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4.6.1.2: guanylate cyclase

This is an abbreviated version!
For detailed information about guanylate cyclase, go to the full flat file.

Word Map on EC 4.6.1.2

Reaction

GTP
=
3',5'-cyclic GMP
+
diphosphate

Synonyms

alpha1 sGC, alpha1 soluble guanylyl cyclase, alpha1beta1 guanylyl cyclase, alpha1beta1 sGC, ANF-RGC, ANPRA, ANPRB, atrial natriuretic factor receptor guanylate cyclase, Atrial natriuretic peptide A-type receptor, Atrial natriuretic peptide B-type receptor, atrial natriuretic peptide receptor 2, BERhGC, BR1-GC, brassinosteroid receptor 1, CaRhGC, CNP-sensitive guanyly cyclase, CNP-sensitive guanylyl cyclase, CsGC-YO1, GC-A, GC-A receptor, GC-B, GC-C, GC-D, GC-G, GC1, GC2, GCA, GCC, gcy-18, gcy-23, GCY-35, gcy-8, GTP-pyrophosphate liase cyclizing, GTP-pyrophosphate lyase, guanyl cyclase, guanyl cyclase B, Guanylate cyclase, guanylate cyclase 1, guanylate cyclase 2, Guanylate cyclase 2D, retinal, Guanylate cyclase 2E, Guanylate cyclase 2F, retinal, guanylate cyclase A, guanylate cyclase B, guanylate cyclase C, Guanylate cyclase, olfactory, guanylyl cyclase, guanylyl cyclase A, guanylyl cyclase B, guanylyl cyclase C, guanylyl cyclase C receptor, guanylyl cyclase-A, guanylyl cyclase-A receptor, guanylyl cyclase-C, guanylyl cyclase-D, guanylyl cyclase-G, Gyc-88E, Gyc-89Da, Gyc-89Db, Gyca-99B, Gycb-100B, H-NOX, hSTAR, Intestinal guanylate cyclase, KSGC, L1 H-NOX, L2 H-NOX, membrane bound guanylate cyclase, membrane bound guanylyl cyclase, membrane guanylate cyclase, membrane guanylyl cyclase receptor, membrane-bound GC, membrane-bound guanylate cyclase, membrane-bound guanylyl cyclase, mGc, More, natriuretic peptide-activated guanylate cyclase, nitric oxid sensitive guanylyl cyclase, nitric oxide sensitive guanylyl cyclase, nitric oxide sensitive-guanylyl cyclase, nitric oxide-sensitive guanylate cyclase, nitric-oxide-sensitive guanylyl cyclase, NO receptor, NO receptor soluble guanylyl cyclase, NO sensitive guanylyl cyclase, NO- and haem-independent sGC, NO- and haem-independent soluble guanylate cyclase, NO-GC, NO-GC1, NO-GC2, NO-independent, heme-dependent soluble guanylate cyclase, NO-sensitive GC, NO-sensitive guanylyl cyclase, NO-sGC, NOGC1, NOsGC, NP-GC, NPR A, NPR-A, NPR-B, NPR1, NPR2, ONE-GC, ONE-GC membrane guanylate cyclase, Pac2, Pac3, particulate GC, particulate guanylate cyclase, particulate guanylyl cyclase, PepR1-GC, peptide hormone receptor guanylyl cyclase-C, PGC, photoreceptor guanylyl cyclase, phytosulfokine receptor, PSK receptor, PSKR1, ratGC, receptor guanylyl cyclase, receptor-type guanylyl cyclase, RET-GC1, retGC, RetGC1, RetGC2, retinal guanylate cyclase, retinal guanylyl cyclase, retinal membrane guanylyl cyclase, rGC, rhodopsin-guanylyl cyclase, Rod outer segment membrane guanylate cyclase, rod outer segment membrane guanylate cyclase type 1, ROS-GC, ROS-GC1, ROS-GC2, sGC, sGC alpha2 inhibitory isoform, sGC alpha2 isoform, sGCalpha1, sGCalpha2beta1, sGCbeta1, sGCbeta3, soluble GC, soluble guanylate cyclase, soluble guanylate cyclase alpha1, soluble guanylate cyclase alpha2, soluble guanylyl cyclase, SONO, STA, STA receptor, Tar4 protein

ECTree

     4 Lyases
         4.6 Phosphorus-oxygen lyases
             4.6.1 Phosphorus-oxygen lyases (only sub-subclass identified to date)
                4.6.1.2 guanylate cyclase

