3.4.24.44: atrolysin E

This is an abbreviated version!
For detailed information about atrolysin E, go to the full flat file.

Reaction

Cleavage of Asn3-/-Gln, Ser9-/-His and Ala14-/-Leu bonds in insulin B chain and Tyr14-/-Gln and Thr8-/-Ser in A chain. Cleaves type IV collagen at Ala73-/-Gln in alpha1(IV) and at Gly7-/-Leu in alpha2(IV) =

Synonyms

atrolysin E/D, Crotalus atrox metalloendopeptidase e, Hemorrhagic toxin e, HT-e

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.24 Metalloendopeptidases

                3.4.24.44 atrolysin E

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Results	in table
2	AA Sequence
1	Application
1	CAS Registry Number
3	Cloned(Commentary)
18	Inhibitors
14	Metals/Ions
11	Molecular Weight [Da]
2	Natural Substrates/ Products (Substrates)
6	Organism
4	PDB ID
2	pH Optimum
2	Posttranslational Modification
4	Purification (Commentary)
1	Reaction
1	Reaction Type
6	Reference
5	Source Tissue
43	Substrates and Products (Substrate)
4	Subunits
5	Synonyms
2	Temperature Optimum [°C]
5	Turnover Number [1/s]

Sequence

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Sequence on EC 3.4.24.44 - atrolysin E

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UNIPROT

ENTRY NAME

ORGANISM

NO. OF AA

NO. OF TRANSM. HELICES

MOLECULAR WEIGHT[Da]

SOURCE

SEQUENCE

LOCALIZATION PREDICTIONThe reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).

P34182 pBLAST

VM2AE_CROAT

Crotalus atrox

478

0

53638

Swiss-Prot

Show Sequence

Secretory Pathway (Reliability: 2)

O57413 pBLAST

VM2T3_PROMU

Protobothrops mucrosquamatus

481

0

54178

Swiss-Prot

Show Sequence

Secretory Pathway (Reliability: 1)

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