3.4.24.63: meprin B
This is an abbreviated version!
For detailed information about meprin B, go to the full flat file.
Word Map on EC 3.4.24.63
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3.4.24.63
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alzheimer
-
amyloid
-
abeta
-
gamma-secretase
-
beta-amyloid
-
plaque
-
amyloid-beta
-
beta-site
-
amyloidogenic
-
alpha-secretase
-
aspartyl
-
cerebral
-
presenilins
-
senile
-
neurodegenerative
-
bace-1
-
swedish
-
sappalpha
-
neuropathology
-
tau
-
neurotoxic
-
app-cleaving
-
neuroblastoma
-
beta-peptide
-
ectodomains
-
dementia
-
protein-cleaving
-
medicine
-
nicastrin
-
drug development
-
amyloidogenesis
-
tangles
-
isostere
-
memapsin
-
peptidomimetic
-
abeta1-40
-
appswe
-
ad-like
-
hydroxyethylene
-
neurofibrillary
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adam10
-
beta-protein
-
ad-associated
-
endoproteolytic
-
insulin-degrading
-
non-amyloidogenic
-
betaapp
-
neprilysin
-
pharmacology
- 3.4.24.63
- alzheimer
-
amyloid
- abeta
- gamma-secretase
- beta-amyloid
- plaque
- amyloid-beta
-
beta-site
-
amyloidogenic
- alpha-secretase
-
aspartyl
- cerebral
-
presenilins
-
senile
- neurodegenerative
- bace-1
-
swedish
-
sappalpha
-
neuropathology
- tau
-
neurotoxic
-
app-cleaving
- neuroblastoma
- beta-peptide
- ectodomains
- dementia
-
protein-cleaving
- medicine
-
nicastrin
- drug development
-
amyloidogenesis
-
tangles
-
isostere
-
memapsin
-
peptidomimetic
- abeta1-40
-
appswe
-
ad-like
-
hydroxyethylene
-
neurofibrillary
- adam10
- beta-protein
-
ad-associated
-
endoproteolytic
-
insulin-degrading
-
non-amyloidogenic
-
betaapp
- neprilysin
- pharmacology
Reaction
Hydrolysis of proteins, including azocasein, and peptides. Hydrolysis of -His5-/-Leu-, -Leu6-/-Cys-, -Ala14-/-Leu- and -Cys19-/-Gly- bonds in insulin B chain =
Synonyms
beta-secretase, cell surface sheddase, h-meprin beta, MEP1B, mephrin beta, meprin A subunit beta, Meprin b, meprin B metalloprotease, meprin beta, meprin beta metalloproteinase, meprin metalloprotease, meprin metalloproteinase, meprin metalloproteinase beta, meprin-beta, meprinbeta, metalloprotease meprin, metalloprotease meprin B, metalloprotease meprin beta, metalloproteinase meprin beta, Mmepb, More, mouse meprin beta, procollagen proteinase, Rmepb
ECTree
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Reference
Reference on EC 3.4.24.63 - meprin B
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Kounnas, M.Z.; Woltz, R.L.; Gorbea, C.M.; Bond, J.S.
Meprin-A and -B. Cell surface endopeptidases of the mouse kidney
J. Biol. Chem.
266
17350-17357
1991
Mus musculus
Wolz, R.L.; Bond, J.S.
Meprins A and B
Methods Enzymol.
248
325-345
1995
Homo sapiens, Mus musculus, Rattus norvegicus
Gorbea, C.M.; Marchand, P.; Jiang, W.; Copeland, N.G.; Gilbert, D.J.; Jenkins, N.A.; Bond, J.S.
Cloning, expression, and chromosomal localization of the mouse meprin beta subunit
J. Biol. Chem.
268
21035-21043
1993
Mus musculus, Mus musculus C57BL
Johnson, G.D.; Hersh, L.B.
Expression of meprin subunit precursors. Membrane anchoring through the beta subunit and mechanism of zymogen activation
J. Biol. Chem.
269
7682-7688
1994
Rattus norvegicus
Bertenshaw, G.P.; Villa, J.P.; Hengst, J.A.; Bond, J.S.
Probing the active sites and mechanisms of rat metalloproteases meprin A and B
Biol. Chem.
383
1175-1183
2002
Rattus norvegicus
Bertenshaw, G.P.; Turk, B.E.; Hubbard, S.J.; Matters, G.L.; Bylander, J.E.; Crisman, J.M.; Cantley, L.C.; Bond, J.S.
Marked differences between metalloproteases meprin A and B in substrate and peptide bond specificity
J. Biol. Chem.
276
13248-13255
2001
Mus musculus
Bertenshaw, G.P.; Norcum, M.T.; Bond, J.S.
