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3.5.4.1: cytosine deaminase

This is an abbreviated version!
For detailed information about cytosine deaminase, go to the full flat file.

Word Map on EC 3.5.4.1

Reaction

cytosine
+
H2O
=
Uracil
 +
NH3

Synonyms

A3DE, APOBEC1, APOBEC3, APOBEC3G, CD, CDA, CDase, codA, CodA protein, Cytosine aminohydrolase, cytosine deaminase, cytosine deaminase I, cytosine deaminase II, cytosine deaminase P, cytosine deaminase S, cytosine deaminase Y, Fca1p, FCY1, isocytosine deaminase, yCD, Zn2+CDase

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.4 In cyclic amidines
                3.5.4.1 cytosine deaminase

Inhibitors

Inhibitors on EC 3.5.4.1 - cytosine deaminase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(1R,2S)-(-)-ephedrine
-
-
(alpha-D-glucopyranosylthio)gold
-
-
(R)-2,10,11-trihydroxy-N-propyl-noraporphine
-
-
(R)-2,10,11-trihydroxyaporphine
-
-
(R)-apomorphine
-
-
(R)-N-allylnorapomorphine
-
-
(R)-propylnorapomorphine
-
-
(S)-carbidopa
-
-
1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol
-
-
2,2'-dipyridyl
-
-
2-hydroxypyrimidine
2-pyrimidinone
-
-
2-thiocytosine
-
weak
2-Thiouracil
-
strong
3,4-dihydroxyphenylacetic acid
-
-
4-chloromercuribenzoic acid
-
-
4-[(2-sulfanyl-1H-imidazol-1-yl)methyl]phenol
-
-
5'-guanidinonaltrindole
-
-
5,5'-dithiobis(2-nitrobenzoic acid)
-
-
5-Azacytosine
-
weak
5-bromo-2-pyrimidinone
-
-
5-fluoro-1H-pyrimidin-2-one
-
19F NMR experiments show that binding of the inhibitor 5-fluoro-1H-pyrimidin-2-one (5FPy) to the wild-type yCD causes an upfield shift, indicating that the bound inhibitor is in the hydrated form, mimicking the transition state or the tetrahedral intermediate in the activation of 5FC. Binding of 5FPy to the E64A mutant enzyme causes a downfield shift, indicating that the bound 5FPy remains in an unhydrated form in the complex with the mutant enzyme
5-fluoro-4-(S)-hydroxyl-3,4-dihydropyrimidine
-
mechanism-based inhibitor
6-amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene
-
-
6-hydroxy-DL-DOPA
-
-
alpha,alpha'-dipyridyl
-
-
aurintricarboxylic acid
-
-
caffeic acid
-
-
cephapirin
-
-
Chloramine T
chloramine-T
deoxyguanosine
-
-
dephostatin
-
-
diethyldicarbonate
-
-
dihydrexidine
-
-
ebselen
-
-
H2O2
-
only Fe2+CDase, Mn2+CDase, Co2+CDase and Zn2+CDase are not inhibited
Hg(CH3COO)2
-
-
hispidin
-
-
hydroquinone
-
-
Iodine
-
complete inhibition, reversed by cytosine
iodoacetamide
-
-
Mersalyl acid
-
-
methyl 3-hydroxy-DL-tyrosinate
-
-
myricetin
-
-
N-acetyldopamine
-
-
N-bromosuccinimide
nordihydroguaiaretic acid
-
-
o-phenanthroline
p-benzoquinone
-
-
p-chloromercuribenzoate
p-chloromercuribenzoic acid
p-chloromercuriphenylsulfonic acid
-
-
p-hydroxymercuribenzoate
-
-
p-mercuribenzoate
phenylmethylsulfonyl fluoride
phosphonocytosine
-
-
piceatannol
-
-
PPNDS tetrasodium
-
-
pyridoxal 5'-phosphate
-
strong, reversed by cytosine
pyridoxal-5'-phosphate
SCH202676
-
-
SKF-89626
-
-