Reference on EC 3.5.4.1 - cytosine deaminase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Sakai, T.; Yu, T.; Omata, S.
Distribution of enzymes related to cytidine degradation in bacteria
Agric. Biol. Chem.
40
1893-1895
1976
Achromobacter liquidum, Achromobacter polymorph, Klebsiella aerogenes, Enterobacter cloacae, Agrobacterium tumefaciens, Alcaligenes faecalis, Alcaligenes viscolactis, Niallia circulans, Bacillus subtilis, Citrobacter freundii, Escherichia coli, Lactiplantibacillus plantarum, Mycobacterium avium, Proteus mirabilis, Proteus vulgaris, Pseudomonas aeruginosa, Pseudomonas putida, Pseudomonas chlororaphis subsp. aureofaciens, Pseudomonas chlororaphis, Pseudomonas cruciviae, Pseudomonas fluorescens, Pseudomonas oleovorans, Pseudomonas schuylkilliensis, Ralstonia solanacearum, Pseudomonas coronafaciens pv. striafaciens, Pseudomonas taetrolens, Pseudomonas trifolii, Serratia marcescens, Serratia polymuthicum, Xanthomonas campestris, Xanthomonas arboricola pv. pruni, Xanthomonas campestris IAM 1671, Enterobacter cloacae IAM 1221, Xanthomonas arboricola pv. pruni IAM 1313, Alcaligenes faecalis IAM 0101, Escherichia coli K12 AKU 0005, Agrobacterium tumefaciens IAM 1526, Agrobacterium tumefaciens AKU 0300, Serratia polymuthicum AKU 0062, Alcaligenes viscolactis IAM 1517, Pseudomonas putida AKU 0820, Achromobacter polymorph AKU 0122
-
Ipata, P.L.; Marmocchi, F.; Magni, G.; Felicioli, R.; Polidoro, G.
Baker's yeast cytosine deaminase. Some enzymic properties and allosteric inhibition by nucleosides and nucleotides
Biochemistry
10
4270-4276
1971
Saccharomyces cerevisiae, Escherichia coli
Balestreri, E.; Felicioli, R.A.; Ipata, P.L.
The effect of pH on the alosteric properties of baker's yeast cytosine deaminase
Biochim. Biophys. Acta
293
443-448
1973
Saccharomyces cerevisiae
-
Holldorf, A.W.
Cytosine
Methods Enzym. Anal. , 3rd Ed. (Bergmeyer, H. U. , ed. )
3
1964-1966
1974
Saccharomyces cerevisiae
-
Sakai, T.; Yu, T.; Tabe, H.; Omata, S.
Purification of cytosine deaminase from Serratia marcescens
Agric. Biol. Chem.
39
1623-1629
1975
Saccharomyces cerevisiae, Escherichia coli, Serratia marcescens
-
Sakai, T.; Yu, T.; Taniguchi, K.; Omata, S.
Purification of cytosine deaminase from Pseudomonas aureofaciens
Agric. Biol. Chem.
39
2015-2020
1975
Klebsiella aerogenes, Enterobacter cloacae, Alcaligenes faecalis, Bacillus subtilis, Saccharomyces cerevisiae, Citrobacter freundii, Escherichia coli, Micrococcus flavus, Proteus mirabilis, Proteus vulgaris, Pseudomonas aeruginosa, Pseudomonas putida, Pseudomonas chlororaphis subsp. aureofaciens, Pseudomonas chlororaphis, Pseudomonas cruciviae, Pseudomonas fluorescens, Pseudomonas fragi, Pseudomonas schuylkilliensis, Ralstonia solanacearum, Pseudomonas coronafaciens pv. striafaciens, Pseudomonas taetrolens, Pseudomonas trifolii, Serratia marcescens, Serratia polymuthicum, Alcaligenes faecalis type S, Serratia marcescens type S, Enterobacter cloacae IAM 1221, Pseudomonas schuylkilliensis type S, Escherichia coli K12 AKU 0005, Pseudomonas chlororaphis type S, Proteus vulgaris type S, Pseudomonas aeruginosa type S, Pseudomonas putida type S, Proteus mirabilis type S, Pseudomonas trifolii type S, Enterobacter cloacae type S, Alcaligenes faecalis AKU 0101, Serratia polymuthicum AKU 0062, Pseudomonas cruciviae type S, Micrococcus flavus AKU 0502, Klebsiella aerogenes type S, Ralstonia solanacearum type S
-
Yu, T.; Sakai, T.; Omata, S.
