3.4.21.41: complement subcomponent C1r
This is an abbreviated version!
For detailed information about complement subcomponent C1r, go to the full flat file.
Word Map on EC 3.4.21.41
Reaction
Selective cleavage of Lys(or Arg)-/-Ile bond in complement subcomponent C1s to form C_overbar_1s_ (EC 3.4.21.42) =
Synonyms
activated complement C1r, C1r, C1r protease, C1r serine protease, C1r-LP, C1rbar-esterase, complement C1r subcomponent-like protein, complement C1r, activated, complement protease C1r, complement subcomponent 1r, CUB, multiprotein complex C1, proteases C1r, serine protease C1r, Xld, xolloid
ECTree
3.4.21.41 complement subcomponent C1rAdvanced search results
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results (Inhibitors
Inhibitors on EC 3.4.21.41 - complement subcomponent C1r
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INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
C1-inhibitor
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regulates the classical and the lectin complement pathway inhibiting complement components C1r and C1s, and MASP-2, factor XIa, Factor XIIa, and plasma kallikrein, mechanism, overview
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C1INH
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sole inhibitor of the activated proteases C1r and C1s. Hereditary angioedema results from functional deficiency of the C1 inhibitor (C1INH) protein, which plays a key role in the classical pathway of complement activation
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C1 inhibitor
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during complex formation, C1 inhibitor dissociates C1r and C1s from the activated C1 macromolecule, a process that is determined primarily by the interaction with C1r
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C1bar-inhibitor
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Ca2+ decreases the rate at which C1rbar complexes with C1bar-inhibitor. C1rbar-(C1bar-inhibitor) interaction is accelerated by heparin. Flufenamic acid inhibits the action of the inhibitor
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additional information
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above 0.0005 mM C1rbar the enzyme aggregates with loss of activity
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additional information
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specific c-Jun amino-terminal kinase inhibitor and the MEK-1 inhibitor PD98059 do not regulate C1r mRNA expression, whereas JSH-23, which inhibits nuclear translocation of NF-kappaB decreases C1r expression selectively in MEF-2 cells
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