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2-aminobenzoyl-GFSPFRSSRQ-ED(2,4-dinitrophenyl) + H2O
?
-
-
-
?
2-aminobenzoyl-GGALRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGA + LRKVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 24% at AL and 76% at RK
-
-
?
2-aminobenzoyl-GGALRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGALR + KVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 24% at AL and 76% at RK
-
-
?
2-aminobenzoyl-GGFARKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFA + RKVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 65% at AR and 35% at RK
-
-
?
2-aminobenzoyl-GGFARKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFAR + KVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 65% at AR and 35% at RK
-
-
?
2-aminobenzoyl-GGFFRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFF + RKVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 100% at FR
-
-
?
2-aminobenzoyl-GGFHRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFH + RKVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 100% at HR
-
-
?
2-aminobenzoyl-GGFIKKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFIK + KVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 0% at IK and 100% at KK
-
-
?
2-aminobenzoyl-GGFIKRVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFIK + RVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 0% at IK and 100% at KR
-
-
?
2-aminobenzoyl-GGFIRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFIR + KVGQ-ethylenediamine-2,4-dinitrophenyl
2-aminobenzoyl-GGFIRRVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFIR + RVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 0% at IR and 100% at RR
-
-
?
2-aminobenzoyl-GGFIRRVGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
?
-
-
-
-
?
2-aminobenzoyl-GGFLKKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFL + KKVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 5% at LL and 95% at KK
-
-
?
2-aminobenzoyl-GGFLKKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLK + KVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 5% at LL and 95% at KK
-
-
?
2-aminobenzoyl-GGFLKRVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFL + KRVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 1% at LK and 99% at KR
-
-
?
2-aminobenzoyl-GGFLKRVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLK + RVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 1% at LK and 99% at KR
-
-
?
2-aminobenzoyl-GGFLRKAGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLR + KAGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 25% at KA and 75% at RK
-
-
?
2-aminobenzoyl-GGFLRKAGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLRK + AGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 25% at KA and 75% at RK
-
-
?
2-aminobenzoyl-GGFLRKDGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLR + KDGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 23% at KD and 77% at RK
-
-
?
2-aminobenzoyl-GGFLRKDGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLRK + DGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 23% at KD and 77% at RK
-
-
?
2-aminobenzoyl-GGFLRKFGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLR + KFGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 17% at KF and 83% at RK
-
-
?
2-aminobenzoyl-GGFLRKFGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLRK + FGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 17% at KF and 83% at RK
-
-
?
2-aminobenzoyl-GGFLRKHGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLR + KHGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 10% at KH and 90% at RK
-
-
?
2-aminobenzoyl-GGFLRKHGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLRK + HGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 10% at KH and 90% at RK
-
-
?
2-aminobenzoyl-GGFLRKIGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLR + KIGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 19% at KI and 81% at RK
-
-
?
2-aminobenzoyl-GGFLRKIGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLRK + IGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 19% at KI and 81% at RK
-
-
?
2-aminobenzoyl-GGFLRKLGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLR + KLGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 26% at KL and 74% at RK
-
-
?
2-aminobenzoyl-GGFLRKLGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLRK + LGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 26% at KL and 74% at RK
-
-
?
2-aminobenzoyl-GGFLRKMGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLR + KMGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 14% at KM and 86% at RK
-
-
?
2-aminobenzoyl-GGFLRKMGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLRK + MGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 14% at KM and 86% at RK
-
-
?
2-aminobenzoyl-GGFLRKNGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLR + KNGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 24% at KN and 76% at RK
-
-
?
2-aminobenzoyl-GGFLRKNGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLRK + NGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 24% at KN and 76% at RK
-
-
?
2-aminobenzoyl-GGFLRKSGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLR + KSGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 25% at KS and 75% at RK
-
-
?
2-aminobenzoyl-GGFLRKSGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLRK + SGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 25% at KS and 75% at RK
-
-
?
2-aminobenzoyl-GGFLRKVGQ-(N-2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-GGFL + RKVGQ-(N-2,4-dinitrophenyl)ethylenediamine
-
percentage cleaved 23% at LR and 77% at RK
-
-
?
2-aminobenzoyl-GGFLRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGF + LRKVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 23% at FL and 77% at RK
-
-
?
2-aminobenzoyl-GGFLRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFL + RKVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 23% at LR and 77% at RK
-
-
?
2-aminobenzoyl-GGFLRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLR + KVGQ-ethylenediamine-2,4-dinitrophenyl
2-aminobenzoyl-GGFLRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLRK + VGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 23% at KV and 77% at RK
-
-
?
2-aminobenzoyl-GGFLRKWGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLR + KWGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 13% at KW and 87% at RK
-
-
?
2-aminobenzoyl-GGFLRKWGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLRK + WGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 13% at KW and 87% at RK
-
-
?
2-aminobenzoyl-GGFLRRVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFL + RRVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 7% at LR and 93% at RR
-
-
?
2-aminobenzoyl-GGFLRRVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLR + RVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 7% at LR and 93% at RR
-
-
?
2-aminobenzoyl-GGFLRRVGQ-N[2,4-dinitrophenyl]-ethylenediamine + H2O
?
-
-
-
?
2-aminobenzoyl-GGFMRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFM + RKVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 29% at MR and 71% at RK
-
-
?
2-aminobenzoyl-GGFMRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFMR + KVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 29% at MR and 71% at RK
-
-
?
2-aminobenzoyl-GGFNRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFN + RKVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 100% at NR
-
-
?
2-aminobenzoyl-GGFSRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFS + RKVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 76% at SR and 24% at RK
-
-
?
2-aminobenzoyl-GGFSRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFSR + KVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 76% at SR and 24% at RK
-
-
?
2-aminobenzoyl-GGFVRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFVR + KVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 100% at RK
-
-
?
2-aminobenzoyl-GGFWRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFW + RKVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 100% at WR
-
-
?
2-aminobenzoyl-GGFYKKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFYKKVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 100% at YK and 0% at KK
-
-
?
2-aminobenzoyl-GGFYKRVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFY + KRVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 64% at YK and 36% at KR
-
-
?
2-aminobenzoyl-GGFYKRVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFYK + RVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 64% at YK and 36% at KR
-
-
?
2-aminobenzoyl-GGFYRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFY + RKVGQ-ethylenediamine-2,4-dinitrophenyl
2-aminobenzoyl-GGFYRRVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFY + RRVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 65% at YR and 35% at RR
-
-
?
2-aminobenzoyl-GGFYRRVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFYR + RVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 65% at YR and 35% at RR
-
-
?
2-aminobenzoyl-GGHLRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGH + LRKVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 26% at HL and 74% at RK
-
-
?
2-aminobenzoyl-GGHLRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGHLR + KVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 26% at HL and 74% at RK
-
-
?
2-aminobenzoyl-GGILRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGI + LRKVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 56% at IL and 44% at RK
-
-
?
2-aminobenzoyl-GGILRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGILR + KVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 56% at IL and 44% at RK
-
-
?
2-aminobenzoyl-GGLLRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGL + LRKVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 73% at LL and 27% at RK
-
-
?
2-aminobenzoyl-GGLLRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGLLR + KVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 73% at LL and 27% at RK
-
-
?
2-aminobenzoyl-GGMLRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGM + LRKVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 81% at ML and 19% at RK
-
-
?
2-aminobenzoyl-GGMLRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGMLR + KVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 81% at ML and 19% at RK
-
-
?