Kinetic properties of cytosine deaminase from Serratia marcescens
Agric. Biol. Chem.
40
543-549
1976
Saccharomyces cerevisiae, Escherichia coli, Pseudomonas chlororaphis subsp. aureofaciens, Serratia marcescens
-
Yu, T.; Sakai, T.; Omata, S.
Kinetic properties of cytosine deaminase from Pseudomonas aureofaciens
Agric. Biol. Chem.
40
551-557
1976
Pseudomonas chlororaphis subsp. aureofaciens, Serratia marcescens, Serratia marcescens type S
-
Ipata, P.L.; Cercignani, G.
Cytosine and cytidine deaminase from yeast
Methods Enzymol.
51
394-401
1978
Saccharomyces cerevisiae
West, T.P.; Shanley, M.S.; O'Donovan, G.A.
Purification and some properties of cytosine deaminase from Salmonella typhimurium
Biochim. Biophys. Acta
791
251-258
1982
Saccharomyces cerevisiae, Escherichia coli, Salmonella enterica subsp. enterica serovar Typhimurium, Salmonella enterica subsp. enterica serovar Typhimurium HD11-AE2
West, T.P.
Effect of pyrophosphate and orotidine monophosphate on cytosine deaminase regulatory properties
Experientia
41
1563-1564
1988
Saccharomyces cerevisiae, Pseudomonas chlororaphis subsp. aureofaciens, Salmonella enterica subsp. enterica serovar Typhimurium, Serratia marcescens, Salmonella enterica subsp. enterica serovar Typhimurium HD11-AE2
Kornblatt, M.J.; Tee, O.S.
Inhibition of yeast cytosine deaminase by 5-bromo-2-pyrimidinone and its covalent hydrate
Eur. J. Biochem.
756
297-300
1986
Saccharomyces cerevisiae
Katsuragi, T.; Sakai, T.; Tonomura, K.
Affinity chromatography of cytosine deaminase from Escherichia coli with immobilized pyrimidine compounds
Agric. Biol. Chem.
50
1713-1719
1986
Escherichia coli
-
Katsuragi, T.; Sakai, T.; Matsumoto, K.; Tonomura, K.
Cytosine deaminase from Escherichia coli-production, purification and some characteristics
Agric. Biol. Chem.
50
1721-1730
1986
Saccharomyces cerevisiae, Escherichia coli, Pseudomonas chlororaphis subsp. aureofaciens, Salmonella enterica subsp. enterica serovar Typhimurium, Serratia marcescens
-
Kim, J.M.; Shimizu, S.; Yamada, H.
Cytosine deaminase that hydrolyzes creatinine to N-methylhydantoin in various cytosine deaminase-forming microorganisms
Arch. Microbiol.
147
58-63
1987
Escherichia coli, Flavobacterium filamentosum, Proteus mirabilis, Pseudomonas putida, Pseudomonas chlororaphis subsp. aureofaciens, Pseudomonas chlororaphis, Pseudomonas cruciviae, Escherichia coli K12 AKU 0005
-
Kim, J.M.; Shimizu, S.; Yamada, H.
Evidence for the presence of a cytosine deaminase that does not catalyze the deimination of creatine
FEBS Lett.
210
77-80
1987
Achromobacter denitrificans, Arthrobacter sp., Arthrobacter sp. J11
-
West, T.P.; Chu, C.P.
Pyrimidine base and nucleoside metabolism in Pseudomonas cepacia
J. Basic Microbiol.
27
283-286
1987
Burkholderia cepacia
-
Yu, T.S.; Kim, J.K.; Kasuragi, T.; Sakai, T.; Tonomura, K.
Purification and properties of cytosine deaminase from Aspergillus fumigatus
J. Ferment. Bioeng.
72
266-269
1991
Arthrobacter sp., Aspergillus fumigatus, Saccharomyces cerevisiae, Salmonella enterica subsp. enterica serovar Typhimurium, Serratia marcescens, Arthrobacter sp. JH-13, Aspergillus fumigatus IFO5840
-
Austin, E.A.; Huber, B.E.