Structure of homo- and hetero-oligomeric meprin metalloproteases
J. Biol. Chem.
278
2522-2532
2003
Rattus norvegicus
Villa, J.P.; Bertenshaw, G.P.; Bond, J.S.
Critical Amino Acids in the Active Site of Meprin Metalloproteinases for Substrate and Peptide Bond Specificity
J. Biol. Chem.
278
42545-42550
2003
Mus musculus
Herzog, C.; Kaushal, G.P.; Haun, R.S.
Generation of biologically active interleukin-1beta by meprin B
Cytokine
31
394-403
2005
Homo sapiens (Q16820)
Ishmael, F.T.; Shier, V.K.; Ishmael, S.S.; Bond, J.S.
Intersubunit and domain interactions of the meprin B metalloproteinase. Disulfide bonds and protein-protein interactions in the MAM and TRAF domains
J. Biol. Chem.
280
13895-13901
2005
Rattus norvegicus
Crisman, J.M.; Zhang, B.; Norman, L.P.; Bond, J.S.
Deletion of the mouse meprin beta metalloprotease gene diminishes the ability of leukocytes to disseminate through extracellular matrix
J. Immunol.
172
4510-4519
2004
Mus musculus
Bylander, J.; Li, Q.; Ramesh, G.; Zhang, B.; Reeves, W.B.; Bond, J.S.
Targeted disruption of the meprin metalloproteinase beta gene protects against renal ischemia-reperfusion injury in mice
Am. J. Physiol.
294
F480-F490
2008
Mus musculus
Schuette, A.; Lottaz, D.; Sterchi, E.E.; Stoecker, W.; Becker-Pauly, C.
Two alpha subunits and one beta subunit of meprin zinc-endopeptidases are differentially expressed in the zebrafish Danio rerio
Biol. Chem.
388
523-531
2007
Danio rerio, Danio rerio (F1QRQ5), Danio rerio (Q5RHM1), Danio rerio (Q5RKM1)
Yoshimura, H.; Ito, M.; Kuwahara, Y.; Ishii, A.; Tsuritani, K.; Nakamura, A.; Hirasawa, Y.; Nagamatsu, T.
Downregulated expression in high IgA (HIGA) mice and the renal protective role of meprinbeta
Life Sci.
82
899-908
2008
Mus musculus
Ambort, D.; Brellier, F.; Becker-Pauly, C.; Stoecker, W.; Andrejevic-Blant, S.; Chiquet, M.; Sterchi, E.E.
Specific processing of tenascin-C by the metalloprotease meprinbeta neutralizes its inhibition of cell spreading
Matrix Biol.
29
31-42
2010
Homo sapiens
Ongeri, E.M.; Anyanwu, O.; Reeves, W.B.; Bond, J.S.
Villin and actin in the mouse kidney brush-border membrane bind to and are degraded by meprins, an interaction that contributes to injury in ischemia-reperfusion
Am. J. Physiol. Renal Physiol.
301
F871-F882
2011
Mus musculus, Rattus norvegicus
García-Caballero, A.; Ishmael, S.; Dang, Y.; Gillie, D.; Bond, J.; Milgram, S.; Stutts, M.
Activation of the epithelial sodium channel by the metalloprotease meprin beta subunit
Channels
5
14-22
2011
Homo sapiens
Jefferson, T.; Causevic, M.; auf dem Keller, U.; Schilling, O.; Isbert, S.; Geyer, R.; Maier, W.; Tschickardt, S.; Jumpertz, T.; Weggen, S.; Bond, J.S.; Overall, C.M.; Pietrzik, C.U.; Becker-Pauly, C.
Metalloprotease meprin beta generates nontoxic N-terminal amyloid precursor protein fragments in vivo
J. Biol. Chem.
286
27741-27750
2011
Homo sapiens, Mus musculus
Niyitegeka, J.M.; Bastidas, A.C.; Newman, R.H.; Taylor, S.S.; Ongeri, E.M.
Isoform-specific interactions between meprin metalloproteases and the catalytic subunit of protein kinase A: significance in acute and chronic kidney injury
Am. J. Physiol. Renal Physiol.
308
F56-68
2015
Mus musculus (Q61847), Mus musculus
Broder, C.; Becker-Pauly, C.
The metalloproteases meprin alpha and meprin beta: Unique enzymes in inflammation, neurodegeneration, cancer and fibrosis
Biochem. J.
450
253-264
2013
Danio rerio, Homo sapiens (Q16820), Mus musculus (Q61847)
Madoux, F.; Tredup, C.; Spicer, T.P.; Scampavia, L.; Chase, P.S.; Hodder, P.S.; Fields, G.B.; Becker-Pauly, C.; Minond, D.
