3.4.24.63: meprin B
This is an abbreviated version!
For detailed information about meprin B, go to the full flat file.
Word Map on EC 3.4.24.63
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3.4.24.63
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alzheimer
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amyloid
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abeta
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gamma-secretase
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beta-amyloid
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plaque
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amyloid-beta
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beta-site
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amyloidogenic
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alpha-secretase
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aspartyl
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cerebral
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presenilins
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senile
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neurodegenerative
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bace-1
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swedish
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sappalpha
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neuropathology
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tau
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neurotoxic
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app-cleaving
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neuroblastoma
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beta-peptide
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ectodomains
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dementia
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protein-cleaving
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medicine
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nicastrin
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drug development
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amyloidogenesis
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tangles
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isostere
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memapsin
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peptidomimetic
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abeta1-40
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appswe
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ad-like
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hydroxyethylene
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neurofibrillary
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adam10
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beta-protein
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ad-associated
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endoproteolytic
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insulin-degrading
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non-amyloidogenic
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betaapp
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neprilysin
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pharmacology
- 3.4.24.63
- alzheimer
-
amyloid
- abeta
- gamma-secretase
- beta-amyloid
- plaque
- amyloid-beta
-
beta-site
-
amyloidogenic
- alpha-secretase
-
aspartyl
- cerebral
-
presenilins
-
senile
- neurodegenerative
- bace-1
-
swedish
-
sappalpha
-
neuropathology
- tau
-
neurotoxic
-
app-cleaving
- neuroblastoma
- beta-peptide
- ectodomains
- dementia
-
protein-cleaving
- medicine
-
nicastrin
- drug development
-
amyloidogenesis
-
tangles
-
isostere
-
memapsin
-
peptidomimetic
- abeta1-40
-
appswe
-
ad-like
-
hydroxyethylene
-
neurofibrillary
- adam10
- beta-protein
-
ad-associated
-
endoproteolytic
-
insulin-degrading
-
non-amyloidogenic
-
betaapp
- neprilysin
- pharmacology
Reaction
Hydrolysis of proteins, including azocasein, and peptides. Hydrolysis of -His5-/-Leu-, -Leu6-/-Cys-, -Ala14-/-Leu- and -Cys19-/-Gly- bonds in insulin B chain =
Synonyms
beta-secretase, cell surface sheddase, h-meprin beta, MEP1B, mephrin beta, meprin A subunit beta, Meprin b, meprin B metalloprotease, meprin beta, meprin beta metalloproteinase, meprin metalloprotease, meprin metalloproteinase, meprin metalloproteinase beta, meprin-beta, meprinbeta, metalloprotease meprin, metalloprotease meprin B, metalloprotease meprin beta, metalloproteinase meprin beta, Mmepb, More, mouse meprin beta, procollagen proteinase, Rmepb
ECTree
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Localization
Localization on EC 3.4.24.63 - meprin B
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additional information
meprin beta is a secreted homodimeric multidomain type-I membrane metallopeptidase
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meprin beta is expressed as a dimeric type 1 transmembrane protein
meprin beta is a membrane-bound protein with a transmembrane helix and a small C-terminal cytosolic domain
meprin beta is expressed as a dimeric type 1 transmembrane protein
meprin beta is a secreted homodimeric multidomain type-I membrane metallopeptidase
meprin beta can be shed from the cell surface by a disintegrin and metalloprotease 10 and 17 (ADAM10/17), the soluble meprin beta is no longer capable of cleaving amyloid precursor protein at the beta-site
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additional information
meprin beta homodimers are essentially membrane bound but may also be shed from the surface by ADAM-10 and -17
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additional information
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meprin beta does not contain an additional inserted domain (I-domain)
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additional information
meprin beta is a type 1 transmembrane protein, but can be released from the cell surface by ectodomain shedding
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additional information
meprin beta is primarily membrane-bound and forms asymmetric disulfide linked homodimer at the cell surface
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additional information
meprin beta localisation changes upon bleomycin treatment
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additional information
the extracellular metalloprotease meprin beta is expressed as a homodimer and is primarily membrane bound. Meprin beta can be released from the cell surface by its known sheddases ADAM10 and ADAM17. Shedding of meprin beta mutant G32R mediated by ADAM17 is impaired
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additional information
meprin beta can be shed from the cell surface by a disintegrin and metalloprotease 10 and 17 (ADAM10/17), the soluble meprin beta is no longer capable of cleaving amyloid precursor protein at the beta-site
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