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3.4.24.61: nardilysin

This is an abbreviated version!
For detailed information about nardilysin, go to the full flat file.

Word Map on EC 3.4.24.61

Reaction

hydrolysis of polypeptides, preferably at -Xaa-/-Arg-Lys-, and less commonly at -Arg-/-Arg-Xaa-, in which Xaa is not Arg or Lys =

Synonyms

hNRDc1, MGE, miniglucagon-generating endopeptidase, More, N-arginine dibasic (NRD) convertase, N-Arginine dibasic convertase, nardilysin, nardilysin (V8), nardilysin convertase, NRD convertase, NRD-convertase, Nrd1, Nrd1 and NRDc, NRDc

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.61 nardilysin

pH Range

pH Range on EC 3.4.24.61 - nardilysin

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pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6 - 9.8
-
enzyme is irreversibly inactivated below pH 6.0 and above pH 9.8
7.3 - 9
-
about half-maximal activity at pH 7.3 and about 90% of maximal activity at pH 9, peptide I as substrate
8.2 - 9.3
-
[Ala17,Tyr20]-somatostatin-28-(10-20)-NH2 as substrate, about half-maximal activity at pH 8.2 and 9.3