2-aminobenzoyl-GGNLRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGN + LRKVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 23% at NL and 77% at RK
-
-
?
2-aminobenzoyl-GGNLRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGNLR + KVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 23% at NL and 77% at RK
-
-
?
2-aminobenzoyl-GGSLRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGS + LRKVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 4% at SL and 96% at RK
-
-
?
2-aminobenzoyl-GGSLRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGSLR + KVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 4% at SL and 96% at RK
-
-
?
2-aminobenzoyl-GGVLRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGV + LRKVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 19% at VL and 81% at RK
-
-
?
2-aminobenzoyl-GGVLRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGVLR + KVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 19% at VL and 81% at RK
-
-
?
2-aminobenzoyl-GGWLRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGW + LRKVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 18% at WL and 82% at RK
-
-
?
2-aminobenzoyl-GGWLRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGWLR + KVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 18% at WL and 82% at RK
-
-
?
2-aminobenzoyl-GGYLRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGY + LRKVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 2% at YL and 98% at RK
-
-
?
2-aminobenzoyl-GGYLRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGYLR + KVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 2% at YL and 98% at RK
-
-
?
2-aminobenzoyl-MISLMKRPPGFSPFRSSRI-NH2 + H2O
desArg10 kallidin (KRPPGFSPF) + ?
-
kallidin model peptide, nardilysin does not release desArg10 kallidin from the physiological precursor low molecular weight kiniogen
-
?
2-aminobenzoyl-MISLMKRPQ-ED(2,4-dinitrophenyl) + H2O
?
-
-
-
?
2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl) + H2O
?
-
fluorogenic substrate based on beta-endorphin, nardilysin hydrolyzes peptides when X1-X2 are F-K, F-R, W-K, M-K,Y-K, or L-K, K-F is not hydrolyzed
-
?
Abz-GGFX(1)X(2)X(3)VGQ-EDDnp + H2O
?
-
X residues are varied
-
?
Abz-GGGFLRRVGQ-EDDnp + H2O
?
-
-
-
-
?
alpha-natriuretic factor ANF + H2O
?
-
-
-
?
alpha-neoendorphin + H2O
?
alpha-Neoendorphin + H2O
Tyr-Gly-Gly-Phe-Leu-Arg + Lys-Tyr-Pro-Leu
amyloid precursor protein + H2O
?
the enzyme enhances alpha-cleavage of amyloid precursor protein, which results in the decreased generation of amyloid beta in vitro
-
-
?
ANF-(1-28) + H2O
?
-
i.e. atrial natriuretic factor, cleavage site: Arg+Arg
-
-
?
beta-endorphin + H2O
Tyr-Gly-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-Phe + Lys-Asn-Ala-Ile-Ile-Lys-Asn-Ala-Tyr-Lys-Lys-Gly-Gln + ?
-
-
-
?
Bovine adrenal medulla dodecapeptide + H2O
Tyr-Gly-Gly-Phe-Met-Arg + Arg-Val-Gly-Arg-Pro-Glu
calcitonin + H2O
?
-
-
-
?
dynorphin A + H2O
Tyr-Gly-Gly-Phe-Leu-Arg + Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln-NH2
dynorphin A-(1-10) + H2O
Tyr-Gly-Gly-Phe-Leu-Arg + Arg-Ile-Arg-Pro
dynorphin A-(1-13) + H2O
Tyr-Gly-Gly-Phe-Leu-Arg + Arg-Ile-Arg-Pro-Lys-Leu-Lys
dynorphin A-(1-9) + H2O
Tyr-Gly-Gly-Phe-Leu-Arg + Arg-Ile-Arg
dynorphin B + H2O
Tyr-Gly-Gly-Phe-Leu-Arg + Arg-Gln-Phe-Lys-Val-Val-Thr
dynorphin B13 + H2O
?
-
-
-
-
?
glucagon + H2O
miniglucagon + ?
heparin-binding epidermal growth factor-like growth factor + H2O
?
substrate is synthesized as a transmembrane protein. Enzyme enhances ectodomain shedding of substrate in coperation with tumor necrosis factor-alpha-converting enzyme. Metalloendopeptidase activity of enzyme is not required for enhancement of shedding
-
-
?
malate dehydrogenase + H2O
?
-
-
-
?
N-(2-(N-methylamino)benzoyl)-GGFLRRVGK(2,4-dinitrophenyl)-NH2 + H2O
?
-
-
-
-
?
peptide I + H2O
Pro-Arg-Glu-Arg-Lys + Ala-Gly-Ala-Lys-Asn-Tyr-NH2
-
i.e. Pro-Arg-Glu-Arg-Lys-Ala-Gly-Ala-Lys-Asn125I-Tyr-NH2
i.e. peptide II
?
Peptide III + H2O
Pro-Arg-Glu-Arg + Arg-Ala-Gly-Ala-Lys-Asn-Tyr-NH2
-
i.e. Pro-Arg-Glu-Arg-Arg-Ala-Gly-Ala-Lys-Asn-Tyr-NH2
-
?
PGC-1alpha + H2O
?
nardilysin and PGC-1alpha interact and colocalize at the uncoupling protein 1 enhancer, where the enzyme represses PGC-1alpha activity
-
-
?
PRAME190-198 + H2O
?
-
nardilysin produces precursors of tumor-associated protein PRAME(190-198) by producing cleavage after Lys200, Arg201 and Lys202 but does not excise precisely at the C terminus (Lys198)
-
-
?
Preproneurotensin-(154-170) + H2O
?
Pro-Gln-Arg-Lys-Tyr-NH2 + H2O
Pro-Gln + Arg-Lys-Tyr-NH2
-
-
-
?
Pro-Glu-Arg-Arg-Tyr-NH2 + H2O
Pro-Glu + Arg-Arg-Tyr-NH2
-
-
-
?
Pro-Gly-Arg-Lys-Tyr-NH2 + H2O
Pro-Gly + Arg-Lys-Tyr-NH2
-
-
-
?
pro-tumour necrosis factor-alpha + H2O
?
-
-
-
?
Somatostatin-14 + H2O
?
-
-
-
-
?
Somatostatin-28 + H2O
Somatostatin-28-(13-28) + somatostatin-28-(1-12)
tumor necrosis factor-alpha + H2O
?
-
-
-
?
[Ala17,Tyr20]-Somatostatin-28-(10-20)-NH2 + H2O
Pro-Arg-Glu + Arg-Lys-Ala-Gly-Ala-Lys-Asn-Tyr-NH2
[Arg0,Ala17]-somatostatin-28-(1-19)-NH2 + H2O
?
-
-
-
-
?
additional information
?
-
2-aminobenzoyl-GGFIRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFIR + KVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 0% at IR and 100% at RK
-
-
?
2-aminobenzoyl-GGFIRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFIR + KVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 100% at RK
-
-
?
2-aminobenzoyl-GGFLRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLR + KVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 23% at FL and 77% at RK
-
-
?
2-aminobenzoyl-GGFLRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLR + KVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 23% at KV and 77% at RK
-
-
?
2-aminobenzoyl-GGFLRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLR + KVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 23% at LR and 77% at RK
-
-
?
2-aminobenzoyl-GGFYRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFY + RKVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 100% at YR
-
-
?
2-aminobenzoyl-GGFYRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFY + RKVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 100% at YR and 0% at RK
-
-
?
alpha-neoendorphin + H2O
?
-
-
-
-
?
alpha-neoendorphin + H2O
?