A first step in the development of gene therapy for colorectal carcinoma: Clonig, sequencing, and expression of Escherichia coli cytosine deaminase
Mol. Pharmacol.
43
380-387
1992
Escherichia coli
Porter, D.J.T.; Austin, E.A.
Cytosine deaminase the roles of divalent metal ions in catalysis
J. Biol. Chem.
268
24005-24011
1993
Escherichia coli
Huber, B.E.; Austin, E.A.; Richards, C.A.; Davis, S.T.; Good, S.S.
Metabolism of 5-fluorocytosine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: Significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase
Proc. Natl. Acad. Sci. USA
91
8302-8306
1994
Escherichia coli
Wei, K.; Huber, B.E.
Cytosine deaminase gene as a positive selection marker
J. Biol. Chem.
271
3812-3816
1996
Escherichia coli
Erbs, P.; Exinger, F.; Jund, R.
Characterization of the Saccharomyces cerevisiae FCY1 gene encoding cytosine deaminase and its homologue FCA1 of Candida albicans
Curr. Genet.
31
1-6
1997
Aspergillus fumigatus, Saccharomyces cerevisiae, Candida albicans, Escherichia coli, Salmonella enterica subsp. enterica serovar Typhimurium, Aspergillus fumigatus IFO5840
Yu, T.S.; Kim, J.; Kim, H.S.
Chemical modification of cytosine deaminase from Aspergillus fumigatus
J. Microbiol.
36
39-42
1998
Aspergillus fumigatus, Saccharomyces cerevisiae, Chromobacterium violaceum, Escherichia coli, Pseudomonas chlororaphis subsp. aureofaciens, Salmonella enterica subsp. enterica serovar Typhimurium, Serratia marcescens, Chromobacterium violaceum YK 391
-
Kim, T.H.; Yu, T.S.
Chemical modification of extracellular cytosine deaminase from Chromobacterium violaceum YK 391
J. Microbiol. Biotechnol.
8
581-587
1998
Arthrobacter sp., Aspergillus fumigatus, Paenibacillus polymyxa, Saccharomyces cerevisiae, Chromobacterium violaceum, Escherichia coli, Pseudomonas chlororaphis subsp. aureofaciens, Salmonella enterica subsp. enterica serovar Typhimurium, Serratia marcescens, Chromobacterium violaceum YK 391
-
Hsu, Y.H.; Hu, C.Y.; Lin, J.J.; Liaw, S.H.
Crystallization and preliminary crystallographic analysis of yeast cytosine deaminase
Acta Crystallogr. Sect. D
59
950-952
2003
Saccharomyces cerevisiae
Porter, D.J.T.
Escherichia coli cytosine deaminase: the kinetics and thermodynamics for binding of cytosine to the apoenzyme and the Zn2+ holoenzyme are similar
Biochim. Biophys. Acta
1476
239-252
2000
Escherichia coli
Ko, T.P.; Lin, J.J.; Hu, C.Y.; Hsu, Y.H.; Wang, A.H.; Liaw, S.H.
Crystal structure of yeast cytosine deaminase. Insights into enzyme mechanism and evolution
J. Biol. Chem.
278
19111-19117
2003
Saccharomyces cerevisiae (Q12178), Saccharomyces cerevisiae
Ireton, G.C.; McDermott, G.; Black, M.E.; Stoddard, B.L.
The structure of Escherichia coli cytosine deaminase
J. Mol. Biol.
315
687-697
2002
Escherichia coli (P25524), Escherichia coli
Ireton, G.C.; Stoddard, B.L.
Microseed matrix screening to improve crystals of yeast cytosine deaminase. [Erratum to document cited in CA141:019564]
Acta Crystallogr. Sect. D
D60
801
2004
Saccharomyces cerevisiae
-
Rehemtulla, A.; Hamstra, D.A.; Kievit, E.; Davis, M.A.; Ng, E.Y.; Dornfeld, K.; Lawrence, T.S.
Extracellular expression of cytosine deaminase results in increased 5-FU production for enhanced enzyme/prodrug therapy
Anticancer Res.
