3.4.24.61: nardilysin
This is an abbreviated version!
For detailed information about nardilysin, go to the full flat file.
Word Map on EC 3.4.24.61
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3.4.24.61
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metalloendopeptidase
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ectodomain
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heparin-binding
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pitrilysins
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adam17
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hb-egf
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insulysin
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insulinase
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hxxeh
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dynorphins
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medicine
- 3.4.24.61
- metalloendopeptidase
- ectodomain
-
heparin-binding
- pitrilysins
- adam17
- hb-egf
- insulysin
- insulinase
-
hxxeh
- dynorphins
- medicine
Reaction
hydrolysis of polypeptides, preferably at -Xaa-/-Arg-Lys-, and less commonly at -Arg-/-Arg-Xaa-, in which Xaa is not Arg or Lys =
Synonyms
hNRDc1, MGE, miniglucagon-generating endopeptidase, More, N-arginine dibasic (NRD) convertase, N-Arginine dibasic convertase, nardilysin, nardilysin (V8), nardilysin convertase, NRD convertase, NRD-convertase, Nrd1, Nrd1 and NRDc, NRDc
ECTree
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Engineering
Engineering on EC 3.4.24.61 - nardilysin
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C948A
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the mutation of a highly conserved cysteine residue in NRD to Ala abolishes the potentiation by tubulin
additional information
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detection and reconstruction of the naturally occurring mutation APP770, overview
additional information
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NRD lacking the characteristic acidic domain is able to bind p42IP4 but addition of tubulin does not significantly potentiate the binding of this deletion mutant to p42IP4. A function-abolishing mutation of the Zn2+-binding motif of NRD does not affect the potentiation by tubulin
additional information
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enzyme-GFP fusion construct, 90-95% of protein is cytoplasmic, 3-6% of protein is nuclear. Nuclear localization signal mutant and N-terminally truncated enzyme-GFP construct, completely cytoplasmic localization. After treatment with leptomycin B or spermidine, increase in nuclear localization of enzyme-GFP fusion protein
additional information
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nardilysin null mice have smaller brains and a thin cerebral cortex, in which are less myelinated fibers with thinner myelin sheaths and smaller axon diameters, compared to wild-type mice. The mutants show hypomyelination in the peripheral nervous system, phenotype, overview. Neuron-specific overexpression of nardilysin induces hypermyelination