-
-
-
?
alpha-Neoendorphin + H2O
Tyr-Gly-Gly-Phe-Leu-Arg + Lys-Tyr-Pro-Leu
-
i.e. Tyr-Gly-Gly-Phe-Leu-Arg-Lys-Tyr-Pro-Leu, cleavage at Arg-Lys processing site
-
?
alpha-Neoendorphin + H2O
Tyr-Gly-Gly-Phe-Leu-Arg + Lys-Tyr-Pro-Leu
-
i.e. Tyr-Gly-Gly-Phe-Leu-Arg-Lys-Tyr-Pro-Leu, cleavage at Arg-Lys processing site
-
?
Bovine adrenal medulla dodecapeptide + H2O
Tyr-Gly-Gly-Phe-Met-Arg + Arg-Val-Gly-Arg-Pro-Glu
-
-
-
-
?
Bovine adrenal medulla dodecapeptide + H2O
Tyr-Gly-Gly-Phe-Met-Arg + Arg-Val-Gly-Arg-Pro-Glu
-
i.e. Tyr-Gly-Gly-Phe-Met-Arg-Arg-Val-Gly-Arg-Pro-Glu
-
?
dynorphin A + H2O
?
-
-
-
-
?
dynorphin A + H2O
?
-
-
-
?
dynorphin A + H2O
?
-
-
-
?
dynorphin A + H2O
Tyr-Gly-Gly-Phe-Leu-Arg + Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln-NH2
-
i.e. Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln-NH2
-
?
dynorphin A + H2O
Tyr-Gly-Gly-Phe-Leu-Arg + Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln-NH2
-
i.e. Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln-NH2
-
?
dynorphin A-(1-10) + H2O
Tyr-Gly-Gly-Phe-Leu-Arg + Arg-Ile-Arg-Pro
-
i.e. Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro, cleavage site: Arg-Arg
-
?
dynorphin A-(1-10) + H2O
Tyr-Gly-Gly-Phe-Leu-Arg + Arg-Ile-Arg-Pro
-
i.e. Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro, cleavage site: Arg-Arg
-
?
dynorphin A-(1-13) + H2O
Tyr-Gly-Gly-Phe-Leu-Arg + Arg-Ile-Arg-Pro-Lys-Leu-Lys
-
i.e. Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys, cleavage site: Arg-Arg
-
?
dynorphin A-(1-13) + H2O
Tyr-Gly-Gly-Phe-Leu-Arg + Arg-Ile-Arg-Pro-Lys-Leu-Lys
-
i.e. Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys, cleavage site: Arg-Arg
-
?
dynorphin A-(1-9) + H2O
Tyr-Gly-Gly-Phe-Leu-Arg + Arg-Ile-Arg
-
i.e. Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg, cleavage site: Arg-Arg
-
?
dynorphin A-(1-9) + H2O
Tyr-Gly-Gly-Phe-Leu-Arg + Arg-Ile-Arg
-
i.e. Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg, cleavage site: Arg-Arg
-
?
dynorphin B + H2O
Tyr-Gly-Gly-Phe-Leu-Arg + Arg-Gln-Phe-Lys-Val-Val-Thr
-
i.e. Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Gln-Phe-Lys-Val-Val-Thr
-
?
dynorphin B + H2O
Tyr-Gly-Gly-Phe-Leu-Arg + Arg-Gln-Phe-Lys-Val-Val-Thr
-
i.e. Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Gln-Phe-Lys-Val-Val-Thr
-
?
Glucagon + H2O
?
-
-
-
-
?
glucagon + H2O
miniglucagon + ?
-
-
miniglucagon, C-terminal glucagon fragment, resulted from cleavage at Arg17-Arg18
-
?
glucagon + H2O
miniglucagon + ?
-
-
miniglucagon, C-terminal glucagon fragment, resulted from cleavage at Arg17-Arg18
-
?
Preproneurotensin-(154-170) + H2O
?
-
cleavage site: prohormonal maturation site, Lys-Arg
-
-
?
Preproneurotensin-(154-170) + H2O
?
-
not monobasic site
-
-
?
somatostatin-28 + H2O
?
-
-
-
-
?
somatostatin-28 + H2O
?
-
-
-
?
somatostatin-28 + H2O
?
-
-
-
?
Somatostatin-28 + H2O
Somatostatin-28-(13-28) + somatostatin-28-(1-12)
-
-
-
-
?
Somatostatin-28 + H2O
Somatostatin-28-(13-28) + somatostatin-28-(1-12)
-
cleavage on amino side of Arg-Lys doublet
-
-
?
Somatostatin-28 + H2O
Somatostatin-28-(13-28) + somatostatin-28-(1-12)
-
cleavage site: Xaa-+-Arg-Lys, the term -+- depicts the point of cleavage
-
-
?
Somatostatin-28 + H2O
Somatostatin-28-(13-28) + somatostatin-28-(1-12)
-
cleavage site: Glu12-+-Arg13-Lys14, the term -+- depicts the point of cleavage
-
-
?
Somatostatin-28 + H2O
Somatostatin-28-(13-28) + somatostatin-28-(1-12)
-
i.e. octacosapeptide
-
-
?
[Ala17,Tyr20]-Somatostatin-28-(10-20)-NH2 + H2O
Pro-Arg-Glu + Arg-Lys-Ala-Gly-Ala-Lys-Asn-Tyr-NH2
-
i.e. model peptide I
-
-
?
[Ala17,Tyr20]-Somatostatin-28-(10-20)-NH2 + H2O
Pro-Arg-Glu + Arg-Lys-Ala-Gly-Ala-Lys-Asn-Tyr-NH2
-
i.e. desiodinated peptide I
-
-
?
[Ala17,Tyr20]-Somatostatin-28-(10-20)-NH2 + H2O
Pro-Arg-Glu + Arg-Lys-Ala-Gly-Ala-Lys-Asn-Tyr-NH2
-
derived from somatostatin-28, mimicking the peptide sequence around the dibasic (i.e. maturation) site
-
-
?
[Ala17,Tyr20]-Somatostatin-28-(10-20)-NH2 + H2O
Pro-Arg-Glu + Arg-Lys-Ala-Gly-Ala-Lys-Asn-Tyr-NH2
-
i.e. Pro-Arg-Glu-Arg-Lys-Ala-Gly-Ala-Lys-Asn-Tyr-NH2
-
-
?
additional information
?
-
-
enhancement of alpha-secretase cleavage of amyloid precursor protein by a metalloendopeptidase nardilysin, resulting in down-regulation of beta-amyloid protein, overview, the enzyme also enhances ectodomain shedding of heparin-binding epidermal growth factor-like growth factor through activation of ADAM17, NRDc is regulatorally involved in the metabolism
-
-
?
additional information
?
-
-
expression of nardilysin synergistically enhances TNF-alpha-converting enzyme-induced TNF-alpha ectodomain-shedding via activation of ADAM proteases ADAM9 and ADAM10, activation is independent of protein kinase C, overview
-
-
?
additional information
?
-
-
the enzyme interacts with the brain-specific protein p42IP4/centaurin-alpha1, the interactionis regulated by phosphatidylinositol 3,4,5-triphosphate and inositol-1,3,4,5-tetrakisphophate, nardilysin might play a role in brain development, overview
-
-
?
additional information
?
-
-
the metalloendopeptidase cleaves N-terminal Arg or Lys residues of peptides
-
-
?
additional information
?
-
NRDc interacts with the NCoR/SMRT corepressor complex
-
-
?
additional information
?