24
1393-1399
2004
Escherichia coli
Mahan, S.D.; Ireton, G.C.; Stoddard, B.L.; Black, M.E.
Alanine-scanning mutagenesis reveals a cytosine deaminase mutant with altered substrate preference
Biochemistry
43
8957-8964
2004
Escherichia coli
Yao, L.; Li, Y.; Wu, Y.; Liu, A.; Yan, H.
Product release is rate-limiting in the activation of the prodrug 5-fluorocytosine by yeast cytosine deaminase
Biochemistry
44
5940-5947
2005
Saccharomyces cerevisiae
Kim, J.; Kim, T.H.; Yu, T.S.
Chemical modification of intracellular cytosine deaminase from Chromobacterium violaceum YK 391
Biotechnol. Bioprocess Eng.
10
180-185
2005
Chromobacterium violaceum, Chromobacterium violaceum YK 391
-
Hwang, K.; Cho, W.; Yoo, J.; Yun, H.; Kim, S.; Im, D.
Adenovirus-mediated interleukin-12 gene transfer combined with cytosine deaminase followed by 5-fluorocytosine treatment exerts potent antitumor activity in Renca tumor-bearing mice
BMC Cancer
5
51
2005
Mus musculus
Li, S.; Yu, B.; An, P.; Chen, G.; Lu, W.; Cai, H.; Guo, W.; Zuo, F.
Combined liposome-mediated cytosine deaminase gene therapy with radiation in killing rectal cancer cells and xenografts in athymic mice
Clin. Cancer Res.
11
3574-3578
2005
Homo sapiens
Kim, J.; Yu, T.S.
Purification and properties of intracellular cytosine deaminase from Chromobacterium violaceum YK 391
J. Microbiol. Biotechnol.
14
1182-1189
2004
Chromobacterium violaceum, Chromobacterium violaceum YK 391
-
Yao, L.; Sklenak, S.; Yan, H.; Cukier, R.I.
A molecular dynamics exploration of the catalytic mechanism of yeast cytosine deaminase
J. Phys. Chem. B
109
7500-7510
2005
Saccharomyces cerevisiae
Mahan, S.D.; Ireton, G.C.; Knoeber, C.; Stoddard, B.L.; Black, M.E.
Random mutagenesis and selection of Escherichia coli cytosine deaminase for cancer gene therapy
Protein Eng. Des. Sel.
17
625-633
2004
Escherichia coli
O'Brien, T.A.; Tuong, D.T.; Basso, L.M.; McIvor, R.S.; Orchard, P.J.
Coexpression of the uracil phosphoribosyltransferase gene with a chimeric human nerve growth factor receptor/cytosine deaminase fusion gene, using a single retroviral vector, augments cytotoxicity of transduced human T cells exposed to 5-fluorocytosine
Hum. Gene Ther.
17
518-530
2006
Saccharomyces cerevisiae
Khatri, A.; Zhang, B.; Doherty, E.; Chapman, J.; Ow, K.; Pwint, H.; Martiniello-Wilks, R.; Russell, P.J.
Combination of cytosine deaminase with uracil phosphoribosyl transferase leads to local and distant bystander effects against RM1 prostate cancer in mice
J. Gene Med.
8
1086-1096
2006
Escherichia coli
Xing, L.; Deng, X.; Kotedia, K.; Ackerstaff, E.; Ponomarev, V.; Clifton Ling, C.; Koutcher, J.A.; Li, G.C.
Non-invasive molecular and functional imaging of cytosine deaminase and uracil phosphoribosyltransferase fused with red fluorescence protein
Acta Oncol.
47
1211-1220
2008
Saccharomyces cerevisiae (Q12178)
Jung, K.; Kim, S.; Lee, K.; Kim, C.; Chung, I.
Cytotoxic effect of a replication-incompetent adenoviral vector with cytosine deaminase gene driven by L-plastin promoter in hepatocellular carcinoma cells
Arch. Pharm. Res.
30
770-777
2007
Escherichia coli
Zhang, J.; Wang, Z.; Wei, F.; Qiu, W.; Zhang, L.; Huang, Q.
Computational modeling and functional analysis of Herpes simplex virus type-1 thymidine kinase and Escherichia coli cytosine deaminase fusion protein
Biochem. Biophys. Res. Commun.
