3.4.24.61: nardilysin
This is an abbreviated version!
For detailed information about nardilysin, go to the full flat file.
Word Map on EC 3.4.24.61
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3.4.24.61
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metalloendopeptidase
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ectodomain
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heparin-binding
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pitrilysins
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adam17
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hb-egf
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insulysin
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insulinase
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hxxeh
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dynorphins
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medicine
- 3.4.24.61
- metalloendopeptidase
- ectodomain
-
heparin-binding
- pitrilysins
- adam17
- hb-egf
- insulysin
- insulinase
-
hxxeh
- dynorphins
- medicine
Reaction
hydrolysis of polypeptides, preferably at -Xaa-/-Arg-Lys-, and less commonly at -Arg-/-Arg-Xaa-, in which Xaa is not Arg or Lys =
Synonyms
hNRDc1, MGE, miniglucagon-generating endopeptidase, More, N-arginine dibasic (NRD) convertase, N-Arginine dibasic convertase, nardilysin, nardilysin (V8), nardilysin convertase, NRD convertase, NRD-convertase, Nrd1, Nrd1 and NRDc, NRDc
ECTree
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Localization
Localization on EC 3.4.24.61 - nardilysin
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strong and specific accumulation of nardilysin in the manchette and axoneme suggests that the enzyme probably contributes either to the establishment of these specific microtubular structures and/or to their functional properties
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p42IP4 (centaurin-alpha), nardilysin and tubulin are found in the cytosol and at the plasma membrane of SH-SY5Y neuroblastoma cells
additional information
although NRDc can also be detected in the cytoplasm, it is enriched in the nucleus in both HeLa and NIH3T3 cells
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enzyme-GFP fusion construct, 90-95% of protein is cytoplasmic, 3-6% of protein is nuclear
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p42IP4 (centaurin-alpha), nardilysin and tubulin are found in the cytosol and at the plasma membrane of SH-SY5Y neuroblastoma cells
although NRDc can also be detected in the cytoplasm, it is enriched in the nucleus in both HeLa and NIH3T3 cells
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accumulation of enzyme as a function of maturation. After 3 h of in vitro culture, enzyme is found as a spherical structure surrounded by condensed chromosomal DNA. After 18 h, enzyme co-localizes with beta-tubulin at the spindle apparatus Cilostamide blocks nuclear accumulation
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enzyme-GFP fusion construct, 90-95% of protein is cytoplasmic, 3-6% of protein is nuclear