Disease on EC 3.4.24.63 - meprin B
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Acquired Immunodeficiency Syndrome
Aspartic peptidase inhibitors: implications in drug development.
Acquired Immunodeficiency Syndrome
Design of potent aspartic protease inhibitors to treat various diseases.
Acquired Immunodeficiency Syndrome
Memapsin 2 (Beta-Secretase) Inhibitor Drug, between Fantasy and Reality.
Alzheimer Disease
A Method for Induced-Fit Docking, Scoring, and Ranking of Flexible Ligands. Application to Peptidic and Pseudopeptidic beta-secretase (BACE 1) Inhibitors.
Alzheimer Disease
A novel approach to identifying beta-secretase inhibitors: bis-statine peptide mimetics discovered using structure and spot synthesis.
Alzheimer Disease
A Novel Immunotherapy for Alzheimer's Disease: Antibodies against the beta-Secretase Cleavage Site of APP.
Alzheimer Disease
A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein.
Alzheimer Disease
A splice variant of beta-secretase deficient in the amyloidogenic processing of the amyloid precursor protein.
Alzheimer Disease
Activation of peroxisome proliferator-activated receptor delta suppresses BACE1 expression by up-regulating SOCS1 in a JAK2/STAT1-dependent manner.
Alzheimer Disease
Activation of protein kinase C modulates BACE1-mediated beta-secretase activity.
Alzheimer Disease
Acylguanidine inhibitors of beta-secretase: optimization of the pyrrole ring substituents extending into the S1 and S3 substrate binding pockets.
Alzheimer Disease
Acylguanidine inhibitors of beta-secretase: optimization of the pyrrole ring substituents extending into the S1' substrate binding pocket.
Alzheimer Disease
Ajmalicine and Reserpine: Indole Alkaloids as Multi-Target Directed Ligands Towards Factors Implicated in Alzheimer's Disease.
Alzheimer Disease
Altered amyloid-beta metabolism and deposition in genomic-based beta-secretase transgenic mice.
Alzheimer Disease
Altered beta-secretase enzyme kinetics and levels of both BACE1 and BACE2 in the Alzheimer's disease brain.
Alzheimer Disease
Alzheimer's beta-secretase cleaves a glycosyltransferase as a physiological substrate.
Alzheimer Disease
Alzheimer's disease beta-secretase BACE1 is not a neuron-specific enzyme.
Alzheimer Disease
Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patients.
Alzheimer Disease
Antisense inhibition at the beta-secretase-site of beta-amyloid precursor protein reduces cerebral amyloid and acetyl cholinesterase activity in Tg2576.
Alzheimer Disease
Apoptogenic interactions of plasmalemmal type-1 VDAC and A? peptides via GxxxG motifs induce Alzheimer's disease - a basic model of apoptosis?
Alzheimer Disease
Application of molecular framework-based data-mining method in the search for beta-secretase 1 inhibitors through drug repurposing.
Alzheimer Disease
Assigning the protonation states of the key aspartates in beta-Secretase using QM/MM X-ray structure refinement.
Alzheimer Disease
Association between promoter polymorphisms in anterior pharynx-defective-1a and sporadic Alzheimer's disease in the North Chinese Han population.
Alzheimer Disease
Astrocytic expression of the Alzheimer's disease beta-secretase (BACE1) is stimulus-dependent.
Alzheimer Disease
BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics.
Alzheimer Disease
BACE-1 inhibitory activities of new substituted phenyl-piperazine coupled to various heterocycles: Chromene, coumarin and quinoline.
Alzheimer Disease
BACE1 activity in cerebrospinal fluid and its relation to markers of AD pathology.
Alzheimer Disease
BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease.
Alzheimer Disease
BACE1 inhibitory effects of lavandulyl flavanones from Sophora flavescens.
Alzheimer Disease
BACE1 knock-outs display deficits in activity-dependent potentiation of synaptic transmission at mossy fiber to CA3 synapses in the hippocampus.
Alzheimer Disease
BACE1 polymorphisms do not influence platelet membrane beta-secretase activity or genetic susceptibility for Alzheimer's disease in the Northern Irish population.