-
NRDc is identifiend as a H3K4me2-binding protein. The H3K4me2-binding activity resides in the N-terminal region of NRDc
-
-
?
additional information
?
-
-
tubulin enhances the binding of NRD to functionally p42IP4
-
-
?
additional information
?
-
-
nardilysin can generate both N termini and C termini of CTL epitopes
-
-
?
additional information
?
-
-
physiological substrates of nardilysin have yet to be identified
-
?
additional information
?
-
-
nardilysin enhances ectodomain shedding of neuregulin1, NRG1, a master regulator of myelination in the peripheral nervous system
-
-
?
additional information
?
-
-
[Tyr18]-pro-oxytocin/neurophysin-(1-18)-NH2, Pro-Glu-D-Arg-Lys-Tyr-NH2, Pro-Glu-Arg-D-Lys-Tyr-NH2
-
-
?
additional information
?
-
-
[Tyr20]-somatostatin-28-(13-20)-NH2, dynorphin A-(1-7), [Ala17]-somatostatin-(6-19)-NH2, prosomatostatin-(56-68)-NH2, the Lys-Arg-doublet in preproenkephalin-(128-140) or pro-oxytocin/neurophysin-(1-20)
-
-
?
additional information
?
-
-
[Tyr20]-somatostatin-28-(13-20)-NH2, dynorphin A-(1-7), [Ala17]-somatostatin-(6-19)-NH2, prosomatostatin-(56-68)-NH2, the Lys-Arg-doublet in preproenkephalin-(128-140) or pro-oxytocin/neurophysin-(1-20)
-
-
?
additional information
?
-
-
cleavage occurs selectively at amino-terminal side of an Arg-residue in dibasic stretches
-
-
?
additional information
?
-
-
cleavage occurs selectively at amino-terminal side of an Arg-residue in dibasic stretches
-
-
?
additional information
?
-
-
cleavage occurs selectively at amino-terminal side of an Arg-residue in dibasic stretches
-
-
?
additional information
?
-
-
no aminopeptidase or carboxypeptidase activity
-
-
?
additional information
?
-
-
strict specificity depending upon sequence around Arg-Lys-pair
-
-
?
additional information
?
-
-
cleavage efficiency is higher for the larger substrates
-
-
?
additional information
?
-
-
independent of the nature of the basic doublet of the peptide
-
-
?
additional information
?
-
-
no substrates are dodecapeptide fragment of corticotropin-releasing factor (i.e. Ala-Tyr-Ser-Asn-Arg-Lys-Leu-Leu-Asp-Ile-Ala-NH2)
-
-
?
additional information
?
-
-
no cleavage of single Arg-Xaa site
-
-
?
additional information
?
-
-
utilization of series of fluorogenic peptides containing the sequence 2-aminobenzoyl-GGX1X2RKX3GQ-ethylenediamine-2,4-dinitrophenyl. Residues at positions X1, X2, and X3 are varied to study effects at the P3, P2, and P29 positions, respectively
-
-
?
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0.0019
2-aminobenzoyl-GFSPFRSSRQED(2,4-dinitrophenyl)
-
pH 7.0, 37°C
0.0074
2-aminobenzoyl-GGALRKVGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGXLRKVGQ-ethylenediamine-2,4-dinitrophenyl
0.0061
2-aminobenzoyl-GGFARKVGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFXRKVGQ-ethylenediamine-2,4-dinitrophenyl
0.0094
2-aminobenzoyl-GGFFRKVGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFXRKVGQ-ethylenediamine-2,4-dinitrophenyl
0.0044
2-aminobenzoyl-GGFHRKVGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFXRKVGQ-ethylenediamine-2,4-dinitrophenyl
0.0075
2-aminobenzoyl-GGFIKKVGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFIXXVGQ-ethylenediamine-2,4-dinitrophenyl
0.0074
2-aminobenzoyl-GGFIKRVGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFIXXVGQ-ethylenediamine-2,4-dinitrophenyl
0.0062 - 0.0072
2-aminobenzoyl-GGFIRKVGQ-ethylenediamine-2,4-dinitrophenyl
0.0033
2-aminobenzoyl-GGFIRRVGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFIXXVGQ-ethylenediamine-2,4-dinitrophenyl
0.0014
2-aminobenzoyl-GGFIRRVGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 7.0, 37°C
0.0073
2-aminobenzoyl-GGFLKKVGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFLXXVGQ-ethylenediamine-2,4-dinitrophenyl
0.0051
2-aminobenzoyl-GGFLKRVGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFLXXVGQ-ethylenediamine-2,4-dinitrophenyl
0.01
2-aminobenzoyl-GGFLRKAGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFLRKXGQ-ethylenediamine-2,4-dinitrophenyl
0.011
2-aminobenzoyl-GGFLRKDGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFLRKXGQ-ethylenediamine-2,4-dinitrophenyl
0.0066
2-aminobenzoyl-GGFLRKFGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFLRKXGQ-ethylenediamine-2,4-dinitrophenyl
0.0048
2-aminobenzoyl-GGFLRKHGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFLRKXGQ-ethylenediamine-2,4-dinitrophenyl
0.0051
2-aminobenzoyl-GGFLRKIGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFLRKXGQ-ethylenediamine-2,4-dinitrophenyl
0.0049
2-aminobenzoyl-GGFLRKLGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFLRKXGQ-ethylenediamine-2,4-dinitrophenyl
0.0075
2-aminobenzoyl-GGFLRKMGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFLRKXGQ-ethylenediamine-2,4-dinitrophenyl
0.0097
2-aminobenzoyl-GGFLRKNGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFLRKXGQ-ethylenediamine-2,4-dinitrophenyl
0.0101
2-aminobenzoyl-GGFLRKSGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFLRKXGQ-ethylenediamine-2,4-dinitrophenyl
0.0057 - 0.0065
2-aminobenzoyl-GGFLRKVGQ-ethylenediamine-2,4-dinitrophenyl
0.0055
2-aminobenzoyl-GGFLRKWGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFLRKXGQ-ethylenediamine-2,4-dinitrophenyl
0.0036
2-aminobenzoyl-GGFLRRVGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFLXXVGQ-ethylenediamine-2,4-dinitrophenyl
0.00023 - 0.03
2-aminobenzoyl-GGFLRRVGQ-N[2,4-dinitrophenyl]-ethylenediamine
0.0072
2-aminobenzoyl-GGFMRKVGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFXRKVGQ-ethylenediamine-2,4-dinitrophenyl
0.003
2-aminobenzoyl-GGFNRKVGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFXRKVGQ-ethylenediamine-2,4-dinitrophenyl
0.004
2-aminobenzoyl-GGFSRKVGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFXRKVGQ-ethylenediamine-2,4-dinitrophenyl
0.0095
2-aminobenzoyl-GGFVRKVGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFXRKVGQ-ethylenediamine-2,4-dinitrophenyl
0.0053
2-aminobenzoyl-GGFWRKVGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFXRKVGQ-ethylenediamine-2,4-dinitrophenyl
0.0039
2-aminobenzoyl-GGFYKKVGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFYXXVGQ-ethylenediamine-2,4-dinitrophenyl
0.003
2-aminobenzoyl-GGFYKRVGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFYXXVGQ-ethylenediamine-2,4-dinitrophenyl
