3.4.24.61: nardilysin
This is an abbreviated version!
For detailed information about nardilysin, go to the full flat file.
Word Map on EC 3.4.24.61
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3.4.24.61
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metalloendopeptidase
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ectodomain
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heparin-binding
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pitrilysins
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adam17
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hb-egf
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insulysin
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insulinase
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hxxeh
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dynorphins
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medicine
- 3.4.24.61
- metalloendopeptidase
- ectodomain
-
heparin-binding
- pitrilysins
- adam17
- hb-egf
- insulysin
- insulinase
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hxxeh
- dynorphins
- medicine
Reaction
hydrolysis of polypeptides, preferably at -Xaa-/-Arg-Lys-, and less commonly at -Arg-/-Arg-Xaa-, in which Xaa is not Arg or Lys =
Synonyms
hNRDc1, MGE, miniglucagon-generating endopeptidase, More, N-arginine dibasic (NRD) convertase, N-Arginine dibasic convertase, nardilysin, nardilysin (V8), nardilysin convertase, NRD convertase, NRD-convertase, Nrd1, Nrd1 and NRDc, NRDc
ECTree
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Inhibitors
Inhibitors on EC 3.4.24.61 - nardilysin
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2-aminobenzoyl-GGFLRRVGQ-N[2,4-dinitrophenyl]-ethylenediamine
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substrate inhibitionl
1,10-phenanthroline
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dynorphin A or [Ala17,Tyr20]-somatostatin-28-(10-20)-NH2 as substrate
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0.02 mM; dynorphin A or [Ala17,Tyr20]-somatostatin-28-NH2 as substrate; strong
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dynorphin A or [Ala17,Tyr20]-somatostatin-28-NH2 as substrate; less efficient than amastatin
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dynorphin A or [Ala17,Tyr20]-somatostatin-28-(10-20)-NH2 as substrate; reversible by low concentrations of Zn2+ or Mn2+; to a lesser extent by Co2+, Ca2+; to a lesser extent by Mg2+ (not)
EDTA
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0.01 mM; not by Cu2+; reversible by low concentrations of Zn2+ or Mn2+; to a lesser extent by Co2+, Ca2+; to a lesser extent by Mg2+ (not)
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dynorphin A or [Ala17,Tyr20]-somatostatin-28-(10-20)-NH2 as substrate
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strong, dynorphin A or [Ala17,Tyr20]-somatostatin-28-NH2 as substrate
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no inhibition by IAA, phosphoramidon, captopril, phenylmethylsulfonyl fluoride, leupeptin, guanidylethylmercaptosuccinic acid (i.e. GEMSA)
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additional information
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Mg2+ (0.1 mM); no inhibition by IAA, phosphoramidon, captopril, phenylmethylsulfonyl fluoride, leupeptin, guanidylethylmercaptosuccinic acid (i.e. GEMSA)
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