Alzheimer Disease
Bepridil and amiodarone simultaneously target the Alzheimer's disease beta- and gamma-secretase via distinct mechanisms.
Alzheimer Disease
Beta-amyloid peptide in regulated secretory vesicles of chromaffin cells: evidence for multiple cysteine proteolytic activities in distinct pathways for beta-secretase activity in chromaffin vesicles.
Alzheimer Disease
Beta-Secretase 1 (BACE1) Is Down-Regulated in Invasive Ductal Carcinoma of Breast.
Alzheimer Disease
Beta-secretase as a target for Alzheimer's disease drug discovery: an overview of in vitro methods for characterization of inhibitors.
Alzheimer Disease
beta-Secretase cleavage of the amyloid precursor protein mediates neuronal apoptosis caused by familial Alzheimer's disease mutations.
Alzheimer Disease
beta-Secretase expression in normal and functionally deprived rat olfactory bulbs: inverse correlation with oxidative metabolic activity.
Alzheimer Disease
Beta-secretase inhibitors in phase I and phase II clinical trials for Alzheimer's disease.
Alzheimer Disease
Beta-secretase processing in the trans-Golgi network preferentially generates truncated amyloid species that accumulate in Alzheimer's disease brain.
Alzheimer Disease
Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease.
Alzheimer Disease
Beta-secretase revealed: starting gate for race to novel therapies for Alzheimer's disease.
Alzheimer Disease
Boom in the development of non-peptidic beta-secretase (BACE1) inhibitors for the treatment of Alzheimer's disease.
Alzheimer Disease
Caffeine Reverses Cognitive Impairment and Decreases Brain Amyloid-beta Levels in Aged Alzheimer's Disease Mice.
Alzheimer Disease
Cellular prion protein regulates beta-secretase cleavage of the Alzheimer's amyloid precursor protein.
Alzheimer Disease
Chalcones Acting as Inhibitors of Cholinesterases, ?-Secretase and ?- Amyloid Aggregation and other Targets for Alzheimer's Disease: A Critical Review.
Alzheimer Disease
Characterization of alpha 2,6-sialyltransferase cleavage by Alzheimer's beta -secretase (BACE1).
Alzheimer Disease
Characterization of Drosophila aspartic proteases that induce the secretion of a Golgi-resident transferase, heparan sulfate 6-O-sulfotransferase.
Alzheimer Disease
Chia Seed Does Not Improve Cognitive Impairment in SAMP8 Mice Fed with High Fat Diet.
Alzheimer Disease
Cholesterol accumulation in Niemann Pick type C (NPC) model cells causes a shift in APP localization to lipid rafts.
Alzheimer Disease
Cognitive outcomes in trials of two BACE inhibitors in Alzheimer's disease.
Alzheimer Disease
Combination of a modified scoring function with two-dimensional descriptors for calculation of binding affinities of bulky, flexible ligands to proteins.
Alzheimer Disease
Comparison of batch and perfusion culture in combination with pilot-scale expanded bed purification for the production of soluble recombinant beta-secretase.
Alzheimer Disease
Control of amyloid-beta-peptide generation by subcellular trafficking of the beta-amyloid precursor protein and beta-secretase.
Alzheimer Disease
Critical role of mitosis in spontaneous late-onset Alzheimer's disease; from a Shugoshin 1 cohesinopathy mouse model.
Alzheimer Disease
CSF biomarkers for Alzheimer's disease: use in early diagnosis and evaluation of drug treatment.
Alzheimer Disease
Current updates on the regulation of beta-secretase movement as a potential restorative focus for management of Alzheimer's disease.
Alzheimer Disease
Cysteine protease inhibitors reduce brain beta-amyloid and beta-secretase activity in vivo and are potential Alzheimer's disease therapeutics.
Alzheimer Disease
Cysteine proteases are the major beta-secretase in the regulated secretory pathway that provides most of the beta-amyloid in Alzheimer's disease: role of BACE 1 in the constitutive secretory pathway.
Alzheimer Disease
Demonstration by FRET of BACE interaction with the amyloid precursor protein at the cell surface and in early endosomes.