0.0083 - 0.0094
2-aminobenzoyl-GGFYRKVGQ-ethylenediamine-2,4-dinitrophenyl
0.0026
2-aminobenzoyl-GGFYRRVGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFYXXVGQ-ethylenediamine-2,4-dinitrophenyl
0.0057
2-aminobenzoyl-GGHLRKVGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGXLRKVGQ-ethylenediamine-2,4-dinitrophenyl
0.0064
2-aminobenzoyl-GGILRKVGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGXLRKVGQ-ethylenediamine-2,4-dinitrophenyl
0.0091
2-aminobenzoyl-GGLLRKVGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGXLRKVGQ-ethylenediamine-2,4-dinitrophenyl
0.0067
2-aminobenzoyl-GGMLRKVGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGXLRKVGQ-ethylenediamine-2,4-dinitrophenyl
0.0054
2-aminobenzoyl-GGNLRKVGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGXLRKVGQ-ethylenediamine-2,4-dinitrophenyl
0.0065
2-aminobenzoyl-GGSLRKVGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGXLRKVGQ-ethylenediamine-2,4-dinitrophenyl
0.0092
2-aminobenzoyl-GGVLRKVGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGXLRKVGQ-ethylenediamine-2,4-dinitrophenyl
0.008
2-aminobenzoyl-GGWLRKVGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGXLRKVGQ-ethylenediamine-2,4-dinitrophenyl
0.0092
2-aminobenzoyl-GGYLRKVGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGXLRKVGQ-ethylenediamine-2,4-dinitrophenyl
0.0041
2-aminobenzoyl-MISLMKRPPGFSPFRSSRINH2
-
pH 7.0, 37°C
0.0035
2-aminobenzoyl-MISLMKRPQED(2,4-dinitrophenyl)
-
pH 7.0, 37°C
0.00054 - 0.0466
2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl)
0.974
alpha-neoendorphin
-
-
0.0014
betaendorphin
-
pH 7.0, 37°C
0.103
Bovine adrenal medulla dodecapeptide
-
-
0.0017
calcitonin
-
pH 7.0, 37°C
0.127
dynorphin A-(1-10)
-
-
0.024
dynorphin A-(1-13)
-
-
0.162
dynorphin A-(1-9)
-
-
0.002
dynorphin B13
-
pH 7.0, 37°C
0.0173
Preproneurotensin-(154-170)
-
-
0.0005 - 0.008
Somatostatin-14
0.0055 - 0.043
Somatostatin-28
0.428
[Ala17,Tyr20]-Somatostatin-28-(10-20)-NH2
0.227
[Arg0,Ala17]-somatostatin-28-(1-19)-NH2
-
-
0.0062
2-aminobenzoyl-GGFIRKVGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFXRKVGQ-ethylenediamine-2,4-dinitrophenyl
0.0072
2-aminobenzoyl-GGFIRKVGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFIXXVGQ-ethylenediamine-2,4-dinitrophenyl
0.0057
2-aminobenzoyl-GGFLRKVGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFLRKXGQ-ethylenediamine-2,4-dinitrophenyl
0.0065
2-aminobenzoyl-GGFLRKVGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFXRKVGQ-ethylenediamine-2,4-dinitrophenyl and hydrolysis of the peptide series 2-aminobenzoyl-GGXLRKVGQ-ethylenediamine-2,4-dinitrophenyl and hydrolysis of the peptide series 2-aminobenzoyl-GGFLXXVGQ-ethylenediamine-2,4-dinitrophenyl
0.00023
2-aminobenzoyl-GGFLRRVGQ-N[2,4-dinitrophenyl]-ethylenediamine
-
pH 6.5, 34°C
0.00031
2-aminobenzoyl-GGFLRRVGQ-N[2,4-dinitrophenyl]-ethylenediamine
-
pH 8.0, 34°C
0.0015
2-aminobenzoyl-GGFLRRVGQ-N[2,4-dinitrophenyl]-ethylenediamine
-
pH 6.0, 34°C
0.00192
2-aminobenzoyl-GGFLRRVGQ-N[2,4-dinitrophenyl]-ethylenediamine
-
pH 8.0, 34°C, 25 mM KCl
0.002
2-aminobenzoyl-GGFLRRVGQ-N[2,4-dinitrophenyl]-ethylenediamine
-
pH 6.5, 34°C, 50 mM KCl
0.0158
2-aminobenzoyl-GGFLRRVGQ-N[2,4-dinitrophenyl]-ethylenediamine
-
pH 6.5, 34°C, 500 mM KCl
0.03
2-aminobenzoyl-GGFLRRVGQ-N[2,4-dinitrophenyl]-ethylenediamine
-
pH 8.2, 34°C
0.0083
2-aminobenzoyl-GGFYRKVGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFYXXVGQ-ethylenediamine-2,4-dinitrophenyl
0.0094
2-aminobenzoyl-GGFYRKVGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFXRKVGQ-ethylenediamine-2,4-dinitrophenyl and hydrolysis of the peptide series 2-aminobenzoyl-GGFLXXVGQ-ethylenediamine-2,4-dinitrophenyl
0.00054
2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl)
-
pH 7.0, 37°C, R-K
0.00117
2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl)
-
pH 7.0, 37°C, KK
0.0077
2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl)
-
pH 7.0, 37°C, F-K
0.0084
2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl)
-
pH 7.0, 37°C, WK
0.0135
2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl)
-
pH 7.0, 37°C, MK
0.0171
2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl)
-
pH 7.0, 37°C, FR
0.0266
2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl)
-
pH 7.0, 37°C, YK
0.0466
2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl)
-
pH 7.0, 37°C, L-K
0.0005
Somatostatin-14
-
pH 7.0, 37°C
0.008
Somatostatin-14
-
pH 7.0, 37°C
0.0055
Somatostatin-28
-
-
0.043
Somatostatin-28
-
-
0.428
[Ala17,Tyr20]-Somatostatin-28-(10-20)-NH2
-
-
0.428
[Ala17,Tyr20]-Somatostatin-28-(10-20)-NH2
-
or peptide I
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.031 - 7.68
2-aminobenzoyl-GFSPFRSSRQED(2,4-dinitrophenyl)
3.88
2-aminobenzoyl-GGALRKVGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGXLRKVGQ-ethylenediamine-2,4-dinitrophenyl
1.08
2-aminobenzoyl-GGFARKVGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFXRKVGQ-ethylenediamine-2,4-dinitrophenyl
2.83
2-aminobenzoyl-GGFFRKVGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFXRKVGQ-ethylenediamine-2,4-dinitrophenyl
6.9
2-aminobenzoyl-GGFHRKVGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFXRKVGQ-ethylenediamine-2,4-dinitrophenyl
0.198
2-aminobenzoyl-GGFIKKVGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFIXXVGQ-ethylenediamine-2,4-dinitrophenyl
12.09
2-aminobenzoyl-GGFIKRVGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFIXXVGQ-ethylenediamine-2,4-dinitrophenyl
1.22 - 1.23
2-aminobenzoyl-GGFIRKVGQ-ethylenediamine-2,4-dinitrophenyl
15.73
2-aminobenzoyl-GGFIRRVGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFIXXVGQ-ethylenediamine-2,4-dinitrophenyl
3.3 - 5.03
2-aminobenzoyl-GGFIRRVGQ-N-(2,4-dinitrophenyl)ethylenediamine
2.16
2-aminobenzoyl-GGFLKKVGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFLXXVGQ-ethylenediamine-2,4-dinitrophenyl
9.75
2-aminobenzoyl-GGFLKRVGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFLXXVGQ-ethylenediamine-2,4-dinitrophenyl
2.04
2-aminobenzoyl-GGFLRKAGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFLRKXGQ-ethylenediamine-2,4-dinitrophenyl
0.24
2-aminobenzoyl-GGFLRKDGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFLRKXGQ-ethylenediamine-2,4-dinitrophenyl
2.94
