3.4.21.41: complement subcomponent C1r
This is an abbreviated version!
For detailed information about complement subcomponent C1r, go to the full flat file.
Reaction
Selective cleavage of Lys(or Arg)-/-Ile bond in complement subcomponent C1s to form C_overbar_1s_ (EC 3.4.21.42) =
Synonyms
activated complement C1r, C1r, C1r protease, C1r serine protease, C1r-LP, C1rbar-esterase, complement C1r subcomponent-like protein, complement C1r, activated, complement protease C1r, complement subcomponent 1r, CUB, multiprotein complex C1, proteases C1r, serine protease C1r, Xld, xolloid
ECTree
Advanced search results
KM Value
KM Value on EC 3.4.21.41 - complement subcomponent C1r
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
0.000022
zymogen C1s
pH 7.4, 37°C, substrate is a fragment consisting of complement control protein domains, CCP1 and CCP2, plus serine
-
additional information
-
activated C1r and its wild-type CCP1/2-SP and CCP2-SP fragments all cleave acetyl-Gly-Lys-methyl ester with KM-values ranging from 1.3 mM to 2.1 mM
-
additional information
additional information
-
KM-values of the C1r fragments with benzyloxycarbonyl-Lys-thiobenzyl ester or benzyloxycarbonyl-Gly-Arg-thiobenzyl ester as substrate
-
additional information
additional information
-
kinetic interaction anaylsis of the C1 complex and regulatory proteins, e.g. the C-reactive protein, overview
-
additional information
additional information
kinetics of activation of C1s and MASP-3 mutants, overview
-