Alzheimer Disease
Demonstration of BACE (beta-secretase) phosphorylation and its interaction with GGA1 in cells by fluorescence-lifetime imaging microscopy.
Alzheimer Disease
Design of Curcumin and Flavonoid Derivatives with Acetylcholinesterase and Beta-Secretase Inhibitory Activities Using in Silico Approaches.
Alzheimer Disease
Design, synthesis and biological Evaluation of Dual acetyl cholinesterase and beta-secretase inhibitors in treatment for alzheimer's Disease.
Alzheimer Disease
Design, synthesis and biological evaluation of novel dual inhibitors of acetylcholinesterase and beta-secretase.
Alzheimer Disease
Design, synthesis, in silico and in vitro screening of 1,2,4-thiadiazole analogues as non-peptide inhibitors of beta-secretase.
Alzheimer Disease
Determination of the active site protonation state of beta-secretase from molecular dynamics simulation and docking experiment: implications for structure-based inhibitor design.
Alzheimer Disease
Differential utilization of upstream AUGs in the beta-secretase mRNA suggests that a shunting mechanism regulates translation.
Alzheimer Disease
Discovery of a novel warhead against beta-secretase through fragment-based lead generation.
Alzheimer Disease
Discovery of isonicotinamide derived beta-secretase inhibitors: in vivo reduction of beta-amyloid.
Alzheimer Disease
Ectodomain shedding of the amyloid precursor protein: cellular control mechanisms and novel modifiers.
Alzheimer Disease
Editorial. BACE or beta-secretase -a target for drug discovery for treatment of Alzheimer's disease.
Alzheimer Disease
Effect of mycelial extract of Clavicorona pyxidata on the production of amyloid beta-peptide and the inhibition of endogenous beta-secretase activity in vitro.
Alzheimer Disease
Efficient inhibition of the Alzheimer's disease beta-secretase by membrane targeting.
Alzheimer Disease
Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease.
Alzheimer Disease
Energy inhibition elevates beta-secretase levels and activity and is potentially amyloidogenic in APP transgenic mice: possible early events in Alzheimer's disease pathogenesis.
Alzheimer Disease
Engineered heparins: novel beta-secretase inhibitors as potential Alzheimer's disease therapeutics.
Alzheimer Disease
Enhanced sleep reverses memory deficits and underlying pathology in Drosophila models of Alzheimer's disease.
Alzheimer Disease
Ensemble-Docking Approach on BACE-1: Pharmacophore Perception and Guidelines for Drug Design.
Alzheimer Disease
Evaluation of cathepsins D and G and EC 3.4.24.15 as candidate beta-secretase proteases using peptide and amyloid precursor protein substrates.
Alzheimer Disease
Evidence that gamma-secretase mediates oxidative stress-induced beta-secretase expression in Alzheimer's disease.
Alzheimer Disease
Experimental traumatic brain injury in rats stimulates the expression, production and activity of Alzheimer's disease beta-secretase (BACE-1).
Alzheimer Disease
Exploring 2D-QSAR for prediction of beta-secretase 1 (BACE1) inhibitory activity against Alzheimer's disease.
Alzheimer Disease
Exploring the binding of BACE-1 inhibitors using comparative binding energy analysis (COMBINE).
Alzheimer Disease
Expression analysis of beta-secretase 1 (BACE1) and its naturally occurring antisense (BACE1-AS) in blood of epileptic patients.
Alzheimer Disease
Expression analysis of beta-secretase 1 (BACE1) enzyme in peripheral blood of patients with Alzheimer's disease.
Alzheimer Disease
Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase.
Alzheimer Disease
Familial Alzheimer's Disease Mutations in Presenilin 1 Do Not Alter Levels of the Secreted Amyloid-beta Protein Precursor Generated by beta-Secretase Cleavage.
Alzheimer Disease
Familial Alzheimer's disease mutations in presenilin 1 do not alter levels of the secreted amyloid-beta protein precursor generated by beta-secretase cleavage.
Alzheimer Disease
Familial Alzheimer's disease mutations inhibit gamma-secretase-mediated liberation of beta-amyloid precursor protein carboxy-terminal fragment.
