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3.4.24.61: nardilysin

This is an abbreviated version!
For detailed information about nardilysin, go to the full flat file.

Word Map on EC 3.4.24.61

Reaction

hydrolysis of polypeptides, preferably at -Xaa-/-Arg-Lys-, and less commonly at -Arg-/-Arg-Xaa-, in which Xaa is not Arg or Lys =

Synonyms

hNRDc1, MGE, miniglucagon-generating endopeptidase, More, N-arginine dibasic (NRD) convertase, N-Arginine dibasic convertase, nardilysin, nardilysin (V8), nardilysin convertase, NRD convertase, NRD-convertase, Nrd1, Nrd1 and NRDc, NRDc

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.61 nardilysin

Substrates Products

Substrates Products on EC 3.4.24.61 - nardilysin

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-aminobenzoyl-GFSPFRSSRQ-ED(2,4-dinitrophenyl) + H2O
?
show the reaction diagram
-
-
-
?
2-aminobenzoyl-GGALRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGA + LRKVGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 24% at AL and 76% at RK
-
-
?
2-aminobenzoyl-GGALRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGALR + KVGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 24% at AL and 76% at RK
-
-
?
2-aminobenzoyl-GGFARKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFA + RKVGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 65% at AR and 35% at RK
-
-
?
2-aminobenzoyl-GGFARKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFAR + KVGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 65% at AR and 35% at RK
-
-
?
2-aminobenzoyl-GGFFRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFF + RKVGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 100% at FR
-
-
?
2-aminobenzoyl-GGFHRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFH + RKVGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 100% at HR
-
-
?
2-aminobenzoyl-GGFIKKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFIK + KVGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 0% at IK and 100% at KK
-
-
?
2-aminobenzoyl-GGFIKRVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFIK + RVGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 0% at IK and 100% at KR
-
-
?
2-aminobenzoyl-GGFIRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFIR + KVGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
2-aminobenzoyl-GGFIRRVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFIR + RVGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 0% at IR and 100% at RR
-
-
?
2-aminobenzoyl-GGFIRRVGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
?
show the reaction diagram
-
-
-
-
?
2-aminobenzoyl-GGFLKKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFL + KKVGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 5% at LL and 95% at KK
-
-
?
2-aminobenzoyl-GGFLKKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLK + KVGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 5% at LL and 95% at KK
-
-
?
2-aminobenzoyl-GGFLKRVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFL + KRVGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 1% at LK and 99% at KR
-
-
?
2-aminobenzoyl-GGFLKRVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLK + RVGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 1% at LK and 99% at KR
-
-
?
2-aminobenzoyl-GGFLRKAGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLR + KAGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 25% at KA and 75% at RK
-
-
?
2-aminobenzoyl-GGFLRKAGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLRK + AGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 25% at KA and 75% at RK
-
-
?
2-aminobenzoyl-GGFLRKDGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLR + KDGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 23% at KD and 77% at RK
-
-
?
2-aminobenzoyl-GGFLRKDGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLRK + DGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 23% at KD and 77% at RK
-
-
?
2-aminobenzoyl-GGFLRKFGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLR + KFGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 17% at KF and 83% at RK
-
-
?
2-aminobenzoyl-GGFLRKFGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLRK + FGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 17% at KF and 83% at RK
-
-
?
2-aminobenzoyl-GGFLRKHGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLR + KHGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 10% at KH and 90% at RK
-
-
?
2-aminobenzoyl-GGFLRKHGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLRK + HGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 10% at KH and 90% at RK
