3.5.4.1: cytosine deaminase
This is an abbreviated version!
For detailed information about cytosine deaminase, go to the full flat file.
Word Map on EC 3.5.4.1
-
3.5.4.1
-
cytidine
-
deaminases
-
5-fluorocytosine
-
deamination
-
prodrugs
-
virion
-
hypermutation
-
viruses
-
5-fluorouracil
-
apolipoprotein
-
retroviruses
-
suicide
-
uracil
-
retroviral
-
apobecs
-
single-stranded
-
antiretroviral
-
polypeptide-like
-
mrna-editing
-
g-to-a
-
bystander
-
activation-induced
-
retrotransposons
-
anti-hiv-1
-
proviral
-
retroelements
-
lentiviruses
-
encapsidation
-
ganciclovir
-
deoxycytidine
-
retrotransposition
-
ssdna
-
fiv
-
samhd1
-
cullin
-
minus-strand
-
replication-competent
-
gene-directed
-
sivmac
-
medicine
-
line-1
-
hsv-tk
-
vpr
-
gdept
-
non-ltr
-
molecular biology
-
xenotropic
-
analysis
-
pharmacology
-
biotechnology
-
trim5alpha
-
diagnostics
-
proviruses
-
nickase
-
agriculture
-
single-cycle
-
elongins
- 3.5.4.1
- cytidine
- deaminases
- 5-fluorocytosine
-
deamination
-
prodrugs
- virion
-
hypermutation
- viruses
- 5-fluorouracil
-
apolipoprotein
- retroviruses
-
suicide
- uracil
-
retroviral
-
apobecs
-
single-stranded
-
antiretroviral
-
polypeptide-like
-
mrna-editing
-
g-to-a
-
bystander
-
activation-induced
-
retrotransposons
-
anti-hiv-1
-
proviral
-
retroelements
- lentiviruses
-
encapsidation
- ganciclovir
- deoxycytidine
-
retrotransposition
- ssdna
- fiv
- samhd1
-
cullin
-
minus-strand
-
replication-competent
-
gene-directed
- sivmac
- medicine
-
line-1
-
hsv-tk
- vpr
-
gdept
-
non-ltr
- molecular biology
-
xenotropic
- analysis
- pharmacology
- biotechnology
- trim5alpha
- diagnostics
- proviruses
-
nickase
- agriculture
-
single-cycle
-
elongins
Reaction
Synonyms
A3DE, APOBEC1, APOBEC3, APOBEC3G, CD, CDA, CDase, codA, CodA protein, Cytosine aminohydrolase, cytosine deaminase, cytosine deaminase I, cytosine deaminase II, cytosine deaminase P, cytosine deaminase S, cytosine deaminase Y, Fca1p, FCY1, isocytosine deaminase, yCD, Zn2+CDase
ECTree
3.5.4.1 cytosine deaminaseAdvanced search results
results (
results (Natural Substrates Products
Natural Substrates Products on EC 3.5.4.1 - cytosine deaminase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
5-fluorocytosine + H2O
5-fluorouracil + NH3
-
recombinant enzyme encoded in an adenoviral vector expressed in murine cancers or human cancer cell lines for prodrug cancer gene therapy, Ad/5HREp-BCD-mediated cytotoxicity under hypoxic conditions, overview
-
-
?
5-fluorocytosine + H2O
5-fluorouracil + NH3
-
recombinant enzyme in transfected cells, cytotoxic effects of the enzyme expressed form the AdLPCD vector, overview
-
-
?
5-fluorocytosine + H2O
5-fluorouracil + NH3
-
recombinant enzyme, combination of cytosine deaminase with uracil phosphoribosyl transferase leads to local and distant bystander effects against RM1 prostate cancer in mice in gene-directed enzyme prodrug therapy, overview
-
-
?
5-fluorocytosine + H2O
5-fluorouracil + NH3
recombinant fusion enzyme, cytotoxicity could be enhanced by concurrently treating TKglyCD-expressing cells with prodrugs ganclocivir and 5-fluorocytosine, overview
-
-
?
5-fluorocytosine + H2O
5-fluorouracil + NH3
used as negative selection marker system, increased 5-fluorocytosine sensitivity in Streptomyces lividans
-
-
?
5-fluorocytosine + H2O
5-fluorouracil + NH3
-
activation of the prodrug 5-fluorocytosine to the anticander drug 5-fluorouracil
-
-
?
5-fluorocytosine + H2O
5-fluorouracil + NH3
-
activation of the prodrug by the recombinant fusion enzyme, overview
-
-
?
