3.4.24.44: atrolysin E

This is an abbreviated version!
For detailed information about atrolysin E, go to the full flat file.

Reaction

Cleavage of Asn3-/-Gln, Ser9-/-His and Ala14-/-Leu bonds in insulin B chain and Tyr14-/-Gln and Thr8-/-Ser in A chain. Cleaves type IV collagen at Ala73-/-Gln in alpha1(IV) and at Gly7-/-Leu in alpha2(IV) =

Synonyms

atrolysin E/D, Crotalus atrox metalloendopeptidase e, Hemorrhagic toxin e, HT-e

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.24 Metalloendopeptidases

                3.4.24.44 atrolysin E

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Results	in table
2	AA Sequence
1	Application
1	CAS Registry Number
3	Cloned(Commentary)
18	Inhibitors
14	Metals/Ions
11	Molecular Weight [Da]
2	Natural Substrates/ Products (Substrates)
6	Organism
4	PDB ID
2	pH Optimum
2	Posttranslational Modification
4	Purification (Commentary)
1	Reaction
1	Reaction Type
6	Reference
5	Source Tissue
43	Substrates and Products (Substrate)
4	Subunits
5	Synonyms
2	Temperature Optimum [°C]
5	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 3.4.24.44 - atrolysin E

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

Basement membranes surrounding capillaries + H2O

?

2 entries

Basement membranes surrounding capillaries + H2O

?

Crotalus atrox

-

contributes to hemorrhagic property by weakening capillary walls, together with atrolysins B and C member of the class P-I hemorrhagic toxins

31259

-

-

?

Basement membranes surrounding capillaries + H2O

?

Crotalus atrox

-

together with hemorrhagic toxins a, b, c, d and f responsible for hemorrhage

31261

-

-

?