Reference on EC 4.6.1.2 - guanylate cyclase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Janssens, P.M.V.; de Jong, C.C.C.
A magnesium-dependent guanylate cyclase in cell-free preparations of Dictyostelium discoideum
Biochem. Biophys. Res. Commun.
150
405-411
1988
Dictyostelium discoideum
Ramarao, C.S.; Garbers, D.L.
Purification and properties of the phosphorylated form of guanylate cyclase
J. Biol. Chem.
263
1524-1529
1988
Arbacia punctulata
Nagao,S.; Nozawa, Y.
Properties of digitonin-solubilized calmodulin-dependent guanylate cyclase from the plasma membranes of Tetrahymena pyriformis NT-1 cells
Arch. Biochem. Biophys.
252
179-187
1987
Tetrahymena pyriformis
Kaever, V.; Szamel, M.; Goppelt, M.; Resch, K.
Characterization and subcellular localization of nucleotide cyclases in calf thymus lymphocytes
Biochim. Biophys. Acta
776
133-143
1984
Bos taurus
Radany, E.W.; Gerzer, R.; Garbers, D.L.
Purification and characterization of particulate guanylate cyclase from sea urchin spermatozoa
J. Biol. Chem.
258
8346-8351
1983
Arbacia punctulata
Ohlstein, E.H.; Wood, K.S.; Ignarro, L.J.
Purification and properties of heme-deficient hepatic soluble guanylate cyclase: effects of heme and other factors on enzyme activation by NO, NO-heme, and protoporphyrin IX
Arch. Biochem. Biophys.
218
187-198
1982
Rattus norvegicus
Gorczyca, W.A.; VanHooser, J.P.; Palczewski, K.
Nucleotide inhibitors and activators of retinal guanylyl cyclase
Biochemistry
33
3217-3222
1994
Bos taurus
Gerzer, R.; Hofmann, F.; Schultz, G.
Purification of a soluble, sodium-nitroprusside-stimulated guanylate cyclase from bovine lung
Eur. J. Biochem.
116
479-486
1981
Bos taurus
Zwiller, J.; Basset, P.; Mandel, P.
Rat brain guanylate cyclase. Purification, amphiphilic properties and immunological characterization
Biochim. Biophys. Acta
658
64-75
1981
Rattus norvegicus
Spruill, W.A.; Steiner, A.L.; Earp, H.S.
Characterization of rat testicular guanylate cyclase during development
Biochim. Biophys. Acta
587
484-494
1979
Rattus norvegicus
Fleischman, D.; Denisevich, M.
Guanylate cyclase of isolated bovine retinal rod axonemes
Biochemistry
18
5060-5066
1979
Bos taurus
Braughler, J.M.; Mittal, C.K.; Murad, F.
Purification of soluble guanylate cyclase from rat liver
Proc. Natl. Acad. Sci. USA
76
219-222
1979
Rattus norvegicus
Garbers, D.L.
Purification of soluble guanylate cyclase from rat lung
J. Biol. Chem.
254
240-243
1979
Rattus norvegicus
Tsai, S.C.; Manganiello, V.C.; Vaughan, M.
Purification of guanylate cyclase from rat liver supernatant
J. Biol. Chem.
253
8452-8457
1978
Rattus norvegicus
-
Nakane, M.; Deguchi, T.
Purification and properties of guanylate cyclase from the synaptosomal soluble fraction of rat brain
Biochim. Biophys. Acta
525
275-285
1978
Rattus norvegicus
Krishnan, N.; Fletcher, R.T.; Chader, G.J.; Krishna, G.
Characterization of guanylate cyclase of rod outer segments of the bovine retina
Biochim. Biophys. Acta
523
506-515
1978
Bos taurus
Asano, T.; Hidaka, H.
Purification of guanylate cyclase from human platelets and effect of arachidonic acid peroxide
Biochem. Biophys. Res. Commun.
78
910-918
1977
Homo sapiens
Craven, P.A.; DeRubertis, F.R.
Properties and subcellular distribution of guanylate cyclase activity in rat renal medulla: correlation with tissue content of guanosine 3 ,5 -monophosphate
Biochemistry
15
5131-5137
1976
Rattus norvegicus
Garbers, D.L.
Sea urchin sperm guanylate cyclase. Purification and loss of cooperativity
J. Biol. Chem.
251
4071-4077
1976
Arbacia punctulata
Durham, J.P.
Guanylate cyclase: assay and properties of the particulate and supernatant enzymes in mouse parotid
Eur. J. Biochem.
61
535-544
1976
Mus musculus
Neer, E.J.; Sukiennnik, E.A.
Guanylate cyclase from the rat renal medulla. Physical properties and comparison with adenylate cyclase
J. Biol. Chem.
250
7905-7909
1975
Rattus norvegicus
Macchia, V.; Varrone, S.; Weissbach, H.; Miller, D.L.; Pastan, I.
Guanylate cyclase in Escherichia coli. Purification and properties
J. Biol. Chem.
250
6214-6217
1975
Escherichia coli
De Jonge, H.R.
Properties of guanylate cyclase and levels of cyclic GMP in rat small intestinal villous and crypt cells
FEBS Lett.
55
143-152
1975
Rattus norvegicus
Boehme, E.; Jung, R.; Mechler, I.
Guanylate cyclase in human platelets
Methods Enzymol.
38C
199-202
1974
Homo sapiens
-
White, A.A.; Zenser, T.V.
Preparation and characterization of guanylate cyclase from bovine lung
Methods Enzymol.
38C
192-195
1974
Bos taurus
Chrisman, T.D.; Garbers, D.L.; Parks, M.A.; Hardman, J.G.
Characterization of particulate and soluble guanylate cyclases from rat lung
J. Biol. Chem.
250
374-381
1975
Rattus norvegicus
Hakki, S.; Sitaramayya, A.
Guanylate cyclase from bovine rod outer segments: solubilization, partial purification, and regulation by inorganic pyrophosphate
Biochemistry
29
1088-1094
1990
Bos taurus
Sun, I.C.; Shapiro, L.; Rosen, O.M.
Purification and characterization of guanylate cyclase from Caulobacter crescentus
Biochem. Biophys. Res. Commun.
61
193-203
1974
Caulobacter vibrioides
Hardman, J.C.; Sutherland, E.W.
Guanyl cyclase, an enzyme catalyzing the formation of guanosine 3 ,5 -monophosphate from guanosine trihosphate
J. Biol. Chem.
244
6363-6370
1969
Rattus norvegicus
Russwurm, M.; Behrends, S.; Harteneck, C.; Koesling, D.
Functional properties of a naturally occurring isoform of soluble guanylyl cyclase
Biochem. J.
335
125-130
1998
Homo sapiens (P33402), Homo sapiens
Hoenicka, M.; Becker, E.M.; Apeler, H.; Sirichoke, T.; Schroeder, H.; Gerzer, R.; Stasch, J.P.
Purified soluble guanylyl cyclase expressed in a baculovirus/Sf9 system: stimulation by YC-1, nitric oxide, and carbon monoxide
J. Mol. Med.
77
14-23
1999
Rattus norvegicus
Serfass, L.; Burstyn, J.N.
Effect of heme oxygenase inhibitors on soluble guanylyl cyclase activity
Arch. Biochem. Biophys.
359
8-16
1998
Bos taurus
Mayer, B.; Schrammel, A.; Klatt, P.; Koesling, D.; Schmidt, K.
Peroxynitrite-induced accumulation of cyclic GMP in endothelial cells and stimulation of purified soluble guanylyl cyclase
J. Biol. Chem.
29
17355-17360
1995
Bos taurus
Nighorn, A.; Byrnes, K.A.; Morton, D.B.
Identification and characterization of a novel beta subunit of soluble guanylyl cyclase that is active in the absence of a second subunit and is relatively insensitive to nitric oxide
J. Biol. Chem.
274
2525-2531
1999
Manduca sexta
Hayashi, F.; Yamazaki, A.
Polymorphism in purified guanylate cyclase from vertebrate rod photoreceptors
Proc. Natl. Acad. Sci. USA
88
4746-4750
1991
Bos taurus, Rhinella marina, Lithobates catesbeianus
Koch, K.W.
Purification and identification of photoreceptor guanylate cyclase
J. Biol. Chem.
266
8634-8637
1991
Bos taurus
Bruene, B.; Schmidt, K.U.; Ullrich, V.
Activation of soluble guanylate cyclase by carbon monoxide and inhibition by superoxide anion
Eur. J. Biochem.
192
683-688
1990
Homo sapiens
Wolbring, G.; Baehr, W.; Palczewski, K.; Schnetkamp, P.P.
Light inhibition of bovine retinal rod guanylyl cyclase mediated by beta gamma-transducin
Biochemistry
38
2611-2616
1999
Bos taurus
Hakki, S.; Crane, M.; Hugues, M.; O'Hanley, P.; Waldman, S.A.
Solubilization and characterization of functionally coupled Escherichia coli heat-stable toxin receptors and particulate guanylate cyclase associated with the cytoskeleton compartment of intestinal membranes
Int. J. Biochem.
25
557-566
1993
Rattus norvegicus
Ivanova, K.; Heim, J.M.; Gerzer, R.
Kinetic characterization of atrial natriuretic factor-sensitive particulate guanylate cyclase
Eur. J. Pharmacol.
189
317-326
1990
Bos taurus
Schrammel, D.; Koesling, D.; Gorren, A.C.F.; Chevion, M.; Schmidt, K.; Mayer, B.
Inhibition of purified soluble guanylyl cyclase by copper ions
Biochem. Pharmacol.
52
1041-1045
1996
Bos taurus
Bocanera, L.V.; Martinetto, H.; Flawia, M.M.; Pisarev, M.A.