Alzheimer Disease
From Kinase Inhibitors to Multitarget Ligands as Powerful Drug Leads for Alzheimer's Disease using Protein-Templated Synthesis.
Alzheimer Disease
Generation of aggregation prone N-terminally truncated amyloid ? peptides by meprin ? depends on the sequence specificity at the cleavage site.
Alzheimer Disease
GGA1 is expressed in the human brain and affects the generation of amyloid beta-peptide.
Alzheimer Disease
Glycosaminoglycan-induced activation of the beta-secretase (BACE1) of Alzheimer's disease.
Alzheimer Disease
Heparin activates beta-secretase (BACE1) of Alzheimer's disease and increases autocatalysis of the enzyme.
Alzheimer Disease
High beta-secretase activity elicits neurodegeneration in transgenic mice despite reductions in amyloid-beta levels: implications for the treatment of Alzheimer disease.
Alzheimer Disease
High resolution imaging study of interactions between the 37 kDa/67 kDa laminin receptor and APP, beta-secretase and gamma-secretase in Alzheimer's disease.
Alzheimer Disease
Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein.
Alzheimer Disease
Hybrid Structure-Based Virtual Screening Protocol for the Identification of Novel BACE1 Inhibitors.
Alzheimer Disease
Hybrid structure-based virtual screening protocol for the identification of novel BACE1 inhibitors.
Alzheimer Disease
Hypoxia-inducible factor 1alpha (HIF-1alpha)-mediated hypoxia increases BACE1 expression and beta-amyloid generation.
Alzheimer Disease
Identification and molecular docking study of fish roe-derived peptides as potent BACE 1, AChE, and BChE inhibitors.
Alzheimer Disease
Identification of beta-secretase (BACE1) substrates using quantitative proteomics.
Alzheimer Disease
In search of an enzyme: the beta-secretase of Alzheimer's disease is an aspartic proteinase.
Alzheimer Disease
In vivo beta-secretase 1 inhibition leads to brain Abeta lowering and increased alpha-secretase processing of amyloid precursor protein without effect on neuregulin-1.
Alzheimer Disease
Increased activity-regulating and neuroprotective efficacy of alpha-secretase-derived secreted amyloid precursor protein conferred by a C-terminal heparin-binding domain.
Alzheimer Disease
Increased beta-Secretase activity in cerebrospinal fluid of Alzheimer's disease subjects.
Alzheimer Disease
Increased CSF- BACE1 Activity Associated with Decreased Hippocampus Volume in Alzheimer's Disease.
Alzheimer Disease
Increased expression of the amyloid precursor beta-secretase in Alzheimer's disease.
Alzheimer Disease
Increased Plasma Beta-Secretase 1 May Predict Conversion to Alzheimer's Disease Dementia in Individuals With Mild Cognitive Impairment.
Alzheimer Disease
Inhibition of amyloid precursor protein processing by beta-secretase through site-directed antibodies.
Alzheimer Disease
Inhibition of cathepsin B reduces beta-amyloid production in regulated secretory vesicles of neuronal chromaffin cells: evidence for cathepsin B as a candidate beta-secretase of Alzheimer's disease.
Alzheimer Disease
Inhibitors of Cathepsin B Improve Memory and Reduce {beta}-Amyloid in Transgenic Alzheimer Disease Mice Expressing the Wild-type, but Not the Swedish Mutant, {beta}-Secretase Site of the Amyloid Precursor Protein.
Alzheimer Disease
Interaction models of substrate peptides and beta-secretase studied by NMR spectroscopy and molecular dynamics simulation.
Alzheimer Disease
Involvement of proteases in glycosyltransferase secretion: Alzheimer's beta-secretase-dependent cleavage and a following processing by an aminopeptidase.
Alzheimer Disease
JNK and ERK1/2 pathways have a dual opposite effect on the expression of BACE1.
Alzheimer Disease
Lack of evidence to support the association of polymorphisms within the alpha- and beta-secretase genes (ADAM10/BACE1) with Alzheimer's disease.
Alzheimer Disease
Large-scale purification of human BACE expressed in mammalian cells and removal of the prosegment with HIV-1 protease to improve crystal diffraction.