2-aminobenzoyl-GGFLRKFGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFLRKXGQ-ethylenediamine-2,4-dinitrophenyl
13.69
2-aminobenzoyl-GGFLRKHGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFLRKXGQ-ethylenediamine-2,4-dinitrophenyl
2.04
2-aminobenzoyl-GGFLRKIGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFLRKXGQ-ethylenediamine-2,4-dinitrophenyl
1.74
2-aminobenzoyl-GGFLRKLGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFLRKXGQ-ethylenediamine-2,4-dinitrophenyl
2.77
2-aminobenzoyl-GGFLRKMGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFLRKXGQ-ethylenediamine-2,4-dinitrophenyl
1.59
2-aminobenzoyl-GGFLRKNGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFLRKXGQ-ethylenediamine-2,4-dinitrophenyl
4.65
2-aminobenzoyl-GGFLRKSGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFLRKXGQ-ethylenediamine-2,4-dinitrophenyl
2.48
2-aminobenzoyl-GGFLRKVGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFXRKVGQ-ethylenediamine-2,4-dinitrophenyl and hydrolysis of the peptide series 2-aminobenzoyl-GGFLRKXGQ-ethylenediamine-2,4-dinitrophenyl and hydrolysis of the peptide series 2-aminobenzoyl-GGXLRKVGQ-ethylenediamine-2,4-dinitrophenyl and hydrolysis of the peptide series 2-aminobenzoyl-GGFLXXVGQ-ethylenediamine-2,4-dinitrophenyl
5.61
2-aminobenzoyl-GGFLRKWGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFLRKXGQ-ethylenediamine-2,4-dinitrophenyl
9.92
2-aminobenzoyl-GGFLRRVGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFLXXVGQ-ethylenediamine-2,4-dinitrophenyl
4.86
2-aminobenzoyl-GGFMRKVGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFXRKVGQ-ethylenediamine-2,4-dinitrophenyl
1.08
2-aminobenzoyl-GGFNRKVGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFXRKVGQ-ethylenediamine-2,4-dinitrophenyl
0.353
2-aminobenzoyl-GGFSRKVGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFXRKVGQ-ethylenediamine-2,4-dinitrophenyl
0.41
2-aminobenzoyl-GGFVRKVGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFXRKVGQ-ethylenediamine-2,4-dinitrophenyl
0.705
2-aminobenzoyl-GGFWRKVGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFXRKVGQ-ethylenediamine-2,4-dinitrophenyl
0.187
2-aminobenzoyl-GGFYKKVGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFYXXVGQ-ethylenediamine-2,4-dinitrophenyl
0.405
2-aminobenzoyl-GGFYKRVGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFYXXVGQ-ethylenediamine-2,4-dinitrophenyl
2.59 - 2.63
2-aminobenzoyl-GGFYRKVGQ-ethylenediamine-2,4-dinitrophenyl
18.99
2-aminobenzoyl-GGFYRRVGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFYXXVGQ-ethylenediamine-2,4-dinitrophenyl
4.36
2-aminobenzoyl-GGHLRKVGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGXLRKVGQ-ethylenediamine-2,4-dinitrophenyl
4.84
2-aminobenzoyl-GGILRKVGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGXLRKVGQ-ethylenediamine-2,4-dinitrophenyl
5.83
2-aminobenzoyl-GGLLRKVGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGXLRKVGQ-ethylenediamine-2,4-dinitrophenyl
7.84
2-aminobenzoyl-GGMLRKVGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGXLRKVGQ-ethylenediamine-2,4-dinitrophenyl
0.953
2-aminobenzoyl-GGNLRKVGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGXLRKVGQ-ethylenediamine-2,4-dinitrophenyl
8.53
2-aminobenzoyl-GGSLRKVGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGXLRKVGQ-ethylenediamine-2,4-dinitrophenyl
3.24
2-aminobenzoyl-GGVLRKVGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGXLRKVGQ-ethylenediamine-2,4-dinitrophenyl
4.95
2-aminobenzoyl-GGWLRKVGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGXLRKVGQ-ethylenediamine-2,4-dinitrophenyl
1.85
2-aminobenzoyl-GGYLRKVGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGXLRKVGQ-ethylenediamine-2,4-dinitrophenyl
0.04 - 9.48
2-aminobenzoyl-MISLMKRPQED(2,4-dinitrophenyl)
0.216 - 6.08
2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl)
3.3 - 5.03
beta-endorphin
0.783 - 6.08
Somatostatin-14
additional information
2-aminobenzoyl-MISLMKRPPGFSPFRSSRI-NH2
-
pH 7.0, 37°C
0.031 - 0.51
2-aminobenzoyl-GFSPFRSSRQED(2,4-dinitrophenyl)
-
pH 7.0, 37°C
7.68
2-aminobenzoyl-GFSPFRSSRQED(2,4-dinitrophenyl)
-
pH 7.0, 37°C
1.22
2-aminobenzoyl-GGFIRKVGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFXRKVGQ-ethylenediamine-2,4-dinitrophenyl
1.23
2-aminobenzoyl-GGFIRKVGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFIXXVGQ-ethylenediamine-2,4-dinitrophenyl
3.3
2-aminobenzoyl-GGFIRRVGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 7.0, 37°C
5.03
2-aminobenzoyl-GGFIRRVGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 7.0, 37°C
2.59
2-aminobenzoyl-GGFYRKVGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFXRKVGQ-ethylenediamine-2,4-dinitrophenyl and hydrolysis of the peptide series 2-aminobenzoyl-GGFLXXVGQ-ethylenediamine-2,4-dinitrophenyl
2.63
2-aminobenzoyl-GGFYRKVGQ-ethylenediamine-2,4-dinitrophenyl
-
pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFYXXVGQ-ethylenediamine-2,4-dinitrophenyl
0.04 - 1.97
2-aminobenzoyl-MISLMKRPQED(2,4-dinitrophenyl)
-
pH 7.0, 37°C
9.48
2-aminobenzoyl-MISLMKRPQED(2,4-dinitrophenyl)
-
pH 7.0, 37°C
0.216
2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl)
-
pH 7.0, 37°C, LK
0.455
2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl)
-
pH 7.0, 37°C, WK and MK
0.498
2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl)
-
pH 7.0, 37°C, KK
0.628
2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl)
-
pH 7.0, 37°C, FK
0.693
2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl)
-
pH 7.0, 37°C, RK
0.78
2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl)
-
pH 7.0, 37°C, YK
6.08
2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl)
-
pH 7.0, 37°C, FK
6.08
2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl)
-
pH 7.0, 37°C, FR
6.08
2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl)
-
pH 7.0, 37°C, RK
6.08
2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl)
-
pH 7.0, 37°C, YK
3.3
beta-endorphin
-
pH 7.0, 37°C
5.03
beta-endorphin
-
pH 7.0, 37°C
1.81
calcitonin
-
pH 7.0, 37°C
2.94
calcitonin
-
pH 7.0, 37°C
0.783
Somatostatin-14
-
pH 7.0, 37°C
0.95
Somatostatin-14
-
pH 7.0, 37°C, reduced somatostatin
6.08
Somatostatin-14
-
pH 7.0, 37°C
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Chesneau, V.; Pierotti, A.R.; Barre, N.; Creminon, C.; Tougard, C.; Cohen, P.