Partial characterization of guanylyl cyclase activity in calf thyroid
Endocr. Res.
25
215-228
1999
Bos taurus
Hasegawa, M.; Kawano, Y.; Matsumoto, Y.; Hidaka, Y.; Fujii, J.i.; Taniguchi, N.; Wada, A.; Hirayama, T.; Shimonishi, Y.
Expression and characterization of the extracellular domain of guanylyl cyclase C from a baculovirus and Sf21 insect cells
Protein Expr. Purif.
15
271-281
1999
Sus scrofa
Stone, J.R.; Marletta, M.A.
Soluble guanylate cyclase from bovine lung: activation with nitric oxide and carbon monoxide and spectral characterization of the ferrous and ferric states
Biochemistry
33
5636-5640
1994
Bos taurus
Aparicio, J.G.; Applebury, M.L.
The bovine photoreceptor outer segment guanylate cyclase: purification, kinetic properties, and molecular size
Protein Expr. Purif.
6
501-511
1995
Bos taurus
Grabow, M.; Chakraborty, G.; Ledeen, R.W.
Characterization of guanylyl cyclase in purified myelin
Neurochem. Res.
21
457-462
1996
Rattus norvegicus
Li, P.L.; Jin, M.W.; Campbell, W.B.
Effect of selective inhibition of soluble guanylyl cyclase on the K(Ca) channel activity in coronary artery smooth muscle
Hypertension
31
303-308
1998
Bos taurus
Chhajlani, V.; Axelsson, K.; Ahlner, J.; Wikberg, J.E.S.
Purification of soluble guanylate cyclase enzyme from human platelets
Biochem. Int.
19
1039-1044
1989
Homo sapiens
Tomita, T.; Tsuyama, S.; Imai, Y.; Kitagawa, T.
Purification of bovine soluble guanylate cyclase and ADP-ribosylation on its small subunit by bacterial toxins
J. Biochem.
122
531-536
1997
Bos taurus
Koutalos, Y.; Nakatani, K.; Tamura, T.; Yau, K.W.
Characterization of guanylate cyclase activity in single retinal rod outer segments
J. Gen. Physiol.
106
863-890
1995
Ambystoma tigrinum
Horio, Y.; Murad, F.
Purification of guanylyl cyclase from rod outer segments
Biochim. Biophys. Acta
1133
81-88
1991
Bos taurus
Chang, C.H.; Kohse, K.P.; Chang, B.; Hirata, M.; Jiang, B.; Douglas, J.E.; Murad, F.
Characterization of ATP-stimulated guanylate cyclase activation in rat lung membranes
Biochim. Biophys. Acta
1052
159-165
1990
Rattus norvegicus
Waldman, S.A.; Leitman, D.C.; Murad, F.
Immunoaffinity purification of soluble guanylyl cyclase
Methods Enzymol.
195
391-396
1991
Rattus norvegicus
Muelsch, A.; Gerzer, R.
Purification of heme-containing soluble guanylyl cyclase
Methods Enzymol.
195
377-383
1991
Bos taurus
Ramarao, C.S.; Garbers, D.L.
Purification of membrane form of guanylyl cyclase
Methods Enzymol.
195
373-376
1991
Arbacia punctulata
Humbert, P.; Niroomand, F.; Fischer, G.; Mayer, B.; Koesling, D.; Hinsch, K.D.; Schultz, G.; Boehme, E.
Preparation of soluble guanylyl cyclase from bovine lung by immunoaffinity chromatography
Methods Enzymol.
195
384-389
1991
Bos taurus
Borges, A.; de Villarroel, S.S.; Winand, N.J.; de Becemberg, I.L.; Alfonzo, M.J.; de Alfonzo, R.G.
Molecular and biochemical characterization of a CNP-sensitive guanylyl cyclase in bovine tracheal smooth muscle
Am. J. Respir. Cell Mol. Biol.
25
98-103
2001
Bos taurus
Serfass, L.; Carr, H.S.; Aschenbrenner, L.M.; Burstyn, J.N.
Calcium ion downregulates soluble guanylyl cyclase activity: Evidence for a two-metal ion catalytic mechanism
Arch. Biochem. Biophys.
387
47-56
2001
Bos taurus
Kosarikov, D.N.; Young, P.; Uversky, V.N.; Gerber, N.C.
Human soluble guanylate cyclase: functional expression, purification and structural characterization
Arch. Biochem. Biophys.
388
185-197
2001
Homo sapiens
Koglin, M.; Behrends, S.
Native human nitric oxide sensitive guanylyl cyclase: purification and characterization
Biochem. Pharmacol.
67
1579-1585
2004
Homo sapiens
Vijayachandra, K.; Guruprasad, M.; Bhandari, R.; Manjunath, U.H.; Somesh, B.P.; Srinivasan, N.; Suguna, K.; Visweswariah, S.S.
Biochemical characterization of the intracellular domain of the human guanylyl cyclase C receptor provides evidence for a catalytically active homotrimer
Biochemistry
39
16075-16083
2000
Homo sapiens
Lamothe, M.; Chang, F.J.; Balashova, N.; Shirokov, R.; Beuve, A.
Functional Characterization of Nitric Oxide and YC-1 Activation of Soluble Guanylyl Cyclase: Structural Implication for the YC-1 Binding Site?
Biochemistry
43
3039-3048
2004
Rattus norvegicus
Hwang, J.Y.; Lange, C.; Helten, A.; Hoeppner-Heitmann, D.; Duda, T.; Sharma, R.K.; Koch, K.W.
Regulatory modes of rod outer segment membrane guanylate cyclase differ in catalytic efficiency and Ca2+-sensitivity
Eur. J. Biochem.
270
3814-3821
2003
Bos taurus
Schmidt, P.; Schramm, M.; Schroder, H.; Stasch, J.P.
Mechanisms of nitric oxide independent activation of soluble guanylyl cyclase
Eur. J. Pharmacol.
468
167-174
2003
Homo sapiens
Roelofs, J.; Van Haastert, P.J.M.
Characterization of two unusual guanylyl cyclases from Dictyostelium
J. Biol. Chem.
277
9167-9174
2002
Dictyostelium discoideum, Dictyostelium sp.
Koglin, M.; Behrends, S.
A Functional domain of the a1 subunit of soluble guanylyl cyclase is necessary for activation of the enzyme by nitric oxide and YC-1 but is not involved in heme binding
J. Biol. Chem.
278
12590-12597
2003
Homo sapiens
Sitaramayya, A.
Soluble guanylate cyclases in the retina
Mol. Cell. Biochem.
230
177-186
2002
Bos taurus, Mus musculus
Rambotti, M.G.; Spreca, A.; Giambanco, I.; Sorci, G.; Donato, R.
Ultracytochemistry as a tool for the study of the cellular and subcellular localization of membrane-bound guanylate cyclase (GC) activity. Applicability to both receptor-activated and receptor-independent GC activity
Mol. Cell. Biochem.
230
85-96
2002
Oryctolagus cuniculus, Homo sapiens, Rattus norvegicus
Martin, E.; Sharina, I.; Kots, A.; Murad, F.
A constitutively activated mutant of human soluble guanylyl cyclase (sGC): Implication for the mechanism of sGC activation
Proc. Natl. Acad. Sci. USA
100
9208-9213
2003
Homo sapiens
Ruiz-Stewart, I.; Tiyyagura, S.R.; Lin, J.E.; Kazerounian, S.; Pitari, G.M.; Schulz, S.; Martin, E.; Murad, F.; Waldman, S.A.
Guanylyl cyclase is an ATP sensor coupling nitric oxide signaling to cell metabolism
Proc. Natl. Acad. Sci. USA
101
37-42
2004
Homo sapiens
Lee, Y.C.; Martin, E.; Murad, F.
Human recombinant soluble guanylyl cyclase: expression, purification, and regulation
Proc. Natl. Acad. Sci. USA
97
10763-10768
2000
Homo sapiens (Q02108), Homo sapiens
Yamazaki, M.; Usukura, J.; Yamazaki, R.K.; Yamazaki, A.
ATP binding is required for physiological activation of retinal guanylate cyclase
Biochem. Biophys. Res. Commun.
338
1291-1298
2005
Bos taurus
Derbyshire, E.R.; Tran, R.; Mathies, R.A.; Marletta, M.A.
Characterization of nitrosoalkane binding and activation of soluble guanylate cyclase
Biochemistry
44
16257-16265
2005
Rattus norvegicus
Karow, D.S.; Pan, D.; Davis, J.H.; Behrends, S.; Mathies, R.A.; Marletta, M.A.
Characterization of functional heme domains from soluble guanylate cyclase
Biochemistry
44
16266-16274
2005
Rattus norvegicus
Winger, J.A.; Marletta, M.A.
Expression and characterization of the catalytic domains of soluble guanylate cyclase: interaction with the heme domain
Biochemistry
44
4083-4090
2005
Rattus norvegicus
Schmidt, K.G.; Geyer, O.; Mittag, T.W.
Adenylyl and guanylyl cyclase activity in the choroid
Exp. Eye Res.
78
901-907
2004
Bos taurus
Linder, J.U.; Castro, L.I.; Guo, Y.L.; Schultz, J.E.
Functional chimeras between the catalytic domains of the mycobacterial adenylyl cyclase Rv1625c and a Paramecium guanylyl cyclase
FEBS Lett.
568
151-154
2004
Paramecium tetraurelia, Paramecium tetraurelia 51s
Gille, A.; Lushington, G.H.; Mou, T.C.; Doughty, M.B.; Johnson, R.A.; Seifert, R.