Alzheimer Disease
Levels of alpha- and beta-secretase cleaved amyloid precursor protein in the cerebrospinal fluid of Alzheimer's disease patients.
Alzheimer Disease
Levels of beta-secretase (BACE1) in cerebrospinal fluid as a predictor of risk in mild cognitive impairment.
Alzheimer Disease
Maturation and endosomal targeting of beta-site amyloid precursor protein-cleaving enzyme. The Alzheimer's disease beta-secretase.
Alzheimer Disease
Measuring human beta-secretase (BACE1) activity using homogeneous time-resolved fluorescence.
Alzheimer Disease
Memapsin 2 (beta-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2.
Alzheimer Disease
Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity.
Alzheimer Disease
Metalloprotease meprin ? is activated by transmembrane serine protease matriptase-2 at the cell surface thereby enhancing APP shedding.
Alzheimer Disease
Modeling of substrate specificity of the Alzheimer's disease amyloid precursor protein beta-secretase.
Alzheimer Disease
Modeling the protonation states of the catalytic aspartates in beta-secretase.
Alzheimer Disease
Molecular docking and 3D-QSAR studies on the binding mechanism of statine-based peptidomimetics with beta-secretase.
Alzheimer Disease
Naphthyl and coumarinyl biarylpiperazine derivatives as highly potent human beta-secretase inhibitors. Design, synthesis, and enzymatic BACE-1 and cell assays.
Alzheimer Disease
Neuroproteases in peptide neurotransmission and neurodegenerative diseases: applications to drug discovery research.
Alzheimer Disease
Neuroprotective effects of beta-secretase inhibitors against rat retinal ganglion cell death.
Alzheimer Disease
Neuroprotective mechanism conferred by 17beta-estradiol on the biochemical basis of Alzheimer's disease.
Alzheimer Disease
NF{kappa}B-dependent Control of BACE1 Promoter Transactivation by A{beta}42.
Alzheimer Disease
NMR studies reveal a novel mode for hFADD to bind with the unstructured hRTN3 which initiates the ER-stress activated apoptosis.
Alzheimer Disease
Novel mutations introduced at the beta-site of amyloid beta protein precursor enhance the production of amyloid beta peptide by BACE1 in vitro and in cells.
Alzheimer Disease
Novel pyrrolyl 2-aminopyridines as potent and selective human beta-secretase (BACE1) inhibitors.
Alzheimer Disease
Oxidative stress activates a positive feedback between the gamma- and beta-secretase cleavages of the beta-amyloid precursor protein.
Alzheimer Disease
pH-dependent conformational dynamics of beta-secretase 1: A molecular dynamics study.
Alzheimer Disease
Phenolic Profiles, Antioxidant, and Inhibitory Activities of Kadsura heteroclita (Roxb.) Craib and Kadsura coccinea (Lem.) A.C. Sm.
Alzheimer Disease
Platelet amyloid precursor protein processing: a bio-marker for Alzheimer's disease.
Alzheimer Disease
Progress in the development of beta-secretase inhibitors for Alzheimer's disease.
Alzheimer Disease
Protein kinase C regulation of intracellular and cell surface amyloid precursor protein (APP) cleavage in CHO695 cells.
Alzheimer Disease
Protein kinase C-dependent alpha-secretase competes with beta-secretase for cleavage of amyloid-beta precursor protein in the trans-golgi network.
Alzheimer Disease
Purification and cloning of amyloid precursor protein beta-secretase from human brain.
Alzheimer Disease
QSAR Classification Models for Predicting the Activity of Inhibitors of Beta-Secretase (BACE1) Associated with Alzheimer's Disease.
Alzheimer Disease
Quantitative Analysis of 18F-PF-06684511, a Novel PET Radioligand for Selective ?-secretase 1 Imaging, in Non-human Primate Brain.
Alzheimer Disease
Rapid and Direct Transport of Cell Surface APP to the Lysosome defines a novel selective pathway.
Alzheimer Disease
Recent Developments of Structure Based beta-Secretase Inhibitors for Alzheimer's Disease.
Alzheimer Disease
Reduction of A? Generation by Schisandrin B through Restraining Beta-Secretase 1 Transcription and Translation.
