in the cells that line the normal intestine and by metastatic colorectal cancer cells
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GC-C
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epithelial cells of the proximal tubule and collecting ducts
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isozyme GC-G
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C-type natriuretic peptide stimulated membrane-bound-GC
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34833, 34850, 34857, 34858, 34866, 34869, 34874, 34879, 34881, 649442, 665511, 666248, 679399, 680671, 684348, 691656, 692446, 693082, 694270, 694411, 707918, 715597, 747134 brenda
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isozyme GC-G
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34838, 34851, 34856, 34877, 34878, 664098, 666731, 680895, 691072, 691541, 691656, 692204 brenda
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GC-A activity is detected on mucus secreting globlet cells, Clara cells and grat alveolar cells
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C57BL/6-derived colorectal cancer cells
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C57BL/6-derived colorectal cancer cells
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alpha1 subunit mRNA with restricted distribution in mesencephalic areas, moderate to high levels in the dorsal aspects of the periaqueductal gray, vestibular lateral and medial nuclei, and in prepositus hypoglossal nuclei, low alpha1 and alpha2 mRNA in the dorsal raphe nucleus, pedunculopontine tegmental nucleus, and oculomotor nuclei. Expression for alpha subunits pronounced in pontine nuclei
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guanylyl cyclase-C protein is expressed predominantly on the somata and dendrites of dopaminergic neurons in the the midbrain ventral tegmental area and substantia nigra compacta
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high levels of beta1 but low levels of alpha subunits in superior colliculus, locus coeruleus presents high levels of beta1 and alpha1 subunits, ventral tegmental nucleus wiht moderate levels of expression for the three sGC subunits
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expressed specifically in the AFD thermosensory neurons
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atypical sGC frequently co-localized in specific sensory neurons
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the isozyme Gyc-89Da is encoded in neurons that are required for larval and adult ecdyses in the fruit fly
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the isozyme Gyc-89Db is encoded in neurons that are required for larval and adult ecdyses in the fruit fly
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midbrain dopamine neuron
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present in the neurokinin 1 receptor-positive neurons in lamina I and many local circuit neurons in laminae I-II, expressed in most inhibitory interneurons
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no co-localization of sGC with phenylethanolamine N-methyltransferase or tyrosine hydroxylase, or NO synthase in neurons
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three membrane bound sensory guanylate cyclases, from developing and adult zebrafish retina
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isozymes GC-E and GC-F are colocalized within the same photoreceptor cells of the retina
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isozymes GC-E and GC-F are colocalized within the same photoreceptor cells of the retina
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atrial natriuretic peptide stimulated membrane-bound GC
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34832, 34836, 34841, 34852, 34860, 34861, 34863, 34870, 34876, 663886, 690841, 693267 brenda
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soluble guanylate cyclase accounts for nearly 10% of the total guanylate cyclase activity of the retina
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three membrane-bound sensory guanylate cyclases expressed in photoreceptor cells of the developing and adult zebrafish retina, expression analysis, overview
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type 1 membrane-bound guanylate cyclase is expressed exclusively in the retina
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isozyme GC-E
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isozyme GC-F
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isozymes GC-E and GC-F are colocalized within the same photoreceptor cells of the retina
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soluble guanylate cyclase accounts for nearly 20% of the total guanylate cyclase activity of the retina
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isozymes GC-E and GC-F are colocalized within the same photoreceptor cells of the retina
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present at high levels in inner retina but barely detectable in outer retina, ganglion cells exhibit moderate staining for sGC, strong immunostaining in subpopulations of bipolar and amacrine cells, weak staining in rod bipolar cells
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natriuretic peptide-activated guanylate cyclase NPR-A is expressed in several layers of the retina including amacrine cells and the ganglion cell layer
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natriuretic peptide-activated guanylate cyclase NPR-B is expressed in several layers of the retina including amacrine cells and the ganglion cell layer
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ROS-GC1
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gastrointestinal tract, muscularis mucosae and vasculature
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tracheal and lung tissue smooth muscle
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lower esophageal sphincter circular smooth muscle
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pulmonary artery smooth muscle layer
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pulmonary artery smooth muscle layer
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gastrointestinal smooth muscle
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protein expression of the alpha1- and beta1-sGC isoforms is significantly lower in the adult compared with the newborn bronchial tissue
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gastrointestinal
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pulmonary artery smooth muscle layer
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vascular
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primary aortic smooth muscle cells
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vascular
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predominantly expressed from round spermatids to spermatozoa in mouse testis at both the mRNA and protein levels
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isozyme GC-G
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NO-GC is distinctly expressed in neurons of the mouse dorsal horn
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present at weaker levels
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smooth muscle, low enzyme expression
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gastrointestinal smooth muscle
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detectable at day 18 of postnatal development and thereafter increasing progressively
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many of the thalamic nuclei contain the three subunits, alpha1 and beta1 mRNA in both the anterior and posterior ventralis nuclei and in the pulvinar and reticular nuclei, alpha2 subunit mRNA is present at low levels in the pulvinar nucleus and barely detectable in other thalamic nuclei
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high levels of mRNA for the three subunits in the medial habenula, in other thalamic nuclei mainly beta1 mRNA
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abundance of the CsCG-YO1 transcript in Y-organs during a molt cycle: the level of CsGC-YO1 in Y-organs is elevated during intermolt, C4, and lower during premolt stages D1-D3
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CsGC-YO1 transcript abundance during a molt cycle, overview
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additional information
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in Purkinje cell somata alpha2- and beta1-subunit present, alpha2-subunit not present in white matter
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additional information
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analysis of sGC in gastrointestinal tissue, immunohistochemic analysis
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additional information
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atypical sGC expressed throughout development
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additional information
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T84 cell and SW480 cell
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additional information
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heart tissue expression pattern, overview
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additional information
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no expression of alpha1 and beta1 subunits of sGC in DU-145 cells
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additional information
tissue distribution, overview
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additional information
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tissue distribution, overview
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additional information
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in Purkinje cell somata alpha2- and beta1-subunit present, alpha2-subunit not present in white matter
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additional information
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no alpha subunits in the substantia nigra
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additional information
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in Purkinje cell somata alpha2- and beta1-subunit present, alpha2-subunit not present in white matter
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additional information
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not detectable in spermatogonia, Sertoli cells, and spermatocytes
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additional information
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GC-G has a broad tissue distribution in rodents
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additional information
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heart tissue expression pattern, overview
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additional information
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brainstem, subnucleus caudalis, where it is present in neuronal cell bodies in the superficial laminae and in astrocytes in deeper lamina
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additional information
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in cortex present at weaker levels, whereas photoreceptors, horizontal cells, Müller cells, and AII amacrine cells are immunonegative
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additional information
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in the superficial dorsal horn present throughout the gray matter, whereas unmyelinated primary afferent fibers terminating in the superficial dorsal horn lack sGC
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additional information
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newborn aged 25 days
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