360
46-50
2007
Escherichia coli (P25524), Escherichia coli
Yao, L.; Yan, H.; Cukier, R.I.
A molecular dynamics study of the ligand release path in yeast cytosine deaminase
Biophys. J.
92
2301-2310
2007
Saccharomyces cerevisiae
Hidaka, A.; Hamaji, Y.; Sasaki, T.; Taniguchi, S.; Fujimori, M.
Exogenous cytosine deaminase gene expression in Bifidobacterium breve I-53-8w for tumor-targeting enzyme/prodrug therapy
Biosci. Biotechnol. Biochem.
71
2921-2926
2007
Escherichia coli
Hamaji, Y.; Fujimori, M.; Sasaki, T.; Matsuhashi, H.; Matsui-Seki, K.; Shimatani-Shibata, Y.; Kano, Y.; Amano, J.; Taniguchi, S.
Strong enhancement of recombinant cytosine deaminase activity in Bifidobacterium longum for tumor-targeting enzyme/prodrug therapy
Biosci. Biotechnol. Biochem.
71
874-883
2007
Escherichia coli
Liu, J.; Harada, H.; Ogura, M.; Shibata, T.; Hiraoka, M.
Adenovirus-mediated hypoxia-targeting cytosine deaminase gene therapy enhances radiotherapy in tumour xenografts
Br. J. Cancer
96
1871-1878
2007
Escherichia coli
Kaliberov, S.A.; Chiz, S.; Kaliberova, L.N.; Krendelchtchikova, V.; Della Manna, D.; Zhou, T.; Buchsbaum, D.J.
Combination of cytosine deaminase suicide gene expression with DR5 antibody treatment increases cancer cell cytotoxicity
Cancer Gene Ther.
13
203-214
2006
Escherichia coli
Guffey, M.B.; Parker, J.N.; Luckett, W.S.; Gillespie, G.Y.; Meleth, S.; Whitley, R.J.; Markert, J.M.
Engineered herpes simplex virus expressing bacterial cytosine deaminase for experimental therapy of brain tumors
Cancer Gene Ther.
14
45-56
2007
Escherichia coli
Chaszczewska-Markowska, M.; Stebelska, K.; Sikorski, A.; Madej, J.; Opolski, A.; Ugorski, M.
Liposomal formulation of 5-fluorocytosine in suicide gene therapy with cytosine deaminase - for colorectal cancer
Cancer Lett.
262
164-172
2008
Escherichia coli, Escherichia coli (P25524)
Ou-Yang, F.; Lan, K.L.; Chen, C.T.; Liu, J.C.; Weng, C.L.; Chou, C.K.; Xie, X.; Hung, J.Y.; Wei, Y.; Hortobagyi, G.N.; Hung, M.C.
Endostatin-cytosine deaminase fusion protein suppresses tumor growth by targeting neovascular endothelial cells
Cancer Res.
66
378-384
2006
Saccharomyces cerevisiae
Shieh, G.S.; Shiau, A.L.; Yo, Y.T.; Lin, P.R.; Chang, C.C.; Tzai, T.S.; Wu, C.L.
Low-dose etoposide enhances telomerase-dependent adenovirus-mediated cytosine deaminase gene therapy through augmentation of adenoviral infection and transgene expression in a syngeneic bladder tumor model
Cancer Res.
66
9957-9966
2006
Escherichia coli
Lee, K.C.; Hamstra, D.A.; Bullarayasamudram, S.; Bhojani, M.S.; Moffat, B.A.; Dornfeld, K.J.; Ross, B.D.; Rehemtulla, A.
Fusion of the HSV-1 tegument protein vp22 to cytosine deaminase confers enhanced bystander effect and increased therapeutic benefit
Gene Ther.
13
127-137
2006
Saccharomyces cerevisiae
Kaliberov, S.A.; Markert, J.M.; Gillespie, G.Y.; Krendelchtchikova, V.; Della Manna, D.; Sellers, J.C.; Kaliberova, L.N.; Black, M.E.; Buchsbaum, D.J.
Mutation of Escherichia coli cytosine deaminase significantly enhances molecular chemotherapy of human glioma
Gene Ther.