Alzheimer Disease
Regulation of Alzheimer's disease amyloid-beta formation by casein kinase I.
Alzheimer Disease
Regulation of amyloid precursor protein (APP) secretion by protein kinase calpha in human ntera 2 neurons (NT2N).
Alzheimer Disease
Regulation of amyloid precursor protein secretion by glutamate receptors in human Ntera 2 neurons.
Alzheimer Disease
Reticulons RTN3 and RTN4-B/C interact with BACE1 and inhibit its ability to produce amyloid beta-protein.
Alzheimer Disease
Reversal of the Swedish familial Alzheimer's disease mutant phenotype in cultured cells treated with phorbol 12,13-dibutyrate.
Alzheimer Disease
RNA aptamers selectively modulate protein recruitment to the cytoplasmic domain of beta-secretase BACE1 in vitro.
Alzheimer Disease
Salidroside attenuates hypoxia-induced abnormal processing of amyloid precursor protein by decreasing BACE1 expression in SH-SY5Y cells.
Alzheimer Disease
Secretase inhibitors for Alzheimer's disease: challenges of a promiscuous protease.
Alzheimer Disease
Serum beta-secretase 1 (BACE1) activity as candidate biomarker for late-onset Alzheimer's disease.
Alzheimer Disease
Simple structure-based approach for predicting the activity of inhibitors of beta-secretase (BACE1) associated with Alzheimer's disease.
Alzheimer Disease
Specificity of memapsin 1 and its implications on the design of memapsin 2 (beta-secretase) inhibitor selectivity.
Alzheimer Disease
Substrate and inhibitor profile of BACE (beta-secretase) and comparison with other mammalian aspartic proteases.
Alzheimer Disease
Swedish mutation within amyloid precursor protein modulates global gene expression towards the pathogenesis of Alzheimer's disease.
Alzheimer Disease
Synthesis, In Silico and In Vitro Evaluation for Acetylcholinesterase and BACE-1 Inhibitory Activity of Some N-Substituted-4-Phenothiazine-Chalcones.
Alzheimer Disease
Targeting BACE with small inhibitory nucleic acids - a future for Alzheimer's disease therapy?
Alzheimer Disease
Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model.
Alzheimer Disease
Temporal Effects of Neuron-specific beta-secretase 1 (BACE1) Knock-in on the Mouse Brain Metabolome: Implications for Alzheimer's Disease.
Alzheimer Disease
The influence of BACE1 on macrophage recruitment and activity in the injured peripheral nerve.
Alzheimer Disease
The metabolism of beta-amyloid converting enzyme and beta-amyloid precursor protein processing.
Alzheimer Disease
The novel membrane protein TMEM59 modulates complex glycosylation, cell surface expression and secretion of the amyloid precursor protein.
Alzheimer Disease
The proteins BACE1 and BACE2 and beta-secretase activity in normal and Alzheimer's disease brain.
Alzheimer Disease
The regulation of beta-secretase by cholesterol and statins in Alzheimer's disease.
Alzheimer Disease
The role of amyloid precursor protein processing by BACE1, the beta-secretase, in Alzheimer disease pathophysiology.
Alzheimer Disease
The search for drug leads targeted to the beta-secretase: an example of the roles of computer assisted approaches in drug discovery.
Alzheimer Disease
The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway.
Alzheimer Disease
Translational regulation of BACE-1 expression in neuronal and non-neuronal cells.
Alzheimer Disease
Variation in RTN3 and PPIL2 Genes Does not Influence Platelet Membrane beta-Secretase Activity or Susceptibility to Alzheimer's Disease in the Northern Irish Population.
Alzheimer Disease
Visualization of beta-secretase cleavage in living cells using a genetically encoded surface-displayed FRET probe.
Alzheimer Disease
Why does beta-secretase zymogen possess catalytic activity? Molecular modeling and molecular dynamics simulation studies.
Alzheimer Disease
Widespread gamma-secretase activity in the cell, but do we need it at the mitochondria?
Alzheimer Disease
[Application of an R-group search strategy into three-dimensional quantitative structure-activity relationship of HEA beta-secretase inhibitors and molecular virtual screening].