Differential inhibition of adenylyl cyclase isoforms and soluble guanylyl cyclase by purine and pyrimidine nucleotides
J. Biol. Chem.
279
19955-19969
2004
Bos taurus
Zhou, Z.; Gross, S.; Roussos, C.; Meurer, S.; Muller-Esterl, W.; Papapetropoulos, A.
Structural and functional characterization of the dimerization region of soluble guanylyl cyclase
J. Biol. Chem.
279
24935-24943
2004
Homo sapiens
Chang, F.J.; Lemme, S.; Sun, Q.; Sunahara, R.K.; Beuve, A.
Nitric oxide-dependent allosteric inhibitory role of a second nucleotide binding site in soluble guanylyl cyclase
J. Biol. Chem.
280
11513-11519
2005
Rattus norvegicus
Russwurm, M.; Koesling, D.
Purification and characterization of NO-sensitive guanylyl cyclase
Methods Enzymol.
396
492-501
2005
Bos taurus
Cary, S.P.; Winger, J.A.; Marletta, M.A.
Tonic and acute nitric oxide signaling through soluble guanylate cyclase is mediated by nonheme nitric oxide, ATP, and GTP
Proc. Natl. Acad. Sci. USA
102
13064-13069
2005
Rattus norvegicus
Veltman, D.M.; Bosgraaf, L.; van Haastert, P.J.M.
Unusual guanylyl cyclases and cGMP signaling in Dictyostelium discoideum
Vitam. Horm.
69
95-115
2004
Dictyostelium discoideum
Woodard, G.E.; Zhao, J.; Rosado, J.A.
Different effect of ATP on ANP receptor guanylyl cyclase in spontaneously hypertensive and normotensive rats
Acta Physiol. (Oxf.)
188
195-206
2006
Rattus norvegicus
Belik, J.; Hehne, N.; Pan, J.; Behrends, S.
Soluble guanylate cyclase-dependent relaxation is reduced in the adult rat bronchial smooth muscle
Am. J. Physiol. Lung Cell Mol. Physiol.
292
L699-L703
2007
Rattus norvegicus
Martin, F.L.; Supaporn, T.; Chen, H.H.; Sandberg, S.M.; Matsuda, Y.; Jougasaki, M.; Burnett, J.C.
Distinct roles for renal particulate and soluble guanylyl cyclases in preserving renal function in experimental acute heart failure
Am. J. Physiol. Regul. Integr. Comp. Physiol.
293
R1580-R1585
2007
Canis lupus familiaris
Duda, T.; Sharma, R.K.
ONE-GC membrane guanylate cyclase, a trimodal odorant signal transducer
Biochem. Biophys. Res. Commun.
367
440-445
2008
Rattus norvegicus
Huang, S.H.; Rio, D.C.; Marletta, M.A.
Ligand binding and inhibition of an oxygen-sensitive soluble guanylate cyclase, Gyc-88E, from Drosophila
Biochemistry
46
15115-15122
2007
Drosophila melanogaster
Madhani, M.; Okorie, M.; Hobbs, A.J.; MacAllister, R.J.
Reciprocal regulation of human soluble and particulate guanylate cyclases in vivo
Br. J. Pharmacol.
149
797-801
2006
Homo sapiens, Mus musculus, Mus musculus C57BL/6
Ro, J.Y.; Lee, J.; Capra, N.F.; Zhang, Y.
Role of soluble guanylate cyclase in the trigeminal subnucleus caudalis in capsaicin-induced muscle hypersensitivity
Brain Res.
1184
141-148
2007
Rattus norvegicus
Bidmon, H.J.; Mohlberg, H.; Habermann, G.; Buse, E.; Zilles, K.; Behrends, S.
Cerebellar localization of the NO-receptive soluble guanylyl cyclase subunits-alpha(2)/beta (1) in non-human primates
Cell Tissue Res.
326
707-714
2006
Callithrix jacchus, Macaca fascicularis, Macaca mulatta
Poulos, T.L.
Soluble guanylate cyclase
Curr. Opin. Struct. Biol.
16
736-743
2006
Bos taurus, Clostridium botulinum, Homo sapiens, Rattus norvegicus, Caldanaerobacter subterraneus subsp. tengcongensis, Vibrio cholerae serotype O1
Mueller, D.; Cortes-Dericks, L.; Budnik, L.T.; Brunswig-Spickenheier, B.; Pancratius, M.; Speth, R.C.; Mukhopadhyay, A.K.; Middendorff, R.
Homologous and lysophosphatidic acid-induced desensitization of the atrial natriuretic peptide receptor, guanylyl cyclase-A, in MA-10 leydig cells
Endocrinology
147
2974-2985
2006
Mus musculus, Rattus norvegicus
Huang, Y.H.; Wei, C.C.; Su, Y.H.; Wu, B.T.; Ciou, Y.Y.; Tu, C.F.; Cooper, T.G.; Yeung, C.H.; Chu, S.T.; Tsai, M.T.; Yang, R.B.
Localization and characterization of an orphan receptor, guanylyl cyclase-G, in mouse testis and sperm
Endocrinology
147
4792-4800
2006
Mus musculus
Isenberg, J.S.; Ridnour, L.A.; Thomas, D.D.; Wink, D.A.; Roberts, D.D.; Espey, M.G.
Guanylyl cyclase-dependent chemotaxis of endothelial cells in response to nitric oxide gradients
Free Radic. Biol. Med.
40
1028-1033
2006
Homo sapiens
Inada, H.; Ito, H.; Satterlee, J.; Sengupta, P.; Matsumoto, K.; Mori, I.
Identification of guanylyl cyclases that function in thermosensory neurons of Caenorhabditis elegans
Genetics
172
2239-2252
2006
Caenorhabditis elegans, Caenorhabditis elegans (Q9GYQ4)
Karmakar, S.; Ukil, A.; Mukherjee, S.; Das, P.K.
Regulation of guanylyl cyclase by intracellular Ca2+ in relation to the infectivity of the protozoan parasite, Leishmania donovani
Int. J. Biochem. Cell Biol.
38
1277-1289
2006
Leishmania donovani (Q8I7Z5), Leishmania donovani, Leishmania donovani MHOM/IN/1983/AG83 (Q8I7Z5)
Yazawa, S.; Tsuchiya, H.; Hori, H.; Makino, R.
Functional characterization of two nucleotide-binding sites in soluble guanylate cyclase
J. Biol. Chem.
281
21763-21770
2006
Bos taurus
Boon, E.M.; Davis, J.H.; Tran, R.; Karow, D.S.; Huang, S.H.; Pan, D.; Miazgowicz, M.M.; Mathies, R.A.; Marletta, M.A.
Nitric oxide binding to prokaryotic homologs of the soluble guanylate cyclase beta1 H-NOX domain
J. Biol. Chem.
281
21892-21902
2006
Legionella pneumophila, Nostoc punctiforme
Martin, E.; Berka, V.; Bogatenkova, E.; Murad, F.; Tsai, A.L.
Ligand selectivity of soluble guanylyl cyclase: effect of the hydrogen-bonding tyrosine in the distal heme pocket on binding of oxygen, nitric oxide, and carbon monoxide
J. Biol. Chem.
281
27836-27845
2006
Caldanaerobacter subterraneus subsp. tengcongensis
Baehr, W.; Karan, S.; Maeda, T.; Luo, D.G.; Li, S.; Bronson, J.D.; Watt, C.B.; Yau, K.W.; Frederick, J.M.; Palczewski, K.
The function of guanylate cyclase 1 and guanylate cyclase 2 in rod and cone photoreceptors
J. Biol. Chem.
282
8837-8847
2007
Mus musculus, Mus musculus C57/BL6J
Winger, J.A.; Derbyshire, E.R.; Marletta, M.A.
Dissociation of nitric oxide from soluble guanylate cyclase and heme-nitric oxide/oxygen binding domain constructs
J. Biol. Chem.
282
897-907
2007
Rattus norvegicus
Ding, J.D.; Weinberg, R.J.
Localization of soluble guanylyl cyclase in the superficial dorsal horn
J. Comp. Neurol.
495
668-678
2006
Rattus norvegicus
Pifarre, P.; Garcia, A.; Mengod, G.
Species differences in the localization of soluble guanylyl cyclase subunits in monkey and rat brain
J. Comp. Neurol.
500
942-957
2007
Macaca fascicularis, Rattus norvegicus
Ding, J.D.; Weinberg, R.J.
Distribution of soluble guanylyl cyclase in rat retina
J. Comp. Neurol.
502
734-745
2007
Rattus norvegicus
Vermehren, A.; Langlais, K.K.; Morton, D.B.
Oxygen-sensitive guanylyl cyclases in insects and their potential roles in oxygen detection and in feeding behaviors
J. Insect Physiol.
52
340-348
2006
Anopheles gambiae, Apis mellifera, Bombyx mori, Caenorhabditis elegans, Drosophila melanogaster, Drosophila pseudoobscura, Manduca sexta, Tribolium castaneum, Caldanaerobacter subterraneus subsp. tengcongensis
Alfonzo, M.J.; de Aguilar, E.P.; de Murillo, A.G.; de Villarroel, S.S.; de Alfonzo, R.G.; Borges, A.; de Becemberg, I.L.
Characterization of a G protein-coupled guanylyl cyclase-B receptor from bovine tracheal smooth muscle
J. Recept. Signal Transduct. Res.
26
269-297
2006
Bos taurus
Veltman, D.M.; Van Haastert, P.J.
Guanylyl cyclase protein and cGMP product independently control front and back of chemotaxing Dictyostelium cells
Mol. Biol. Cell
17
3921-3929
2006
Dictyostelium discoideum (Q963L5)
Pitari, G.M.; Li, T.; Baksh, R.I.; Waldman, S.A.