Development of high throughput screening assays and pilot screen for inhibitors of metalloproteases meprin alpha and beta
Biopolymers
102
396-406
2014
Homo sapiens (Q16820)
Arnold, P.; Schmidt, F.; Prox, J.; Zunke, F.; Pietrzik, C.; Lucius, R.; Becker-Pauly, C.
Calcium negatively regulates meprin beta activity and attenuates substrate cleavage
FASEB J.
29
3549-3557
2015
Homo sapiens (Q16820)
Hirano, M.; Ma, B.; Kawasaki, N.; Oka, S.; Kawasaki, T.
Role of interaction of mannan-binding protein with meprins at the initial step of complement activation in ischemia/reperfusion injury to mouse kidney
Glycobiology
22
84-95
2012
Mus musculus (Q61847), Mus musculus BALB/c (Q61847)
Li, Y.; Fan, Y.; Tang, J.; Li, J.; Yu, C.
Meprin-beta regulates production of pro-inflammatory factors via a disintegrin and metalloproteinase-10 (ADAM-10) dependent pathway in macrophages
Int. Immunopharmacol.
18
77-84
2014
Homo sapiens (Q16820)
Bien, J.; Jefferson, T.; Causevic, M.; Jumpertz, T.; Munter, L.; Multhaup, G.; Weggen, S.; Becker-Pauly, C.; Pietrzik, C.
The metalloprotease meprin beta generates amino terminal-truncated amyloid beta peptide species
J. Biol. Chem.
287
33304-33313
2012
Homo sapiens (Q16820), Homo sapiens
Keiffer, T.R.; Bond, J.S.
Meprin metalloproteases inactivate interleukin 6
J. Biol. Chem.
289
7580-7588
2014
Rattus norvegicus (P28826), Homo sapiens (Q16820), Homo sapiens
Chaudhuri, A.; Sarkar, I.; Chakraborty, S.
Comparative analysis of binding sites of human meprins with hydroxamic acid derivative by molecular dynamics simulation study
J. Biomol. Struct. Dyn.
32
1969-1978
2014
Homo sapiens (Q16820)
Prox, J.; Arnold, P.; Becker-Pauly, C.
Meprin alpha and meprin beta: procollagen proteinases in health and disease
Matrix Biol.
44-46
7-13
2015
Homo sapiens (Q16820), Mus musculus (Q61847)
Arolas, J.; Broder, C.; Jefferson, T.; Guevara, T.; Sterchi, E.; Bode, W.; Stoecker, W.; Becker-Pauly, C.; Gomis-Rueth, F.
Structural basis for the sheddase function of human meprin beta metalloproteinase at the plasma membrane
Proc. Natl. Acad. Sci. USA
109
16131-16136
2012
Homo sapiens (Q16820)
Broder, C.; Arnold, P.; Vadon-Le Goff, S.; Konerding, M.A.; Bahr, K.; Mueller, S.; Overall, C.M.; Bond, J.S.; Koudelka, T.; Tholey, A.; Hulmes, D.J.; Moali, C.; Becker-Pauly, C.
Metalloproteases meprin ? and meprin ? are C- and N-procollagen proteinases important for collagen assembly and tensile strength
Proc. Natl. Acad. Sci. USA
110
14219-14224
2013
Mus musculus (Q61847)
Herzog, C.; Marisiddaiah, R.; Haun, R.; Kaushal, G.
Basement membrane protein nidogen-1 is a target of meprin beta in cisplatin nephrotoxicity
Toxicol. Lett.
236
110-116
2015
Mus musculus (Q61847), Mus musculus C57BL/6N (Q61847)
Schulze, A.; Wermann, M.; Demuth, H.U.; Yoshimoto, T.; Ramsbeck, D.; Schlenzig, D.; Schilling, S.
Continuous assays for meprin alpha and beta using prolyl tripeptidyl aminopeptidase (PtP) from Porphyromonas gingivalis
Anal. Biochem.
559
11-16
2018
Homo sapiens (Q16820)
Jaeckle, F.; Schmidt, F.; Wichert, R.; Arnold, P.; Prox, J.; Mangold, M.; Ohler, A.; Pietrzik, C.U.; Koudelka, T.; Tholey, A.; Guetschow, M.; Stirnberg, M.; Becker-Pauly, C.
Metalloprotease meprin beta is activated by transmembrane serine protease matriptase-2 at the cell surface thereby enhancing APP shedding
Biochem. J.
470
91-103
2015
Homo sapiens (Q16820)
Ramsbeck, D.; Hamann, A.; Schlenzig, D.; Schilling, S.; Buchholz, M.
First insight into structure-activity relationships of selective meprin beta inhibitors
Bioorg. Med. Chem. Lett.