Alzheimer Disease
[Effect of PNS on the activity and content of BACE1 in the brain of SAMP8 mice with Alzheimer's disease].
Amyloidosis
BACE1 gene deletion prevents neuron loss and memory deficits in 5XFAD APP/PS1 transgenic mice.
Amyotrophic Lateral Sclerosis
Inhibition of Amyloid Precursor Protein Beta-Secretase Cleavage Site Affects Survival and Motor Functions of Amyotrophic Lateral Sclerosis Transgenic Mice.
Brain Injuries, Traumatic
Experimental traumatic brain injury in rats stimulates the expression, production and activity of Alzheimer's disease beta-secretase (BACE-1).
Brain Injuries, Traumatic
Long-term accumulation of amyloid-beta, beta-secretase, presenilin-1, and caspase-3 in damaged axons following brain trauma.
Brain Ischemia
Hypoxia-inducible factor 1alpha (HIF-1alpha)-mediated hypoxia increases BACE1 expression and beta-amyloid generation.
Brain Ischemia
Toward prevention of Alzheimers disease--potential nutraceutical strategies for suppressing the production of amyloid beta peptides.
Carcinoma
Structure of the mouse metalloprotease meprin beta gene (Mep1b): alternative splicing in cancer cells.
Carcinoma, Ductal
Beta-Secretase 1 (BACE1) Is Down-Regulated in Invasive Ductal Carcinoma of Breast.
Crohn Disease
Specific processing of tenascin-C by the metalloprotease meprinbeta neutralizes its inhibition of cell spreading.
Dementia
Increased Plasma Beta-Secretase 1 May Predict Conversion to Alzheimer's Disease Dementia in Individuals With Mild Cognitive Impairment.
Dementia, Vascular
Hypoxia-inducible factor 1alpha (HIF-1alpha)-mediated hypoxia increases BACE1 expression and beta-amyloid generation.
Down Syndrome
Alpha- and beta-secretase activity as a function of age and beta-amyloid in Down syndrome and normal brain.
Down Syndrome
Characterization of a mouse model overexpressing beta-site APP-cleaving enzyme 2 reveals a new role for BACE2.
Glomerulonephritis
Downregulated expression in high IgA (HIGA) mice and the renal protective role of meprinbeta.
Glomerulonephritis
Metalloprotease meprin beta in rat kidney: glomerular localization and differential expression in glomerulonephritis.
Infections
Construction of a small peptide library related to inhibitor OM99-2 and its structure-activity relationship to beta-secretase.
Ischemic Attack, Transient
Increased beta-secretase activity and expression in rats following transient cerebral ischemia.
Ischemic Stroke
Mutant ubiquitin-mediated beta-secretase stability via activation of caspase-3 is related to beta-amyloid accumulation in ischemic striatum in rats.
Leukemia-Lymphoma, Adult T-Cell
Design of potent aspartic protease inhibitors to treat various diseases.
Memory Disorders
Inhibitors of Cathepsin B Improve Memory and Reduce {beta}-Amyloid in Transgenic Alzheimer Disease Mice Expressing the Wild-type, but Not the Swedish Mutant, {beta}-Secretase Site of the Amyloid Precursor Protein.
Memory Disorders
Temporal memory deficits in Alzheimer's mouse models: rescue by genetic deletion of BACE1.
Neoplasms
Interferon-gamma and tumor necrosis factor-alpha regulate amyloid-beta plaque deposition and beta-secretase expression in Swedish mutant APP transgenic mice.
Neoplasms
Meprin B: transcriptional and posttranscriptional regulation of the meprin beta metalloproteinase subunit in human and mouse cancer cells.
Neoplasms
Structure of the mouse metalloprotease meprin beta gene (Mep1b): alternative splicing in cancer cells.
Neoplasms
Targeted disruption of the meprin metalloproteinase beta gene protects against renal ischemia-reperfusion injury in mice.
Neuroblastoma
A novel reciprocal and biphasic relationship between membrane cholesterol and beta-secretase activity in SH-SY5Y cells and in human platelets.