Exisulind and guanylyl cyclase C induce distinct antineoplastic signaling mechanisms in human colon cancer cells
Mol. Cancer Ther.
5
1190-1196
2006
Homo sapiens
Rothkegel, C.; Schmidt, P.M.; Atkins, D.J.; Hoffmann, L.S.; Schmidt, H.H.; Schroeder, H.; Stasch, J.P.
Dimerization region of soluble guanylate cyclase characterized by bimolecular fluorescence complementation in vivo
Mol. Pharmacol.
72
1181-1190
2007
Rattus norvegicus
Kwezi, L.; Meier, S.; Mungur, L.; Ruzvidzo, O.; Irving, H.; Gehring, C.
The Arabidopsis thaliana brassinosteroid receptor (AtBRI1) contains a domain that functions as a guanylyl cyclase in vitro
PLoS ONE
2
e449
2007
Arabidopsis thaliana
Hodson, C.A.; Ambrogi, I.G.; Scott, R.O.; Mohler, P.J.; Milgram, S.L.
Polarized apical sorting of guanylyl cyclase C is specified by a cytosolic signal
Traffic
7
456-464
2006
Rattus norvegicus
Mingone, C.J.; Ahmad, M.; Gupte, S.A.; Chow, J.L.; Wolin, M.S.
Heme oxygenase-1 induction depletes heme and attenuates pulmonary artery relaxation and guanylate cyclase activation by nitric oxide
Am. J. Physiol. Heart Circ. Physiol.
294
H1244-H1250
2008
Bos taurus
Cabilla, J.P.; Ronchetti, S.A.; Nudler, S.I.; Miler, E.A.; Quinteros, F.A.; Duvilanski, B.H.
Nitric oxide sensitive-guanylyl cyclase subunits expression changes during estrous cycle in anterior pituitary glands
Am. J. Physiol. Endocrinol. Metab.
296
731-737
2009
Rattus norvegicus
Garin-Laflam, M.P.; Steinbrecher, K.A.; Rudolph, J.A.; Mao, J.; Cohen Md, M.B.
Activation of guanylate cyclase C signaling pathway protects intestinal epithelial cells from acute radiation-induced apoptosis
Am. J. Physiol. Gastrointest. Liver Physiol.
296
740-749
2009
Mus musculus, Mus musculus BALB/c
Jebelovszki, E.; Kiraly, C.; Erdei, N.; Feher, A.; Pasztor, E.T.; Rutkai, I.; Forster, T.; Edes, I.; Koller, A.; Bagi, Z.
High-fat diet-induced obesity leads to increased NO sensitivity of rat coronary arterioles: role of soluble guanylate cyclase activation
Am. J. Physiol. Heart Circ. Physiol.
294
H2558-H2564
2008
Rattus norvegicus
Zhou, Z.; Pyriochou, A.; Kotanidou, A.; Dalkas, G.; van Eickels, M.; Spyroulias, G.; Roussos, C.; Papapetropoulos, A.
Soluble guanylyl cyclase activation by HMR-1766 (ataciguat) in cells exposed to oxidative stress
Am. J. Physiol. Heart Circ. Physiol.
295
H1763-H1771
2008
Mus musculus
Schmidt, E.P.; Damarla, M.; Rentsendorj, O.; Servinsky, L.E.; Zhu, B.; Moldobaeva, A.; Gonzalez, A.; Hassoun, P.M.; Pearse, D.B.
Soluble guanylyl cyclase contributes to ventilator-induced lung injury in mice
Am. J. Physiol. Lung Cell Mol. Physiol.
295
L1056-L1065
2008
Mus musculus, Mus musculus C57BL/6
Perkins, W.J.; Kost, S.L.; Danielson, M.A.
Prolonged NO treatment decreases alpha adrenoreceptor agonist responsiveness in porcine pulmonary artery due to persistent soluble guanylyl cyclase activation
Am. J. Physiol. Lung Cell Mol. Physiol.
296
666-673
2009
Sus scrofa
Egemnazarov, B.; Sydykov, A.; Schermuly, R.T.; Weissmann, N.; Stasch, J.P.; Sarybaev, A.S.; Seeger, W.; Grimminger, F.; Ghofrani, H.A.
Novel soluble guanylyl cyclase stimulator BAY 41-2272 attenuates ischemia/reperfusion induced lung injury
Am. J. Physiol. Lung Cell Mol. Physiol.
296
L462-L469
2008
Oryctolagus cuniculus
Zhou, Z.; Sayed, N.; Pyriochou, A.; Roussos, C.; Fulton, D.; Beuve, A.; Papapetropoulos, A.
Protein kinase G phosphorylates soluble guanylyl cyclase on serine 64 and inhibits its activity
Arterioscler. Thromb. Vasc. Biol.
28
1803-1810
2008
Rattus norvegicus
Knorr, A.; Hirth-Dietrich, C.; Alonso-Alija, C.; Haerter, M.; Hahn, M.; Keim, Y.; Wunder, F.; Stasch, J.P.
Nitric oxide-independent activation of soluble guanylate cyclase by BAY 60-2770 in experimental liver fibrosis
Arzneimittelforschung
58
71-80
2008
Rattus norvegicus
Singh, S.; Gray, T.; Wurster, R.D.
Nitric oxide and carbon monoxide synthesizing enzymes and soluble guanylyl cyclase within neurons of adult human cardiac ganglia
Auton. Neurosci.
145
93-98
2009
Homo sapiens
Rosenzweig, D.H.; Nair, K.S.; Levay, K.; Peshenko, I.V.; Crabb, J.W.; Dizhoor, A.M.; Slepak, V.Z.
Interaction of retinal guanylate cyclase with the alpha subunit of transducin: potential role in transducin localization
Biochem. J.
417
803-812
2009
Bos taurus, Mus musculus, Homo sapiens (Q02846)
Derbyshire, E.R.; Gunn, A.; Ibrahim, M.; Spiro, T.G.; Britt, R.D.; Marletta, M.A.
Characterization of two different five-coordinate soluble guanylate cyclase ferrous-nitrosyl complexes
Biochemistry
47
3892-3899
2008
Rattus norvegicus
Capece, L.; Estrin, D.A.; Marti, M.A.
Dynamical characterization of the heme NO oxygen binding (HNOX) domain. Insight into soluble guanylate cyclase allosteric transition
Biochemistry
47
9416-9427
2008
Caldanaerobacter subterraneus subsp. tengcongensis
Coffey, M.J.; Phare, S.M.; Luo, M.; Peters-Golden, M.
Guanylyl cyclase and protein kinase G mediate nitric oxide suppression of 5-lipoxygenase metabolism in rat alveolar macrophages
Biochim. Biophys. Acta
1781
299-305
2008
Rattus norvegicus
Raetscho, N.; Scholten, A.; Koch, K.W.
Expression profiles of three novel sensory guanylate cyclases and guanylate cyclase-activating proteins in the zebrafish retina
Biochim. Biophys. Acta
1793
1110-1114
2009
Danio rerio (Q90WX0), Danio rerio (Q90WX1), Danio rerio (Q90WX2), Danio rerio
Antosova, M.; Strapkova, A.; Turcan, T.
Exogenous irritant-induced airway hyperreactivity and inhibition of soluble guanylyl cyclase
Biol. Res. Nurs.
10
93-101
2008
Cavia porcellus
Tian, X.; Michal, A.M.; Li, P.; Wolfe, H.R.; Waldman, S.A.; Wickstrom, E.
STa peptide analogs for probing guanylyl cyclase C
Biopolymers
90
713-723
2008
Homo sapiens, Mus musculus
Kumar, P.; Bolden, G.; Arise, K.K.; Krazit, S.T.; Pandey, K.N.
Regulation of natriuretic peptide receptor-A gene expression and stimulation of its guanylate cyclase activity by transcription factor Ets-1
Biosci. Rep.
29
57-70
2009
Mus musculus
Winger, J.A.; Derbyshire, E.R.; Lamers, M.H.; Marletta, M.A.; Kuriyan, J.
The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase
BMC Struct. Biol.
8
42
2008
Chlamydomonas reinhardtii (Q5YLC2), Chlamydomonas reinhardtii
El-Awady, M.S.; Smirnov, S.V.; Watson, M.L.
Desensitization of the soluble guanylyl cyclase/cGMP pathway by lipopolysaccharide in rat isolated pulmonary artery but not aorta
Br. J. Pharmacol.
155
1164-1173
2008
Rattus norvegicus
Oppermann, M.; Dao, V.T.; Suvorava, T.; Bas, M.; Kojda, G.
Effect of oral organic nitrates on expression and activity of vascular soluble guanylyl cyclase
Br. J. Pharmacol.
155
335-342
2008
Oryctolagus cuniculus, Mus musculus, Mus musculus C57BL/6
Haramis, G.; Zhou, Z.; Pyriochou, A.; Koutsilieris, M.; Roussos, C.; Papapetropoulos, A.
cGMP-independent anti-tumour actions of the inhibitor of soluble guanylyl cyclase, ODQ, in prostate cancer cell lines
Br. J. Pharmacol.
155
804-813
2008
Homo sapiens
Hoenicka, M.; Schmid, C.
Cardiovascular effects of modulators of soluble guanylyl cyclase activity
Cardiovasc. Hematol. Agents Med. Chem.
6
287-301
2008
Bos taurus, Canis lupus familiaris, Oryctolagus cuniculus, Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa, Ovis aries (Q8SPV3)
Ruiz-Torres, M.P.; Griera, M.; Chamorro, A.; Diez-Marques, M.L.; Rodriguez-Puyol, D.; Rodriguez-Puyol, M.
Tirofiban increases soluble guanylate cyclase in rat vascular walls: pharmacological and pathophysiological consequences
Cardiovasc. Res.
