3.4.24.63: meprin B

This is an abbreviated version!
For detailed information about meprin B, go to the full flat file.

Word Map on EC 3.4.24.63

Reaction

Hydrolysis of proteins, including azocasein, and peptides. Hydrolysis of -His5-/-Leu-, -Leu6-/-Cys-, -Ala14-/-Leu- and -Cys19-/-Gly- bonds in insulin B chain =

Synonyms

More, Meprin b, beta-secretase, meprin metalloproteinase, metalloprotease meprin B, meprin B metalloprotease, mouse meprin beta, mephrin beta, meprin metalloproteinase beta, meprinbeta, metalloprotease meprin, meprin beta, MEP1B, meprin metalloprotease, procollagen proteinase, meprin beta metalloproteinase, meprin-beta, meprin A subunit beta, h-meprin beta, metalloprotease meprin beta, Mmepb, Rmepb, metalloproteinase meprin beta, cell surface sheddase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.63 meprin B

KI Value

KI Value on EC 3.4.24.63 - meprin B

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.000008
3-[(E)-[4-formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]pyridin-2-yl]diazenyl]-7-nitronaphthalene-1,5-disulfonic acid
pH 7.5, 25°C
0.00003
3-[[(3-carboxyphenyl)sulfonyl-[2-(hydroxyamino)-2-oxo-ethyl]amino]methyl]benzoic acid
0.00003
3-[[[2-(hydroxyamino)-2-oxo-ethyl]-(4-methoxyphenyl)sulfonylamino]methyl]benzoic acid
52.9
Abz-MGWMDEIDK(Dnp)SG-OH
pH 8.0, 37°C, recombinant enzyme
0.0003 - 0.232
actinonin
0.018
batimastat
pH and temperature not specified in the publication
0.041 - 0.41
captopril
0.014
DL-Pro-DL-Leu-Gly-NH2
pH and temperature not specified in the publication
0.0089
galardin
pH and temperature not specified in the publication
0.0074
N-isobutyl-N-(4-methoxyphenylsulfonyl)glycyl hydroxamic acid
pH and temperature not specified in the publication
0.0074
N4-hydroxy-N1-[3-(1H-indol-3-yl)-1-(methylamino)-1-oxopropan-2-yl]-2-(2-methylpropyl)butanediamide
pH and temperature not specified in the publication
0.017
NF 449
pH 8.0, 37°C, recombinant enzyme
0.000022 - 0.00007
NF449
8.58
NNGH
pH 8.0, 37°C, recombinant enzyme
0.000008 - 2.64
PPNDS
0.014
Pro-Leu-Gly-hydroxamate
pH and temperature not specified in the publication
additional information
additional information
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