3.5.4.1: cytosine deaminase
This is an abbreviated version!
For detailed information about cytosine deaminase, go to the full flat file.
Word Map on EC 3.5.4.1
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3.5.4.1
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cytidine
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deaminases
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5-fluorocytosine
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deamination
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prodrugs
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virion
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hypermutation
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viruses
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5-fluorouracil
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apolipoprotein
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retroviruses
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suicide
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uracil
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retroviral
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apobecs
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single-stranded
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antiretroviral
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polypeptide-like
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mrna-editing
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g-to-a
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bystander
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activation-induced
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retrotransposons
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anti-hiv-1
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proviral
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retroelements
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lentiviruses
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encapsidation
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ganciclovir
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deoxycytidine
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retrotransposition
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ssdna
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fiv
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samhd1
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cullin
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minus-strand
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replication-competent
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gene-directed
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sivmac
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medicine
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line-1
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hsv-tk
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vpr
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gdept
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non-ltr
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molecular biology
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xenotropic
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analysis
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pharmacology
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biotechnology
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trim5alpha
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diagnostics
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proviruses
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nickase
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agriculture
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single-cycle
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elongins
- 3.5.4.1
- cytidine
- deaminases
- 5-fluorocytosine
-
deamination
-
prodrugs
- virion
-
hypermutation
- viruses
- 5-fluorouracil
-
apolipoprotein
- retroviruses
-
suicide
- uracil
-
retroviral
-
apobecs
-
single-stranded
-
antiretroviral
-
polypeptide-like
-
mrna-editing
-
g-to-a
-
bystander
-
activation-induced
-
retrotransposons
-
anti-hiv-1
-
proviral
-
retroelements
- lentiviruses
-
encapsidation
- ganciclovir
- deoxycytidine
-
retrotransposition
- ssdna
- fiv
- samhd1
-
cullin
-
minus-strand
-
replication-competent
-
gene-directed
- sivmac
- medicine
-
line-1
-
hsv-tk
- vpr
-
gdept
-
non-ltr
- molecular biology
-
xenotropic
- analysis
- pharmacology
- biotechnology
- trim5alpha
- diagnostics
- proviruses
-
nickase
- agriculture
-
single-cycle
-
elongins
Reaction
Synonyms
A3DE, APOBEC1, APOBEC3, APOBEC3G, CD, CDA, CDase, codA, CodA protein, Cytosine aminohydrolase, cytosine deaminase, cytosine deaminase I, cytosine deaminase II, cytosine deaminase P, cytosine deaminase S, cytosine deaminase Y, Fca1p, FCY1, isocytosine deaminase, yCD, Zn2+CDase
ECTree
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Reaction
Reaction on EC 3.5.4.1 - cytosine deaminase
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cytosine + H2O = uracil + NH3
active site architecture and substrate binding, catalytic mechanism
cytosine + H2O = uracil + NH3
substrate binding involves a significant conformational change that sequesters the reaction complex from solvent, active site architecture and substrate binding, catalytic mechanism
cytosine + H2O = uracil + NH3
E64 side-chain carboxyl group acts as proton shuttle between the Zn-bound water molecule and cytosine. In course of reaction, cytosine reorients to favor nucleophilic attack by a Zn-bound hydroxide. F114 may be important for reactant binding and product release
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