Isolation and characterization of a dibasic selective metalloendopeptidase from rat testes that cleaves at the amino terminus of arginine residues
J. Biol. Chem.
269
2056-2061
1994
Rattus norvegicus
brenda
Gomez, S.; Gluschankof, P.; Morel, A.; Cohen, P.
The somatostatin-28 convertase of rat brain cortex is associated with secretory granule membranes
J. Biol. Chem.
260
10541-10545
1985
Rattus norvegicus
brenda
Gluschankof, P.; Gomez, S.; Morel, A.; Cohen, P.
Enzymes that process somatostatin precursors. A novel endoprotease that cleaves before the arginine-lysine doublet is involved in somatostatin-28 convertase activity of rat brain cortex
J. Biol. Chem.
262
9615-9620
1987
Rattus norvegicus
brenda
Pierotti, A.R.; Prat, A.; Chesneau, V.; Gaudoux, F.; Leseney, A.M.; Foulon, T.; Cohen, P.
N-Arginine dibasic convertase, a metalloendopeptidase as a prototype of a class of processing enzymes
Proc. Natl. Acad. Sci. USA
91
6078-6082
1994
Rattus norvegicus
brenda
Cohen, P.; Pierotti, A.R.; Chesneau, V.; Foulon, T.; Prat, A.
N-arginine dibasic convertase
Methods Enzymol.
248
703-716
1995
Rattus norvegicus
brenda
Cohen, P.; Clamagirand, C.; Gluschankof, P.; Gomez, S.; Creminon, C.; Plevrakis, I.; Clavreul, C.; Fahy, C.; Boussetta, H.; et al.
Somatostatin-28 and pro-ocytocin/neurophysin convertases: basic pair selective endoproteases involved in pro-hormone processing in the rat brain cortex and bovine corpus luteum
Biochimie
70
17-23
1988
Rattus norvegicus
brenda
Foulon, T.; Cadel, S.; Prat, A.; Chesneau, V.; Hospital, V.; Segretain, D.; Cohen, P.
NRD convertase and aminopeptidase B: two processing metallopeptidases with a selectivity for basic residues
Ann. Endocrinol. (Paris)
58
357-364
1997
Rattus norvegicus
brenda
Csuhai, E.; Juliano, M.A.; Juliano, L.; Hersh, L.B.
Kinetic analysis of spermine binding to NRD convertase
Arch. Biochem. Biophys.
362
291-300
1999
Rattus norvegicus
brenda
Ma, Z.; Chow, K.M.; Csuhai, E.; Hersh, L.B.
The use of proteolysis to study the structure of nardilysin
Arch. Biochem. Biophys.
401
198-204
2002
Mus musculus
brenda
Chow, K.M.; Oakley, O.; Goodman, J.; Ma, Z.; Juliano, M.A.; Juliano, L.; Hersh, L.B.
Nardilysin cleaves peptides at monobasic sites
Biochemistry
42
2239-2244
2003
Mus musculus
brenda
Chow, K.M.; Csuhai, E.; Juliano, M.A.; St Pyrek, J.; Juliano, L.; Hersh, L.B.
Studies on the subsite specificity of rat nardilysin (N-arginine dibasic convertase)
J. Biol. Chem.
275
19545-19551
2000
Rattus norvegicus
brenda
Ma, Z.; Chow, K.M.; Yao, J.; Hersh, L.B.
Nuclear shuttling of the peptidase nardilysin
Arch. Biochem. Biophys.
422
153-160
2004
Mus musculus
brenda
Ma, Z.; Wang, X.; Hockman, S.; Snow, E.C.; Hersh, L.B.
Subcellular localization of nardilysin during mouse oocyte maturation
Arch. Biochem. Biophys.
434
187-194
2005
Mus musculus
brenda
Chow, K.M.; Ma, Z.; Cai, J.; Pierce, W.M.; Hersh, L.B.
Nardilysin facilitates complex formation between mitochondrial malate dehydrogenase and citrate synthase
Biochim. Biophys. Acta
1723
292-301
2005
Rattus norvegicus
brenda
Fontes, G.; Lajoix, A.D.; Bergeron, F.; Cadel, S.; Prat, A.; Foulon, T.; Gross, R.; Dalle, S.; Le-Nguyen, D.; Tribillac, F.; Bataille, D.
Miniglucagon (MG)-generating endopeptidase, which processes glucagon into MG, is composed of N-arginine dibasic convertase and aminopeptidase B
Endocrinology
146
702-712
2005
Mus musculus, Rattus norvegicus
brenda
Nishi, E.; Hiraoka, Y.; Yoshida, K.; Okawa, K.; Kita, T.
Nardilysin enhances ectodomain shedding of heparin-binding epidermal growth factor-like growth factor through activation of tumor necrosis factor-alpha-converting enzyme
J. Biol. Chem.
281
31164-31172
2006
Homo sapiens (O43847)
brenda
Stricker, R.; Chow, K.M.; Walther, D.; Hanck, T.; Hersh, L.B.; Reiser, G.
Interaction of the brain-specific protein p42IP4/centaurin-alpha1 with the peptidase nardilysin is regulated by the cognate ligands of p42IP4, PtdIns(3,4,5)P3 and Ins(1,3,4,5)P4, with stereospecificity
J. Neurochem.
98
343-354
2006
Rattus norvegicus
brenda
Hiraoka, Y.; Yoshida, K.; Ohno, M.; Matsuoka, T.; Kita, T.; Nishi, E.
Ectodomain shedding of TNF-alpha is enhanced by nardilysin via activation of ADAM proteases
Biochem. Biophys. Res. Commun.
370
154-158
2008
Homo sapiens
brenda
Hiraoka, Y.; Ohno, M.; Yoshida, K.; Okawa, K.; Tomimoto, H.; Kita, T.; Nishi, E.
Enhancement of alpha-secretase cleavage of amyloid precursor protein by a metalloendopeptidase nardilysin
J. Neurochem.
102
1595-1605
2007
Homo sapiens
brenda
Bernstein, H.; Stricker, R.; Dobrowolny, H.; Truebner, K.; Bogerts, B.; Reiser, G.
Histochemical evidence for wide expression of the metalloendopeptidase nardilysin in human brain neurons
Neuroscience
146
1513-1523
2007
Homo sapiens
brenda
Bernstein, H.G.; Stricker, R.; Lendeckel, U.; Bertram, I.; Dobrowolny, H.; Steiner, J.; Bogerts, B.; Reiser, G.
Reduced neuronal co-localisation of nardilysin and the putative alpha-secretases ADAM10 and ADAM17 in Alzheimers disease and Down syndrome brains
Age (Dordr. )
31
11-25
2009
Homo sapiens
brenda
Korovkina, V.P.; Stamnes, S.J.; Brainard, A.M.; England, S.K.
Nardilysin convertase regulates the function of the maxi-K channel isoform mK44 in human myometrium
Am. J. Physiol. Cell Physiol.
296
C433-C440
2009
Homo sapiens
brenda
Ohno, M.; Hiraoka, Y.; Matsuoka, T.; Tomimoto, H.; Takao, K.; Miyakawa, T.; Oshima, N.; Kiyonari, H.; Kimura, T.; Kita, T.; Nishi, E.