82
125-132
2009
Rattus norvegicus
Brahmajothi, M.V.; Campbell, D.L.
Heterogeneous expression of NO-activated soluble guanylyl cyclase in mammalian heart: implications for NO- and redox-mediated indirect versus direct regulation of cardiac ion channel function
Channels
1
353-365
2008
Homo sapiens, Mustela putorius furo
Sayed, N.; Kim, D.D.; Fioramonti, X.; Iwahashi, T.; Duran, W.N.; Beuve, A.
Nitroglycerin-induced S-nitrosylation and desensitization of soluble guanylyl cyclase contribute to nitrate tolerance
Circ. Res.
103
606-614
2008
Cricetinae
Nishida, T.; Yu, J.D.; Minamishima, S.; Sips, P.Y.; Searles, R.J.; Buys, E.S.; Janssens, S.; Brouckaert, P.; Bloch, K.D.; Ichinose, F.
Protective effects of nitric oxide synthase 3 and soluble guanylate cyclase on the outcome of cardiac arrest and cardiopulmonary resuscitation in mice
Crit. Care Med.
37
256-262
2009
Mus musculus
Schreier, B.; Boerner, S.; Voelker, K.; Gambaryan, S.; Schaefer, S.C.; Kuhlencordt, P.; Gassner, B.; Kuhn, M.
The heart communicates with the endothelium through the guanylyl cyclase-A receptor: acute handling of intravascular volume in response to volume expansion
Endocrinology
149
4193-4199
2008
Mus musculus
Ribeiro, M.; Straub, V.A.; Schofield, M.; Picot, J.; Benjamin, P.R.; OShea, M.; Korneev, S.A.
Characterization of NO-sensitive guanylyl cyclase: expression in an identified interneuron involved in NO-cGMP-dependent memory formation
Eur. J. Neurosci.
28
1157-1165
2008
Lymnaea stagnalis (B2MVM0)
Dhaese, I.; Vanneste, G.; Sips, P.; Buys, E.; Brouckaert, P.; Lefebvre, R.A.
Involvement of soluble guanylate cyclase alpha1 and alpha2, and SKCa channels in NANC relaxation of mouse distal colon
Eur. J. Pharmacol.
589
251-259
2008
Mus musculus
Schermuly, R.T.; Stasch, J.P.; Pullamsetti, S.S.; Middendorff, R.; Mueller, D.; Schlueter, K.D.; Dingendorf, A.; Hackemack, S.; Kolosionek, E.; Kaulen, C.; Dumitrascu, R.; Weissmann, N.; Mittendorf, J.; Klepetko, W.; Seeger, W.; Ghofrani, H.A.; Grimminger, F.
Expression and function of soluble guanylate cyclase in pulmonary arterial hypertension
Eur. Respir. J.
32
881-891
2008
Homo sapiens, Mus musculus, Rattus norvegicus
Grimminger, F.; Weimann, G.; Frey, R.; Voswinckel, R.; Thamm, M.; Boelkow, D.; Weissmann, N.; Mueck, W.; Unger, S.; Wensing, G.; Schermuly, R.T.; Ghofrani, H.A.
First acute haemodynamic study of soluble guanylate cyclase stimulator riociguat in pulmonary hypertension
Eur. Respir. J.
33
785-792
2009
Homo sapiens
Vazquez-Padron, R.I.; Pham, S.M.; Mateu, D.; Khan, S.; Aitouche, A.
An internal ribosome entry site mediates the initiation of soluble guanylyl cyclase beta2 mRNA translation
FEBS J.
275
3598-3607
2008
Homo sapiens (O75343), Homo sapiens
Jankowska, A.; Burczy?ska, B.; Duda, T.; Warchol, J.B.
Rod outer segment membrane guanylate cyclase type 1 (ROS-GC1) calcium-modulated transduction system in the sperm
Fertil. Steril.
93
904-912
2008
Homo sapiens
Bolin, C.; Cardozo-Pelaez, F.
Characterization of oxidized guanosine 5-triphosphate as a viable inhibitor of soluble guanylyl cyclase
Free Radic. Biol. Med.
46
828-835
2009
Bos taurus, Rattus norvegicus
Matsuda, N.M.; Lemos, M.C.; Feitosa, R.L.
The effect of guanylate cyclase inhibitors on non-adrenergic and non-cholinergic neurogenic relaxations of the South American opossum lower esophageal sphincter
Fundam. Clin. Pharmacol.
22
299-304
2008
Didelphis albiventris
Zheng, J.; Nakatsuji, T.; Roer, R.D.; Watson, R.D.
Studies of a receptor guanylyl cyclase cloned from Y-organs of the blue crab (Callinectes sapidus), and its possible functional link to ecdysteroidogenesis
Gen. Comp. Endocrinol.
155
780-788
2008
Callinectes sapidus (Q24LS5), Callinectes sapidus
Stasch, J.P.; Hobbs, A.J.
NO-independent, haem-dependent soluble guanylate cyclase stimulators
Handb. Exp. Pharmacol.
191
277-308
2009
Homo sapiens
Schmidt, H.H.; Schmidt, P.M.; Stasch, J.P.
NO- and haem-independent soluble guanylate cyclase activators
Handb. Exp. Pharmacol.
191
309-339
2009
Homo sapiens
Mergia, E.; Koesling, D.; Friebe, A.
Genetic mouse models of the NO receptor soluble guanylyl cyclases
Handb. Exp. Pharmacol.
191
33-46
2009
Mus musculus
Kuhn, M.
Function and dysfunction of mammalian membrane guanylyl cyclase receptors: lessons from genetic mouse models and implications for human diseases
Handb. Exp. Pharmacol.
191
47-69
2009
Homo sapiens, Homo sapiens (P16066), Homo sapiens (P20594), Homo sapiens (P25092), Homo sapiens (P51841), Mus musculus
Zhang, Q.; Saito, Y.; Naya, N.; Imagawa, K.; Somekawa, S.; Kawata, H.; Takeda, Y.; Uemura, S.; Kishimoto, I.; Nakao, K.
The specific mineralocorticoid receptor blocker eplerenone attenuates left ventricular remodeling in mice lacking the gene encoding guanylyl cyclase-A
Hypertens. Res.
31
1251-1256
2008
Mus musculus
Usami, S.; Kishimoto, I.; Saito, Y.; Harada, M.; Kuwahara, K.; Nakagawa, Y.; Nakanishi, M.; Yasuno, S.; Kangawa, K.; Nakao, K.
Association of CT dinucleotide repeat polymorphism in the 5-flanking region of the guanylyl cyclase (GC)-A gene with essential hypertension in the Japanese
Hypertens. Res.
31
89-96
2008
Homo sapiens
Ellis, D.Z.; Dismuke, W.M.; Chokshi, B.M.
Characterization of soluble guanylate cyclase in NO-induced increases in aqueous humor outflow facility and in the trabecular meshwork
Invest. Ophthalmol. Vis. Sci.
50
1808-1813
2008
Homo sapiens, Sus scrofa
Lin, H.; Cheng, C.F.; Hou, H.H.; Lian, W.S.; Chao, Y.C.; Ciou, Y.Y.; Djoko, B.; Tsai, M.T.; Cheng, C.J.; Yang, R.B.
Disruption of guanylyl cyclase-G protects against acute renal injury
J. Am. Soc. Nephrol.
19
339-348
2008
Mus musculus (Q6TL19), Mus musculus
Sharina, I.G.; Jelen, F.; Bogatenkova, E.P.; Thomas, A.; Martin, E.; Murad, F.
Alpha1 soluble guanylyl cyclase (sGC) splice forms as potential regulators of human sGC activity
J. Biol. Chem.
283
15104-15113
2008
Homo sapiens (Q02108), Homo sapiens
Roy, B.; Halvey, E.J.; Garthwaite, J.
An enzyme-linked receptor mechanism for nitric oxide-activated guanylyl cyclase
J. Biol. Chem.
283
18841-18851
2008
Bos taurus
Marro, M.L.; Peiro, C.; Panayiotou, C.M.; Baliga, R.S.; Meurer, S.; Schmidt, H.H.; Hobbs, A.J.
Characterization of the human alpha1 beta1 soluble guanylyl cyclase promoter: key role for NF-kappaB(p50) and CCAAT-binding factors in regulating expression of the nitric oxide receptor
J. Biol. Chem.
283
20027-20036
2008
Homo sapiens
Hu, X.; Murata, L.B.; Weichsel, A.; Brailey, J.L.; Roberts, S.A.; Nighorn, A.; Montfort, W.R.
Allostery in recombinant soluble guanylyl cyclase from Manduca sexta
J. Biol. Chem.
283
20968-20977
2008
Manduca sexta (Q8IT60), Manduca sexta
Peshenko, I.V.; Olshevskaya, E.V.; Dizhoor, A.M.
Binding of guanylyl cyclase activating protein 1 (GCAP1) to retinal guanylyl cyclase (RetGC1). The role of individual EF-hands
J. Biol. Chem.
283
21747-21757
2008
Homo sapiens
Hartmann, M.; Skryabin, B.V.; Mueller, T.; Gazinski, A.; Schroeter, J.; Gassner, B.; Nikolaev, V.O.; Buenemann, M.; Kuhn, M.
Alternative splicing of the guanylyl cyclase-A receptor modulates atrial natriuretic peptide signaling
J. Biol. Chem.
283
28313-28320
2008
Mus musculus (P18293)
Makino, C.L.; Peshenko, I.V.; Wen, X.H.; Olshevskaya, E.V.; Barrett, R.; Dizhoor, A.M.
