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Literature summary for 3.4.21.41 extracted from

  • Gaultier, A.; Arandjelovic, S.; Niessen, S.; Overton, C.D.; Linton, M.F.; Fazio, S.; Campana, W.M.; Cravatt, B.F.; Gonias, S.L.
    Regulation of tumor necrosis factor receptor-1 and the IKK-NF-kappaB pathway by LDL receptor-related protein explains the antiinflammatory activity of this receptor (2008), Blood, 111, 5316-5325.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.41

Activating Compound

Activating Compound Comment Organism Structure
additional information regulation of C1r by low-density lipoprotein receptor-related protein 1 Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
additional information specific c-Jun amino-terminal kinase inhibitor and the MEK-1 inhibitor PD98059 do not regulate C1r mRNA expression, whereas JSH-23, which inhibits nuclear translocation of NF-kappaB decreases C1r expression selectively in MEF-2 cells Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
90000
-
 immunoblot analysis, in PEA-10 and B-41 cells, single-chain form, which is the zymogen Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MEF cell MEF-2 cell, low-density lipoprotein receptor-related protein 1-deficient macrophages show increased expression of C1r Mus musculus
-
additional information PEA-10 cell and B-41 cell Mus musculus
-
RAW-264.7 cell C1r mRNA expression is significantly increased in RAW 264.7 cells in which low-density lipoprotein receptor–related protein 1 is silenced Mus musculus
-

Synonyms

Synonyms Comment Organism
C1r
-
 Mus musculus