3.4.24.61: nardilysin

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For detailed information about nardilysin, go to the full flat file.

Word Map on EC 3.4.24.61

3.4.24.61

metalloendopeptidase

ectodomain

heparin-binding

pitrilysins

adam17

hb-egf

insulysin

insulinase

hxxeh

dynorphins

medicine

Reaction

hydrolysis of polypeptides, preferably at -Xaa-/-Arg-Lys-, and less commonly at -Arg-/-Arg-Xaa-, in which Xaa is not Arg or Lys =

Synonyms

hNRDc1, MGE, miniglucagon-generating endopeptidase, More, N-arginine dibasic (NRD) convertase, N-Arginine dibasic convertase, nardilysin, nardilysin (V8), nardilysin convertase, NRD convertase, NRD-convertase, Nrd1, Nrd1 and NRDc, NRDc

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.24 Metalloendopeptidases

3.4.24.61 nardilysin

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Results	in table
2	Activating Compound
34	AA Sequence
3	Application
2	CAS Registry Number
9	Cloned(Commentary)
125	Disease/ Diagnostics
4	Expression
20	General Information
50	Inhibitors
92	KM Value [mM]
20	Localization
15	Metals/Ions
17	Molecular Weight [Da]
18	Natural Substrates/ Products (Substrates)
40	Organism
7	pH Optimum
4	pH Range
1	pH Stability
12	Protein Variants
10	Purification (Commentary)
1	Reaction
1	Reaction Type
40	Reference
50	Source Tissue
172	Substrates and Products (Substrate)
7	Subunits
55	Synonyms
5	Temperature Optimum [°C]
1	Temperature Stability [°C]
66	Turnover Number [1/s]

Cloned

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Cloned on EC 3.4.24.61 - nardilysin

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2 entries

expression of the wild-type enzyme and the mutant E235A in COS-7 or HEK-293T cells, co-expression with ADAM17

Homo sapiens

683793

full-length cDNA from a testis library

Rattus norvegicus

649325

heterologous expression of hNRDc1 by both human myometrial smooth muscle cells and ltk- mouse fibroblasts. Analysation of the regulatory function of hNRDc1 regarding mK44 (a splice variant of maxi-K chanel). Data indicate that hNRDc1 is involved in regulating the excitation of smooth muscle cells.

isolation of cDNA

overexpression of V5-tagged NRDc from a a lentivirus vector in TACE-deficient fibroblasts, co-expression of NRDc with ADAM10, recombinant wild-type NRDc and mutant E235A are synthesized using a Bac-to-Bac baculovirus expression system, co-expression of the C-terminally V5-tagged wild-type enzyme with the TNF-alpha-converting enzyme in COS-7 cells

rat, testis

recombinant enzyme expressed in Sf9 cells

Mus musculus

650203