A role for GCAP2 in regulating the photoresponse. Guanylyl cyclase activation and rod electrophysiology in GUCA1B knock-out mice
J. Biol. Chem.
283
29135-29143
2008
Mus musculus
Maron, B.A.; Zhang, Y.Y.; Handy, D.E.; Beuve, A.; Tang, S.S.; Loscalzo, J.; Leopold, J.A.
Aldosterone increases oxidant stress to impair guanylyl cyclase activity by cysteinyl thiol oxidation in vascular smooth muscle cells
J. Biol. Chem.
284
7665-7672
2009
Bos taurus
Behnen, P.; Scholten, A.; Raetscho, N.; Koch, K.W.
The cone-specific calcium sensor guanylate cyclase activating protein 4 from the zebrafish retina
J. Biol. Inorg. Chem.
14
89-99
2009
Bos taurus, Danio rerio
Powers-Martin, K.; Barron, A.M.; Auckland, C.H.; McCooke, J.K.; McKitrick, D.J.; Arnolda, L.F.; Phillips, J.K.
Immunohistochemical assessment of cyclic guanosine monophosphate (cGMP) and soluble guanylate cyclase (sGC) within the rostral ventrolateral medulla
J. Biomed. Sci.
15
801-812
2008
Rattus norvegicus
Frey, R.; Mueck, W.; Unger, S.; Artmeier-Brandt, U.; Weimann, G.; Wensing, G.
Pharmacokinetics, pharmacodynamics, tolerability, and safety of the soluble guanylate cyclase activator cinaciguat (BAY 58-2667) in healthy male volunteers
J. Clin. Pharmacol.
48
1400-1410
2008
Homo sapiens
Frey, R.; Mueck, W.; Unger, S.; Artmeier-Brandt, U.; Weimann, G.; Wensing, G.
Single-dose pharmacokinetics, pharmacodynamics, tolerability, and safety of the soluble guanylate cyclase stimulator BAY 63-2521: an ascending-dose study in healthy male volunteers
J. Clin. Pharmacol.
48
926-934
2008
Homo sapiens
Morton, D.B.; Stewart, J.A.; Langlais, K.K.; Clemens-Grisham, R.A.; Vermehren, A.
Synaptic transmission in neurons that express the Drosophila atypical soluble guanylyl cyclases, Gyc-89Da and Gyc-89Db, is necessary for the successful completion of larval and adult ecdysis
J. Exp. Biol.
211
1645-1656
2008
Drosophila melanogaster (Q9VEU5), Drosophila melanogaster (Q9VEU6), Drosophila melanogaster
Snook, A.E.; Stafford, B.J.; Li, P.; Tan, G.; Huang, L.; Birbe, R.; Schulz, S.; Schnell, M.J.; Thakur, M.; Rothstein, J.L.; Eisenlohr, L.C.; Waldman, S.A.
Guanylyl cyclase C-induced immunotherapeutic responses opposing tumor metastases without autoimmunity
J. Natl. Cancer Inst.
100
950-961
2008
Mus musculus (Q3UWA6), Mus musculus, Mus musculus BALB/c (Q3UWA6)
Schmidtko, A.; Gao, W.; Koenig, P.; Heine, S.; Motterlini, R.; Ruth, P.; Schlossmann, J.; Koesling, D.; Niederberger, E.; Tegeder, I.; Friebe, A.; Geisslinger, G.
cGMP produced by NO-sensitive guanylyl cyclase essentially contributes to inflammatory and neuropathic pain by using targets different from cGMP-dependent protein kinase I
J. Neurosci.
28
8568-8576
2008
Mus musculus
Moreno, J.A.; Sullivan, K.A.; Carbone, D.L.; Hanneman, W.H.; Tjalkens, R.B.
Manganese potentiates nuclear factor-kappaB-dependent expression of nitric oxide synthase 2 in astrocytes by activating soluble guanylate cyclase and extracellular responsive kinase signaling pathways
J. Neurosci. Res.
86
2028-2038
2008
Mus musculus, Mus musculus C57BL/6
Lee, H.G.; Kim, S.Y.; Kim, d.u..S.; Seo, S.R.; Lee, S.I.; Shin, D.M.; De Smet, P.; Seo, J.T.
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one inhibits neurite outgrowth and causes neurite retraction in PC12 cells independently of soluble guanylyl cyclase
J. Neurosci. Res.
87
269-277
2009
Homo sapiens
Fusi, F.; Ferrara, A.; Koorbanally, C.; Crouch, N.R.; Mulholland, D.A.; Sgaragli, G.
Vascular myorelaxing activity of isolates from South African Hyacinthaceae partly mediated by activation of soluble guanylyl cyclase in rat aortic ring preparations
J. Pharm. Pharmacol.
60
489-497
2008
Rattus norvegicus
Murthy, K.S.
Inhibitory phosphorylation of soluble guanylyl cyclase by muscarinic m2 receptors via Gbetagamma-dependent activation of c-Src kinase
J. Pharmacol. Exp. Ther.
325
183-189
2008
Oryctolagus cuniculus
Nagayama, T.; Zhang, M.; Hsu, S.; Takimoto, E.; Kass, D.A.
Sustained soluble guanylate cyclase stimulation offsets nitric-oxide synthase inhibition to restore acute cardiac modulation by sildenafil
J. Pharmacol. Exp. Ther.
326
380-387
2008
Mus musculus
Fernandes, D.; de Sordi, R.; Pacheco, L.K.; Nardi, G.M.; Heckert, B.T.; Villela, C.G.; Lobo, A.R.; Barja-Fidalgo, C.; Assreuy, J.
Late but not early inhibition of soluble guanylate cyclase decreases mortality in a rat sepsis model
J. Pharmacol. Exp. Ther.
328
991-999
2008
Rattus norvegicus (P19686), Rattus norvegicus (Q80WY4)
Szmidt-Jaworska, A.; Jaworski, K.; Kopcewicz, J.
Effect of light on soluble guanylyl cyclase activity in Pharbitis nil seedlings
J. Photochem. Photobiol. B Biol.
93
9-15
2008
Ipomoea nil (Q0PY32), Ipomoea nil
Gambaryan, S.; Kobsar, A.; Hartmann, S.; Birschmann, I.; Kuhlencordt, P.J.; Mueller-Esterl, W.; Lohmann, S.M.; Walter, U.
NO-synthase-/NO-independent regulation of human and murine platelet soluble guanylyl cyclase activity
J. Thromb. Haemost.
6
1376-1384
2008
Homo sapiens, Mus musculus
Nakachi, M.; Matsumoto, M.; Terry, P.M.; Cerny, R.L.; Moriyama, H.
Identification of guanylate cyclases and related signaling proteins in sperm tail from sea stars by mass spectrometry
Mar. Biotechnol.
10
564-571
2008
Asterias amurensis (Q8TA72), Asterias amurensis, Asterias forbesi, Patiria pectinifera
Punathil, T.; Katiyar, S.K.
Inhibition of non-small cell lung cancer cell migration by grape seed proanthocyanidins is mediated through the inhibition of nitric oxide, guanylate cyclase, and ERK1/2
Mol. Carcinog.
48
232-242
2008
Homo sapiens
Duda, T.; Bharill, S.; Wojtas, I.; Yadav, P.; Gryczynski, I.; Gryczynski, Z.; Sharma, R.K.
Atrial natriuretic factor receptor guanylate cyclase signaling: new ATP-regulated transduction motif
Mol. Cell. Biochem.
324
39-53
2009
Mus musculus
Maddison, L.A.; Lu, J.; Victoroff, T.; Scott, E.; Baier, H.; Chen, W.
A gain-of-function screen in zebrafish identifies a guanylate cyclase with a role in neuronal degeneration
Mol. Genet. Genomics
281
551-563
2009
Danio rerio
Mayer, B.; Kleschyov, A.L.; Stessel, H.; Russwurm, M.; Munzel, T.; Koesling, D.; Schmidt, K.
Inactivation of soluble guanylate cyclase by stoichiometric S-nitrosation
Mol. Pharmacol.
75
886-891
2008
Bos taurus
De Backer, O.; Elinck, E.; Sips, P.; Buys, E.; Brouckaert, P.; Lefebvre, R.A.
Role of the soluble guanylyl cyclase alpha1/alpha2 subunits in the relaxant effect of CO and CORM-2 in murine gastric fundus
Naunyn Schmiedebergs Arch. Pharmacol.
378
493-502
2008
Mus musculus
Dhaese, I.; Vanneste, G.; Sips, P.; Buys, E.S.; Brouckaert, P.; Lefebvre, R.A.
Small intestinal motility in soluble guanylate cyclase alpha1 knockout mice: (Jejunal phenotyping of sGCalpha1 knockout mice)
Naunyn Schmiedebergs Arch. Pharmacol.
379
473-487
2008
Mus musculus
Alzoubi, K.H.; Alkadhi, K.A.
Calmodulin and guanylyl cyclase inhibitors block the in vivo expression of gLTP in sympathetic ganglia from chronically stressed rats
Neurosci. Res.
63
95-99
2009
Rattus norvegicus
Iino, S.; Horiguchi, K.; Nojyo, Y.
Interstitial cells of Cajal are innervated by nitrergic nerves and express nitric oxide-sensitive guanylate cyclase in the guinea-pig gastrointestinal tract
Neuroscience
152
437-448
2008
Cavia porcellus
Kollau, A.; Beretta, M.; Russwurm, M.; Koesling, D.; Keung, W.M.; Schmidt, K.; Mayer, B.
Mitochondrial nitrite reduction coupled to soluble guanylate cyclase activation: lack of evidence for a role in the bioactivation of nitroglycerin
Nitric Oxide
20
53-60
2009
Bos taurus
Abdelalim, E.M.; Masuda, C.; Tooyama, I.
