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3.4.24.61: nardilysin

This is an abbreviated version!
For detailed information about nardilysin, go to the full flat file.

Word Map on EC 3.4.24.61

Reaction

hydrolysis of polypeptides, preferably at -Xaa-/-Arg-Lys-, and less commonly at -Arg-/-Arg-Xaa-, in which Xaa is not Arg or Lys =

Synonyms

hNRDc1, MGE, miniglucagon-generating endopeptidase, More, N-arginine dibasic (NRD) convertase, N-Arginine dibasic convertase, nardilysin, nardilysin (V8), nardilysin convertase, NRD convertase, NRD-convertase, Nrd1, Nrd1 and NRDc, NRDc

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.61 nardilysin

Expression

Expression on EC 3.4.24.61 - nardilysin

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
differentiation of SH-SY5Y cells by stimulation with 10 microM retinoic acid (RA) results in upregulation of NRD protein levels, with a 6fold rise after 15 days
-
protein expression is frequently elevated both in the serum and cancer epithelium of gastric cancer patients
the enzyme is highly expressed in neuroblastoma cells
there is strongly decreased neuronal enzyme expression in Down syndrome. The enzyme is down-regulated (about 1.21fold) in brains of individuals with bipolar disorder