27
2428-2431
2017
Homo sapiens (Q16820)
Schneppenheim, J.; Scharfenberg, F.; Lucius, R.; Becker-Pauly, C.; Arnold, P.
Meprin beta and BMP-1 are differentially regulated by CaCl2
Cell Calcium
65
8-13
2017
Homo sapiens (Q16820)
Scharfenberg, F.; Armbrust, F.; Marengo, L.; Pietrzik, C.; Becker-Pauly, C.
Regulation of the alternative beta-secretase meprin beta by ADAM-mediated shedding
Cell. Mol. Life Sci.
76
3193-3206
2019
Homo sapiens (Q16820), Homo sapiens, Mus musculus (Q61847)
Chaudhuri, A.; Bera, A.K.; Sarkar, I.; Chakraborty, S.
Insights from analysis of binding sites of human meprins screening of inhibitors by molecular dynamics simulation study
Comb. Chem. High Throughput Screen.
19
246-258
2016
Homo sapiens (Q16820)
Chaudhuri, A.; Chakraborty, S.
Structure-activity relationship of astacin metalloproteases A comparative study using EDTA
Curr. Enzyme Inhib.
14
131-140
2018
Mus musculus (Q61847), Rattus norvegicus (P28826)
-
Wichert, R.; Scharfenberg, F.; Colmorgen, C.; Koudelka, T.; Schwarz, J.; Wetzel, S.; Potempa, B.; Potempa, J.; Bartsch, J.W.; Sagi, I.; Tholey, A.; Saftig, P.; Rose-John, S.; Becker-Pauly, C.
Meprin beta induces activities of A disintegrin and metalloproteinases 9, 10, and 17 by specific prodomain cleavage
FASEB J.
33
11925-11940
2019
Homo sapiens (Q16820), Mus musculus (Q61847), Mus musculus C57/BL6N (Q61847)
Becker-Pauly, C.; Pietrzik, C.U.
The metalloprotease meprin beta is an alternative beta-secretase of APP
Front. Mol. Neurosci.
9
159
2016
Homo sapiens (Q16820), Homo sapiens
Martin, B.L.; Conley, S.M.; Harris, R.S.; Stanley, C.D.; Niyitegeka, J.M.; Ongeri, E.M.
Hypoxia associated proteolytic processing of OS-9 by the metalloproteinase meprin beta
Int. J. Nephrol.
2016
2851803
2016
Mus musculus (Q61847), Mus musculus C57BL/6 (Q61847)
Sato, Y.; Kobayashi, D.; Kohno, T.; Kidani, Y.; Prox, J.; Becker-Pauly, C.; Hattori, M.
Determination of cleavage site of Reelin between its sixth and seventh repeat and contribution of meprin metalloproteases to the cleavage
J. Biochem.
159
305-312
2015
Mus musculus (Q61847)
Schaeffler, H.; Li, W.; Helm, O.; Krueger, S.; Boeger, C.; Peters, F.; Roecken, C.; Sebens, S.; Lucius, R.; Becker-Pauly, C.; Arnold, P.
The cancer-associated meprin beta variant G32R provides an additional activation site and promotes cancer cell invasion
J. Cell Sci.
132
jes220665
2019
Homo sapiens (Q16820)
Ramsbeck, D.; Hamann, A.; Richter, G.; Schlenzig, D.; Geissler, S.; Nykiel, V.; Cynis, H.; Schilling, S.; Buchholz, M.
Structure-guided design, synthesis, and characterization of next-generation meprin beta inhibitors
J. Med. Chem.
61
4578-4592
2018
Homo sapiens (Q16820)
Becker-Pauly, C.; Rose-John, S.
Meprin and ADAM metalloproteases two sides of the same coin?
Matrix Metalloproteinase Biology (ed. Sagi I. and Gaffney J.P.)
2015
115-130
2015
Homo sapiens
-
Schoenherr, C.; Bien, J.; Isbert, S.; Wichert, R.; Prox, J.; Altmeppen, H.; Kumar, S.; Walter, J.; Lichtenthaler, S.F.; Weggen, S.; Glatzel, M.; Becker-Pauly, C.; Pietrzik, C.U.
Generation of aggregation prone N-terminally truncated amyloid beta peptides by meprin beta depends on the sequence specificity at the cleavage site
Mol. Neurodegener.
11
19
2016
Mus musculus (Q61847), Mus musculus C57BL/6 (Q61847)
Schlenzig, D.; Wermann, M.; Ramsbeck, D.; Moenke-Wedler, T.; Schilling, S.
Expression, purification and initial characterization of human meprin beta from Pichia pastoris
Protein Expr. Purif.
116
75-81
2015
Homo sapiens (Q16820)
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