Expression of natriuretic peptide-activated guanylate cyclases by cholinergic and dopaminergic amacrine cells of the rat retina
Peptides
29
622-628
2008
Rattus norvegicus (P16067), Rattus norvegicus (P18910)
Sun, L.; Wang, H.; Hu, J.; Han, J.; Matsunami, H.; Luo, M.
Guanylyl cyclase-D in the olfactory CO2 neurons is activated by bicarbonate
Proc. Natl. Acad. Sci. USA
106
2041-2046
2009
Mus musculus
Lauber, T.; Tidten, N.; Matecko, I.; Zeeb, M.; Roesch, P.; Marx, U.C.
Design and characterization of a soluble fragment of the extracellular ligand-binding domain of the peptide hormone receptor guanylyl cyclase-C
Protein Eng. Des. Sel.
22
1-7
2009
Sus scrofa (P55204)
Mathis, K.J.; Emmons, T.L.; Curran, D.F.; Day, J.E.; Tomasselli, A.G.
High yield purification of soluble guanylate cyclase from bovine lung
Protein Expr. Purif.
60
58-63
2008
Bos taurus (P16068), Bos taurus (P19687), Bos taurus
Emmons, T.L.; Mathis, K.J.; Shuck, M.E.; Reitz, B.A.; Curran, D.F.; Walker, M.C.; Leone, J.W.; Day, J.E.; Bienkowski, M.J.; Fischer, H.D.; Tomasselli, A.G.
Purification and characterization of recombinant human soluble guanylate cyclase produced from baculovirus-infected insect cells
Protein Expr. Purif.
65
133-139
2009
Homo sapiens
Bartholomew, J.; Reichart, J.; Mundy, R.; Recktenwald, J.; Keyser, S.; Riddle, M.; Kuruvilla, H.
GTP avoidance in Tetrahymena thermophila requires tyrosine kinase activity, intracellular calcium, NOS, and guanylyl cyclase
Purinergic Signal.
4
171-181
2008
Tetrahymena thermophila, Tetrahymena thermophila B2086
Vanneste, G.; Van Nassauw, L.; Kalfin, R.; Van Colen, I.; Elinck, E.; Van Crombruggen, K.; Timmermans, J.P.; Lefebvre, R.A.
Jejunal cholinergic, nitrergic, and soluble guanylate cyclase activity in postoperative ileus
Surgery
144
410-426
2008
Rattus norvegicus (Q02108), Rattus norvegicus (Q02153)
Toque, H.A.; Antunes, E.; Teixeira, C.E.; De Nucci, G.
Increased cyclic guanosine monophosphate synthesis and calcium entry blockade account for the relaxant activity of the nitric oxide-independent soluble guanylyl cyclase stimulator BAY 41-2272 in the rabbit penile urethra
Urology
72
711-715
2008
Oryctolagus cuniculus
Murphy, B.A.; Fakira, K.A.; Song, Z.; Beuve, A.; Routh, V.H.
AMP-activated protein kinase and nitric oxide regulate the glucose sensitivity of ventromedial hypothalamic glucose-inhibited neurons
Am. J. Physiol. Cell Physiol.
297
C750-C758
2009
Rattus norvegicus
Morbidelli, L.; Pyriochou, A.; Filippi, S.; Vasileiadis, I.; Roussos, C.; Zhou, Z.; Loutrari, H.; Waltenberger, J.; Stoessel, A.; Giannis, A.; Ziche, M.; Papapetropoulos, A.
The soluble guanylyl cyclase inhibitor NS-2028 reduces vascular endothelial growth factor-induced angiogenesis and permeability
Am. J. Physiol. Regul. Integr. Comp. Physiol.
298
R824-R832
2010
Homo sapiens
Newton, M.; Niewczas, I.; Clark, J.; Bellamy, T.C.
A real-time fluorescent assay of the purified nitric oxide receptor, guanylyl cyclase
Anal. Biochem.
402
129-136
2010
Homo sapiens
Sovershaev, M.A.; Egorina, E.M.; Hansen, J.B.; Osterud, B.; Pacher, P.; Stasch, J.P.; Evgenov, O.V.
Soluble guanylate cyclase agonists inhibit expression and procoagulant activity of tissue factor
Arterioscler. Thromb. Vasc. Biol.
29
1578-1586
2009
Homo sapiens
Spyridonidou, K.; Fousteris, M.; Antonia, M.; Chatzianastasiou, A.; Papapetropoulos, A.; Nikolaropoulos, S.
Tricyclic indole and dihydroindole derivatives as new inhibitors of soluble guanylate cyclase
Bioorg. Med. Chem. Lett.
19
4810-4813
2009
Rattus norvegicus
von Wantoch Rekowski, M.; Pyriochou, A.; Papapetropoulos, N.; Stoessel, A.; Papapetropoulos, A.; Giannis, A.
Synthesis and biological evaluation of oxadiazole derivatives as inhibitors of soluble guanylyl cyclase
Bioorg. Med. Chem.
18
1288-1296
2010
Rattus norvegicus
Ma, X.; Beuve, A.; van den Akker, F.
Crystal structure of the signaling helix coiled-coil domain of the beta1 subunit of the soluble guanylyl cyclase
BMC Struct. Biol.
10
2-2
2010
Rattus norvegicus (P20595)
James, L.R.; Griffiths, C.H.; Garthwaite, J.; Bellamy, T.C.
Inhibition of nitric oxide-activated guanylyl cyclase by calmodulin antagonists
Br. J. Pharmacol.
158
1454-1464
2009
Bos taurus
Miller, T.W.; Isenberg, J.S.; Roberts, D.D.
Thrombospondin-1 is an inhibitor of pharmacological activation of soluble guanylate cyclase
Br. J. Pharmacol.
159
1542-1547
2010
Homo sapiens
Mueck, W.; Frey, R.
Population pharmacokinetics and pharmacodynamics of cinaciguat, a soluble guanylate cyclase activator, in patients with acute decompensated heart failure
Clin. Pharmacokinet.
49
119-129
2010
Homo sapiens
Li, Y.; Saito, Y.; Kuwahara, K.; Rong, X.; Kishimoto, I.; Harada, M.; Adachi, Y.; Nakanishi, M.; Kinoshita, H.; Horiuchi, M.; Murray, M.; Nakao, K.
Guanylyl cyclase-A inhibits angiotensin II type 2 receptor-mediated pro-hypertrophic signaling in the heart
Endocrinology
150
3759-3765
2009
Mus musculus
Cardoso, M.H.; Morganti, R.P.; Lilla, S.; Murad, F.; De Nucci, G.; Antunes, E.; Marcondes, S.
The role of superoxide anion in the inhibitory effect of SIN-1 in thrombin-activated human platelet adhesion
Eur. J. Pharmacol.
627
229-234
2010
Homo sapiens
Riego, J.A.; Broniowska, K.A.; Kettenhofen, N.J.; Hogg, N.
Activation and inhibition of soluble guanylyl cyclase by S-nitrosocysteine: involvement of amino acid transport system L
Free Radic. Biol. Med.
47
269-274
2009
Homo sapiens
Suryanarayana, S.; Goettle, M.; Huebner, M.; Gille, A.; Mou, T.C.; Sprang, S.R.; Richter, M.; Seifert, R.
Differential inhibition of various adenylyl cyclase isoforms and soluble guanylyl cyclase by 2,3-O-(2,4,6-trinitrophenyl)-substituted nucleoside 5-triphosphates
J. Pharmacol. Exp. Ther.
330
687-695
2009
Homo sapiens
Hidaka, A.; Azuma, Y.T.; Nakajima, H.; Takeuchi, T.
Nitric oxide and carbon monoxide act as inhibitory neurotransmitters in the longitudinal muscle of C57BL/6J mouse distal colon
J. Pharmacol. Sci.
112
231-241
2010
Mus musculus
Park, W.S.; Ko, J.H.; Ko, E.A.; Son, Y.K.; Hong, d.a..H.; Jung, I.D.; Park, Y.M.; Choi, T.H.; Kim, N.; Han, J.
The guanylyl cyclase activator YC-1 directly inhibits the voltage-dependent K+ channels in rabbit coronary arterial smooth muscle cells
J. Pharmacol. Sci.
112
64-72
2010
Oryctolagus cuniculus
Spohr, F.; Busch, C.J.; Teschendorf, P.; Weimann, J.
Selective inhibition of guanylate cyclase prevents impairment of hypoxic pulmonary vasoconstriction in endotoxemic mice
J. Physiol. Pharmacol.
60(2)
107-112
2009
Mus musculus
Ribeiro, M.; Schofield, M.; Kemenes, I.; Benjamin, P.R.; OShea, M.; Korneev, S.A.
Atypical guanylyl cyclase from the pond snail Lymnaea stagnalis: cloning, sequence analysis and characterization of expression
Neuroscience
165
794-800
2010
Lymnaea stagnalis (B2MVM2), Lymnaea stagnalis
Haase, N.; Haase, T.; Kraehling, J.R.; Behrends, S.
Direct fusion of subunits of heterodimeric nitric oxide sensitive guanylyl cyclase leads to functional enzymes with preserved biochemical properties: evidence for isoform specific activation by ciguates
Biochem. Pharmacol.
80
1676-1683
2010
Rattus norvegicus
Baskaran, P.; Heckler, E.J.; van den Akker, F.; Beuve, A.
Aspartate 102 in the heme domain of soluble guanylyl cyclase has a key role in NO activation
Biochemistry
50
4291-4297
2011
Rattus norvegicus
Peshenko, I.V.; Olshevskaya, E.V.; Savchenko, A.B.; Karan, S.; Palczewski, K.; Baehr, W.; Dizhoor, A.M.