Nardilysin regulates axonal maturation and myelination in the central and peripheral nervous system
Nat. Neurosci.
12
1506-1513
2009
Mus musculus
brenda
Kessler, J.H.; Khan, S.; Seifert, U.; Le Gall, S.; Chow, K.M.; Paschen, A.; Bres-Vloemans, S.A.; de Ru, A.; van Montfoort, N.; Franken, K.L.; Benckhuijsen, W.E.; Brooks, J.M.; van Hall, T.; Ray, K.; Mulder, A.; Doxiadis, I.I.; van Swieten, P.F.; Overkleeft, H.S.; Prat, A.; Tomkinson, B.; Neefjes, J.; Klo, K.l.o.e.
Antigen processing by nardilysin and thimet oligopeptidase generates cytotoxic T cell epitopes
Nat. Immunol.
12
45-53
2011
Homo sapiens
brenda
Borrmann, C.; Stricker, R.; Reiser, G.
Tubulin potentiates the interaction of the metalloendopeptidase nardilysin with the neuronal scaffold protein p42IP4/centaurin-alpha1 (ADAP1)
Cell Tissue Res.
346
89-98
2011
Homo sapiens
brenda
Li, J.; Chu, M.; Wang, S.; Chan, D.; Qi, S.; Wu, M.; Zhou, Z.; Li, J.; Nishi, E.; Qin, J.; Wong, J.
Identification and Characteriation of Nardilysin as a Novel Dimethyl H3K4 Binding Protein Involved in Transcriptional Regulation
J. Biol. Chem.
287
10089-10098
2012
Homo sapiens (O43847)
brenda
Borrmann, C.; Stricker, R.; Reiser, G.
Retinoic acid-induced upregulation of the metalloendopeptidase nardilysin is accelerated by co-expression of the brain-specific protein p42(IP4) (centaurin alpha1; ADAP1) in neuroblastoma cells
Neurochem. Int.
59
936-944
2011
Homo sapiens
brenda
Bernstein, H.; Stricker, R.; Dobrowolny, H.; Steiner, J.; Bogerts, B.; Trbner, K.; Reiser, G.
Nardilysin in human brain diseases: both friend and foe
Amino Acids
45
269-278
2013
Homo sapiens (O43847), Homo sapiens
brenda
Kanda, K.; Komekado, H.; Sawabu, T.; Ishizu, S.; Nakanishi, Y.; Nakatsuji, M.; Akitake-Kawano, R.; Ohno, M.; Hiraoka, Y.; Kawada, M.; Kawada, K.; Sakai, Y.; Matsumoto, K.; Kunichika, M.; Kimura, T.; Seno, H.; Nishi, E.; Chiba, T.
Nardilysin and ADAM proteases promote gastric cancer cell growth by activating intrinsic cytokine signalling via enhanced ectodomain shedding of TNF-alpha
EMBO Mol. Med.
4
396-411
2012
Homo sapiens (O43847), Homo sapiens
brenda
Hiraoka, Y.; Matsuoka, T.; Ohno, M.; Nakamura, K.; Saijo, S.; Matsumura, S.; Nishi, K.; Sakamoto, J.; Chen, P.; Inoue, K.; Fushiki, T.; Kita, T.; Kimura, T.; Nishi, E.
Critical roles of nardilysin in the maintenance of body temperature homoeostasis
Nat. Commun.
5
3224
2014
Mus musculus (Q8BHG1)
brenda
Ohno, M.; Hiraoka, Y.; Lichtenthaler, S.; Nishi, K.; Saijo, S.; Matsuoka, T.; Tomimoto, H.; Araki, W.; Takahashi, R.; Kita, T.; Kimura, T.; Nishi, E.
Nardilysin prevents amyloid plaque formation by enhancing alpha-secretase activity in an Alzheimers disease mouse model
Neurobiol. Aging
35
213-222
2014
Mus musculus (Q8BHG1), Mus musculus
brenda
Segretain, D.; Gilleron, J.; Bacro, J.N.; Di Marco, M.; Carette, D.; Pointis, G.
Ultrastructural localization and distribution of nardilysin in mammalian male germ cells
Basic Clin. Androl.
26
5
2016
Mus musculus (Q8BHG1), Mus musculus
brenda
Yoh, T.; Hatano, E.; Kasai, Y.; Fuji, H.; Nishi, K.; Toriguchi, K.; Sueoka, H.; Ohno, M.; Seo, S.; Iwaisako, K.; Taura, K.; Yamaguchi, R.; Kurokawa, M.; Fujimoto, J.; Kimura, T.; Uemoto, S.; Nishi, E.
Serum nardilysin, a surrogate marker for epithelial-mesenchymal transition, predicts prognosis of intrahepatic cholangiocarcinoma after surgical resection
Clin. Cancer Res.
25
619-628
2019
Homo sapiens (O43847), Homo sapiens
brenda
Chen, F.H.; Wang, Y.; Jiang, Y.X.; Zhang, G.H.; Wang, Z.M.; Yang, H.
Clinical determination of serum nardilysin levels in predicting 30-day mortality among adults with malignant cerebral infarction
Clin. Chim. Acta
494
8-13
2019
Homo sapiens (O43847), Homo sapiens
brenda
Nishi, K.; Sato, Y.; Ohno, M.; Hiraoka, Y.; Saijo, S.; Sakamoto, J.; Chen, P.M.; Morita, Y.; Matsuda, S.; Iwasaki, K.; Sugizaki, K.; Harada, N.; Mukumoto, Y.; Kiyonari, H.; Furuyama, K.; Kawaguchi, Y.; Uemoto, S.; Kita, T.; Inagaki, N.; Kimura, T.; Nishi, E.
Nardilysin is required for maintaining pancreatic beta-cell function
Diabetes
65
3015-3027
2016
Mus musculus (Q8BHG1)
brenda
Ikuta, K.; Fukuda, A.; Ogawa, S.; Masuo, K.; Goto, N.; Hiramatsu, Y.; Tsuda, M.; Kimura, Y.; Matsumoto, Y.; Kimura, Y.; Maruno, T.; Kanda, K.; Nishi, K.; Takaori, K.; Uemoto, S.; Takaishi, S.; Chiba, T.; Nishi, E.; Seno, H.
Nardilysin inhibits pancreatitis and suppresses pancreatic ductal adenocarcinoma initiation in mice
Gut
68
882-892
2019
Mus musculus (Q8BHG1)
brenda
Kanda, K.; Sakamoto, J.; Matsumoto, Y.; Ikuta, K.; Goto, N.; Morita, Y.; Ohno, M.; Nishi, K.; Eto, K.; Kimura, Y.; Nakanishi, Y.; Ikegami, K.; Yoshikawa, T.; Fukuda, A.; Kawada, K.; Sakai, Y.; Ito, A.; Yoshida, M.; Kimura, T.; Chiba, T.; Nishi, E.; Seno, H.
Nardilysin controls intestinal tumorigenesis through HDAC1/p53-dependent transcriptional regulation
JCI Insight
3
91316
2018
Homo sapiens (O43847), Homo sapiens, Mus musculus (Q8BHG1)
brenda
Kimura, Y.; Ikuta, K.; Kimura, T.; Chiba, T.; Oshima, H.; Oshima, M.; Nishi, E.; Seno, H.
Nardilysin regulates inflammation, metaplasia, and tumors in murine stomach
Sci. Rep.
7
43052
2017
Mus musculus (Q8BHG1), Mus musculus
brenda