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3.4.24.63: meprin B

This is an abbreviated version!
For detailed information about meprin B, go to the full flat file.

Word Map on EC 3.4.24.63

Reaction

Hydrolysis of proteins, including azocasein, and peptides. Hydrolysis of -His5-/-Leu-, -Leu6-/-Cys-, -Ala14-/-Leu- and -Cys19-/-Gly- bonds in insulin B chain =

Synonyms

beta-secretase, cell surface sheddase, h-meprin beta, MEP1B, mephrin beta, meprin A subunit beta, Meprin b, meprin B metalloprotease, meprin beta, meprin beta metalloproteinase, meprin metalloprotease, meprin metalloproteinase, meprin metalloproteinase beta, meprin-beta, meprinbeta, metalloprotease meprin, metalloprotease meprin B, metalloprotease meprin beta, metalloproteinase meprin beta, Mmepb, More, mouse meprin beta, procollagen proteinase, Rmepb

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.63 meprin B

Reference

Reference on EC 3.4.24.63 - meprin B

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kounnas, M.Z.; Woltz, R.L.; Gorbea, C.M.; Bond, J.S.
Meprin-A and -B. Cell surface endopeptidases of the mouse kidney
J. Biol. Chem.
266
17350-17357
1991
Mus musculus
Manually annotated by BRENDA team
Wolz, R.L.; Bond, J.S.
Meprins A and B
Methods Enzymol.
248
325-345
1995
Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Gorbea, C.M.; Marchand, P.; Jiang, W.; Copeland, N.G.; Gilbert, D.J.; Jenkins, N.A.; Bond, J.S.
Cloning, expression, and chromosomal localization of the mouse meprin beta subunit
J. Biol. Chem.
268
21035-21043
1993
Mus musculus, Mus musculus C57BL
Manually annotated by BRENDA team
Johnson, G.D.; Hersh, L.B.
Expression of meprin subunit precursors. Membrane anchoring through the beta subunit and mechanism of zymogen activation
J. Biol. Chem.
269
7682-7688
1994
Rattus norvegicus
Manually annotated by BRENDA team
Bertenshaw, G.P.; Villa, J.P.; Hengst, J.A.; Bond, J.S.
Probing the active sites and mechanisms of rat metalloproteases meprin A and B
Biol. Chem.
383
1175-1183
2002
Rattus norvegicus
Manually annotated by BRENDA team
Bertenshaw, G.P.; Turk, B.E.; Hubbard, S.J.; Matters, G.L.; Bylander, J.E.; Crisman, J.M.; Cantley, L.C.; Bond, J.S.
Marked differences between metalloproteases meprin A and B in substrate and peptide bond specificity
J. Biol. Chem.
276
13248-13255
2001
Mus musculus
Manually annotated by BRENDA team
Bertenshaw, G.P.; Norcum, M.T.; Bond, J.S.
Structure of homo- and hetero-oligomeric meprin metalloproteases
J. Biol. Chem.
278
2522-2532
2003
Rattus norvegicus
Manually annotated by BRENDA team
Villa, J.P.; Bertenshaw, G.P.; Bond, J.S.
Critical Amino Acids in the Active Site of Meprin Metalloproteinases for Substrate and Peptide Bond Specificity
J. Biol. Chem.
278
42545-42550
2003
Mus musculus
Manually annotated by BRENDA team
Herzog, C.; Kaushal, G.P.; Haun, R.S.
Generation of biologically active interleukin-1beta by meprin B
Cytokine
31
394-403
2005
Homo sapiens (Q16820)
Manually annotated by BRENDA team
Ishmael, F.T.; Shier, V.K.; Ishmael, S.S.; Bond, J.S.
Intersubunit and domain interactions of the meprin B metalloproteinase. Disulfide bonds and protein-protein interactions in the MAM and TRAF domains
J. Biol. Chem.
280
13895-13901
2005
Rattus norvegicus
Manually annotated by BRENDA team
Crisman, J.M.; Zhang, B.; Norman, L.P.; Bond, J.S.
Deletion of the mouse meprin beta metalloprotease gene diminishes the ability of leukocytes to disseminate through extracellular matrix
J. Immunol.
172
4510-4519
2004
Mus musculus
Manually annotated by BRENDA team
Bylander, J.; Li, Q.; Ramesh, G.; Zhang, B.; Reeves, W.B.; Bond, J.S.
