Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-Nitrophenyl-4-guanidinobenzoate | - |
Homo sapiens | |
C1bar-inhibitor | irreversible | Homo sapiens | |
diisopropyl fluorophosphate | - |
Homo sapiens | |
leupeptin | competitive | Homo sapiens | |
NaCl | above 200 mM | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
20 | - |
acetyl-Gly-Lys methyl ester | - |
Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
85000 | - |
2 * 85000, the C1rbar subunits consist of one polypeptide chain of 56000 Da, A-chain, that is disulfide-linked to a 27000 Da B-chain, SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
complement component C1s | Homo sapiens | activates the proenzyme form of C1s by limited proteolysis | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | the proenzyme is C1r | Homo sapiens |
proteolytic modification | activation of the proenzyme C1r can be mimicked under certain conditions by digestion of C1r with trypsin or plasmin | Homo sapiens |
side-chain modification | C1rbar contains about 40 carbohydrate residues per molecule | Homo sapiens |
side-chain modification | the zymogen C1r is a glycoprotein | Homo sapiens |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-Arg methyl ester + H2O | - |
Homo sapiens | acetyl-Arg + methanol | - |
? | |
complement component C1s | activates the proenzyme form of C1s by limited proteolysis | Homo sapiens | ? | - |
? | |
complement component C1s + H2O | cleavage of a single Arg-Ile or Lys-Ile bond in C1s | Homo sapiens | complement component C1sbar | - |
? | |
N-acetyl-Gly-Lys methyl ester + H2O | - |
Homo sapiens | N-acetyl-Gly-Lys + methanol | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 85000, the C1rbar subunits consist of one polypeptide chain of 56000 Da, A-chain, that is disulfide-linked to a 27000 Da B-chain, SDS-PAGE | Homo sapiens |
More | on activation the single polypeptide chain of C1r is cleaved probably at a single position, the C1rbar subunits consist of 1 polypeptide chain of 56000 Da, A-chain, that is disulfide-linked to a 27000 Da B-chain | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | 8.5 | - |
Homo sapiens |