Enzymatic properties and regulation of the native isozymes of retinal membrane guanylyl cyclase (RetGC) from mouse photoreceptors
Biochemistry
50
5590-5600
2011
Mus musculus
Ramanathan, S.; Mazzalupo, S.; Boitano, S.; Montfort, W.R.
Thrombospondin-1 and angiotensin II inhibit soluble guanylyl cyclase through an increase in intracellular calcium concentration
Biochemistry
50
7787-7799
2011
Homo sapiens
Shpakov, A.; Derkach, K.; Chistyakova, O.; Pertseva, M.
Changes in the functional activity of membrane-bound guanylate cyclase forms in tissues of diabetic rats
Dokl. Biochem. Biophys.
433
219-222
2010
Rattus norvegicus
Mulaudzi, T.; Ludidi, N.; Ruzvidzo, O.; Morse, M.; Hendricks, N.; Iwuoha, E.; Gehring, C.
Identification of a novel Arabidopsis thaliana nitric oxide-binding molecule with guanylate cyclase activity in vitro
FEBS Lett.
585
2693-2697
2011
Arabidopsis thaliana
Makino, R.; Park, S.Y.; Obayashi, E.; Iizuka, T.; Hori, H.; Shiro, Y.
Oxygen binding and redox properties of the heme in soluble guanylate cyclase: implications for the mechanism of ligand discrimination
J. Biol. Chem.
286
15678-15687
2011
Bos taurus
Kwezi, L.; Ruzvidzo, O.; Wheeler, J.I.; Govender, K.; Iacuone, S.; Thompson, P.E.; Gehring, C.; Irving, H.R.
The phytosulfokine (PSK) receptor is capable of guanylate cyclase activity and enabling cyclic GMP-dependent signaling in plants
J. Biol. Chem.
286
22580-22588
2011
Arabidopsis thaliana
Robinson, J.W.; Potter, L.R.
ATP potentiates competitive inhibition of guanylyl cyclase A and B by the staurosporine analog, Go6976: Reciprocal regulation of ATP and GTP binding
J. Biol. Chem.
286
33841-33844
2011
Homo sapiens
Secca, T.; Sciaccaluga, M.; Marra, A.; Barberini, L.; Bicchierai, M.C.
Biochemical activity and multiple locations of particulate guanylate cyclase in Rhyacophila dorsalis acutidens (Insecta: Trichoptera) provide insights into the cGMP signalling pathway in Malpighian tubules
J. Insect Physiol.
57
521-528
2011
Rhyacophila dorsalis
Ashton, A.
Guanylyl cyclase activity in plants?
Proc. Natl. Acad. Sci. USA
108
E96
2011
Arabidopsis thaliana
Gong, R.; Ding, C.; Hu, J.; Lu, Y.; Liu, F.; Mann, E.; Xu, F.; Cohen, M.B.; Luo, M.
Role for the membrane receptor guanylyl cyclase-C in attention deficiency and hyperactive behavior
Science
333
1642-1646
2011
Mus musculus
Baehre, H.; Danker, K.Y.; Stasch, J.P.; Kaever, V.; Seifert, R.
Nucleotidyl cyclase activity of soluble guanylyl cyclase in intact cells
Biochem. Biophys. Res. Commun.
443
1195-1199
2014
Homo sapiens
Seeger, F.; Quintyn, R.; Tanimoto, A.; Williams, G.J.; Tainer, J.A.; Wysocki, V.H.; Garcin, E.D.
Interfacial residues promote an optimal alignment of the catalytic center in human soluble guanylate cyclase: heterodimerization is required but not sufficient for activity
Biochemistry
53
2153-2165
2014
Homo sapiens (Q02108), Homo sapiens
Shpakov, A.O.; Derkach, K.V.; Uspenskaya, Z.I.
Glucose and cyclic adenosine monophosphate stimulate activities of adenylate cyclase and guanylate cyclase of Tetrahymena pyriformis infusoria
Bull. Exp. Biol. Med.
152
427-430
2012
Tetrahymena pyriformis
Arshad, N.; Ballal, S.; Visweswariah, S.S.
Site-specific N-linked glycosylation of receptor guanylyl cyclase C regulates ligand binding, ligand-mediated activation and interaction with vesicular integral membrane protein 36, VIP36
J. Biol. Chem.
288
3907-3917
2013
Homo sapiens
Baskaran, P.; Heckler, E.J.; van den Akker, F.; Beuve, A.
Identification of residues in the heme domain of soluble guanylyl cyclase that are important for basal and stimulated catalytic activity
PLoS ONE
6
e26976
2011
Rattus norvegicus (P20595)
Allerston, C.K.; von Delft, F.; Gileadi, O.
Crystal structures of the catalytic domain of human soluble guanylate cyclase
PLoS ONE
8
e57644
2013
Homo sapiens (Q02108), Homo sapiens
Ghosh, A.; Stuehr, D.J.
Soluble guanylyl cyclase requires heat shock protein 90 for heme insertion during maturation of the NO-active enzyme
Proc. Natl. Acad. Sci. USA
109
12998-13003
2012
Rattus norvegicus
Purohit, R.; Weichsel, A.; Montfort, W.R.
Crystal structure of the alpha subunit PAS domain from soluble guanylyl cyclase
Protein Sci.
22
1439-1444
2013
Manduca sexta (O77105)
Robinson, J.W.; Potter, L.R.
Guanylyl cyclases A and B are asymmetric dimers that are allosterically activated by ATP binding to the catalytic domain
Sci. Signal.
5
ra65
2012
Homo sapiens
Yang, S.; Zhang, J.; Ji, K.; Jiao, D.; Fan, R.; Dong, C.
Characterization and expression of soluble guanylate cyclase in skins and melanocytes of sheep
Acta Histochem.
118
219-224
2016
Ovis aries
Tanwar, M.; Sharma, K.; Moar, P.; Kateriya, S.
Biochemical characterization of the engineered soluble photoactivated guanylate cyclases from microbes expands optogenetic tools
Appl. Biochem. Biotechnol.
185
1014-1028
2018
Naegleria gruberi, Turneriella parva, Turneriella parva DSM 21527
Soemmer, A.; Sandner, P.; Behrends, S.
BAY 60-2770 activates two isoforms of nitric oxide sensitive guanylyl cyclase Evidence for stable insertion of activator drugs
Biochem. Pharmacol.
147
10-20
2018
Homo sapiens
Makino, R.; Obata, Y.; Tsubaki, M.; Iizuka, T.; Hamajima, Y.; Kato-Yamada, Y.; Mashima, K.; Shiro, Y.
Mechanistic insights into the activation of soluble guanylate cyclase by carbon monoxide a multistep mechanism proposed for the BAY 41-2272 induced formation of 5-coordinate CO-heme
Biochemistry
57
1620-1631
2018
Bos taurus
Duda, T.; Wen, X.H.; Isayama, T.; Sharma, R.K.; Makino, C.L.
Bicarbonate modulates photoreceptor guanylate cyclase (ROS-GC) catalytic activity
J. Biol. Chem.
290
11052-11060
2015
Bos taurus (O02740), Bos taurus (P55203)
Peshenko, I.V.; Olshevskaya, E.V.; Dizhoor, A.M.
Evaluating the role of retinal membrane guanylyl cyclase 1 (RetGC1) domains in binding guanylyl cyclase-activating proteins (GCAPs)
J. Biol. Chem.
290
6913-6924
2015
Homo sapiens (Q02846)
Dickey, D.M.; Edmund, A.B.; Otto, N.M.; Chaffee, T.S.; Robinson, J.W.; Potter, L.R.
Catalytically active guanylyl cyclase B requires endoplasmic reticulum-mediated glycosylation, and mutations that inhibit this process cause dwarfism
J. Biol. Chem.
291
11385-11393
2016
Homo sapiens (P20594)
Otto, N.M.; McDowell, W.G.; Dickey, D.M.; Potter, L.R.
A glutamate-substituted mutant mimics the phosphorylated and active form of guanylyl cyclase-A
Mol. Pharmacol.
92
67-74
2017
Homo sapiens (P16066)
Kollau, A.; Opelt, M.; Woelkart, G.; Gorren, A.C.F.; Russwurm, M.; Koesling, D.; Mayer, B.; Schrammel, A.
Irreversible activation and stabilization of soluble guanylate cyclase by the protoporphyrin IX mimetic cinaciguat
Mol. Pharmacol.
93
73-78
2018
Sus scrofa
Scheib, U.; Broser, M.; Constantin, O.M.; Yang, S.; Gao, S.; Mukherjee, S.; Stehfest, K.; Nagel, G.; Gee, C.E.; Hegemann, P5
Rhodopsin-cyclases for photocontrol of cGMP/cAMP and 2.3 A structure of the adenylyl cyclase domain
Nat. Commun.
9
2046
2018
Blastocladiella emersonii, Catenaria anguillulae (A0A1Y2HEJ3), Catenaria anguillulae, Catenaria anguillulae PL171 (A0A1Y2HEJ3)
Agullo, L.; Buch, I.; Gutierrez-de-Teran, H.; Garcia-Dorado, D.; Villa-Freixa, J.
Computational exploration of the binding mode of heme-dependent stimulators into the active catalytic domain of soluble guanylate cyclase
Proteins
84
1534-1548
2016
Homo sapiens (Q02153)
Cortese-Krott, M.M.; Mergia, E.; Kramer, C.M.; Lueckstaedt, W.; Yang, J.; Wolff, G.; Panknin, C.; Bracht, T.; Sitek, B.; Pernow, J.; Stasch, J.P.; Feelisch, M.; Koesling, D.; Kelm, M.
Identification of a soluble guanylate cyclase in RBCs preserved activity in patients with coronary artery disease
Redox Biol.
14
328-337
2018
Homo sapiens
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