Targeted disruption of the meprin metalloproteinase beta gene protects against renal ischemia-reperfusion injury in mice
Am. J. Physiol.
294
F480-F490
2008
Mus musculus
Manually annotated by BRENDA team
Schuette, A.; Lottaz, D.; Sterchi, E.E.; Stoecker, W.; Becker-Pauly, C.
Two alpha subunits and one beta subunit of meprin zinc-endopeptidases are differentially expressed in the zebrafish Danio rerio
Biol. Chem.
388
523-531
2007
Danio rerio, Danio rerio (F1QRQ5), Danio rerio (Q5RHM1), Danio rerio (Q5RKM1)
Manually annotated by BRENDA team
Yoshimura, H.; Ito, M.; Kuwahara, Y.; Ishii, A.; Tsuritani, K.; Nakamura, A.; Hirasawa, Y.; Nagamatsu, T.
Downregulated expression in high IgA (HIGA) mice and the renal protective role of meprinbeta
Life Sci.
82
899-908
2008
Mus musculus
Manually annotated by BRENDA team
Ambort, D.; Brellier, F.; Becker-Pauly, C.; Stoecker, W.; Andrejevic-Blant, S.; Chiquet, M.; Sterchi, E.E.
Specific processing of tenascin-C by the metalloprotease meprinbeta neutralizes its inhibition of cell spreading
Matrix Biol.
29
31-42
2010
Homo sapiens
Manually annotated by BRENDA team
Ongeri, E.M.; Anyanwu, O.; Reeves, W.B.; Bond, J.S.
Villin and actin in the mouse kidney brush-border membrane bind to and are degraded by meprins, an interaction that contributes to injury in ischemia-reperfusion
Am. J. Physiol. Renal Physiol.
301
F871-F882
2011
Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
García-Caballero, A.; Ishmael, S.; Dang, Y.; Gillie, D.; Bond, J.; Milgram, S.; Stutts, M.
Activation of the epithelial sodium channel by the metalloprotease meprin beta subunit
Channels
5
14-22
2011
Homo sapiens
Manually annotated by BRENDA team
Jefferson, T.; Causevic, M.; auf dem Keller, U.; Schilling, O.; Isbert, S.; Geyer, R.; Maier, W.; Tschickardt, S.; Jumpertz, T.; Weggen, S.; Bond, J.S.; Overall, C.M.; Pietrzik, C.U.; Becker-Pauly, C.
Metalloprotease meprin beta generates nontoxic N-terminal amyloid precursor protein fragments in vivo
J. Biol. Chem.
286
27741-27750
2011
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Niyitegeka, J.M.; Bastidas, A.C.; Newman, R.H.; Taylor, S.S.; Ongeri, E.M.
Isoform-specific interactions between meprin metalloproteases and the catalytic subunit of protein kinase A: significance in acute and chronic kidney injury
Am. J. Physiol. Renal Physiol.
308
F56-68
2015
Mus musculus (Q61847), Mus musculus
Manually annotated by BRENDA team
Broder, C.; Becker-Pauly, C.
The metalloproteases meprin alpha and meprin beta: Unique enzymes in inflammation, neurodegeneration, cancer and fibrosis
Biochem. J.
450
253-264
2013
Danio rerio, Homo sapiens (Q16820), Mus musculus (Q61847)
Manually annotated by BRENDA team
Madoux, F.; Tredup, C.; Spicer, T.P.; Scampavia, L.; Chase, P.S.; Hodder, P.S.; Fields, G.B.; Becker-Pauly, C.; Minond, D.
Development of high throughput screening assays and pilot screen for inhibitors of metalloproteases meprin alpha and beta
Biopolymers
102
396-406
2014
Homo sapiens (Q16820)
Manually annotated by BRENDA team
Arnold, P.; Schmidt, F.; Prox, J.; Zunke, F.; Pietrzik, C.; Lucius, R.; Becker-Pauly, C.
Calcium negatively regulates meprin beta activity and attenuates substrate cleavage
FASEB J.
29
3549-3557
2015
Homo sapiens (Q16820)
Manually annotated by BRENDA team
Hirano, M.; Ma, B.; Kawasaki, N.; Oka, S.; Kawasaki, T.
Role of interaction of mannan-binding protein with meprins at the initial step of complement activation in ischemia/reperfusion injury to mouse kidney
Glycobiology
22
84-95
2012
Mus musculus (Q61847), Mus musculus BALB/c (Q61847)
Manually annotated by BRENDA team
Li, Y.; Fan, Y.; Tang, J.; Li, J.; Yu, C.
Meprin-beta regulates production of pro-inflammatory factors via a disintegrin and metalloproteinase-10 (ADAM-10) dependent pathway in macrophages
