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Literature summary for 4.6.1.2 extracted from
- Interaction of retinal guanylate cyclase with the alpha subunit of transducin: potential role in transducin localization (2009), Biochem. J., 417, 803-812.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| transient expression in COS-7 cells | Mus musculus |
| transient expression in COS-7 cells | Bos taurus |
| transient expression in COS-7 cells as GST-tagged enzyme, reconstitution of the Galphat-retGC interaction in COS-7 cells, overview | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | mouse line lacking retGC-1, GCE null, light-induced transducin redistribution occurs faster in mice lacking ret-GC1, phenotype, overview | Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | retGC is a transmembrane protein localized in the outer segment | Mus musculus | 16020 | - |
| membrane | retGC is a transmembrane protein localized in the outer segment | Bos taurus | 16020 | - |
| membrane | retGC is a transmembrane protein localized in the outer segment | Homo sapiens | 16020 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Mus musculus |  |
| Mg2+ | - |
Bos taurus | |
| Mg2+ | - |
Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 115000 | - |
x * 115000, SDS-PAGE | Bos taurus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GTP | Mus musculus | the retinal isozyme retGC-1 influences transducin movement, not through its cyclase activity, but through direct interaction with Galphat protein, overview | 3',5'-cyclic GMP + diphosphate | - |
? | |
| GTP | Bos taurus | the retinal isozyme retGC-1 influences transducin movement, not through its cyclase activity, but through direct interaction with Galphat protein, overview | 3',5'-cyclic GMP + diphosphate | - |
? | |
| GTP | Homo sapiens | the retinal isozyme retGC-1 influences transducin movement, not through its cyclase activity, but through direct interaction with Galphat protein, overview | 3',5'-cyclic GMP + diphosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Homo sapiens | Q02846 | - |
- |
| Mus musculus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant GST-tagged retGC from COS-7 cells by glutathione affinity chromatography | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| eye | retina and rod segements, retGC is a transmembrane protein localized in the outer segment | Mus musculus | - |
| eye | retina and rod segements, retGC is a transmembrane protein localized in the outer segment | Bos taurus | - |
| eye | retina and rod segements, retGC is a transmembrane protein localized in the outer segment | Homo sapiens | - |
| retina | - |
Mus musculus | - |
| retina | - |
Bos taurus | - |
| retina | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GTP | - |
Mus musculus | 3',5'-cyclic GMP + diphosphate | - |
? | |
| GTP | - |
Bos taurus | 3',5'-cyclic GMP + diphosphate | - |
? | |
| GTP | - |
Homo sapiens | 3',5'-cyclic GMP + diphosphate | - |
? | |
| GTP | the retinal isozyme retGC-1 influences transducin movement, not through its cyclase activity, but through direct interaction with Galphat protein, overview | Mus musculus | 3',5'-cyclic GMP + diphosphate | - |
? | |
| GTP | the retinal isozyme retGC-1 influences transducin movement, not through its cyclase activity, but through direct interaction with Galphat protein, overview | Bos taurus | 3',5'-cyclic GMP + diphosphate | - |
? | |
| GTP | the retinal isozyme retGC-1 influences transducin movement, not through its cyclase activity, but through direct interaction with Galphat protein, overview | Homo sapiens | 3',5'-cyclic GMP + diphosphate | - |
? | |
| additional information | the enzyme binds the human rod Galphat protein without altering cyclase activity, interactions with ligands, overview | Bos taurus | ? | - |
? | |
| additional information | the enzyme binds the human rod Galphat protein without altering cyclase activity, overview | Mus musculus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 115000, SDS-PAGE | Bos taurus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| retGC | - |
Mus musculus |
| retGC | - |
Bos taurus |
| retGC | - |
Homo sapiens |
| retinal guanylate cyclase | - |
Mus musculus |
| retinal guanylate cyclase | - |
Bos taurus |
| retinal guanylate cyclase | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Mus musculus |
| 30 | - |
assay at | Bos taurus |
| 30 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.2 | - |
assay at | Mus musculus |
| 7.2 | - |
assay at | Bos taurus |
| 7.2 | - |
assay at | Homo sapiens |
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