-
-
?
2-aminobenzoyl-GGFLRKIGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLR + KIGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 19% at KI and 81% at RK
-
-
?
2-aminobenzoyl-GGFLRKIGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLRK + IGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 19% at KI and 81% at RK
-
-
?
2-aminobenzoyl-GGFLRKLGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLR + KLGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 26% at KL and 74% at RK
-
-
?
2-aminobenzoyl-GGFLRKLGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLRK + LGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 26% at KL and 74% at RK
-
-
?
2-aminobenzoyl-GGFLRKMGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLR + KMGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 14% at KM and 86% at RK
-
-
?
2-aminobenzoyl-GGFLRKMGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLRK + MGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 14% at KM and 86% at RK
-
-
?
2-aminobenzoyl-GGFLRKNGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLR + KNGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 24% at KN and 76% at RK
-
-
?
2-aminobenzoyl-GGFLRKNGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLRK + NGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 24% at KN and 76% at RK
-
-
?
2-aminobenzoyl-GGFLRKSGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLR + KSGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 25% at KS and 75% at RK
-
-
?
2-aminobenzoyl-GGFLRKSGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLRK + SGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 25% at KS and 75% at RK
-
-
?
2-aminobenzoyl-GGFLRKVGQ-(N-2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-GGFL + RKVGQ-(N-2,4-dinitrophenyl)ethylenediamine
show the reaction diagram
-
percentage cleaved 23% at LR and 77% at RK
-
-
?
2-aminobenzoyl-GGFLRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGF + LRKVGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 23% at FL and 77% at RK
-
-
?
2-aminobenzoyl-GGFLRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFL + RKVGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 23% at LR and 77% at RK
-
-
?
2-aminobenzoyl-GGFLRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLR + KVGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
2-aminobenzoyl-GGFLRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLRK + VGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 23% at KV and 77% at RK
-
-
?
2-aminobenzoyl-GGFLRKWGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLR + KWGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 13% at KW and 87% at RK
-
-
?
2-aminobenzoyl-GGFLRKWGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLRK + WGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 13% at KW and 87% at RK
-
-
?
2-aminobenzoyl-GGFLRRVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFL + RRVGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 7% at LR and 93% at RR
-
-
?
2-aminobenzoyl-GGFLRRVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLR + RVGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 7% at LR and 93% at RR
-
-
?
2-aminobenzoyl-GGFLRRVGQ-N[2,4-dinitrophenyl]-ethylenediamine + H2O
?
show the reaction diagram
-
-
-
?
2-aminobenzoyl-GGFMRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFM + RKVGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 29% at MR and 71% at RK
-
-
?
2-aminobenzoyl-GGFMRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFMR + KVGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 29% at MR and 71% at RK
-
-
?
2-aminobenzoyl-GGFNRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFN + RKVGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 100% at NR
-
-
?
2-aminobenzoyl-GGFSRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFS + RKVGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 76% at SR and 24% at RK
-
-
?
2-aminobenzoyl-GGFSRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFSR + KVGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 76% at SR and 24% at RK
-
-
?
2-aminobenzoyl-GGFVRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFVR + KVGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 100% at RK
-
-
?
2-aminobenzoyl-GGFWRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFW + RKVGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 100% at WR
-
-
?
2-aminobenzoyl-GGFYKKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFYKKVGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 100% at YK and 0% at KK
-
-
?
