3.4.21.41: complement subcomponent C1r

This is an abbreviated version!
For detailed information about complement subcomponent C1r, go to the full flat file.

Word Map on EC 3.4.21.41

3.4.21.41

c1s

multimolecular

autoactivation

chordin

masp-1

ccp1

mannan-binding

collagen-like

c1s-c1r-c1r-c1s

angioedema

dorsoventral

mbl-associated

dorsal-ventral

medicine

Reaction

Selective cleavage of Lys(or Arg)-/-Ile bond in complement subcomponent C1s to form C_overbar_1s_ (EC 3.4.21.42) =

Synonyms

activated complement C1r, C1r, C1r protease, C1r serine protease, C1r-LP, C1rbar-esterase, complement C1r subcomponent-like protein, complement C1r, activated, complement protease C1r, complement subcomponent 1r, CUB, multiprotein complex C1, proteases C1r, serine protease C1r, Xld, xolloid

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.21 Serine endopeptidases

3.4.21.41 complement subcomponent C1r

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Results	in table
2	Activating Compound
958	AA Sequence
1	Application
1	CAS Registry Number
15	Cloned(Commentary)
5	Crystallization (Commentary)
9	Disease/ Diagnostics
2	Expression
10	General Information
2	General Stability
30	Inhibitors
2	kcat/KM [mM/s]
7	KM Value [mM]
4	Localization
4	Metals/Ions
9	Molecular Weight [Da]
14	Natural Substrates/ Products (Substrates)
46	Organism
16	PDB ID
4	pH Optimum
2	pI Value
17	Posttranslational Modification
21	Protein Variants
11	Purification (Commentary)
1	Reaction
1	Reaction Type
46	Reference
3	Renatured (Commentary)
30	Source Tissue
1	Storage Stability
45	Substrates and Products (Substrate)
17	Subunits
30	Synonyms
1	Temperature Optimum [°C]
3	Temperature Stability [°C]
5	Turnover Number [1/s]

Molecular Weight

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Molecular Weight on EC 3.4.21.41 - complement subcomponent C1r

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16600

gel filtration

790000

83000

2 * 83000, SDS-PAGE of reduced protein, gel filtration in 6 M guanidinium hydrochloride

81393

85000

Homo sapiens

2 * 85000, the C1rbar subunits consist of one polypeptide chain of 56000 Da, A-chain, that is disulfide-linked to a 27000 Da B-chain, SDS-PAGE

81395

88000

Homo sapiens

x * 88000, C1r zymogen, domain structure, overview

683195

90000

Mus musculus

immunoblot analysis, in PEA-10 and B-41 cells, single-chain form, which is the zymogen

696932

additional information

3 entries