14
1111-1119
2007
Escherichia coli
Song, Y.; Kong, B.; Ma, D.; Qu, X.; Jiang, S.
Procaspase-3 enhances the in vitro effect of cytosine deaminase-thymidine kinase disuicide gene therapy on human ovarian cancer
Int. J. Gynecol. Cancer
16
156-164
2006
Escherichia coli
Zamboni, S.; Mallano, A.; Flego, M.; Ascione, A.; Dupuis, M.L.; Gellini, M.; Barca, S.; Cianfriglia, M.
Genetic construction, expression, and characterization of a single chain anti-CEA antibody fused to cytosine deaminase from yeast
Int. J. Oncol.
32
1245-1251
2008
Saccharomyces cerevisiae
Chen, J.K.; Hu, L.J.; Wang, D.; Lamborn, K.R.; Deen, D.F.
Cytosine deaminase/5-fluorocytosine exposure induces bystander and radiosensitization effects in hypoxic glioblastoma cells in vitro
Int. J. Radiat. Oncol. Biol. Phys.
67
1538-1547
2007
Saccharomyces cerevisiae
Matsubara, T.; Dupuis, M.; Aida, M.
An insight into the environmental effects of the pocket of the active site of the enzyme. Ab initio ONIOM-molecular dynamics (MD) study on cytosine deaminase
J. Comput. Chem.
29
458-465
2008
Saccharomyces cerevisiae (Q12178)
Li, C.; Wildes, F.; Winnard, P.; Artemov, D.; Penet, M.F.; Bhujwalla, Z.M.
Conjugation of poly-L-lysine to bacterial cytosine deaminase improves the efficacy of enzyme/prodrug cancer therapy
J. Med. Chem.
51
3572-3582
2008
Escherichia coli
Stolworthy, T.S.; Korkegian, A.M.; Willmon, C.L.; Ardiani, A.; Cundiff, J.; Stoddard, B.L.; Black, M.E.
Yeast cytosine deaminase mutants with increased thermostability impart sensitivity to 5-fluorocytosine
J. Mol. Biol.
377
854-869
2008
Saccharomyces cerevisiae (Q12178), Saccharomyces cerevisiae
Yao, L.; Yan, H.; Cukier, R.I.
A combined ONIOM quantum chemical-molecular dynamics study of zinc-uracil bond breaking in yeast cytosine deaminase
J. Phys. Chem. B
110
26320-26326
2006
Saccharomyces cerevisiae
Xu, Q.; Guo, H.; Gorin, A.; Guo, H.
Stabilization of a transition-state analogue at the active site of yeast cytosine deaminase: importance of proton transfers
J. Phys. Chem. B
111
6501-6506
2007
Saccharomyces cerevisiae (Q12178), Saccharomyces cerevisiae
Tirandaz, H.; Salehi-Najafabadi, A.; Eslamifar, A.
Cytosine deaminase producing Clostridium may be used in detection of tumors
Med. Hypotheses
67
1257-1258
2006
Homo sapiens
Maier, A.G.; Braks, J.A.; Waters, A.P.; Cowman, A.F.
Negative selection using yeast cytosine deaminase/uracil phosphoribosyl transferase in Plasmodium falciparum for targeted gene deletion by double crossover recombination
Mol. Biochem. Parasitol.
150
118-121
2006
Saccharomyces cerevisiae
Negroni, L.; Samson, M.; Guigonis, J.M.; Rossi, B.; Pierrefite-Carle, V.; Baudoin, C.
Treatment of colon cancer cells using the cytosine deaminase/5-fluorocytosine suicide system induces apoptosis, modulation of the proteome, and Hsp90beta phosphorylation
Mol. Cancer Ther.
6
2747-2756
2007
Escherichia coli
Fogar, P.; Navaglia, F.; Basso, D.; Greco, E.; Zambon, C.F.; Fadi, E.; Falda, A.; Stranges, A.; Vannozzi, F.; Danesi, R.; Pedrazzoli, S.; Plebani, M.
Suicide gene therapy with the yeast fusion gene cytosine deaminase/uracil phosphoribosyltransferase is not enough for pancreatic cancer
Pancreas
35
224-231
2007
Saccharomyces cerevisiae (Q12178), Saccharomyces cerevisiae
Dubeau, M.; Ghinet, M.G.; Jacques, P.; Clermont, N.; Beaulieu, C.; Brzezinski, R.
