3.4.24.44: atrolysin E

This is an abbreviated version!
For detailed information about atrolysin E, go to the full flat file.

Reaction

Cleavage of Asn3-/-Gln, Ser9-/-His and Ala14-/-Leu bonds in insulin B chain and Tyr14-/-Gln and Thr8-/-Ser in A chain. Cleaves type IV collagen at Ala73-/-Gln in alpha1(IV) and at Gly7-/-Leu in alpha2(IV) =

Synonyms

atrolysin E/D, Crotalus atrox metalloendopeptidase e, Hemorrhagic toxin e, HT-e

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.24 Metalloendopeptidases

                3.4.24.44 atrolysin E

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Results	in table
2	AA Sequence
1	Application
1	CAS Registry Number
3	Cloned(Commentary)
18	Inhibitors
14	Metals/Ions
11	Molecular Weight [Da]
2	Natural Substrates/ Products (Substrates)
6	Organism
4	PDB ID
2	pH Optimum
2	Posttranslational Modification
4	Purification (Commentary)
1	Reaction
1	Reaction Type
6	Reference
5	Source Tissue
43	Substrates and Products (Substrate)
4	Subunits
5	Synonyms
2	Temperature Optimum [°C]
5	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 3.4.24.44 - atrolysin E

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

1,10-phenanthroline

2 entries

alpha2-Macroglobulin

Crotalus atrox

-

inhibits proteolytic and hemorrhagic activities

668847

-

antihemorrhagins from serum of Crotalus atrox

Crotalus atrox

-

inhibits proteolytic and hemorrhagic activities

668847

-

EDTA

4 entries

Human plasma alpha2-macroglobulin

Crotalus atrox

-

-

31259

-

Pyroglutamate peptides

Crotalus atrox

-

e.g. pyro-Glu-Asn-Trp or pyro-Glu-Glu-Trp

31259

-

synthetic carboxyalkyl peptide

Crotalus atrox

-

effective inhibitor

668847

-

Synthetic peptide inhibitors with N-[1-(R,S)-carboxypentyl] moiety

Crotalus atrox

-

-

31259

-

venom-derived pyroglutamyl-containing peptide

Crotalus atrox

-

effective inhibitor

668847

-

additional information

2 entries

-

1,10-phenanthroline

Crotalus atrox

-

-

31259, 31260, 31261

1,10-phenanthroline

Crotalus atrox

-

inhibits proteolytic and hemorrhagic activities

668847

EDTA

Crotalus atrox

-

-

31259, 31260

EDTA

Crotalus atrox

-

Zn2+ restores

31261

EDTA

Crotalus atrox

-

insulin A-chain

31276

EDTA

Crotalus atrox

-

inhibits proteolytic and hemorrhagic activities

668847

additional information

Crotalus atrox

-

synthetic peptide inhibitors with N-[1-(R,S)-3-dicarboxypropyl] moiety

31259

-

additional information

Crotalus atrox

-

no inhibition by aprotinin (insulin A-chain as substrate)

31276

-