Int. Immunopharmacol.
18
77-84
2014
Homo sapiens (Q16820)
Manually annotated by BRENDA team
Bien, J.; Jefferson, T.; Causevic, M.; Jumpertz, T.; Munter, L.; Multhaup, G.; Weggen, S.; Becker-Pauly, C.; Pietrzik, C.
The metalloprotease meprin beta generates amino terminal-truncated amyloid beta peptide species
J. Biol. Chem.
287
33304-33313
2012
Homo sapiens (Q16820), Homo sapiens
Manually annotated by BRENDA team
Keiffer, T.R.; Bond, J.S.
Meprin metalloproteases inactivate interleukin 6
J. Biol. Chem.
289
7580-7588
2014
Rattus norvegicus (P28826), Homo sapiens (Q16820), Homo sapiens
Manually annotated by BRENDA team
Chaudhuri, A.; Sarkar, I.; Chakraborty, S.
Comparative analysis of binding sites of human meprins with hydroxamic acid derivative by molecular dynamics simulation study
J. Biomol. Struct. Dyn.
32
1969-1978
2014
Homo sapiens (Q16820)
Manually annotated by BRENDA team
Prox, J.; Arnold, P.; Becker-Pauly, C.
Meprin alpha and meprin beta: procollagen proteinases in health and disease
Matrix Biol.
44-46
7-13
2015
Homo sapiens (Q16820), Mus musculus (Q61847)
Manually annotated by BRENDA team
Arolas, J.; Broder, C.; Jefferson, T.; Guevara, T.; Sterchi, E.; Bode, W.; Stoecker, W.; Becker-Pauly, C.; Gomis-Rueth, F.
Structural basis for the sheddase function of human meprin beta metalloproteinase at the plasma membrane
Proc. Natl. Acad. Sci. USA
109
16131-16136
2012
Homo sapiens (Q16820)
Manually annotated by BRENDA team
Broder, C.; Arnold, P.; Vadon-Le Goff, S.; Konerding, M.A.; Bahr, K.; Mueller, S.; Overall, C.M.; Bond, J.S.; Koudelka, T.; Tholey, A.; Hulmes, D.J.; Moali, C.; Becker-Pauly, C.
Metalloproteases meprin ? and meprin ? are C- and N-procollagen proteinases important for collagen assembly and tensile strength
Proc. Natl. Acad. Sci. USA
110
14219-14224
2013
Mus musculus (Q61847)
Manually annotated by BRENDA team
Herzog, C.; Marisiddaiah, R.; Haun, R.; Kaushal, G.
Basement membrane protein nidogen-1 is a target of meprin beta in cisplatin nephrotoxicity
Toxicol. Lett.
236
110-116
2015
Mus musculus (Q61847), Mus musculus C57BL/6N (Q61847)
Manually annotated by BRENDA team
Schulze, A.; Wermann, M.; Demuth, H.U.; Yoshimoto, T.; Ramsbeck, D.; Schlenzig, D.; Schilling, S.
Continuous assays for meprin alpha and beta using prolyl tripeptidyl aminopeptidase (PtP) from Porphyromonas gingivalis
Anal. Biochem.
559
11-16
2018
Homo sapiens (Q16820)
Manually annotated by BRENDA team
Jaeckle, F.; Schmidt, F.; Wichert, R.; Arnold, P.; Prox, J.; Mangold, M.; Ohler, A.; Pietrzik, C.U.; Koudelka, T.; Tholey, A.; Guetschow, M.; Stirnberg, M.; Becker-Pauly, C.
Metalloprotease meprin beta is activated by transmembrane serine protease matriptase-2 at the cell surface thereby enhancing APP shedding
Biochem. J.
470
91-103
2015
Homo sapiens (Q16820)
Manually annotated by BRENDA team
Ramsbeck, D.; Hamann, A.; Schlenzig, D.; Schilling, S.; Buchholz, M.
First insight into structure-activity relationships of selective meprin beta inhibitors
Bioorg. Med. Chem. Lett.
27
2428-2431
2017
Homo sapiens (Q16820)
Manually annotated by BRENDA team
Schneppenheim, J.; Scharfenberg, F.; Lucius, R.; Becker-Pauly, C.; Arnold, P.
Meprin beta and BMP-1 are differentially regulated by CaCl2
Cell Calcium
65
8-13
2017
Homo sapiens (Q16820)
Manually annotated by BRENDA team
Scharfenberg, F.; Armbrust, F.; Marengo, L.; Pietrzik, C.; Becker-Pauly, C.
Regulation of the alternative beta-secretase meprin beta by ADAM-mediated shedding
Cell. Mol. Life Sci.
76
3193-3206
2019
Homo sapiens (Q16820), Homo sapiens, Mus musculus (Q61847)
Manually annotated by BRENDA team