Cytosine deaminase as a negative selection marker for gene disruption and replacement in the genus Streptomyces and other actinobacteria
Appl. Environ. Microbiol.
75
1211-1214
2009
Escherichia coli (P25524), Escherichia coli
Mallano, A.; Zamboni, S.; Carpinelli, G.; Santoro, F.; Flego, M.; Ascione, A.; Gellini, M.; Tombesi, M.; Podo, F.; Cianfriglia, M.
Generation and characterization of a human single-chain fragment variable (scFv) antibody against cytosine deaminase from yeast
BMC Biotechnol.
8
68
2008
Saccharomyces cerevisiae (Q12178), Saccharomyces cerevisiae
Kucerova, L.; Matuskova, M.; Pastorakova, A.; Tyciakova, S.; Jakubikova, J.; Bohovic, R.; Altanerova, V.; Altaner, C.
Cytosine deaminase expressing human mesenchymal stem cells mediated tumour regression in melanoma bearing mice
J. Gene Med.
10
1071-1082
2008
Saccharomyces cerevisiae (Q12178), Saccharomyces cerevisiae
McManus, B.A.; Moran, G.P.; Higgins, J.A.; Sullivan, D.J.; Coleman, D.C.
A Ser29Leu substitution in the cytosine deaminase Fca1p is responsible for clade-specific flucytosine resistance in Candida dubliniensis
Antimicrob. Agents Chemother.
53
4678-4685
2009
Candida dubliniensis, Candida dubliniensis isolates SA113, SA109, Eg202, Eg204 and p7276
Fuchita, M.; Ardiani, A.; Zhao, L.; Serve, K.; Stoddard, B.L.; Black, M.E.
Bacterial cytosine deaminase mutants created by molecular engineering show improved 5-fluorocytosine-mediated cell killing in vitro and in vivo
Cancer Res.
69
4791-4799
2009
Escherichia coli, Escherichia coli GIA39(DE3)
You, M.H.; Kim, W.J.; Shim, W.; Lee, S.R.; Lee, G.; Choi, S.; Kim, D.Y.; Kim, Y.M.; Kim, H.; Han, S.U.
Cytosine deaminase-producing human mesenchymal stem cells mediate an antitumor effect in a mouse xenograft model
J. Gastroenterol. Hepatol.
24
1393-1400
2009
Escherichia coli (Q6Q8Q1)
Park, J.I.; Cao, L.; Platt, V.M.; Huang, Z.; Stull, R.A.; Dy, E.E.; Sperinde, J.J.; Yokoyama, J.S.; Szoka, F.C.
Antitumor therapy mediated by 5-fluorocytosine and a recombinant fusion protein containing TSG-6 hyaluronan binding domain and yeast cytosine deaminase
Mol. Pharm.
6
801-812
2009
Saccharomyces cerevisiae
Li, M.; Shandilya, S.M.; Carpenter, M.A.; Rathore, A.; Brown, W.L.; Perkins, A.L.; Harki, D.A.; Solberg, J.; Hook, D.J.; Pandey, K.K.; Parniak, M.A.; Johnson, J.R.; Krogan, N.J.; Somasundaran, M.; Ali, A.; Schiffer, C.A.; Harris, R.S.
First-in-class small molecule inhibitors of the single-strand DNA cytosine deaminase APOBEC3G
ACS Chem. Biol.
7
506-517
2012
Homo sapiens
Hall, R.S.; Fedorov, A.A.; Xu, C.; Fedorov, E.V.; Almo, S.C.; Raushel, F.M.
Three-dimensional structure and catalytic mechanism of cytosine deaminase
Biochemistry
50
5077-5085
2011
Escherichia coli
Wang, J.; Sklenak, S.; Liu, A.; Felczak, K.; Wu, Y.; Li, Y.; Yan, H.
Role of glutamate 64 in the activation of the prodrug 5-fluorocytosine by yeast cytosine deaminase
Biochemistry
51
475-486
2012
Saccharomyces cerevisiae
Yata, V.K.; Ghosh, S.S.