2-aminobenzoyl-GGFYKRVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFY + KRVGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 64% at YK and 36% at KR
-
-
?
2-aminobenzoyl-GGFYKRVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFYK + RVGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 64% at YK and 36% at KR
-
-
?
2-aminobenzoyl-GGFYRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFY + RKVGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
2-aminobenzoyl-GGFYRRVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFY + RRVGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 65% at YR and 35% at RR
-
-
?
2-aminobenzoyl-GGFYRRVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFYR + RVGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 65% at YR and 35% at RR
-
-
?
2-aminobenzoyl-GGHLRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGH + LRKVGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 26% at HL and 74% at RK
-
-
?
2-aminobenzoyl-GGHLRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGHLR + KVGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 26% at HL and 74% at RK
-
-
?
2-aminobenzoyl-GGILRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGI + LRKVGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 56% at IL and 44% at RK
-
-
?
2-aminobenzoyl-GGILRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGILR + KVGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 56% at IL and 44% at RK
-
-
?
2-aminobenzoyl-GGLLRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGL + LRKVGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 73% at LL and 27% at RK
-
-
?
2-aminobenzoyl-GGLLRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGLLR + KVGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 73% at LL and 27% at RK
-
-
?
2-aminobenzoyl-GGMLRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGM + LRKVGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 81% at ML and 19% at RK
-
-
?
2-aminobenzoyl-GGMLRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGMLR + KVGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 81% at ML and 19% at RK
-
-
?
2-aminobenzoyl-GGNLRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGN + LRKVGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 23% at NL and 77% at RK
-
-
?
2-aminobenzoyl-GGNLRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGNLR + KVGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 23% at NL and 77% at RK
-
-
?
2-aminobenzoyl-GGSLRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGS + LRKVGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 4% at SL and 96% at RK
-
-
?
2-aminobenzoyl-GGSLRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGSLR + KVGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 4% at SL and 96% at RK
-
-
?
2-aminobenzoyl-GGVLRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGV + LRKVGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 19% at VL and 81% at RK
-
-
?
2-aminobenzoyl-GGVLRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGVLR + KVGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 19% at VL and 81% at RK
-
-
?
2-aminobenzoyl-GGWLRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGW + LRKVGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 18% at WL and 82% at RK
-
-
?
2-aminobenzoyl-GGWLRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGWLR + KVGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 18% at WL and 82% at RK
-
-
?
2-aminobenzoyl-GGYLRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGY + LRKVGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 2% at YL and 98% at RK
-
-
?
2-aminobenzoyl-GGYLRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGYLR + KVGQ-ethylenediamine-2,4-dinitrophenyl
show the reaction diagram
-
percentage cleaved 2% at YL and 98% at RK
-
-
?
2-aminobenzoyl-MISLMKRPPGFSPFRSSRI-NH2 + H2O
desArg10 kallidin (KRPPGFSPF) + ?
show the reaction diagram
-
kallidin model peptide, nardilysin does not release desArg10 kallidin from the physiological precursor low molecular weight kiniogen
-
?
2-aminobenzoyl-MISLMKRPQ-ED(2,4-dinitrophenyl) + H2O
?
show the reaction diagram
-
-
-
?
2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl) + H2O
?
show the reaction diagram
-
fluorogenic substrate based on beta-endorphin, nardilysin hydrolyzes peptides when X1-X2 are F-K, F-R, W-K, M-K,Y-K, or L-K, K-F is not hydrolyzed
-
?
Abz-GGFX(1)X(2)X(3)VGQ-EDDnp + H2O
?
show the reaction diagram
-
X residues are varied
-
?
Abz-GGGFLRRVGQ-EDDnp + H2O
?
show the reaction diagram
-
-
-
-
?
alpha-natriuretic factor ANF + H2O
?