Chaudhuri, A.; Bera, A.K.; Sarkar, I.; Chakraborty, S.
Insights from analysis of binding sites of human meprins screening of inhibitors by molecular dynamics simulation study
Comb. Chem. High Throughput Screen.
19
246-258
2016
Homo sapiens (Q16820)
Manually annotated by BRENDA team
Chaudhuri, A.; Chakraborty, S.
Structure-activity relationship of astacin metalloproteases A comparative study using EDTA
Curr. Enzyme Inhib.
14
131-140
2018
Mus musculus (Q61847), Rattus norvegicus (P28826)
-
Manually annotated by BRENDA team
Wichert, R.; Scharfenberg, F.; Colmorgen, C.; Koudelka, T.; Schwarz, J.; Wetzel, S.; Potempa, B.; Potempa, J.; Bartsch, J.W.; Sagi, I.; Tholey, A.; Saftig, P.; Rose-John, S.; Becker-Pauly, C.
Meprin beta induces activities of A disintegrin and metalloproteinases 9, 10, and 17 by specific prodomain cleavage
FASEB J.
33
11925-11940
2019
Homo sapiens (Q16820), Mus musculus (Q61847), Mus musculus C57/BL6N (Q61847)
Manually annotated by BRENDA team
Becker-Pauly, C.; Pietrzik, C.U.
The metalloprotease meprin beta is an alternative beta-secretase of APP
Front. Mol. Neurosci.
9
159
2016
Homo sapiens (Q16820), Homo sapiens
Manually annotated by BRENDA team
Martin, B.L.; Conley, S.M.; Harris, R.S.; Stanley, C.D.; Niyitegeka, J.M.; Ongeri, E.M.
Hypoxia associated proteolytic processing of OS-9 by the metalloproteinase meprin beta
Int. J. Nephrol.
2016
2851803
2016
Mus musculus (Q61847), Mus musculus C57BL/6 (Q61847)
Manually annotated by BRENDA team
Sato, Y.; Kobayashi, D.; Kohno, T.; Kidani, Y.; Prox, J.; Becker-Pauly, C.; Hattori, M.
Determination of cleavage site of Reelin between its sixth and seventh repeat and contribution of meprin metalloproteases to the cleavage
J. Biochem.
159
305-312
2015
Mus musculus (Q61847)
Manually annotated by BRENDA team
Schaeffler, H.; Li, W.; Helm, O.; Krueger, S.; Boeger, C.; Peters, F.; Roecken, C.; Sebens, S.; Lucius, R.; Becker-Pauly, C.; Arnold, P.
The cancer-associated meprin beta variant G32R provides an additional activation site and promotes cancer cell invasion
J. Cell Sci.
132
jes220665
2019
Homo sapiens (Q16820)
Manually annotated by BRENDA team
Ramsbeck, D.; Hamann, A.; Richter, G.; Schlenzig, D.; Geissler, S.; Nykiel, V.; Cynis, H.; Schilling, S.; Buchholz, M.
Structure-guided design, synthesis, and characterization of next-generation meprin beta inhibitors
J. Med. Chem.
61
4578-4592
2018
Homo sapiens (Q16820)
Manually annotated by BRENDA team
Becker-Pauly, C.; Rose-John, S.
Meprin and ADAM metalloproteases two sides of the same coin?
Matrix Metalloproteinase Biology (ed. Sagi I. and Gaffney J.P.)
2015
115-130
2015
Homo sapiens
-
Manually annotated by BRENDA team
Schoenherr, C.; Bien, J.; Isbert, S.; Wichert, R.; Prox, J.; Altmeppen, H.; Kumar, S.; Walter, J.; Lichtenthaler, S.F.; Weggen, S.; Glatzel, M.; Becker-Pauly, C.; Pietrzik, C.U.
Generation of aggregation prone N-terminally truncated amyloid beta peptides by meprin beta depends on the sequence specificity at the cleavage site
Mol. Neurodegener.
11
19
2016
Mus musculus (Q61847), Mus musculus C57BL/6 (Q61847)
Manually annotated by BRENDA team
Schlenzig, D.; Wermann, M.; Ramsbeck, D.; Moenke-Wedler, T.; Schilling, S.
Expression, purification and initial characterization of human meprin beta from Pichia pastoris
Protein Expr. Purif.
116
75-81
2015
Homo sapiens (Q16820)
Manually annotated by BRENDA team
Biasin, V.; Wygrecka, M.; Marsh, L.M.; Becker-Pauly, C.; Brcic, L.; Ghanim, B.; Klepetko, W.; Olschewski, A.; Kwapiszewska, G.
Meprin beta contributes to collagen deposition in lung fibrosis
Sci. Rep.
7
39969
2017
Homo sapiens (Q16820), Mus musculus (Q61847)
Manually annotated by BRENDA team