Synthesis and characterization of a novel chitosan based E. coli cytosine deaminase nanocomposite for potential application in prodrug enzyme therapy
Biotechnol. Lett.
33
153-157
2011
Escherichia coli
Kucerova, L.; Matuskova, M.; Hlubinova, K.; Bohovic, R.; Feketeova, L.; Janega, P.; Babal, P.; Poturnajova, M.
Bystander cytotoxicity in human medullary thyroid carcinoma cells mediated by fusion yeast cytosine deaminase and 5-fluorocytosine
Cancer Lett.
311
101-112
2011
Saccharomyces cerevisiae
Renard, M.; Henry, M.; Guetard, D.; Vartanian, J.P.; Wain-Hobson, S.
APOBEC1 and APOBEC3 cytidine deaminases as restriction factors for hepadnaviral genomes in non-humans in vivo
J. Mol. Biol.
400
323-334
2010
Mus musculus (P51908), Mus musculus (Q99J72), Mus musculus
Doerrschuck, E.; Fischer, N.; Bravo, I.G.; Hanschmann, K.M.; Kuiper, H.; Spoetter, A.; Moeller, R.; Cichutek, K.; Muenk, C.; Toenjes, R.R.
Restriction of porcine endogenous retrovirus by porcine APOBEC3 cytidine deaminases
J. Virol.
85
3842-3857
2011
Sus scrofa
Dang, Y.; Abudu, A.; Son, S.; Harjes, E.; Spearman, P.; Matsuo, H.; Zheng, Y.H.
Identification of a single amino acid required for APOBEC3 antiretroviral cytidine deaminase activity
J. Virol.
85
5691-5695
2011
Homo sapiens
Suspene, R.; Aynaud, M.M.; Guetard, D.; Henry, M.; Eckhoff, G.; Marchio, A.; Pineau, P.; Dejean, A.; Vartanian, J.P.; Wain-Hobson, S.
Somatic hypermutation of human mitochondrial and nuclear DNA by APOBEC3 cytidine deaminases, a pathway for DNA catabolism
Proc. Natl. Acad. Sci. USA
108
4858-4863
2011
Homo sapiens
Manta, B.; Raushel, F.M.; Himo, F.
Reaction mechanism of zinc-dependent cytosine deaminase from Escherichia coli: a quantum-chemical study
J. Phys. Chem. B
118
5644-5652
2014
Escherichia coli (P25524), Escherichia coli
Zhao, Y.; She, N.; Zhang, X.; Wang, C.; Mo, Y.
Product release mechanism and the complete enzyme catalysis cycle in yeast cytosine deaminase (yCD) A computational study
Biochim. Biophys. Acta
1865
1020-1029
2017
Saccharomyces cerevisiae (Q12178), Saccharomyces cerevisiae, Saccharomyces cerevisiae ATCC 204508 (Q12178)
Blacklock, K.M.; Yachnin, B.J.; Woolley, G.A.; Khare, S.D.
Computational design of a photocontrolled cytosine deaminase
J. Am. Chem. Soc.
140
14-17
2018
Saccharomyces cerevisiae (Q12178), Saccharomyces cerevisiae, Saccharomyces cerevisiae ATCC 204508 (Q12178)
Mesa-Pereira, B.; Medina, C.; Camacho, E.; Flores, A.; Santero, E.
Improved cytotoxic effects of Salmonella-producing cytosine deaminase in tumour cells
Microb. Biotechnol.
8
169-176
2015
Escherichia coli
Shao, M.; Michno, J.M.; Hotton, S.K.; Blechl, A.; Thomson, J.
A bacterial gene codA encoding cytosine deaminase is an effective conditional negative selectable marker in Glycine max
Plant Cell Rep.
34
1707-1716
2015
Escherichia coli (P25524), Escherichia coli
Leonhardt, N.; Divol, F.; Chiarenza, S.; Deschamps, S.; Renaud, J.; Giacalone, C.; Laurent, N.; Berthome, R.; Peret, B.
Tissue-specific inactivation by cytosine deaminase/uracil phosphoribosyl transferase as a tool to study plant biology
Plant J.
101
731-741
2019
Saccharomyces cerevisiae (Q12178), Saccharomyces cerevisiae ATCC 204508 (Q12178)
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