show the reaction diagram
-
-
-
?
alpha-neoendorphin + H2O
?
show the reaction diagram
alpha-Neoendorphin + H2O
Tyr-Gly-Gly-Phe-Leu-Arg + Lys-Tyr-Pro-Leu
show the reaction diagram
amyloid precursor protein + H2O
?
show the reaction diagram
the enzyme enhances alpha-cleavage of amyloid precursor protein, which results in the decreased generation of amyloid beta in vitro
-
-
?
ANF-(1-28) + H2O
?
show the reaction diagram
-
i.e. atrial natriuretic factor, cleavage site: Arg+Arg
-
-
?
beta-endorphin + H2O
Tyr-Gly-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-Phe + Lys-Asn-Ala-Ile-Ile-Lys-Asn-Ala-Tyr-Lys-Lys-Gly-Gln + ?
show the reaction diagram
-
-
-
?
Bovine adrenal medulla dodecapeptide + H2O
Tyr-Gly-Gly-Phe-Met-Arg + Arg-Val-Gly-Arg-Pro-Glu
show the reaction diagram
calcitonin + H2O
?
show the reaction diagram
-
-
-
?
dynorphin A + H2O
?
show the reaction diagram
dynorphin A + H2O
Tyr-Gly-Gly-Phe-Leu-Arg + Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln-NH2
show the reaction diagram
dynorphin A-(1-10) + H2O
Tyr-Gly-Gly-Phe-Leu-Arg + Arg-Ile-Arg-Pro
show the reaction diagram
dynorphin A-(1-13) + H2O
Tyr-Gly-Gly-Phe-Leu-Arg + Arg-Ile-Arg-Pro-Lys-Leu-Lys
show the reaction diagram
dynorphin A-(1-9) + H2O
Tyr-Gly-Gly-Phe-Leu-Arg + Arg-Ile-Arg
show the reaction diagram
dynorphin B + H2O
Tyr-Gly-Gly-Phe-Leu-Arg + Arg-Gln-Phe-Lys-Val-Val-Thr
show the reaction diagram
dynorphin B13 + H2O
?
show the reaction diagram
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?
Glucagon + H2O
?
show the reaction diagram
glucagon + H2O
miniglucagon + ?
show the reaction diagram
heparin-binding epidermal growth factor-like growth factor + H2O
?
show the reaction diagram
substrate is synthesized as a transmembrane protein. Enzyme enhances ectodomain shedding of substrate in coperation with tumor necrosis factor-alpha-converting enzyme. Metalloendopeptidase activity of enzyme is not required for enhancement of shedding
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?
malate dehydrogenase + H2O
?
show the reaction diagram
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?
N-(2-(N-methylamino)benzoyl)-GGFLRRVGK(2,4-dinitrophenyl)-NH2 + H2O
?
show the reaction diagram
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?
peptide I + H2O
Pro-Arg-Glu-Arg-Lys + Ala-Gly-Ala-Lys-Asn-Tyr-NH2
show the reaction diagram
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i.e. Pro-Arg-Glu-Arg-Lys-Ala-Gly-Ala-Lys-Asn125I-Tyr-NH2
i.e. peptide II
?
Peptide III + H2O
Pro-Arg-Glu-Arg + Arg-Ala-Gly-Ala-Lys-Asn-Tyr-NH2
show the reaction diagram
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i.e. Pro-Arg-Glu-Arg-Arg-Ala-Gly-Ala-Lys-Asn-Tyr-NH2
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?
PGC-1alpha + H2O
?
show the reaction diagram
nardilysin and PGC-1alpha interact and colocalize at the uncoupling protein 1 enhancer, where the enzyme represses PGC-1alpha activity
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?
PRAME190-198 + H2O
?
show the reaction diagram
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nardilysin produces precursors of tumor-associated protein PRAME(190-198) by producing cleavage after Lys200, Arg201 and Lys202 but does not excise precisely at the C terminus (Lys198)
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?
Preproneurotensin-(154-170) + H2O
?
show the reaction diagram
Pro-Gln-Arg-Lys-Tyr-NH2 + H2O
Pro-Gln + Arg-Lys-Tyr-NH2
show the reaction diagram
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?
Pro-Glu-Arg-Arg-Tyr-NH2 + H2O
Pro-Glu + Arg-Arg-Tyr-NH2
show the reaction diagram
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?
Pro-Gly-Arg-Lys-Tyr-NH2 + H2O
Pro-Gly + Arg-Lys-Tyr-NH2
show the reaction diagram
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?
pro-tumour necrosis factor-alpha + H2O
?
show the reaction diagram
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?
Somatostatin-14 + H2O
?
show the reaction diagram
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?
somatostatin-28 + H2O
?
show the reaction diagram
Somatostatin-28 + H2O
Somatostatin-28-(13-28) + somatostatin-28-(1-12)
show the reaction diagram
tumor necrosis factor-alpha + H2O
?
show the reaction diagram
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?
[Ala17,Tyr20]-Somatostatin-28-(10-20)-NH2 + H2O
Pro-Arg-Glu + Arg-Lys-Ala-Gly-Ala-Lys-Asn-Tyr-NH2
show the reaction diagram
[Arg0,Ala17]-somatostatin-28-(1-19)-NH2 + H2O
?
show the reaction diagram
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?
additional information
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