Cloned (Comment) | Organism |
---|---|
recombinantly expressed | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00073 | - |
actin | pH 7.5, 37°C | Rattus norvegicus | |
0.00117 | - |
villin | pH 7.5, 37°C | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
purified from stably transfected human embryonic kidney HEK-293 cells | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
actin + H2O | villin and actin bind to the cytoplasmic tail of meprin beta | Mus musculus | ? | - |
? | |
actin + H2O | villin and actin bind to the cytoplasmic tail of meprin beta | Rattus norvegicus | ? | - |
? | |
villin + H2O | villin and actin bind to the cytoplasmic tail of meprin beta | Mus musculus | ? | - |
? | |
villin + H2O | villin and actin bind to the cytoplasmic tail of meprin beta | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Meprin b | - |
Mus musculus |
Meprin b | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.625 | - |
actin | pH 7.5, 37°C | Rattus norvegicus | |
150 | - |
villin | pH 7.5, 37°C | Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
malfunction | following ischemia-reperfusion, meprins and villin redistribute from the brush-border membranes to the cytosol. A 37-kDa actin fragment is detected in protein fractions from wild-type, but not in comparable preparations from meprin knockout mice | Rattus norvegicus |
malfunction | following ischemia-reperfusion, meprins and villin redistribute from the brush-border membranes to the cytosol. A 37-kDa actin fragment is detected in protein fractions from wildtype, but not in comparable preparations from meprin knockout mice | Mus musculus |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
860 | - |
actin | pH 7.5, 37°C | Rattus norvegicus | |
128200 | - |
villin | pH 7.5, 37°C | Rattus norvegicus |