5-fluorocytosine + H2O
5-fluorouracil + NH3
inside a cell, cytosine and 5-fluorocytosine compete for the active site of the enzyme
-
-
?
5-fluorocytosine + H2O
5-fluorouracil + NH3
-
recombinant enzyme in gene therapy in human glioblastoma cell lines Y87-1 and Y87-2
-
-
?
5-fluorocytosine + H2O
5-fluorouracil + NH3
recombinant protein of cytosine deaminase used as antigen for biopanning approach, antibody-directed enzyme-prodrug therapy (GDEPT/ADEPT), binding of specific single chain fragment variable (scFv) with cytosine deaminase does not interfere with enzyme activity
-
-
?
cytosine + H2O
uracil + NH3
-
-
137029, 209484, 209487, 209488, 209489, 209493, 209496, 209497, 209498, 209502, 209503, 209504, 209505, 209506, 209507, 209508, 675179, 684772, 685669, 685673, 685848, 685938, 687168, 688280
-
-
?
cytosine + H2O
uracil + NH3
-
treatment of BDIX rat colon cancer cells using the cytosine deaminase/5-fluorocytosine suicide system induces apoptosis, modulation of the proteome, and Hsp90beta phosphorylation, mechanism of the anticancer effect, overview
-
-
?
cytosine + H2O
uracil + NH3
-
-
-
-
?
cytosine + H2O
uracil + NH3
-
-
209484, 209485, 209486, 209487, 209488, 209489, 209492, 209493, 209494, 209495, 209497, 209501, 209506, 209507, 209508, 654095, 673932, 685615, 685937, 687192, 688612, 713064
-
-
?
cytosine + H2O
uracil + NH3
the enzyme is a pyrimidine salvage pathway enzyme, inside a cell, cytosine and 5-fluorocytosine compete for the active site of the enzyme
-
-
?
cytosine + H2O
uracil + NH3
-
-
-
-
?
cytosine + H2O
uracil + NH3
-
-
-
-
?
cytosine + H2O
uracil + NH3
-
-
-
-
?
additional information
?
-
enzyme is an important member of the pyrimidine salvage pathway
-
-
?
additional information
?
-
-
enzyme is an important member of the pyrimidine salvage pathway
-
-
?
additional information
?
-
-
adenovirus-mediated hypoxia-targeting cytosine deaminase gene therapy enhances radiotherapy in tumour xenografts of murine tumors, e.g. in human cervical epithelial adenocarcinoma cell line HeLa and human pancreatic carcinoma cell line MIA PaCa-2, as well as in human colon carcinoma cell lines WiDr and HT29, overview
-
-
?
additional information
?
-
-
combination of cytosine deaminase suicide gene expression with treatment with antibody against human death receptor DR5 increases cancer cell cytotoxicity, the death receptors are involved in TNF-related factor-induced apoptosis, overview
-
-
?
additional information
?
-
-
low-dose etoposide enhances telomerase-dependent adenovirus-mediated cytosine deaminase gene therapy through augmentation of adenoviral infection and transgene expression in a syngeneic bladder tumor model, overview
-
-
?
additional information
?
-
-
the enzyme is useful in gene therapy of cancers, conjugation of poly-L-lysine to cytosine deaminase improves the efficacy of enzyme/prodrug cancer therapy, e.g. by a 50times higher cellular uptake than that of control molecules in human breast MDA-MB-231 cancer cells and increase stability after uptake into cells, uptake and intracellular distribution, mechanisms, overview
-
-
?
additional information
?
-
-
the enzyme is useful in treatment of human ovarian cancer by genetic prodrug activation therapy with procaspase-3 co-expression improving the method, overview
-
-
?
additional information
?
-
-
a small fraction of human mitochondrial genomes are edited by APOBEC3 deaminases in the cytoplasm. Nuclear DNA tably segments of MYC and TP53, can be hyperedited by APOBEC3A
-
-
?
additional information
?
-
-
cytosine deaminase gene therapy combined with radiation treatment in breast cancer is evaluated in a 4T1murine breast carcinoma model, overview
-
-
?
additional information
?
-
-
cytosine deaminase/5-fluorocytosine exposure induces bystander and radiosensitization effects in hypoxic glioblastoma cell lines Y87-1 and Y87-2 in vitro, overview
-
-
?
additional information
?
-
-
the cytosine deaminase gene acts as a suicide gene by catalyzing the conversion of 5-fluorocytosine to cytotoxic 5-fluorouracil, fusion of the HSV-1 tegument protein vp22 to cytosine deaminase confers enhanced bystander effect and increased therapeutic benefit in cancer gene therapy of gliosarcoma cells and murine 9L tumors, overview
-
-
?