Source Tissue

Source Tissue on EC 4.6.1.2 - guanylate cyclase

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
brain natriuretic peptide stimulated membrane-bound GC
Manually annotated by BRENDA team
-
2-4 months old
Manually annotated by BRENDA team
-
prominent for beta1 and to a lesser extent for the other subunits
Manually annotated by BRENDA team
-
high expression of beta1 and moderate to low expression of both alpha subunits
Manually annotated by BRENDA team
-
coronary
Manually annotated by BRENDA team
-
atypical sGC primarily expressed
Manually annotated by BRENDA team
co-expression of both alpha and beta subunits of NO-sensitive sGC
Manually annotated by BRENDA team
-
the guanylyl cyclase messenger system is potentially responsive to hormones/neurotranmitters that may control the degree of relaxation in this vascular tissue
Manually annotated by BRENDA team
-
vascular
Manually annotated by BRENDA team
-
lower esophageal sphincter circular smooth muscle
Manually annotated by BRENDA team
-
high levels of alpha2, and moderate levels of alpha1 and beta1 in the lateral amygdaloid nucleus. In the hippocampal formation the presence of alpha1 and alpha2 mRNA is higher in the dentate gyrus and in the presubiculum and lower in the different CA subfields, beta1 mRNA particularly enriched in the hippocampal fields. In the hilus, large neurons contain significantly higher levels of beta1 and alpha2
Manually annotated by BRENDA team
low enzyme content
Manually annotated by BRENDA team
-
expression of the beta1 subunit moderate in the ventromedial, dorsomedial, arcuate, and geniculate nuclei. In these hypothalamic nuclei levels for the alpha subunits are low, all three subunits show moderate levels in the interpeduncular nucleus
Manually annotated by BRENDA team
-
in the anterior region expression of atypical sGCs in sensory neurons that innervate the dorsal and terminal organs, believed to be the main chemosensory organs of the larvae. Along the lateral body wall of larvae expressed by individual sensory neurons that express each of the subunits that appear to innervate basiconic sensilla and trachea. In the terminal segments, atypical sGCs are expressed in neurons that innervate peg sensilla on the caudal sensory cones
Manually annotated by BRENDA team
-
sGC alpha2 and beta1 subunits expressed strongly by dentate gyrus granule cells and CA1-CA3 pyramidal neurons, expression of alpha1 mRNA is high in CA2 pyramidal cells but low in the other CA subfields
Manually annotated by BRENDA team
-
expression of alpha1 and beta1 subunits of sGC
Manually annotated by BRENDA team
-
alveolar
Manually annotated by BRENDA team
-
brain- and atrial natriuretic peptide stimulated membrane-bound GC
Manually annotated by BRENDA team
-
high expression of beta1 and moderate to low expression of both alpha subunits
Manually annotated by BRENDA team
-
isozyme GC-D is exclusively expressed in the olfactory neuroepithelium in rodents
Manually annotated by BRENDA team
-
the membrane guanylate cyclase is exclusively expressed in the CO2-responsive olfactory sensory neurons
Manually annotated by BRENDA team
-
adrenal medulla derived cell line
Manually annotated by BRENDA team
-
very low expression of alpha1 and beta1 subunits of sGC
Manually annotated by BRENDA team
-
atypical sGC primarily expressed
Manually annotated by BRENDA team
-
shows high levels of expression for beta1 mRNA and moderate for alpha1 and alpha2 mRNAs
Manually annotated by BRENDA team
-
anterior, sGC alpha2 inhibitory isoform and sGC alpha2 isoform are expressed
Manually annotated by BRENDA team
sGC protein enriched at the leading edge of the cell during chemotaxis
Manually annotated by BRENDA team
-
isozyme GC-G
Manually annotated by BRENDA team
-
expression of soluble guanylate cyclase is significantly higher in white vs. black sheep skin both at the mRNA and protein levels
Manually annotated by BRENDA team
-
upon development, mRNA expression of guanylyl cyclase GCA decreases about 5fold during aggregation and subsequently rises, reaching a maximum during the slug stage
Manually annotated by BRENDA team
-
upper villous and crypt cells
Manually annotated by BRENDA team
-
shows high expression of beta1, moderate of alpha2, and low of alpha1
Manually annotated by BRENDA team
-
moderate expression of beta1, alpha subunits expression is very low
Manually annotated by BRENDA team
-
atrial natriuretic peptide stimulated membrane-bound GC and guanylin-stimulated GC-C
Manually annotated by BRENDA team
-
colon cancer cell line
Manually annotated by BRENDA team
-
GC-B is the predominant functional membrane-bound guanylyl cyclase subtype
Manually annotated by BRENDA team
additional information