Neuroblastoma
Apolipoprotein receptor 2 and X11 alpha/beta mediate apolipoprotein E-induced endocytosis of amyloid-beta precursor protein and beta-secretase, leading to amyloid-beta production.
Neuroblastoma
Down-regulation of seladin-1 increases bace1 levels and activity through enhanced GGA3 depletion during apoptosis.
Neuroblastoma
Heparin activates beta-secretase (BACE1) of Alzheimer's disease and increases autocatalysis of the enzyme.
Neuroblastoma
Heparin promotes beta-secretase cleavage of the Alzheimer's amyloid precursor protein.
Neuroblastoma
Late compartments of amyloid precursor protein transport in SY5Y cells are involved in beta-amyloid secretion.
Neuroblastoma
Oxidative stress promotes JNK-dependent amyloidogenic processing of normally expressed human APP by differential modification of alpha-, beta- and gamma-secretase expression.
Neuroblastoma
Pulse-chase experiments revealed beta-secretase cleavage from immature full-length amyloid precursor protein harboring the Swedish mutation. Implications for distinct pathways.
Neuroblastoma
Regulation of alpha- and beta-secretase activity by oxysterols: cerebrosterol stimulates processing of APP via the alpha-secretase pathway.
Neuroblastoma
Thiamine deficiency increases beta-secretase activity and accumulation of beta-amyloid peptides.
Neuroblastoma
Up-regulation of the {alpha}-secretase ADAM10 by retinoic acid receptors and acitretin.
Neurodegenerative Diseases
A pathogenic PrP mutation and doppel interfere with polarized sorting of the prion protein.
Neurodegenerative Diseases
Neuroactive venom compounds obtained from Phlogiellus bundokalbo as potential leads for neurodegenerative diseases: insights on their acetylcholinesterase and beta-secretase inhibitory activities in vitro.
Neuroinflammatory Diseases
Contrasting effects of acute and long-term corticosterone treatment on amyloid-?, beta-secretase 1 expression, and nuclear factor kappa B nuclear translocation.
Neuroinflammatory Diseases
From Kinase Inhibitors to Multitarget Ligands as Powerful Drug Leads for Alzheimer's Disease using Protein-Templated Synthesis.
Neuroinflammatory Diseases
Immunotherapy against APP beta-secretase cleavage site improves cognitive function and reduces neuroinflammation in Tg2576 mice without a significant effect on brain abeta levels.
Paraparesis, Tropical Spastic
Design of potent aspartic protease inhibitors to treat various diseases.
Periodontitis
Periodontitis Deteriorates Cognitive Function and Impairs Neurons and Glia in a Mouse Model of Alzheimer's Disease.
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating
Expression analysis of BDNF, BACE1 and their antisense transcripts in inflammatory demyelinating polyradiculoneuropathy.
Prion Diseases
Cellular prion protein regulates beta-secretase cleavage of the Alzheimer's amyloid precursor protein.
Reperfusion Injury
Targeted disruption of the meprin metalloproteinase beta gene protects against renal ischemia-reperfusion injury in mice.
Retinal Diseases
Neuroprotective effects of beta-secretase inhibitors against rat retinal ganglion cell death.
Seizures
Association between BACE1 gene polymorphisms and focal seizures in a Chinese Han population.
Sepsis
The Role of Secretase Pathway in Long-term Brain Inflammation and Cognitive Impairment in an Animal Model of Severe Sepsis.
Skin Diseases
Syndecan-1 shedding by meprin ? impairs keratinocyte adhesion and differentiation in hyperkeratosis.
Spinal Cord Diseases
Design of potent aspartic protease inhibitors to treat various diseases.
Stroke
Caspase inhibition attenuates accumulation of beta-amyloid by reducing beta-secretase production and activity in rat brains after stroke.
Stroke
Hypoxia-inducible factor 1alpha (HIF-1alpha)-mediated hypoxia increases BACE1 expression and beta-amyloid generation.
Teratocarcinoma
Meprin B: transcriptional and posttranscriptional regulation of the meprin beta metalloproteinase subunit in human and mouse cancer cells.
Thiamine Deficiency
Thiamine deficiency increases beta-secretase activity and accumulation of beta-amyloid peptides.
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