3.4.24.63: meprin B

This is an abbreviated version!
For detailed information about meprin B, go to the full flat file.

Word Map on EC 3.4.24.63

Reaction

Hydrolysis of proteins, including azocasein, and peptides. Hydrolysis of -His5-/-Leu-, -Leu6-/-Cys-, -Ala14-/-Leu- and -Cys19-/-Gly- bonds in insulin B chain =

Synonyms

More, Meprin b, beta-secretase, meprin metalloproteinase, metalloprotease meprin B, meprin B metalloprotease, mouse meprin beta, mephrin beta, meprin metalloproteinase beta, meprinbeta, metalloprotease meprin, meprin beta, MEP1B, meprin metalloprotease, procollagen proteinase, meprin beta metalloproteinase, meprin-beta, meprin A subunit beta, h-meprin beta, metalloprotease meprin beta, Mmepb, Rmepb, metalloproteinase meprin beta, cell surface sheddase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.63 meprin B

KM Value

KM Value on EC 3.4.24.63 - meprin B

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0000007
(7-methoxycoumarin-4-yl)acetyl-YVADAPK-(K-epsilon-DNP)-NH2
pH 7.5, 25°C
0.0218
Abz-MGWMDEIDK(Dnp)SG-OH
pH 8.0, 37°C, recombinant enzyme
0.032
Abz-VKMDAE-EDDnp
pH 7.5, 37°C
0.015
Abz-VNLDAE-EDDnp
pH 7.5, 37°C
0.0271
Abz-YVAEAPK(Dnp)G-OH
pH 8.0, 37°C, recombinant enzyme
0.00073
actin
-
pH 7.5, 37°C
0.282
alpha-MSH
-
pH 7.5, 37°C, mutant K185Y
0.00104
bradykinin
-
pH 7.5, 37°C
0.211 - 0.22
cholecystokinin 8 sulfate
0.0481
gastri-releasing peptide-(14-27)
-
pH 7.5, 37°C
0.0071
gastrin
-
pH 7.5, 37°C
0.00104 - 0.0296
gastrin 17
0.22
glucagon
-
pH 7.5, 37°C
0.184
KKGYVADAP-4-nitroanilide
0.074
KKGYVADAP-7-amido-4-methylcoumarin
0.1
orcokinin
-
pH 7.5, 37°C
0.211
sCCK8NH2
-
pH 7.5, 37°C
0.00117
villin
-
pH 7.5, 37°C
-
additional information
additional information
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